Pim van der Harst

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. ncbi Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hum Mol Genet 19:387-95. 2010
  2. ncbi Effects of rosuvastatin on coronary flow reserve and metabolic mismatch in patients with heart failure (from the CORONA Study)
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 105:517-21. 2010
  3. ncbi Effect of fosinopril treatment on serum C-reactive protein levels in patients with microalbuminuria
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 102:223-5. 2008
  4. ncbi Possible association between telomere length and renal dysfunction in patients with chronic heart failure
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 102:207-10. 2008
  5. ncbi Telomere length and outcome in heart failure
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Ann Med 42:36-44. 2010
  6. ncbi The case for statin therapy in chronic heart failure
    Pim van der Harst
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700, Groningen RB, The Netherlands
    Clin Res Cardiol 97:139-46. 2008
  7. ncbi Effect of withdrawal of pravastatin therapy on C-reactive protein and low-density lipoprotein cholesterol
    Pim van der Harst
    Department of Experimental Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 100:1548-51. 2007
  8. ncbi Telomere length of circulating leukocytes is decreased in patients with chronic heart failure
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 49:1459-64. 2007
  9. ncbi Effects of C-reactive protein and cholesterol on responsiveness in vitro of the internal thoracic artery to angiotensin II in patients having coronary artery bypass grafting
    Pim van der Harst
    Department of Cardiology, Thoraxcenter, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 98:751-3. 2006
  10. ncbi Vascular function and mild renal impairment in stable coronary artery disease
    Pim van der Harst
    Department of Cardiology, Medical Center Groningen, University of Groningen, The Netherlands
    Arterioscler Thromb Vasc Biol 26:379-84. 2006

Detail Information

Publications55

  1. ncbi Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hum Mol Genet 19:387-95. 2010
    ..011), fractional UA excretion (P = 3.36 x 10(-5)) and high-sensitive CRP (P = 1.18 x 10(-3)) also after adjusting for serum UA levels. We argue that GCKR locus affects serum UA levels through a factor that also affects triglycerides...
  2. ncbi Effects of rosuvastatin on coronary flow reserve and metabolic mismatch in patients with heart failure (from the CORONA Study)
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 105:517-21. 2010
    ....
  3. ncbi Effect of fosinopril treatment on serum C-reactive protein levels in patients with microalbuminuria
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 102:223-5. 2008
    ..Male gender was associated with a significantly larger reduction in CRP compared to female gender. In conclusion, contrary to previous observational studies, no effect of angiotensin-converting enzyme inhibition on CRP levels was found...
  4. ncbi Possible association between telomere length and renal dysfunction in patients with chronic heart failure
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 102:207-10. 2008
    ..Further studies will be needed to determine whether shorter leukocyte telomere length is the cause or consequence in this population and whether it plays a role in the prognosis of renal dysfunction in HF...
  5. ncbi Telomere length and outcome in heart failure
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Ann Med 42:36-44. 2010
    ..Senescence is a potential factor in the pathogenesis and progression of heart failure. In heart failure telomeres are shorter, but the prognostic value associated with telomere length has not been defined...
  6. ncbi The case for statin therapy in chronic heart failure
    Pim van der Harst
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700, Groningen RB, The Netherlands
    Clin Res Cardiol 97:139-46. 2008
    ....
  7. ncbi Effect of withdrawal of pravastatin therapy on C-reactive protein and low-density lipoprotein cholesterol
    Pim van der Harst
    Department of Experimental Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 100:1548-51. 2007
    ..In conclusion, withdrawal from pravastatin treatment resulted in an increase in CRP to approximately baseline levels, which is not related to the increase in LDL cholesterol...
  8. ncbi Telomere length of circulating leukocytes is decreased in patients with chronic heart failure
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 49:1459-64. 2007
    ..This study sought to test the hypothesis that patients with chronic heart failure (CHF) have shorter telomeres compared with age-balanced and gender-balanced healthy individuals...
