Petra van der Groep

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc HIF-1α overexpression in ductal carcinoma in situ of the breast in BRCA1 and BRCA2 mutation carriers
    Petra van der Groep
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e56055. 2013
  2. doi request reprint Molecular profile of ductal carcinoma in situ of the breast in BRCA1 and BRCA2 germline mutation carriers
    P van der Groep
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Pathol 62:926-30. 2009
  3. pmc Necrosis related HIF-1alpha expression predicts prognosis in patients with endometrioid endometrial carcinoma
    Laura M S Seeber
    Department of Gynaecological Oncology, University Medical Centre Utrecht, The Netherlands
    BMC Cancer 10:307. 2010
  4. ncbi request reprint High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer
    Petra van der Groep
    Department of Pathology, University Medical Center, 3508 GA, Utrecht, The Netherlands
    Breast Cancer Res Treat 111:475-80. 2008
  5. pmc Expression of hypoxia-inducible factor-1alpha and cell cycle proteins in invasive breast cancer are estrogen receptor related
    Reinhard Bos
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Breast Cancer Res 6:R450-9. 2004
  6. doi request reprint Loss of p120-catenin induces metastatic progression of breast cancer by inducing anoikis resistance and augmenting growth factor receptor signaling
    Ron C J Schackmann
    Department of Pathology, Cancer Center, and Division of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Cancer Res 73:4937-49. 2013
  7. ncbi request reprint No amplifications of hypoxia-inducible factor-1alpha gene in invasive breast cancer: a tissue microarray study
    Marije M Vleugel
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Cell Oncol 26:347-51. 2004
  8. doi request reprint Promoter hypermethylation patterns in fallopian tube epithelium of BRCA1 and BRCA2 germ line mutation carriers
    Jonathan G Bijron
    Department of Pathology, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Endocr Relat Cancer 19:69-81. 2012
  9. ncbi request reprint Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma
    Reinhard Bos
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Cancer 97:1573-81. 2003
  10. doi request reprint Why prostate tumour delineation based on apparent diffusion coefficient is challenging: an exploration of the tissue microanatomy
    Alie Borren
    Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands
    Acta Oncol 52:1629-36. 2013

