Research Topics
Genomes and Genes
| Petra van der GroepSummaryAffiliation: University Medical Center Utrecht Country: The Netherlands Publications
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Detail Information
Publications
HIF-1α overexpression in ductal carcinoma in situ of the breast in BRCA1 and BRCA2 mutation carriersPetra van der Groep
Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
PLoS ONE 8:e56055. 2013..Hypoxia-related proteins are therefore putative targets for therapy and molecular imaging for early detection and monitoring therapy response in BRCA mutation patients...
Molecular profile of ductal carcinoma in situ of the breast in BRCA1 and BRCA2 germline mutation carriersP van der Groep
Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
J Clin Pathol 62:926-30. 2009....- Necrosis related HIF-1alpha expression predicts prognosis in patients with endometrioid endometrial carcinomaLaura M S Seeber
Department of Gynaecological Oncology, University Medical Centre Utrecht, The Netherlands
BMC Cancer 10:307. 2010..This possibly contributes to survival of cancer cells. The aim of this study was to evaluate the prognostic value of HIF-1alpha and p27kip expression in patients with endometrioid endometrial cancer... 
High frequency of HIF-1alpha overexpression in BRCA1 related breast cancerPetra van der Groep
Department of Pathology, University Medical Center, 3508 GA, Utrecht, The Netherlands
Breast Cancer Res Treat 111:475-80. 2008..This points to an important role of hypoxia and its key regulator HIF-1alpha in hereditary breast carcinogenesis...- Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinomaReinhard Bos
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Cancer 97:1573-81. 2003..Therefore, the use of immunohistochemical assessment of HIF-1alpha as a new predictor of poor outcome may improve clinical decision-making regarding adjuvant treatment of patients with lymph node negative breast carcinoma... - Expression of hypoxia-inducible factor-1alpha and cell cycle proteins in invasive breast cancer are estrogen receptor relatedReinhard Bos
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Breast Cancer Res 6:R450-9. 2004..In this study we undertook a detailed evaluation of the relationships between HIF-1alpha and cell cycle-associated proteins... - Immunophenotyping invasive breast cancer: paving the road for molecular imagingJeroen F Vermeulen
Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
BMC Cancer 12:240. 2012..Because development of new tracers is labor-intensive and costly, we searched for the smallest panel of tumor membrane markers that would allow detection of the wide spectrum of invasive breast cancers... - Nuclear Kaiso expression is associated with high grade and triple-negative invasive breast cancerJeroen F Vermeulen
Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
PLoS ONE 7:e37864. 2012..In conclusion, our data indicate that nuclear Kaiso is common in clinically aggressive ductal breast cancer, while cytoplasmic Kaiso and a p120-mediated relief of Kaiso-dependent transcriptional repression characterize ILC... - Promoter hypermethylation patterns in fallopian tube epithelium of BRCA1 and BRCA2 germ line mutation carriersJonathan G Bijron
Department of Pathology, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
Endocr Relat Cancer 19:69-81. 2012..Methylation could, therefore, play an important role in the increased risk of gynaecological malignancies in BRCA mutation carriers... - Loss of expression of FANCD2 protein in sporadic and hereditary breast cancerPetra van der Groep
Department of Pathology, University Medical Center, Utrecht, The Netherlands
Breast Cancer Res Treat 107:41-7. 2008..FANCD2 is of independent prognostic value in sporadic breast cancer... - Protein expression of B-cell lymphoma gene 6 (BCL-6) in invasive breast cancer is associated with cyclin D1 and hypoxia-inducible factor-1alpha (HIF-1alpha)Reinhard Bos
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Oncogene 22:8948-51. 2003..The cases with amplification in BCL-6 showed an increased (25%) incidence of BCL-6 protein overexpression. Thus, this study is the first to show that BCL-6 oncogene activation plays a role in cancers other than lymphomas... - No amplifications of hypoxia-inducible factor-1alpha gene in invasive breast cancer: a tissue microarray studyMarije M Vleugel
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Cell Oncol 26:347-51. 2004..The aim of this study was to evaluate the presence of HIF-1alpha gene amplifications in invasive breast cancer as an explanation for HIF-1alpha protein overexpression... - Lympho-vascular invasion in BRCA related breast cancer compared to sporadic controlsMarise R Heerma van Voss
Department of Pathology, University Medical Center Utrecht, The Netherlands
BMC Cancer 10:145. 2010.... - Expression of the stem cell marker ALDH1 in BRCA1 related breast cancerMarise R Heerma van Voss
Department of Pathology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
Cell Oncol (Dordr) 34:3-10. 2011..Since ALDH1 is a marker of both mammary stem cells and breast cancer stem cells, we compared ALDH1 expression in malignant tissue of BRCA1 mutation carriers to non-carriers... - Reverse proteomic antibody screening identifies anti adhesive VHH targeting VLA-3Arjan J Groot
Department of Pathology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
Mol Immunol 46:2022-8. 2009..Our approach provides a fast and efficient method to screen for novel cell surface markers on normal and tumor cells that may find diagnostic or therapeutic application in disease management or treatment... - Pathology of hereditary breast cancerPetra van der Groep
