Research Topics
Genomes and Genes
Species | Yvonne T van der SchouwSummaryAffiliation: University Medical Center Utrecht Country: The Netherlands Publications
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Detail Information
Publications
Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western womenYvonne T van der Schouw
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, Netherlands
Circulation 111:465-71. 2005..We investigated whether habitual low phytoestrogen intake is associated with manifest cardiovascular disease risk...- Menopausal complaints, oestrogens, and heart disease risk: an explanation for discrepant findings on the benefits of post-menopausal hormone therapyYvonne T van der Schouw
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
Eur Heart J 26:1358-61. 2005..We suggest epidemiological approaches to test our hypothesis... - The usual intake of lignans but not that of isoflavones may be related to cardiovascular risk factors in U.S. menYvonne T van der Schouw
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
J Nutr 135:260-6. 2005..Diets high in lignan intake may increase apoB-containing lipoproteins and decrease fasting insulin secretion, but these findings require confirmation... - PTPN1 polymorphisms are associated with total and low-density lipoprotein cholesterolFlorianne Bauer
Department of Medical Genetics DBG, Complex Genetics Section, University Medical Center Utrecht, Utrecht, The Netherlands
Eur J Cardiovasc Prev Rehabil 17:28-34. 2010..Our aim was to investigate the association between single nucleotide polymorphisms (SNPs) of the PTPN1 gene and metabolic endophenotypes and insulin sensitivity... - Relations between body composition, functional and hormonal parameters and quality of life in healthy postmenopausal womenCorinne E I Lebrun
Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands; Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands
Maturitas 55:82-92. 2006..Our results suggest that in elderly and late postmenopausal women hormonal factors do not predict quality of life... - Reproductive factors, metabolic factors, and coronary artery calcification in older womenFemke Atsma
Department of Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Menopause 15:899-904. 2008..This cohort study investigated the relationship between reproductive factors and coronary artery calcification in elderly women and whether this relationship could be explained by metabolic disturbances... - Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?Marek K Brandys
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands
Am J Med Genet B Neuropsychiatr Genet 153:695-9. 2010..The percentages of BMI-increasing alleles were equal between cases and controls. This study found no evidence that genetic variants regulating BMI in the general population are significantly associated with susceptibility to AN... - Vasomotor menopausal symptoms are associated with increased risk of coronary heart diseaseGerrie Cor M Gast
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Menopause 18:146-51. 2011..We investigated whether VMS are related to an increased risk of future coronary heart disease (CHD) and whether possible associations can be explained by CVD risk factors... - No association of PTPN1 polymorphisms with macronutrient intake and measures of adiposityFlorianne Bauer
Complex Genetics Section, Department of Medical Genetics DBG, University Medical Center Utrecht, Utrecht, The Netherlands
Obesity (Silver Spring) 16:2767-71. 2008..Associations were studied using linear regression analysis. There were no statistically significant associations of SNPs in the PTPN1 gene with dietary phenotypes or measures of obesity... - Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: a randomized controlled trialMarielle H Emmelot-Vonk
Department of Geriatric Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
JAMA 299:39-52. 2008..Serum testosterone levels decline significantly with aging. Testosterone supplementation to older men might beneficially affect the aging processes... - High dietary glycemic load and glycemic index increase risk of cardiovascular disease among middle-aged women: a population-based follow-up studyJoline W J Beulens
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
J Am Coll Cardiol 50:14-21. 2007..The goal of this work was to assess whether high dietary glycemic load and glycemic index are associated with an increased risk of cardiovascular disease (CVD)... - Vasomotor symptoms, estradiol levels and cardiovascular risk profile in womenGerrie Cor M Gast
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Maturitas 66:285-90. 2010..Furthermore, we examined the association between estradiol levels and VMS, and whether an association between VMS and cardiovascular risk factors can be explained by estradiol levels... - Lifetime endogenous estrogen exposure and electrocardiographic frontal T axis changes in postmenopausal womenFemke Atsma