Collaborators

Detail Information

Publications36

  1. pmc HIF-1α overexpression in ductal carcinoma in situ of the breast in BRCA1 and BRCA2 mutation carriers
    Petra van der Groep
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e56055. 2013
    ..Hypoxia-related proteins are therefore putative targets for therapy and molecular imaging for early detection and monitoring therapy response in BRCA mutation patients...
  2. doi request reprint Molecular profile of ductal carcinoma in situ of the breast in BRCA1 and BRCA2 germline mutation carriers
    P van der Groep
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Pathol 62:926-30. 2009
    ....
  3. pmc Necrosis related HIF-1alpha expression predicts prognosis in patients with endometrioid endometrial carcinoma
    Laura M S Seeber
    Department of Gynaecological Oncology, University Medical Centre Utrecht, The Netherlands
    BMC Cancer 10:307. 2010
    ..This possibly contributes to survival of cancer cells. The aim of this study was to evaluate the prognostic value of HIF-1alpha and p27kip expression in patients with endometrioid endometrial cancer...
  4. ncbi request reprint High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer
    Petra van der Groep
    Department of Pathology, University Medical Center, 3508 GA, Utrecht, The Netherlands
    Breast Cancer Res Treat 111:475-80. 2008
    ..This points to an important role of hypoxia and its key regulator HIF-1alpha in hereditary breast carcinogenesis...
  5. pmc Expression of hypoxia-inducible factor-1alpha and cell cycle proteins in invasive breast cancer are estrogen receptor related
    Reinhard Bos
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Breast Cancer Res 6:R450-9. 2004
    ..In this study we undertook a detailed evaluation of the relationships between HIF-1alpha and cell cycle-associated proteins...
  6. doi request reprint Loss of p120-catenin induces metastatic progression of breast cancer by inducing anoikis resistance and augmenting growth factor receptor signaling
    Ron C J Schackmann
    Department of Pathology, Cancer Center, and Division of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Cancer Res 73:4937-49. 2013
    ..Our results establish a preclinical platform to develop tailored intervention regimens that target GFR signals to treat p120-negative metastatic breast cancers...
  7. ncbi request reprint No amplifications of hypoxia-inducible factor-1alpha gene in invasive breast cancer: a tissue microarray study
    Marije M Vleugel
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Cell Oncol 26:347-51. 2004
    ..The aim of this study was to evaluate the presence of HIF-1alpha gene amplifications in invasive breast cancer as an explanation for HIF-1alpha protein overexpression...
  8. doi request reprint Promoter hypermethylation patterns in fallopian tube epithelium of BRCA1 and BRCA2 germ line mutation carriers
    Jonathan G Bijron
    Department of Pathology, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Endocr Relat Cancer 19:69-81. 2012
    ..Methylation could, therefore, play an important role in the increased risk of gynaecological malignancies in BRCA mutation carriers...
  9. ncbi request reprint Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma
    Reinhard Bos
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Cancer 97:1573-81. 2003
    ..In this study, the prognostic value of HIF-1alpha expression and its correlation with various clinicopathologic variables in patients with invasive breast carcinoma were investigated...
  10. doi request reprint Why prostate tumour delineation based on apparent diffusion coefficient is challenging: an exploration of the tissue microanatomy
    Alie Borren
    Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands
    Acta Oncol 52:1629-36. 2013
    ..Therefore, in this study the relationship between ADC and histological variables was investigated on voxel level to understand the strengths and limitations of DWI for prostate tumour delineation...
  11. pmc Pathology of hereditary breast cancer
    Petra van der Groep
    Department of Pathology, University Medical Center Utrecht, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    Cell Oncol (Dordr) 34:71-88. 2011
    ..However, in still a part of familial hereditary breast cancers no relationship to any of these breast cancer susceptibility genes can be found. Research on new susceptibility genes is therefore ongoing...
  12. pmc Immunophenotyping invasive breast cancer: paving the road for molecular imaging
    Jeroen F Vermeulen
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    BMC Cancer 12:240. 2012
    ..Because development of new tracers is labor-intensive and costly, we searched for the smallest panel of tumor membrane markers that would allow detection of the wide spectrum of invasive breast cancers...
  13. pmc Nuclear Kaiso expression is associated with high grade and triple-negative invasive breast cancer
    Jeroen F Vermeulen
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e37864. 2012
    ..In conclusion, our data indicate that nuclear Kaiso is common in clinically aggressive ductal breast cancer, while cytoplasmic Kaiso and a p120-mediated relief of Kaiso-dependent transcriptional repression characterize ILC...
  14. pmc Lympho-vascular invasion in BRCA related breast cancer compared to sporadic controls
    Marise R Heerma van Voss
    Department of Pathology, University Medical Center Utrecht, The Netherlands
    BMC Cancer 10:145. 2010
    ....
  15. pmc Loss of expression of FANCD2 protein in sporadic and hereditary breast cancer
    Petra van der Groep
    Department of Pathology, University Medical Center, Utrecht, The Netherlands
    Breast Cancer Res Treat 107:41-7. 2008
    ..FANCD2 is of independent prognostic value in sporadic breast cancer...
  16. ncbi request reprint Protein expression of B-cell lymphoma gene 6 (BCL-6) in invasive breast cancer is associated with cyclin D1 and hypoxia-inducible factor-1alpha (HIF-1alpha)
    Reinhard Bos
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Oncogene 22:8948-51. 2003
    ..The cases with amplification in BCL-6 showed an increased (25%) incidence of BCL-6 protein overexpression. Thus, this study is the first to show that BCL-6 oncogene activation plays a role in cancers other than lymphomas...
  17. doi request reprint HIF-1α and NOTCH signaling in ductal and lobular carcinomas of the breast
    Cigdem Ercan
    Department of Pathology, University Medical Center Utrecht Cancer Center, Utrecht, The Netherlands
    Cell Oncol (Dordr) 35:435-42. 2012
    ..Hypoxia-induced stabilization of HIF transcription factors has been shown to lead to NOTCH activation in vitro in different contexts and tissues, causing differentiation arrest and induction of proliferation and migration...
  18. pmc Expression of the stem cell marker ALDH1 in BRCA1 related breast cancer
    Marise R Heerma van Voss
    Department of Pathology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Cell Oncol (Dordr) 34:3-10. 2011
    ..Since ALDH1 is a marker of both mammary stem cells and breast cancer stem cells, we compared ALDH1 expression in malignant tissue of BRCA1 mutation carriers to non-carriers...