Department of Pathology, University Medical Center Utrecht, P O Box 85500, 3508 GA, Utrecht, The Netherlands
Cell Oncol (Dordr) 34:71-88. 2011..However, in still a part of familial hereditary breast cancers no relationship to any of these breast cancer susceptibility genes can be found. Research on new susceptibility genes is therefore ongoing... - Expression of hypoxia-inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breastArno Kuijper
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Breast Cancer Res 7:R808-18. 2005..We studied the expression and prognostic relevance of HIF-1alpha and its downstream targets in phyllodes tumors and fibroadenomas of the breast... - HIF-1α and NOTCH signaling in ductal and lobular carcinomas of the breastCigdem Ercan
Department of Pathology, University Medical Center Utrecht Cancer Center, Utrecht, The Netherlands
Cell Oncol (Dordr) 35:435-42. 2012..Hypoxia-induced stabilization of HIF transcription factors has been shown to lead to NOTCH activation in vitro in different contexts and tissues, causing differentiation arrest and induction of proliferation and migration... - Molecular subtyping of male breast cancer by immunohistochemistryRobert Kornegoor
Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
Mod Pathol 25:398-404. 2012..This distribution of molecular subtypes in male breast cancer is clearly different compared with female breast cancers, pointing to possible important differences in carcinogenesis... - Differential expression of growth factor receptors and membrane-bound tumor markers for imaging in male and female breast cancerJeroen F Vermeulen
Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
PLoS ONE 8:e53353. 2013..We therefore investigated expression profiles of growth factor receptors and membrane-bound tumor markers in male breast cancer and gynecomastia, in comparison with female breast cancer... - Subcellular FIH-1 expression patterns in invasive breast cancer in relation to HIF-1α expressionAgon Hyseni
Department of Pathology, University Medical Centre Utrecht, The Netherlands
Cell Oncol (Dordr) 34:565-70. 2011.... - Oncogenic KRAS desensitizes colorectal tumor cells to epidermal growth factor receptor inhibition and activationWinan J van Houdt
Department of Surgery, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
Neoplasia 12:443-52. 2010..Our results demonstrate a causal role for oncogenic KRAS in desensitizing tumor cells not only to EGFR inhibitors but also to EGF itself... - Identification by phage display of single-domain antibody fragments specific for the ODD domain in hypoxia-inducible factor 1alphaArjan J Groot
Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
Lab Invest 86:345-56. 2006..These are the first single-domain antibody fragments that may be used in exploration of HIF-1alpha as a possible therapeutic target through molecular applications... - HIF-1 alpha expression is associated with an atheromatous inflammatory plaque phenotype and upregulated in activated macrophagesAryan Vink
Department of Pathology, University Medical Center Utrecht, Ultrecht, The Netherlands
Atherosclerosis 195:e69-75. 2007..The transcription factor hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a key regulator of angiogenesis and is also involved in inflammatory reactions. We studied HIF-1 alpha expression in different atherosclerotic plaque phenotypes... - The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressorsArjan B Brenkman
Department of Metabolic and Endocrine Diseases and Netherlands Metabolomics Centre, University Medical Centre Utrecht, Utrecht, The Netherlands
Cancer Res 68:7597-605. 2008..Thus, Pin1 is identified as a novel negative FOXO regulator, interconnecting FOXO phosphorylation and monoubiquitination in response to cellular stress to regulate p27(kip1)... - Expression and localization of hypoxia proteins in prostate cancer: prognostic implications after radical prostatectomyJudith Jans
Department of Urology, University Medical Center Utrecht, The Netherlands
Urology 75:786-92. 2010..Given the substantial role of hypoxia in prostate cancer development and treatment, this investigation focuses on the Hypoxia Inducible Factor (HIF-1alpha) pathway... - Expression of hypoxia-inducible factor-1α and -2α in whole-mount prostate histology: Relation with dynamic contrast-enhanced MRI and Gleason scoreAlie Borren
Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands
Oncol Rep 29:2249-54. 2013..However, HIF-1α and HIF-2α were not correlated with DCE-MRI parameters. Given the pronounced expression of HIF-2α and independence of Gleason score, HIF expression may function as a biomarker to guide boost dose prescription... - Receptor conversion in distant breast cancer metastasesLaurien D C Hoefnagel
Department of Pathology, University Medical Center Utrecht, The Netherlands
Breast Cancer Res 12:R75. 2010.... - Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomographyReinhard Bos
Department of Pathology, Positron Emission Tomography Research Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
J Clin Oncol 20:379-87. 2002..Together, these features explain why breast cancers vary in (18)FDG uptake and elucidate the low uptake in lobular breast cancer... - Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistanceRon C J Schackmann
Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
J Clin Invest 121:3176-88. 2011.... - Hypoxia and angiogenesis in endometrioid endometrial carcinogenesisNicole Horrée
Department of Surgical Gynecology and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
Cell Oncol 29:219-27. 2007..Hypoxia-inducible factor 1alpha (HIF-1alpha) plays an essential role in the adaptive response of cells to hypoxia, triggering biologic events associated with aggressive tumor behavior...