Yvonne T van der Schouw

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc Low fertility and the risk of type 2 diabetes in women
    Clara C Elbers
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Hum Reprod 26:3472-8. 2011
  2. pmc Polymorphisms of the TUB gene are associated with body composition and eating behavior in middle-aged women
    Jana V van Vliet-Ostaptchouk
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 3:e1405. 2008
  3. pmc Age of mother and grandmother in relation to a subject's breast cancer risk
    M C de Haan
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Br J Cancer 102:1400-4. 2010
  4. pmc Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans
    Clara C Elbers
    Complex Genetics Section, Department of Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 4:e7070. 2009
  5. pmc Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study
    Cecile M Povel
    National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Cardiovasc Diabetol 11:133. 2012
  6. pmc Age at menopause, reproductive life span, and type 2 diabetes risk: results from the EPIC-InterAct study
    Judith S Brand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetes Care 36:1012-9. 2013
  7. ncbi Menopausal complaints, oestrogens, and heart disease risk: an explanation for discrepant findings on the benefits of post-menopausal hormone therapy
    Yvonne T van der Schouw
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Eur Heart J 26:1358-61. 2005
  8. ncbi Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western women
    Yvonne T van der Schouw
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, Netherlands
    Circulation 111:465-71. 2005
  9. ncbi The usual intake of lignans but not that of isoflavones may be related to cardiovascular risk factors in U.S. men
    Yvonne T van der Schouw
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Nutr 135:260-6. 2005
  10. doi PTPN1 polymorphisms are associated with total and low-density lipoprotein cholesterol
    Florianne Bauer
    Department of Medical Genetics DBG, Complex Genetics Section, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Cardiovasc Prev Rehabil 17:28-34. 2010

Detail Information

Publications79

  1. pmc Low fertility and the risk of type 2 diabetes in women
    Clara C Elbers
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Hum Reprod 26:3472-8. 2011
    ..Thus far, it is unknown whether low fertility is independently associated with future T2D risk...
  2. pmc Polymorphisms of the TUB gene are associated with body composition and eating behavior in middle-aged women
    Jana V van Vliet-Ostaptchouk
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 3:e1405. 2008
    ..Mutations in TUB cause late-onset obesity, insulin-resistance and neurosensory deficits in mice. An association of common variants in the TUB gene with body weight in humans has been reported...
  3. pmc Age of mother and grandmother in relation to a subject's breast cancer risk
    M C de Haan
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Br J Cancer 102:1400-4. 2010
    ..On theoretical grounds, the age of the grandmother and the age of the mother at delivery of her daughter may affect the breast cancer risk of the granddaughter...
  4. pmc Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans
    Clara C Elbers
    Complex Genetics Section, Department of Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 4:e7070. 2009
    ..This advantage could lie in overall health benefits, because lower carbohydrate intake, consuming meals with a low GI and GL, and/or higher alcohol consumption, are known to be associated with a lower risk of chronic diseases...
  5. pmc Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study
    Cecile M Povel
    National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Cardiovasc Diabetol 11:133. 2012
    ..Aim of this study is to investigate the association of single nucleotide polymorphisms (SNPs) involved in these mechanisms with MetS...
  6. pmc Age at menopause, reproductive life span, and type 2 diabetes risk: results from the EPIC-InterAct study
    Judith S Brand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetes Care 36:1012-9. 2013
    ..We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk...
  7. ncbi Menopausal complaints, oestrogens, and heart disease risk: an explanation for discrepant findings on the benefits of post-menopausal hormone therapy
    Yvonne T van der Schouw
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Eur Heart J 26:1358-61. 2005
    ..We suggest epidemiological approaches to test our hypothesis...
  8. ncbi Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western women
    Yvonne T van der Schouw
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, Netherlands
    Circulation 111:465-71. 2005
    ..We investigated whether habitual low phytoestrogen intake is associated with manifest cardiovascular disease risk...