  19. doi request reprint Reverse proteomic antibody screening identifies anti adhesive VHH targeting VLA-3
    Arjan J Groot
    Department of Pathology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Mol Immunol 46:2022-8. 2009
    ..Our approach provides a fast and efficient method to screen for novel cell surface markers on normal and tumor cells that may find diagnostic or therapeutic application in disease management or treatment...
  20. pmc Expression of the RNA helicase DDX3 and the hypoxia response in breast cancer
    Guus M Bol
    Department of Pathology, University Medical Center, Utrecht, The Netherlands
    PLoS ONE 8:e63548. 2013
    ..However, the relation between DDX3 and hypoxia has not been addressed in human tumors. In this paper, we studied the relation between DDX3 and the hypoxic responsive proteins in human breast cancer...
  21. pmc Differential expression of growth factor receptors and membrane-bound tumor markers for imaging in male and female breast cancer
    Jeroen F Vermeulen
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e53353. 2013
    ..We therefore investigated expression profiles of growth factor receptors and membrane-bound tumor markers in male breast cancer and gynecomastia, in comparison with female breast cancer...
  22. doi request reprint Expression of hypoxia-inducible factor-1α and -2α in whole-mount prostate histology: relation with dynamic contrast-enhanced MRI and Gleason score
    Alie Borren
    Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands
    Oncol Rep 29:2249-54. 2013
    ..However, HIF-1α and HIF-2α were not correlated with DCE-MRI parameters. Given the pronounced expression of HIF-2α and independence of Gleason score, HIF expression may function as a biomarker to guide boost dose prescription...
  23. pmc Expression of hypoxia-inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breast
    Arno Kuijper
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Breast Cancer Res 7:R808-18. 2005
    ..We studied the expression and prognostic relevance of HIF-1alpha and its downstream targets in phyllodes tumors and fibroadenomas of the breast...
  24. doi request reprint Molecular subtyping of male breast cancer by immunohistochemistry
    Robert Kornegoor
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    Mod Pathol 25:398-404. 2012
    ..This distribution of molecular subtypes in male breast cancer is clearly different compared with female breast cancers, pointing to possible important differences in carcinogenesis...
  25. pmc Subcellular FIH-1 expression patterns in invasive breast cancer in relation to HIF-1α expression
    Agon Hyseni
    Department of Pathology, University Medical Centre Utrecht, The Netherlands
    Cell Oncol (Dordr) 34:565-70. 2011
    ....
  26. pmc Oncogenic KRAS desensitizes colorectal tumor cells to epidermal growth factor receptor inhibition and activation
    Winan J van Houdt
    Department of Surgery, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Neoplasia 12:443-52. 2010
    ..Our results demonstrate a causal role for oncogenic KRAS in desensitizing tumor cells not only to EGFR inhibitors but also to EGF itself...
  27. ncbi request reprint Identification by phage display of single-domain antibody fragments specific for the ODD domain in hypoxia-inducible factor 1alpha
    Arjan J Groot
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    Lab Invest 86:345-56. 2006
    ..These are the first single-domain antibody fragments that may be used in exploration of HIF-1alpha as a possible therapeutic target through molecular applications...
  28. ncbi request reprint HIF-1 alpha expression is associated with an atheromatous inflammatory plaque phenotype and upregulated in activated macrophages
    Aryan Vink
    Department of Pathology, University Medical Center Utrecht, Ultrecht, The Netherlands
    Atherosclerosis 195:e69-75. 2007
    ..The transcription factor hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a key regulator of angiogenesis and is also involved in inflammatory reactions. We studied HIF-1 alpha expression in different atherosclerotic plaque phenotypes...
  29. doi request reprint The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors
    Arjan B Brenkman
    Department of Metabolic and Endocrine Diseases and Netherlands Metabolomics Centre, University Medical Centre Utrecht, Utrecht, The Netherlands
    Cancer Res 68:7597-605. 2008
    ..Thus, Pin1 is identified as a novel negative FOXO regulator, interconnecting FOXO phosphorylation and monoubiquitination in response to cellular stress to regulate p27(kip1)...
  30. doi request reprint Expression and localization of hypoxia proteins in prostate cancer: prognostic implications after radical prostatectomy
    Judith Jans
    Department of Urology, University Medical Center Utrecht, The Netherlands
    Urology 75:786-92. 2010
    ..Given the substantial role of hypoxia in prostate cancer development and treatment, this investigation focuses on the Hypoxia Inducible Factor (HIF-1alpha) pathway...
  31. pmc Receptor conversion in distant breast cancer metastases
    Laurien D C Hoefnagel
    Department of Pathology, University Medical Center Utrecht, The Netherlands
    Breast Cancer Res 12:R75. 2010
    ....
  32. ncbi request reprint Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography
    Reinhard Bos
    Department of Pathology, Positron Emission Tomography Research Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 20:379-87. 2002
    ..At present, no satisfactory biologic explanation exists for this phenomenon. This study compared (18)FDG uptake in vivo with biomarkers expected to be involved in the underlying biologic mechanisms...
  33. pmc Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance
    Ron C J Schackmann
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Invest 121:3176-88. 2011
    ....
  34. doi request reprint Regulation of E2F1 by the von Hippel-Lindau tumour suppressor protein predicts survival in renal cell cancer patients
    Dorus A Mans
    Department of Medical Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Pathol 231:117-29. 2013
    ..Cox regression analysis shows significant prediction of E2F1 expression for disease-free survival and overall survival, implying that E2F1 expression in kidney tumour is a novel prognostic factor for patients with RCC...
  35. doi request reprint Cannabinoid receptor-2 immunoreactivity is associated with survival in squamous cell carcinoma of the head and neck
    Thomas J W Klein Nulent
    Department of Oral and Maxillofacial Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Br J Oral Maxillofac Surg 51:604-9. 2013
    ..6, 95% CI 1.5-8.7, p=0.004). Depth of invasion (HR 2.2, 95% CI 1.2-4.2, p=0.01) and vascular invasion (HR 2.5, 95% CI 1.4-4.5, p=0.001) were also associated with survival. ..
  36. ncbi request reprint Hypoxia and angiogenesis in endometrioid endometrial carcinogenesis
    Nicole Horrée
    Department of Surgical Gynecology and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cell Oncol 29:219-27. 2007
    ..Hypoxia-inducible factor 1alpha (HIF-1alpha) plays an essential role in the adaptive response of cells to hypoxia, triggering biologic events associated with aggressive tumor behavior...