  9. ncbi Effects of C-reactive protein and cholesterol on responsiveness in vitro of the internal thoracic artery to angiotensin II in patients having coronary artery bypass grafting
    Pim van der Harst
    Department of Cardiology, Thoraxcenter, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 98:751-3. 2006
    ..In conclusion, our results suggest that CRP and cholesterol act synergistically on vascular responsiveness to angiotensin II...
  10. ncbi Vascular function and mild renal impairment in stable coronary artery disease
    Pim van der Harst
    Department of Cardiology, Medical Center Groningen, University of Groningen, The Netherlands
    Arterioscler Thromb Vasc Biol 26:379-84. 2006
    ....
  11. ncbi Usefulness of preoperative C-reactive protein and soluble intercellular adhesion molecule-1 level for predicting future cardiovascular events after coronary artery bypass grafting
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 97:1697-701. 2006
    ....
  12. ncbi Statins in the treatment of chronic heart failure: biological and clinical considerations
    Pim van der Harst
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands
    Cardiovasc Res 71:443-54. 2006
    ..We emphasize the importance of additional research specifically in CHF models and patients...
  13. ncbi Erythropoietin stimulates normal endothelial progenitor cell-mediated endothelial turnover, but attributes to neovascularization only in the presence of local ischemia
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, P O Box 30001, 9700 RB Groningen, The Netherlands
    Cardiovasc Drugs Ther 22:265-74. 2008
    ..We aimed to evaluate whether ischemia is required for erythropoietin (EPO) induced stimulation of endothelial progenitor cells (EPCs) and their related effects on endothelial and cardiac function...
  14. ncbi Renal dysfunction is associated with shorter telomere length in heart failure
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Clin Res Cardiol 98:629-34. 2009
    ..We explored the association between leukocyte telomere length, a marker for biological age, and renal function in patients with CHF...
  15. ncbi Differential associations between renal function and "modifiable" risk factors in patients with chronic heart failure
    Tom D J Smilde
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Res Cardiol 98:121-9. 2009
    ..Our aim was to determine different pathophysiologic markers that are associated with reduced renal function in CHF...
  16. ncbi Anaemia is associated with shorter leucocyte telomere length in patients with chronic heart failure
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Eur J Heart Fail 12:348-53. 2010
    ..We hypothesize that short telomere length contributes to the susceptibility to develop anaemia in patients with CHF...
  17. ncbi Rosuvastatin attenuates angiotensin II-induced neointimal formation after stent implantation in the rat
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Coron Artery Dis 19:47-53. 2008
    ..We investigated the efficacy of oral rosuvastatin treatment to reduce in-stent neointima formation, both in the absence and presence of high levels of the proproliferative substance angiotensin II (Ang II)...
  18. ncbi Effect of intensive versus moderate lipid lowering on endothelial function and vascular responsiveness to angiotensin II in stable coronary artery disease
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 96:1361-4. 2005
    ..05). Endothelium improvement was accompanied by decreased vascular response to angiotensin II (p = 0.039). These findings suggest a mechanism for the clinical benefit of intensive lipid-lowering treatment in coronary heart disease...
  19. ncbi Circulating leukocyte and carotid atherosclerotic plaque telomere length: interrelation, association with plaque characteristics, and restenosis after endarterectomy
    Jardi Huzen
    University Medical Centre Groningen, Department of Cardiology, University of Groningen, Hanzeplein 1, PO Box 9700 RB Groningen, The Netherlands
    Arterioscler Thromb Vasc Biol 31:1219-25. 2011
    ..The goal of the present study was to determine whether leukocyte telomere length is related to atherosclerotic plaque telomere length and whether it is associated with plaque characteristics or recurrence of disease...
  20. ncbi Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase A
    Hisko Oeseburg
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands
    Arterioscler Thromb Vasc Biol 30:1407-14. 2010
    ..Here we investigated whether the antidiabetic hormone glucagon-like peptide 1 (GLP-1) could prevent oxidative stress-induced cellular senescence in endothelial cells...