  9. ncbi The usual intake of lignans but not that of isoflavones may be related to cardiovascular risk factors in U.S. men
    Yvonne T van der Schouw
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Nutr 135:260-6. 2005
    ..Diets high in lignan intake may increase apoB-containing lipoproteins and decrease fasting insulin secretion, but these findings require confirmation...
  10. doi PTPN1 polymorphisms are associated with total and low-density lipoprotein cholesterol
    Florianne Bauer
    Department of Medical Genetics DBG, Complex Genetics Section, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Cardiovasc Prev Rehabil 17:28-34. 2010
    ..Our aim was to investigate the association between single nucleotide polymorphisms (SNPs) of the PTPN1 gene and metabolic endophenotypes and insulin sensitivity...
  11. ncbi Relations between body composition, functional and hormonal parameters and quality of life in healthy postmenopausal women
    Corinne E I Lebrun
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands
    Maturitas 55:82-92. 2006
    ..To investigate whether body composition, functional status and serum hormone levels are associated with quality of life in healthy postmenopausal women...
  12. doi Reproductive factors, metabolic factors, and coronary artery calcification in older women
    Femke Atsma
    Department of Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Menopause 15:899-904. 2008
    ..This cohort study investigated the relationship between reproductive factors and coronary artery calcification in elderly women and whether this relationship could be explained by metabolic disturbances...
  13. doi Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?
    Marek K Brandys
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 153:695-9. 2010
    ..The percentages of BMI-increasing alleles were equal between cases and controls. This study found no evidence that genetic variants regulating BMI in the general population are significantly associated with susceptibility to AN...
  14. ncbi High dietary glycemic load and glycemic index increase risk of cardiovascular disease among middle-aged women: a population-based follow-up study
    Joline W J Beulens
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Coll Cardiol 50:14-21. 2007
    ..The goal of this work was to assess whether high dietary glycemic load and glycemic index are associated with an increased risk of cardiovascular disease (CVD)...
  15. doi No association of PTPN1 polymorphisms with macronutrient intake and measures of adiposity
    Florianne Bauer
    Complex Genetics Section, Department of Medical Genetics DBG, University Medical Center Utrecht, Utrecht, The Netherlands
    Obesity (Silver Spring) 16:2767-71. 2008
    ..Associations were studied using linear regression analysis. There were no statistically significant associations of SNPs in the PTPN1 gene with dietary phenotypes or measures of obesity...
  16. doi Vasomotor menopausal symptoms are associated with increased risk of coronary heart disease
    Gerrie Cor M Gast
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Menopause 18:146-51. 2011
    ..We investigated whether VMS are related to an increased risk of future coronary heart disease (CHD) and whether possible associations can be explained by CVD risk factors...
  17. ncbi Analysis of case-cohort data: a comparison of different methods
    N Charlotte Onland-Moret
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Epidemiol 60:350-5. 2007
    ..However, adaptation of the model is necessary because of the sampling. We compared three methods that were proposed in the literature, which differ in weighting of study subjects: Prentice's, Barlow's, and Self and Prentice's method...
  18. doi Vasomotor symptoms, estradiol levels and cardiovascular risk profile in women
    Gerrie Cor M Gast
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Maturitas 66:285-90. 2010
    ..Furthermore, we examined the association between estradiol levels and VMS, and whether an association between VMS and cardiovascular risk factors can be explained by estradiol levels...
  19. doi Lifetime endogenous estrogen exposure and electrocardiographic frontal T axis changes in postmenopausal women
    Femke Atsma
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Maturitas 63:347-51. 2009
    ..The aim of this study was to investigate the relation between reproductive factors and the electrocardiographic frontal T axis in postmenopausal women...
  20. doi Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: a randomized controlled trial
    Marielle H Emmelot-Vonk
    Department of Geriatric Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    JAMA 299:39-52. 2008
    ..Serum testosterone levels decline significantly with aging. Testosterone supplementation to older men might beneficially affect the aging processes...