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Maturitas 63:347-51. 2009..The aim of this study was to investigate the relation between reproductive factors and the electrocardiographic frontal T axis in postmenopausal women... - Analysis of case-cohort data: a comparison of different methodsN Charlotte Onland Moret
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
J Clin Epidemiol 60:350-5. 2007..However, adaptation of the model is necessary because of the sampling. We compared three methods that were proposed in the literature, which differ in weighting of study subjects: Prentice's, Barlow's, and Self and Prentice's method... - Age at menopause, cause-specific mortality and total life expectancyMarlies E Ossewaarde
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Epidemiology 16:556-62. 2005..In particular, ischemic heart disease mortality is 2% lower. Although the risk of death from uterine or ovarian cancer is increased by 5%, the net effect of a later menopause is an increased lifespan... - Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: a meta-analysisFemke Atsma
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Menopause 13:265-79. 2006..However, there was a modest effect of early menopause on cardiovascular disease. The effect was more pronounced for women with an artificial menopause than for women with a natural menopause... - Lifetime cumulative number of menstrual cycles and serum sex hormone levels in postmenopausal womenMariana Chavez-MacGregor
Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
Breast Cancer Res Treat 108:101-12. 2008..Lifetime cumulative number of menstrual cycles is related to breast cancer risk. The aim of this study is to investigate the relation between this index and serum sex hormone levels in postmenopausal women... - Peroxisome proliferator-activated receptor gamma-2 P12A polymorphism and risk of acute myocardial infarction, coronary heart disease and ischemic stroke: a case-cohort study and meta-analysesMohammad Hadi Zafarmand
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, Str 6 131, 3584 CX, Utrecht, The Netherlands
Vasc Health Risk Manag 4:427-36. 2008..Yet, the risk relation has not been confirmed, and data on ischemic stroke (IS) is scarce. We therefore investigated the role of this polymorphism on occurrence of AMI, coronary heart disease (CHD) and IS... - Heart disease risk determines menopausal age rather than the reverseHelen S Kok
Julius Center for Health Sciences and Primary Care, Utrecht University, Utrecht, The Netherlands
J Am Coll Cardiol 47:1976-83. 2006..This offers a novel explanation for the inconsistent findings on cardiovascular disease rate and its relationship to menopausal age and effects of hormone replacement therapy... - Soy protein containing isoflavones and mammographic density in a randomized controlled trial in postmenopausal womenMartijn Verheus
Julius Center for Health Sciences and Primary Care, University Medical Center, Room Str 6 131, P O Box 85500, Utrecht 3508 GA, Utrecht, The Netherlands
Cancer Epidemiol Biomarkers Prev 17:2632-8. 2008..The aim of the present study was to determine the effect of daily soy supplementation on mammographic density, one of the strongest known risk factors for breast cancer... - Alcohol and endogenous sex steroid levels in postmenopausal women: a cross-sectional studyN Charlotte Onland-Moret
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room: Str. 6.131, P.O. Box 85500, 3508 GA Utrecht, The Netherlands
J Clin Endocrinol Metab 90:1414-9. 2005..This finding supports the hypothesis that alcohol use may increase breast cancer risk at least partially through an effect on sex steroid levels... - Cigarette smoking and endogenous sex hormones in postmenopausal womenJudith S Brand
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 CA Utrecht, The Netherlands
J Clin Endocrinol Metab 96:3184-92. 2011..Sex hormones play a key role in women's health, but little is known about lifestyle factors that influence their levels... - Hormone therapy and coronary heart disease risk by vasomotor menopausal symptomsGerrie Cor M Gast
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands Department of Obstetrics and Gynaecology, Lund University Hospital, Lund, Sweden
Maturitas 70:373-8. 2011..We examined whether the association between hormone therapy (HT) use and coronary heart disease (CHD) risk differed between women with and without vasomotor symptoms (VMS)... - Dietary phytoestrogen intake and cognitive function in older womenSanne Kreijkamp Kaspers
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
J Gerontol A Biol Sci Med Sci 62:556-62. 2007..Aging is associated with a decline in cognitive function; we explored the possible influence of dietary phytoestrogens on this decline... - The M235T variant of the angiotensinogen gene is related to development of self-reported hypertension during pregnancy: the Prospect-EPIC cohort studyMohammad Hadi Zafarmand