  21. ncbi Long-term effects of pravastatin and fosinopril on peripheral endothelial function in albuminuric subjects
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Atherosclerosis 196:349-55. 2008
    ..01). In conclusion, after 4 years of follow-up, pravastatin treatment tended to increase FMD and this effect was predominantly present in men. Fosinopril treatment did not modify FMD during long-term follow-up...
  22. ncbi Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1
    Niek Verweij
    Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Hypertension 61:602-8. 2013
    ..The discovery of genetic variants in the kallikrein-kinin system and in the genes encoding pre-pro-ET-1 and pre-pro-ADM provides novel insights into the (co-)regulation of these vasoactive peptides in the vascular system...
  23. ncbi Telomere length and psychological well-being in patients with chronic heart failure
    Jardi Huzen
    Department of Cardiology, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Age Ageing 39:223-7. 2010
    ..Shorter telomere length indicates a more advanced biological age. It is unknown whether psychological well-being is associated with telomere length in patients with the somatic condition of chronic heart failure (CHF)...
  24. ncbi Plasma renin and outcome in the community: data from PREVEND
    Rudolf A de Boer
    Department of Cardiology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, Groningen 9713GZ, The Netherlands
    Eur Heart J 33:2351-9. 2012
    ..The renin-angiotensin system plays a central role in patients with established cardiovascular (CV) disease, but the prognostic effect of plasma renin in the community is unclear...
  25. ncbi Influence of age on the prognostic value of mid-regional pro-adrenomedullin in the general population
    Frank P Brouwers
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Heart 98:1348-53. 2012
    ..The aim of this study was to evaluate the prognostic performance of MR-proADM in the general population, controlling for these potential confounders...
  26. ncbi Use of cystatin C levels in estimating renal function and prognosis in patients with chronic systolic heart failure
    Kevin Damman
    Department of Cardiology, University Medical Center Groningen, Hanzeplein 1, P O Box 30001, 9700 RB Groningen, The Netherlands
    Heart 98:319-24. 2012
    ..Estimates of glomerular filtration rate (GFR), including creatinine and creatinine based formulae, are inaccurate in extremes of GFR and substantially biased in patients with chronic heart failure (CHF)...
  27. ncbi Vascular response to angiotensin II predicts long-term prognosis in patients undergoing coronary artery bypass grafting
    Pim van der Harst
    Department of Cardiology, University Hospital Groningen, The Netherlands
    Hypertension 44:930-4. 2004
    ..In conclusion, these results suggest that in patients undergoing CABG, a diminished vascular responsiveness of the thoracic artery to exogenous angiotensin II is related to an increased risk of future cardiovascular events...
  28. ncbi Telomere biology in cardiovascular disease: the TERC-/- mouse as a model for heart failure and ageing
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands
    Cardiovasc Res 81:244-52. 2009
    ..The TERC(-/-) mice provide exciting opportunities to expand our knowledge of telomere biology in cardiovascular disease and the potential identification of novel targets of treatment...
  29. ncbi Aging, telomeres and heart failure
    Liza S M Wong
    Division of Experimental Cardiology, Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Heart Fail Rev 15:479-86. 2010
    ..In this review, we will elaborate on the current knowledge of aging of the heart, telomere biology and its potential role in the development of heart failure...
  30. ncbi Low-dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit
    Erik Lipsic
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur J Heart Fail 10:22-9. 2008
    ..However, the increased haematocrit associated with EPO treatment might exert concomitant deleterious effects...
  31. ncbi Activation of liver X receptor-alpha reduces activation of the renal and cardiac renin-angiotensin-aldosterone system
    Irma Kuipers
    Department of Experimental Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Lab Invest 90:630-6. 2010
    ..In conclusion, LXR-alpha activation blunts ISO-induced increases in mRNA expression of renin, AT(1)R and ACE in the heart and kidney. These findings suggest a role for LXR-alpha in RAAS regulation...