  21. ncbi Heart disease risk determines menopausal age rather than the reverse
    Helen S Kok
    Julius Center for Health Sciences and Primary Care, Utrecht University, Utrecht, The Netherlands
    J Am Coll Cardiol 47:1976-83. 2006
    ..The purpose of this study was to investigate whether a harmful cardiovascular risk profile accelerates menopause...
  22. ncbi Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: a meta-analysis
    Femke Atsma
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Menopause 13:265-79. 2006
    ..The aim was to obtain valid estimates of the cardiovascular disease risk associated with postmenopausal status and early menopause...
  23. ncbi Age at menopause, cause-specific mortality and total life expectancy
    Marlies E Ossewaarde
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Epidemiology 16:556-62. 2005
    ..The net effect on mortality is unclear. We determined the association of age at menopause with longevity and with the balance between cardiovascular and cancer mortality...
  24. pmc Lifetime cumulative number of menstrual cycles and serum sex hormone levels in postmenopausal women
    Mariana Chavez-MacGregor
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Breast Cancer Res Treat 108:101-12. 2008
    ..Lifetime cumulative number of menstrual cycles is related to breast cancer risk. The aim of this study is to investigate the relation between this index and serum sex hormone levels in postmenopausal women...
  25. doi HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort
    Jana V van Vliet-Ostaptchouk
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Hum Genet 16:652-6. 2008
    ..These data provide evidence that variants near the HHEX gene contribute to the risk of T2D in a Dutch population...
  26. ncbi Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns
    Mariken de Krom
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Diabetes 56:276-80. 2007
    ..In conclusion, we identified common allelic variants specifically associated with distinctly different eating patterns, namely extreme snacking behavior or excessive portion size...
  27. ncbi Dietary phytoestrogen intake and cognitive function in older women
    Sanne Kreijkamp-Kaspers
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:556-62. 2007
    ..Aging is associated with a decline in cognitive function; we explored the possible influence of dietary phytoestrogens on this decline...
  28. doi Cigarette smoking and endogenous sex hormones in postmenopausal women
    Judith S Brand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 CA Utrecht, The Netherlands
    J Clin Endocrinol Metab 96:3184-92. 2011
    ..Sex hormones play a key role in women's health, but little is known about lifestyle factors that influence their levels...
  29. pmc Peroxisome proliferator-activated receptor gamma-2 P12A polymorphism and risk of acute myocardial infarction, coronary heart disease and ischemic stroke: a case-cohort study and meta-analyses
    Mohammad Hadi Zafarmand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, Str 6 131, 3584 CX, Utrecht, The Netherlands
    Vasc Health Risk Manag 4:427-36. 2008
    ..Yet, the risk relation has not been confirmed, and data on ischemic stroke (IS) is scarce. We therefore investigated the role of this polymorphism on occurrence of AMI, coronary heart disease (CHD) and IS...
  30. doi Soy protein containing isoflavones and mammographic density in a randomized controlled trial in postmenopausal women
    Martijn Verheus
    Julius Center for Health Sciences and Primary Care, University Medical Center, Room Str 6 131, P O Box 85500, Utrecht 3508 GA, Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 17:2632-8. 2008
    ..The aim of the present study was to determine the effect of daily soy supplementation on mammographic density, one of the strongest known risk factors for breast cancer...
  31. ncbi Alcohol and endogenous sex steroid levels in postmenopausal women: a cross-sectional study
    N Charlotte Onland-Moret
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Endocrinol Metab 90:1414-9. 2005
    ..This finding supports the hypothesis that alcohol use may increase breast cancer risk at least partially through an effect on sex steroid levels...
  32. ncbi Using genome-wide pathway analysis to unravel the etiology of complex diseases
    Clara C Elbers
    Department of Biomedical Genetics, University Medical Center Utrecht, The Netherlands
    Genet Epidemiol 33:419-31. 2009
    ..However, the limitations discussed in this study, need to be addressed before these methods can be widely used...