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, Str 6 131, 3584 CX, Utrecht, The Netherlands
Hypertens Res 31:1299-305. 2008..The findings of this study among Caucasian Dutch women, aged 49 to 70 years, demonstrated that the presence of the T allele of the M235T polymorphism in the AGT is associated with self-reported hypertensive disorders in pregnancy... - Association of endogenous sex hormone with C-reactive protein levels in middle-aged and elderly menHamid Reza Nakhai Pour
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
Clin Endocrinol (Oxf) 66:394-8. 2007..Whether endogenous sex hormone levels in men are also related to systemic subclinical inflammation is still unknown... - Serum ferritin is a risk factor for stroke in postmenopausal womenDaphne L van der A
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, HP Str 6.131, PO Box 85500, 3508 GA Utrecht, The Netherlands
Stroke 36:1637-41. 2005..CONCLUSIONS: Neither serum iron nor transferrin saturation was associated with an increased stroke risk. However, higher serum ferritin concentrations in postmenopausal women are associated with an increased risk of ischemic stroke... - Dietary phytoestrogens and plasma lipids in Dutch postmenopausal women; a cross-sectional studySanne Kreijkamp-Kaspers
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500 Room D 01.335 Utrecht, GA3508 The Netherlands
Atherosclerosis 178:95-100. 2005..It is premature to advise postmenopausal women with low phytoestrogen intake to change their diet towards a phytoestrogen rich diet with the sole aim to prevent cardiovascular disease... - Higher dietary intake of lignans is associated with better cognitive performance in postmenopausal womenOscar H Franco
Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
J Nutr 135:1190-5. 2005..02 (1.11-3.71)]. Isoflavone intake was not related to cognitive function. From our results we conclude that higher dietary intake of lignans is associated with better cognitive function in postmenopausal women... - Change in abdominal obesity and risk of coronary calcificationSiamak Sabour
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
J Epidemiol Community Health 65:287-8. 2011..A prospective follow-up study was conducted to examine the relationship between 9 year change in abdominal obesity and risk of coronary artery calcification (CAC)... - Fat mass rather than muscle strength is the major determinant of physical function and disability in postmenopausal women younger than 75 years of ageCorinne E I Lebrun
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Menopause 13:474-81. 2006..CONCLUSIONS: Our results support the role of fat mass as the primary risk marker for disability, which might later accelerate by the age-related decrease in lean mass and the development of sarcopenia after the age of 75 years... - Randomized controlled trial of the effects of soy protein containing isoflavones on vascular function in postmenopausal womenSanne Kreijkamp-Kaspers
The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands
Am J Clin Nutr 81:189-95. 2005..Whether certain subgroups of women (eg, equol producers) do benefit from the intervention remains to be elucidated... - Vasomotor symptoms are associated with a lower bone mineral densityGerrie Cor M Gast
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Menopause 16:231-8. 2009..The severity of vasomotor symptoms has been hypothesized to be linked to a lower bone mineral density (BMD). We examined whether women with vasomotor symptoms are different from women without symptoms with regard to BMD... - Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preferenceFlorianne Bauer
Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands
Am J Clin Nutr 90:951-9. 2009..New genetic loci, most of which are expressed in the brain, have recently been reported to contribute to the development of obesity. The brain, especially the hypothalamus, is strongly involved in regulating weight and food intake... - Non-transferrin-bound iron and risk of coronary heart disease in postmenopausal womenDaphne L van der A
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Circulation 113:1942-9. 2006..CONCLUSIONS: Our results show no excess risk of CHD or AMI within the highest NTBI tertile compared with the lowest but rather seem to demonstrate a decreased risk. Additional studies are warranted to confirm our findings... - Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patternsMariken de Krom
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
Diabetes 56:276-80. 2007..In conclusion, we identified common allelic variants specifically associated with distinctly different eating patterns, namely extreme snacking behavior or excessive portion size... - Effects of dehydroepiandrosterone and atamestane supplementation on frailty in elderly menMajon Muller
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Stratenum 6.131, P.O. Box 85500, 3508 GA Utrecht, The Netherlands
