Neeltje E M van Haren

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi request reprint Focal gray matter changes in schizophrenia across the course of the illness: a 5-year follow-up study
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 32:2057-66. 2007
  2. ncbi request reprint Progressive brain volume loss in schizophrenia over the course of the illness: evidence of maturational abnormalities in early adulthood
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Biol Psychiatry 63:106-13. 2008
  3. doi request reprint Confounders of excessive brain volume loss in schizophrenia
    N E van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, The Netherlands Electronic address
    Neurosci Biobehav Rev 37:2418-23. 2013
  4. pmc The genetic and environmental determinants of the association between brain abnormalities and schizophrenia: the schizophrenia twins and relatives consortium
    Neeltje E M van Haren
    University Medical Center Utrecht, Department of Psychiatry, Division of Neuroscience, Rudolf Magnus Institute, Utrecht, The Netherlands
    Biol Psychiatry 71:915-21. 2012
  5. doi request reprint Changes in cortical thickness during the course of illness in schizophrenia
    Neeltje E M van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan, The Netherlands
    Arch Gen Psychiatry 68:871-80. 2011
  6. doi request reprint The course of brain abnormalities in schizophrenia: can we slow the progression?
    N E van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Psychopharmacol 26:8-14. 2012
  7. ncbi request reprint Cigarette smoking and progressive brain volume loss in schizophrenia
    N E M Van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:454-8. 2010
  8. doi request reprint Schizophrenia as a progressive brain disease
    N E M Van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Eur Psychiatry 23:245-54. 2008
  9. doi request reprint Heritability of changes in brain volume over time in twin pairs discordant for schizophrenia
    Rachel G H Brans
    Department of Psychiatry, A01 126, University Medical Center Utrecht, Heidelberglaan 100, Utrecht CX 3584, The Netherlands
    Arch Gen Psychiatry 65:1259-68. 2008
  10. doi request reprint Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder
    Astrid C van der Schot
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Arch Gen Psychiatry 66:142-51. 2009

Detail Information

Publications42

  1. ncbi request reprint Focal gray matter changes in schizophrenia across the course of the illness: a 5-year follow-up study
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 32:2057-66. 2007
    ..Moreover, the progression in left frontal density loss appears to be related to an increased number of psychotic episodes, with atypical antipsychotic medication attenuating these changes...
  2. ncbi request reprint Progressive brain volume loss in schizophrenia over the course of the illness: evidence of maturational abnormalities in early adulthood
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Biol Psychiatry 63:106-13. 2008
    ..Thus, one would expect the progression in brain volume change in schizophrenia to follow a more complex trajectory over time...
  3. doi request reprint Confounders of excessive brain volume loss in schizophrenia
    N E van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, The Netherlands Electronic address
    Neurosci Biobehav Rev 37:2418-23. 2013
    ..Atypical antipsychotics have been found to be related to smaller decreases in tissue loss. Moreover, independent of antipsychotic medication intake, the brain volume abnormalities appear associated to the outcome of the illness...
  4. pmc The genetic and environmental determinants of the association between brain abnormalities and schizophrenia: the schizophrenia twins and relatives consortium
    Neeltje E M van Haren
    University Medical Center Utrecht, Department of Psychiatry, Division of Neuroscience, Rudolf Magnus Institute, Utrecht, The Netherlands
    Biol Psychiatry 71:915-21. 2012
    ..We aim to define the relative contributions of genetic and nongenetic factors to the association between structural brain abnormalities and Sz in a uniquely powered cohort (Schizophrenia Twins and Relatives consortium)...
  5. doi request reprint Changes in cortical thickness during the course of illness in schizophrenia
    Neeltje E M van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan, The Netherlands
    Arch Gen Psychiatry 68:871-80. 2011
    ..Whether cortical thickness changes in schizophrenia over time are more pronounced relative to the changes that can be attributed to normal aging has not been studied...
  6. doi request reprint The course of brain abnormalities in schizophrenia: can we slow the progression?
    N E van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Psychopharmacol 26:8-14. 2012
    ..Before being able to intervene with therapies and prevent the brain from shrinking, one has to understand the underlying mechanism of the progressive changes in the brains of schizophrenia patients...
  7. ncbi request reprint Cigarette smoking and progressive brain volume loss in schizophrenia
    N E M Van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:454-8. 2010
    ..Moreover, smoking was not associated with brain volume change over time in the healthy subjects. However, extremely heavy smoking may contribute to excessive gray matter volume loss in schizophrenia...
  8. doi request reprint Schizophrenia as a progressive brain disease
    N E M Van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Eur Psychiatry 23:245-54. 2008
    ..One of the main challenges for the coming years, however, will be the search for gene-by-environment interactions on the progressive brain changes in schizophrenia...
  9. doi request reprint Heritability of changes in brain volume over time in twin pairs discordant for schizophrenia
    Rachel G H Brans
    Department of Psychiatry, A01 126, University Medical Center Utrecht, Heidelberglaan 100, Utrecht CX 3584, The Netherlands
    Arch Gen Psychiatry 65:1259-68. 2008
    ..Some brain volume changes are progressive over the course of the illness. Whether these progressive brain volume changes are mediated by genetic or disease-related factors is unknown...