  33. ncbi Alcohol consumption in relation to aortic stiffness and aortic wave reflections: a cross-sectional study in healthy postmenopausal women
    Aafje Sierksma
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 24:342-8. 2004
    ..Moderate alcohol consumption has been postulated to be cardioprotective. Such an effect might be reflected in large-artery properties, such as arterial stiffness and wave reflections...
  34. doi Association between physical performance characteristics and independence in activities of daily living in middle-aged and elderly men
    Marjolein E M den Ouden
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Geriatr Gerontol Int 13:274-80. 2013
    ..This study investigated the association between physical performance characteristics and functioning independently in middle-aged and elderly men...
  35. doi Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference
    Florianne Bauer
    Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands
    Am J Clin Nutr 90:951-9. 2009
    ..New genetic loci, most of which are expressed in the brain, have recently been reported to contribute to the development of obesity. The brain, especially the hypothalamus, is strongly involved in regulating weight and food intake...
  36. doi Hormone therapy and coronary heart disease risk by vasomotor menopausal symptoms
    Gerrie Cor M Gast
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Maturitas 70:373-8. 2011
    ..We examined whether the association between hormone therapy (HT) use and coronary heart disease (CHD) risk differed between women with and without vasomotor symptoms (VMS)...
  37. ncbi Serum ferritin is a risk factor for stroke in postmenopausal women
    Daphne L van der A
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, HP Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Stroke 36:1637-41. 2005
    ..Iron is an essential element for the human body. It has, however, been suggested that excessive iron stores may increase the risk of vascular disease. So far, epidemiologic studies on stroke are sparse...
  38. ncbi Dietary phytoestrogens and plasma lipids in Dutch postmenopausal women; a cross-sectional study
    Sanne Kreijkamp-Kaspers
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500 Room D 01 335 Utrecht, GA3508 The Netherlands
    Atherosclerosis 178:95-100. 2005
    ..Little is known about the effects of intake within the range of western diets on these endpoints. Design: We conducted a population-based cross-sectional study in 301 women aged 60-75 years...
  39. ncbi Higher dietary intake of lignans is associated with better cognitive performance in postmenopausal women
    Oscar H Franco
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    J Nutr 135:1190-5. 2005
    ..02 (1.11-3.71)]. Isoflavone intake was not related to cognitive function. From our results we conclude that higher dietary intake of lignans is associated with better cognitive function in postmenopausal women...
  40. ncbi Association of endogenous sex hormone with C-reactive protein levels in middle-aged and elderly men
    Hamid Reza Nakhai Pour
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Clin Endocrinol (Oxf) 66:394-8. 2007
    ..Whether endogenous sex hormone levels in men are also related to systemic subclinical inflammation is still unknown...
  41. doi The M235T variant of the angiotensinogen gene is related to development of self-reported hypertension during pregnancy: the Prospect-EPIC cohort study
    Mohammad Hadi Zafarmand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, Str 6 131, 3584 CX, Utrecht, The Netherlands
    Hypertens Res 31:1299-305. 2008
    ..The findings of this study among Caucasian Dutch women, aged 49 to 70 years, demonstrated that the presence of the T allele of the M235T polymorphism in the AGT is associated with self-reported hypertensive disorders in pregnancy...
  42. doi Parental history of type 2 diabetes and cardiometabolic biomarkers in offspring
    Ali Abbasi
    Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Clin Invest 42:974-82. 2012
    ..We aimed to investigate the associations of parental history of T2D with cardiometabolic biomarkers and to subsequently investigate to what extent these putative associations were explained by modifiable factors...
  43. ncbi C-reactive protein is independently associated with glucose but not with insulin resistance in healthy men
    Anne G Niehoff
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetes Care 30:1627-9. 2007
  44. ncbi Intake of dietary phytoestrogens by Dutch women
    Lital Keinan Boker
    The Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, 3508 GA, Utrecht, The Netherlands
    J Nutr 132:1319-28. 2002
    ..In this population, phytoestrogen intake consisted largely of lignans...