J Clin Endocrinol Metab 91:3988-91. 2006..CONCLUSIONS: The results of this double-blind, randomized trial do not support the hypothesis that hormone replacement with DHEA and/or atamestane might improve the course of frailty... - Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypesAnnet F M van Abeelen
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
Eur J Endocrinol 158:669-76. 2008..Single nucleotide polymorphisms (SNPs) in UCP-3 might result in a reduced function or expression of UCP-3 and therefore lead to an increased capacity to store energy as fat... - Testosterone, SHBG and differential white blood cell count in middle-aged and older menJudith S Brand
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
Maturitas 71:274-8. 2012..We examined the associations between endogenous testosterone, SHBG and total and differential white blood cell (WBC) counts in men... - Using genome-wide pathway analysis to unravel the etiology of complex diseasesClara C Elbers
Department of Biomedical Genetics, University Medical Center Utrecht, The Netherlands
Genet Epidemiol 33:419-31. 2009..However, the limitations discussed in this study, need to be addressed before these methods can be widely used... - High dietary menaquinone intake is associated with reduced coronary calcificationJoline W J Beulens
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
Atherosclerosis 203:489-93. 2009..This may be due to different effects of vitamin K(1) (phylloquinone) and vitamin K(2) (menaquinone, MK), but few studies included both... - Genes involved in initial follicle recruitment may be associated with age at menopauseMarlies Voorhuis
Department of Reproductive Medicine and Gynecology, University Medical Center, P O Box 85500, 3508 GA Utrecht, The Netherlands
J Clin Endocrinol Metab 96:E473-9. 2011..Because menopause occurs when the follicle pool in the ovaries has become exhausted, genes involved in primordial follicle recruitment can be considered as candidate genes for timing of menopause... - Alcohol consumption in relation to aortic stiffness and aortic wave reflections: a cross-sectional study in healthy postmenopausal womenAafje Sierksma
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Arterioscler Thromb Vasc Biol 24:342-8. 2004..This supports the presence of a decreased risk of cardiovascular disease with moderate alcohol consumption, which may be mediated in part by HDL cholesterol... - Dietary phytoestrogens and vascular function in postmenopausal women: a cross-sectional studySanne Kreijkamp-Kaspers
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
J Hypertens 22:1381-8. 2004..41, 95% confidence interval = 0.22-0.76, P for trend over tertiles = 0.004). CONCLUSION: The results of this study suggest a protective effect of dietary lignan intake on blood pressure and hypertension, even at low levels... - Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trialSanne Kreijkamp-Kaspers
The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
JAMA 292:65-74. 2004.... - Paraoxonase (PON1) and the risk for coronary heart disease and myocardial infarction in a general population of Dutch womenThomas M van Himbergen
Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
Atherosclerosis 199:408-14. 2008..3-69.5, P < 0.0001, multivariate model). In conclusion, this study shows that in middle-aged women paraoxonase activity was associated with an increased risk for AMI and that the risk was modified by the effects of smoking... - Pulse pressure amplification and risk of cardiovascular diseaseMarie Elise Nijdam
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Am J Hypertens 21:388-92. 2008..The purpose of this study was to investigate the relationship between PPA and cardiovascular risk factors and cardiovascular risk in a population-based sample of 40- to 80-year old men... - No added value of age at menopause and the lifetime cumulative number of menstrual cycles for cardiovascular risk prediction in postmenopausal womenFemke Atsma
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Int J Cardiol 130:190-5. 2008..The aim of the present study was to investigate the added value of age at menopause and the lifetime cumulative number of menstrual cycles in cardiovascular risk prediction in postmenopausal women... - Best reproducibility of the ankle-arm index was calculated using Doppler and dividing highest ankle pressure by highest arm pressureFemke Atsma
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
J Clin Epidemiol 58:1282-8. 2005..The AAI should be calculated for each foot separately by dividing the highest ankle SBP by the highest arm SBP... - Arterial stiffness in postmenopausal women: determinants of pulse wave velocityCorinne E I Lebrun
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht and Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
J Hypertens 20:2165-72. 2002..Increased PWV marks an increased risk of stroke, coronary heart disease, and death within 10-12 years... - C-reactive protein is independently associated with glucose but not with insulin resistance in healthy menAnne G Niehoff