  10. doi request reprint Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder
    Astrid C van der Schot
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Arch Gen Psychiatry 66:142-51. 2009
    ..Structural neuroimaging studies suggest the presence of subtle abnormalities in the brains of patients with bipolar disorder. The influence of genetic and/or environmental factors on these brain abnormalities is unknown...
  11. doi request reprint Genetic and environmental influences on focal brain density in bipolar disorder
    Astrid C van der Schot
    Department of Psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Brain 133:3080-92. 2010
    ....
  12. doi request reprint Overlapping and segregating structural brain abnormalities in twins with schizophrenia or bipolar disorder
    Hilleke E Hulshoff Pol
    Department of Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, The Netherlands
    Arch Gen Psychiatry 69:349-59. 2012
    ..Although both disorders are characterized by changes in brain structure, family studies suggest more segregating than overlapping neuroanatomical abnormalities in both disorders...
  13. ncbi request reprint Gray and white matter density changes in monozygotic and same-sex dizygotic twins discordant for schizophrenia using voxel-based morphometry
    Hilleke E Hulshoff Pol
    Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Center Utrecht, A01 126, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Neuroimage 31:482-8. 2006
    ..Focal changes in the left anterior hemisphere may therefore be particularly relevant as endophenotype in genetic studies of schizophrenia...
  14. doi request reprint Cannabis use and progressive cortical thickness loss in areas rich in CB1 receptors during the first five years of schizophrenia
    Monica Rais
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:855-65. 2010
    ..First-episode schizophrenia patients who use cannabis show a more pronounced cortical thinning than non-using patients in areas known for their high density of CB1 receptors, such as the ACC and the DLPFC...
  15. ncbi request reprint Gray and white matter volume abnormalities in monozygotic and same-gender dizygotic twins discordant for schizophrenia
    Hilleke E Hulshoff Pol
    Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 55:126-30. 2004
    ....
  16. doi request reprint Brain plasticity and intellectual ability are influenced by shared genes
    Rachel G H Brans
    Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands
    J Neurosci 30:5519-24. 2010
    ..Thus, not only does the brain continue to change well into adulthood, these changes are functionally relevant because they are related to intelligence...
  17. doi request reprint Hippocampal volume change in schizophrenia
    P Cédric M P Koolschijn
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, A 01 126, University Medical Center Utrecht, PO Box 85060, 3584 CX Utrecht, The Netherlands
    J Clin Psychiatry 71:737-44. 2010
    ..The aim of this study is to examine the extent to which hippocampal volume change in patients with schizophrenia is confounded by effects of age and/or antipsychotic medication...
  18. doi request reprint Longitudinal MRI study in schizophrenia patients and their healthy siblings
    Rachel G H Brans
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, A01 126, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Br J Psychiatry 193:422-3. 2008
    ..Whole brain and cerebral grey matter volumes decreased excessively in patients compared with their siblings and the controls, suggesting that the progressive brain loss in schizophrenia may be related to the disease process...
  19. pmc Focal and global brain measurements in siblings of patients with schizophrenia
    Heleen B M Boos
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Schizophr Bull 38:814-25. 2012
    ..This large magnetic resonance imaging study examined brain structures in patients with schizophrenia, their nonpsychotic siblings, and healthy control subjects using global and focal brain measurements...
  20. doi request reprint Mapping reliability in multicenter MRI: voxel-based morphometry and cortical thickness
    Hugo G Schnack
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Brain Mapp 31:1967-82. 2010
    ..g., around the thalamus). These tools will facilitate the design and analysis of multisite VBM and CORT studies for detecting group differences and estimating heritability...
  21. pmc Genetic schizophrenia risk variants jointly modulate total brain and white matter volume
    Afke F Terwisscha van Scheltinga
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht
    Biol Psychiatry 73:525-31. 2013
    ..It is likely that subsets of disease-associated SNPs are associated with distinct heritable disease-associated phenotypes. Therefore, we examined the shared genetic susceptibility modulating schizophrenia and brain volume...
  22. doi request reprint Exercise therapy, cardiorespiratory fitness and their effect on brain volumes: a randomised controlled trial in patients with schizophrenia and healthy controls
    Thomas W Scheewe
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 23:675-85. 2013
    ..However, cardiorespiratory fitness improvement attenuated brain volume changes in schizophrenia patients and increased thickness in large areas of the left cortex in both schizophrenia patients and healthy controls...
  23. doi request reprint Classification of schizophrenia patients and healthy controls from structural MRI scans in two large independent samples
    Mireille Nieuwenhuis
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, P O Box 85500 3508 GA Utrecht, The Netherlands
    Neuroimage 61:606-12. 2012
    ..Larger training samples gave more reliable models: Models based on sample sizes smaller than N=130 should be considered unstable and can even score below chance...
  24. ncbi request reprint Brain volume changes in first-episode schizophrenia: a 1-year follow-up study
    Wiepke Cahn
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 59:1002-10. 2002
    ..One would expect global gray matter to decrease progressively, particularly in first-episode patients, because clinical deterioration is greatest in the early stages of the disease...