  32. ncbi Plasma matrix metalloproteinase-9 and ACE-inhibitor-induced improvement of urinary albumin excretion in non-diabetic, microalbuminuric subjects
    Ruud M A van de Wal
    St Antonius Hospital, Department of Cardiology, Koekoekslaan 1, Nieuwegein, The Netherlands
    J Renin Angiotensin Aldosterone Syst 8:177-80. 2007
    ....
  33. ncbi Ischemic patterns assessed by positron emission tomography predict adverse outcome in patients with idiopathic dilated cardiomyopathy
    Richard M de Jong
    Thoraxcenter, Department of Cardiology, University Medical Centre Groningen, Hanzeplein 1, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    J Nucl Cardiol 16:769-74. 2009
    ..Our aim was to assess the prognostic relevance of PET-mismatch between stress myocardial perfusion and glucose uptake on clinical outcome in DCM...
  34. ncbi Activation of liver X receptors with T0901317 attenuates cardiac hypertrophy in vivo
    Irma Kuipers
    Department of Experimental Cardiology, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur J Heart Fail 12:1042-50. 2010
    ..Liver X receptor has also been shown to exert anti-proliferative and anti-inflammatory properties. In this study, we evaluated the effect of LXR activation on cardiac hypertrophy in vitro and in vivo...
  35. ncbi Metformin in non-diabetic patients presenting with ST elevation myocardial infarction: rationale and design of the glycometabolic intervention as adjunct to primary percutaneous intervention in ST elevation myocardial infarction (GIPS)-III trial
    Chris P H Lexis
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, PO Box 30 001, Groningen, The Netherlands
    Cardiovasc Drugs Ther 26:417-26. 2012
    ..We will study the efficacy of metformin with the aim to preserve left ventricular ejection fraction in non-diabetic patients presenting with ST elevation myocardial infarction (STEMI)...
  36. ncbi Telomere biology in healthy aging and disease
    Hisko Oeseburg
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands
    Pflugers Arch 459:259-68. 2010
    ..In the current review, we will discuss the role of telomere biology in relation to aging and aging associated diseases...
  37. ncbi Telomere length of circulating leukocyte subpopulations and buccal cells in patients with ischemic heart failure and their offspring
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 6:e23118. 2011
    ..We additionally measured TL of offspring of patients and controls to examine heritability throughout different cell types...
  38. ncbi The emerging role of telomere biology in cardiovascular disease
    Jardi Huzen
    Department of Cardiology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Front Biosci 15:35-45. 2010
    ..If telomeres can be proven to be not only associated but also causally involved in the pathogenesis of cardiovascular disease it might provide exciting new avenues for the development of future preventive and therapeutic strategies...
  39. ncbi Bradykinin protects against oxidative stress-induced endothelial cell senescence
    Hisko Oeseburg
    Department of Experimental Cardiology, AB 43, University Medical Center Groningen, Antonius Deusinglaan 1, Building 3211, 9713 AV Groningen, The Netherlands
    Hypertension 53:417-22. 2009
    ..Therefore, we conclude that bradykinin protects endothelial cells from superoxide-induced senescence through bradykinin B2 receptor- and NO-mediated inhibition of DNA damage...
  40. ncbi Predictors of angiotensin-converting enzyme inhibitor-induced reduction of urinary albumin excretion in nondiabetic patients
    Ruud M A van de Wal
    St Antonius Hospital, Department of Cardiology, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands
    Hypertension 48:870-6. 2006
    ....
  41. ncbi Clinical impact of vasomotor function assessment and the role of ACE-inhibitors and statins
    Folkert W Asselbergs
    Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    Vascul Pharmacol 42:125-40. 2005
    ..Overall, at this moment, there is no place in clinical practice for the use of endothelial function as a method for risk assessment or target of pharmacological interventions...
  42. ncbi Nuclear hormone receptors as regulators of the renin-angiotensin-aldosterone system
    Irma Kuipers
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hypertension 51:1442-8. 2008
  43. ncbi Telomere biology in heart failure
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Eur J Heart Fail 10:1049-56. 2008
    ..In heart failure, telomere length is severely reduced. In the current review, we will discuss the emerging role of telomere biology in the pathophysiology of heart failure...