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Diabetes Care 30:1627-9. 2007 - Factor V Leiden mutation accelerates the onset of natural menopauseKristel M van Asselt
Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
Menopause 10:477-81. 2003..Several lifestyle factors have been investigated, but never factors of the clotting cascade. The objective of this study, then, was to determine the effect of factor V Leiden mutation and smoking with respect to age at menopause... - Carbohydrate quantity and quality and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition-Netherlands (EPIC-NL) studyIvonne Sluijs
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
Am J Clin Nutr 92:905-11. 2010..Carbohydrate quantity and quality may play an important role in the development of type 2 diabetes... - Menstrual cycle characteristics and risk of coronary heart disease and type 2 diabetesGerrie Cor M Gast
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Fertil Steril 94:2379-81. 2010..This association could not be explained by metabolic risk factors or altered hormone levels... - Current smoking at menopause rather than duration determines the onset of natural menopauseKristel M van Asselt
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
Epidemiology 15:634-9. 2004..A major problem in analyzing the effect of smoking duration on menopausal age is that both exposure and outcome are age-dependent... - Menopausal complaints are associated with cardiovascular risk factorsGerrie Cor M Gast
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
Hypertension 51:1492-8. 2008..These findings substantiate the view that differences in the presence of menopausal symptoms as a reason for using hormone therapy could explain discrepant findings between observational research and trials... - Dietary phytoestrogens and breast cancer riskLital Keinan-Boker
Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Netherlands
Am J Clin Nutr 79:282-8. 2004..0 (95% CI: 0.7, 1.5) and 0.7 (0.5, 1.1), respectively. Tests for trend were nonsignificant. CONCLUSION: In Western populations, a high intake of isoflavones or mammalian lignans is not significantly related to breast cancer risk... - Higher usual dietary intake of phytoestrogens is associated with lower aortic stiffness in postmenopausal womenYvonne T van der Schouw
Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
Arterioscler Thromb Vasc Biol 22:1316-22. 2002..Phytoestrogens have been postulated to protect against cardiovascular diseases, but few studies have focused on the effect of Western dietary phytoestrogen intake... - Endogenous sex hormones and metabolic syndrome in aging menMajon Muller
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, Room D 01.335, 3508 GA Utrecht, The Netherlands
J Clin Endocrinol Metab 90:2618-23. 2005.... - Soy isoflavones, body composition, and physical performanceLinda Kok
The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
Maturitas 52:102-10. 2005..CONCLUSIONS: The results of the present trial do not support the view that soy isoflavones have favorable effects on body composition and physical performance in postmenopausal women... - Indicators for the total duration of premenopausal endogenous estrogen exposure in relation to BMDMaria L C Hagemans
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room D 01.335, PO Box 85500, 3508 GA Utrecht, The Netherlands
Hum Reprod 19:2163-9. 2004..03) explained only 0.16% of the variance in BMD. CONCLUSIONS: We conclude that it is not necessary to use more reproductive factors besides age at menopause and menarche in determining total duration of endogenous estrogen exposure... - The M235T polymorphism in the AGT gene and CHD risk: evidence of a Hardy-Weinberg equilibrium violation and publication bias in a meta-analysisMohammad Hadi Zafarmand
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
PLoS ONE 3:e2533. 2008..The M235T polymorphism in the AGT gene has been related to an increased risk of hypertension. This finding may also suggest an increased risk of coronary heart disease (CHD)... - No relationship between circulating levels of sex steroids and mammographic breast density: the Prospect-EPIC cohortMartijn Verheus
Julius Center for Health Sciences and Primary Care, Room Str 6, 131, PO Box 85500, University Medical Center Utrecht, Utrecht 3508 GA, The Netherlands
Breast Cancer Res 9:R53. 2007..The objective of the present study was to study the relation between circulating oestrogens and androgens as well as sex hormone binding globulin (SHBG) in relation to breast density... - Elevated blood pressure and electrocardiographic frontal T axis and spatial QRS-T angle changes in postmenopausal womenFemke Atsma
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
J Electrocardiol 41:360-4. 2008..We determined whether increased blood pressure is a risk factor for changes in these parameters in postmenopausal women free of left ventricular hypertrophy...