  45. pmc Dietary fiber, carbohydrate quality and quantity, and mortality risk of individuals with diabetes mellitus
    Koert N J Burger
    University Medical Center, Utrecht, The Netherlands
    PLoS ONE 7:e43127. 2012
    ..Dietary fiber, carbohydrate quality and quantity are associated with mortality risk in the general population. Whether this is also the case among diabetes patients is unknown...
  46. doi Vascular status and physical functioning: the association between vascular status and physical functioning in middle-aged and elderly men: a cross-sectional study
    Ilse E M A Arts
    Faculty Chair Care for the Chronically Ill and Elderly, Hogeschool Utrecht, Utrecht, The Netherlands
    Eur J Cardiovasc Prev Rehabil 17:211-6. 2010
    ..The aim of this study was to investigate the association of vascular status with muscle strength and physical functioning in middle aged and elderly men...
  47. doi Dietary patterns and the risk of type 2 diabetes in overweight and obese individuals
    Florianne Bauer
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Mailbox STR 6 131, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Eur J Nutr 52:1127-34. 2013
    ..In this paper, we aim to clarify the role of dietary patterns in the development of type 2 diabetes in overweight and obese individuals...
  48. doi Change in abdominal obesity and risk of coronary calcification
    Siamak Sabour
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Epidemiol Community Health 65:287-8. 2011
    ..A prospective follow-up study was conducted to examine the relationship between 9 year change in abdominal obesity and risk of coronary artery calcification (CAC)...
  49. ncbi Randomized controlled trial of the effects of soy protein containing isoflavones on vascular function in postmenopausal women
    Sanne Kreijkamp-Kaspers
    The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands
    Am J Clin Nutr 81:189-95. 2005
    ..The incidence of cardiovascular disease increases after menopause, possibly because of the decline in estrogen. Soy protein, a rich source of estrogen-like isoflavones, is hypothesized to improve vascular function...
  50. doi Vasomotor symptoms are associated with a lower bone mineral density
    Gerrie Cor M Gast
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Menopause 16:231-8. 2009
    ..The severity of vasomotor symptoms has been hypothesized to be linked to a lower bone mineral density (BMD). We examined whether women with vasomotor symptoms are different from women without symptoms with regard to BMD...
  51. doi Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes
    Annet F M van Abeelen
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Eur J Endocrinol 158:669-76. 2008
    ..Single nucleotide polymorphisms (SNPs) in UCP-3 might result in a reduced function or expression of UCP-3 and therefore lead to an increased capacity to store energy as fat...
  52. ncbi Effects of dehydroepiandrosterone and atamestane supplementation on frailty in elderly men
    Majon Muller
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Stratenum 6 131, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Endocrinol Metab 91:3988-91. 2006
    ..Therefore, hormone replacement might improve the course of frailty by increasing lean body mass and muscle strength, decreasing fat mass, and improving the subjective quality of life...
  53. ncbi Fat mass rather than muscle strength is the major determinant of physical function and disability in postmenopausal women younger than 75 years of age
    Corinne E I Lebrun
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Menopause 13:474-81. 2006
    ..We investigated the relative role of fat mass, lean mass, and muscle strength in the development of disability in a group of healthy postmenopausal women younger than 75 years...
  54. ncbi Arterial stiffness in postmenopausal women: determinants of pulse wave velocity
    Corinne E I Lebrun
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht and Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Hypertens 20:2165-72. 2002
    ..Increased PWV marks an increased risk of stroke, coronary heart disease, and death within 10-12 years...
  55. ncbi No association of estrogen receptor alpha and cytochrome P450c17alpha polymorphisms with age at menopause in a Dutch cohort
    Helen S Kok
    Julius Center for Health Sciences and Primary Care, Department of Medical Genetics, University Medical Center Utrecht, The Netherlands
    Hum Reprod 20:536-42. 2005
    ..This study aims to investigate whether PvuII, XbaI and B-variant polymorphisms of the ERalpha gene, and the MspAI polymorphism of the cytochrome P450c17alpha (CYP17) gene are associated with age at menopause in a Dutch cohort...