  44. ncbi Statins in the treatment of chronic heart failure: a systematic review
    Pim van der Harst
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Netherlands
    PLoS Med 3:e333. 2006
    ..The efficacy of statin therapy in patients with established chronic heart failure (CHF) is a subject of much debate...
  45. ncbi CCR5Delta32 genotype is associated with outcome in type 2 diabetes mellitus
    Friso L H Muntinghe
    Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Diabetes Res Clin Pract 86:140-5. 2009
    ..To test whether the genetic variant CCR5Delta32 in the CC-chemokine receptor 5, which is known to lead to CCR5 deficiency, is associated with mortality in type 2 diabetes patients...
  46. ncbi Seventy-five genetic loci influencing the human red blood cell
    Pim van der Harst
    Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    Nature 492:369-75. 2012
    ..Our findings provide extensive new insights into genetic mechanisms and biological pathways controlling red blood cell formation and function...
  47. ncbi A genome-wide association study of circulating galectin-3
    Rudolf A de Boer
    Department of Cardiology, University of Groningen, University Medical Center Groningen, The Netherlands
    PLoS ONE 7:e47385. 2012
    ..97 × 10(-465) and rs4652 P = 1.50 × 10(-421)) and were also associated with LGALS3 gene-expression. The origins of our associations should be further validated by means of functional experiments...
  48. ncbi Erythropoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor mediated neovascularization
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands
    Eur Heart J 28:2018-27. 2007
    ..We studied the effects of EPO on homing and incorporation of endothelial progenitor cells (EPC) into the myocardial microvasculature and myocardial expression of angiogenic factors...
  49. ncbi Bone marrow dysfunction in chronic heart failure patients
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, Groningen 9700 RB, The Netherlands
    Eur J Heart Fail 12:676-84. 2010
    ..To investigate whether chronic heart failure (CHF) is associated with a general dysfunction of the haematopoietic compartment...
  50. ncbi Peroxiredoxin 4, a novel circulating biomarker for oxidative stress and the risk of incident cardiovascular disease and all-cause mortality
    Ali Abbasi
    Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Am Heart Assoc 1:e002956. 2012
    ..We subsequently examined the incremental value of Prx4 for the risk prediction of CVD compared with the Framingham risk score (FRS)...
  51. ncbi Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci
    Folkert W Asselbergs
    Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Hum Genet 91:823-38. 2012
    ..The explained phenotypic variance from this approach was comparable to that from a meta-analysis of GWAS data, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids...
  52. ncbi Effects of angiotensin II and angiotensin II type 1 receptor blockade on neointimal formation after stent implantation
    Hendrik C Groenewegen
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands
    Int J Cardiol 126:209-15. 2008
    ....
  53. ncbi Pharmacogenetics in heart failure: promises and challenges
    Rudolf A de Boer
    University Medical Centre Groningen, Thoraxcentre, Department of Cardiology, P O Box 30 001, Groningen 9700RB, The Netherlands
    Expert Opin Pharmacother 10:1713-25. 2009
    ..Prospective large-scale pharmacogenetic studies are warranted as we believe that they will identify new targets for therapy and specific populations that benefit from specific treatments...
  54. ncbi Pharmacoepigenetics in heart failure
    Irene Mateo Leach
    Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands
    Curr Heart Fail Rep 7:83-90. 2010
    ..In this review, we discuss recent evidence of epigenetic changes that play an important role in the development of cardiac hypertrophy and heart failure and may dictate response to therapy...
  55. ncbi Genetic and pharmacological inhibition of galectin-3 prevents cardiac remodeling by interfering with myocardial fibrogenesis
    Lili Yu
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Circ Heart Fail 6:107-17. 2013
    ..Galectin-3 has been implicated in the development of organ fibrosis. It is unknown whether it is a relevant therapeutic target in cardiac remodeling and heart failure...