  56. ncbi Dietary phytoestrogens and breast cancer risk
    Lital Keinan-Boker
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Netherlands
    Am J Clin Nutr 79:282-8. 2004
    ..A high intake of phytoestrogens, particularly isoflavones, has been suggested to decrease breast cancer risk. Results from human studies are inconclusive...
  57. ncbi Soy isoflavones, body composition, and physical performance
    Linda Kok
    The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Maturitas 52:102-10. 2005
    ..Decline in estradiol levels after menopause is hypothesized to contribute to this risk. Thus, hormone therapy (HT) might prevent or delay those changes. However, HT has serious side effects and alternative approaches are needed...
  58. ncbi Non-transferrin-bound iron and risk of coronary heart disease in postmenopausal women
    Daphne L van der A
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Circulation 113:1942-9. 2006
    ..We hypothesized that a labile iron component associated with non-transferrin-bound iron (NTBI) that appears in individuals with overt or cryptic iron overload might be more suitable for establishing correlations with CHD...
  59. doi Testosterone, SHBG and differential white blood cell count in middle-aged and older men
    Judith S Brand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Maturitas 71:274-8. 2012
    ..We examined the associations between endogenous testosterone, SHBG and total and differential white blood cell (WBC) counts in men...
  60. doi Genes involved in initial follicle recruitment may be associated with age at menopause
    Marlies Voorhuis
    Department of Reproductive Medicine and Gynecology, University Medical Center, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Endocrinol Metab 96:E473-9. 2011
    ..Because menopause occurs when the follicle pool in the ovaries has become exhausted, genes involved in primordial follicle recruitment can be considered as candidate genes for timing of menopause...
  61. doi Pulse pressure amplification and risk of cardiovascular disease
    Marie Elise Nijdam
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Hypertens 21:388-92. 2008
    ..The purpose of this study was to investigate the relationship between PPA and cardiovascular risk factors and cardiovascular risk in a population-based sample of 40- to 80-year old men...
  62. ncbi Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial
    Sanne Kreijkamp-Kaspers
    The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    JAMA 292:65-74. 2004
    ..Isoflavones, estrogenlike compounds naturally occurring in plant foods, might confer positive effects with fewer adverse effects...
  63. doi Paraoxonase (PON1) and the risk for coronary heart disease and myocardial infarction in a general population of Dutch women
    Thomas M van Himbergen
    Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Atherosclerosis 199:408-14. 2008
    ..3-69.5, P < 0.0001, multivariate model). In conclusion, this study shows that in middle-aged women paraoxonase activity was associated with an increased risk for AMI and that the risk was modified by the effects of smoking...
  64. doi High dietary menaquinone intake is associated with reduced coronary calcification
    Joline W J Beulens
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Atherosclerosis 203:489-93. 2009
    ..This may be due to different effects of vitamin K(1) (phylloquinone) and vitamin K(2) (menaquinone, MK), but few studies included both...
  65. ncbi Dietary phytoestrogens and vascular function in postmenopausal women: a cross-sectional study
    Sanne Kreijkamp-Kaspers
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Hypertens 22:1381-8. 2004
    ..To investigate the effects of low levels of intake of phytoestrogens in Western habitual diet on vascular function...
  66. pmc No relationship between circulating levels of sex steroids and mammographic breast density: the Prospect-EPIC cohort
    Martijn Verheus
    Julius Center for Health Sciences and Primary Care, Room Str 6, 131, PO Box 85500, University Medical Center Utrecht, Utrecht 3508 GA, The Netherlands
    Breast Cancer Res 9:R53. 2007
    ..The objective of the present study was to study the relation between circulating oestrogens and androgens as well as sex hormone binding globulin (SHBG) in relation to breast density...
  67. ncbi Elevated blood pressure and electrocardiographic frontal T axis and spatial QRS-T angle changes in postmenopausal women
    Femke Atsma
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Electrocardiol 41:360-4. 2008
    ..We determined whether increased blood pressure is a risk factor for changes in these parameters in postmenopausal women free of left ventricular hypertrophy...
  68. ncbi Current smoking at menopause rather than duration determines the onset of natural menopause
    Kristel M van Asselt
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Epidemiology 15:634-9. 2004
    ..A major problem in analyzing the effect of smoking duration on menopausal age is that both exposure and outcome are age-dependent...
  69. ncbi Use of hormones in the menopausal transition period in the Netherlands between 1993 and 1997
    Franzel J B van Duijnhoven
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Maturitas 53:462-75. 2006
    ..To describe the patterns and to assess the indicators of hormone use during the menopausal transition period in a Dutch population...
  70. ncbi No added value of age at menopause and the lifetime cumulative number of menstrual cycles for cardiovascular risk prediction in postmenopausal women
    Femke Atsma
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Int J Cardiol 130:190-5. 2008
    ..The aim of the present study was to investigate the added value of age at menopause and the lifetime cumulative number of menstrual cycles in cardiovascular risk prediction in postmenopausal women...
  71. pmc The M235T polymorphism in the AGT gene and CHD risk: evidence of a Hardy-Weinberg equilibrium violation and publication bias in a meta-analysis
    Mohammad Hadi Zafarmand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 3:e2533. 2008
    ..The M235T polymorphism in the AGT gene has been related to an increased risk of hypertension. This finding may also suggest an increased risk of coronary heart disease (CHD)...
  72. ncbi Higher usual dietary intake of phytoestrogens is associated with lower aortic stiffness in postmenopausal women
    Yvonne T van der Schouw
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 22:1316-22. 2002
    ..Phytoestrogens have been postulated to protect against cardiovascular diseases, but few studies have focused on the effect of Western dietary phytoestrogen intake...
  73. doi Menopausal complaints are associated with cardiovascular risk factors
    Gerrie Cor M Gast
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Hypertension 51:1492-8. 2008
    ..These findings substantiate the view that differences in the presence of menopausal symptoms as a reason for using hormone therapy could explain discrepant findings between observational research and trials...
  74. ncbi Endogenous sex hormones and metabolic syndrome in aging men
    Majon Muller
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, Room D 01 335, 3508 GA Utrecht, The Netherlands
    J Clin Endocrinol Metab 90:2618-23. 2005
    ..Sex hormone levels in men change during aging. These changes may be associated with insulin sensitivity and the metabolic syndrome...
  75. doi Carbohydrate quantity and quality and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition-Netherlands (EPIC-NL) study
    Ivonne Sluijs
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
    Am J Clin Nutr 92:905-11. 2010
    ..Carbohydrate quantity and quality may play an important role in the development of type 2 diabetes...
  76. doi Menstrual cycle characteristics and risk of coronary heart disease and type 2 diabetes
    Gerrie Cor M Gast
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Fertil Steril 94:2379-81. 2010
    ..This association could not be explained by metabolic risk factors or altered hormone levels...
  77. ncbi Factor V Leiden mutation accelerates the onset of natural menopause
    Kristel M van Asselt
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Menopause 10:477-81. 2003
    ..Several lifestyle factors have been investigated, but never factors of the clotting cascade. The objective of this study, then, was to determine the effect of factor V Leiden mutation and smoking with respect to age at menopause...
  78. ncbi Indicators for the total duration of premenopausal endogenous estrogen exposure in relation to BMD
    Maria L C Hagemans
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room D 01 335, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Hum Reprod 19:2163-9. 2004
    ..The present study investigates whether combining more information on reproductive factors is useful in estimating individual total duration of exposure to endogenous estrogens...
  79. ncbi Best reproducibility of the ankle-arm index was calculated using Doppler and dividing highest ankle pressure by highest arm pressure
    Femke Atsma
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Clin Epidemiol 58:1282-8. 2005
    ..To investigate which method of ankle-arm index (AAI) measurement in terms of selected arteries and blood pressure devices yields the highest reproducibility...