  25. doi request reprint Duration of untreated illness in schizophrenia is not associated with 5-year brain volume change
    Geartsje Boonstra
    Department of Psychiatry, University Medical Center Utrecht, P B 85500, 3508 GA, Utrecht, The Netherlands
    Schizophr Res 132:84-90. 2011
    ..We aimed to investigate the relationship between DUI, outcome and brain volume at illness onset or brain volume change during the first five years of the illness in first-episode patients...
  26. ncbi request reprint Brain volumes as predictor of outcome in recent-onset schizophrenia: a multi-center MRI study
    Neeltje E M van Haren
    Department of Psychiatry A 01 126, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    Schizophr Res 64:41-52. 2003
    ..No significant correlations were found between the brain volume measures and any of these measures. Gray matter volume at illness onset does not predict outcome after 2 years in recent-onset schizophrenia...
  27. doi request reprint Tract-based diffusion tensor imaging in patients with schizophrenia and their non-psychotic siblings
    Heleen B M Boos
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Eur Neuropsychopharmacol 23:295-304. 2013
    ..However, changes in the arcuate fasciculus may be relevant to (the risk to develop) psychosis, while a general and widespread loss of fiber integrity may be related to illness progression...
  28. ncbi request reprint Genes contributing to subcortical volumes and intellectual ability implicate the thalamus
    Marc M Bohlken
    Department of Psychiatry, UMC Utrecht, The Netherlands
    Hum Brain Mapp 35:2632-42. 2014
    ..This genetic factor is also implicated in cerebral brain volume. The thalamus, with its widespread cortical connections, may thus play a key role in human intelligence...
  29. ncbi request reprint A controlled study of brain structure in monozygotic twins concordant and discordant for schizophrenia
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 56:454-61. 2004
    ..We examined monozygotic twins concordant and discordant for schizophrenia to clarify the role of genetic and environmental factors in determining brain abnormalities...
  30. doi request reprint Cortical thickness and voxel-based morphometry in depressed elderly
    P Cédric M P Koolschijn
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:398-404. 2010
    ..In contrast to most findings of the literature to date, the results from this study indicate that lifetime depression as well as current state does not seem to influence brain structure in depressed female elderly...
  31. doi request reprint IQ change over time in schizophrenia and healthy individuals: a meta-analysis
    Anna M Hedman
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Schizophr Res 146:201-8. 2013
    ..The aims of this quantitative meta-analysis are to gather, integrate and estimate the overall mean effect size of IQ change over time in schizophrenia as compared to healthy individuals...
  32. ncbi request reprint Reliability of brain volumes from multicenter MRI acquisition: a calibration study
    Hugo G Schnack
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Brain Mapp 22:312-20. 2004
    ..84 for gray matter, and > or = 0.78 for white matter volume. Calibration of segmentation procedures allows morphologic MRI data acquired at different research sites to be combined reliably in multicenter studies...
  33. doi request reprint Hypothalamus volume in twin pairs discordant for schizophrenia
    P Cédric M P Koolschijn
    Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 18:312-5. 2008
    ..Higher within-twin pair similarities in monozygotic compared to dizygotic twin pairs, suggests that hypothalamus volume might be partly genetically controlled...
  34. doi request reprint Brain volume changes after withdrawal of atypical antipsychotics in patients with first-episode schizophrenia
    Geartsje Boonstra
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    J Clin Psychopharmacol 31:146-53. 2011
    ..We found evidence suggestive of decreasing volumes of the putamen and nucleus accumbens over time after discontinuation of medication. This might suggest that discontinuation reverses effects of atypical medication...
  35. doi request reprint Effects of brain-derived neurotrophic factor Val66Met polymorphism on hippocampal volume change in schizophrenia
    P Cédric M P Koolschijn
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Hippocampus 20:1010-7. 2010
    ..Nevertheless, our findings may support the possibility that BDNF affects brain morphology differently in schizophrenia patients and healthy subjects...
  36. doi request reprint Altered white matter connectivity in never-medicated patients with schizophrenia
    Rene C W Mandl
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Hum Brain Mapp 34:2353-65. 2013
    ..We interpret these group-related differences as disease-related axonal or glial aberrations that cannot be attributed to antipsychotic medication use...
  37. doi request reprint Can structural MRI aid in clinical classification? A machine learning study in two independent samples of patients with schizophrenia, bipolar disorder and healthy subjects
    Hugo G Schnack
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands Electronic address
    Neuroimage 84:299-306. 2014
    ..The results also suggest that gray matter pathology in schizophrenia and bipolar disorder differs to such an extent that they can be reliably differentiated using machine learning paradigms. ..
  38. doi request reprint Brain volume abnormalities in major depressive disorder: a meta-analysis of magnetic resonance imaging studies
    P Cédric M P Koolschijn
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Brain Mapp 30:3719-35. 2009
    ..In this comprehensive meta-analysis the magnitude and extent of brain volume differences between 2,418 patients with major depressive disorder and 1,974 healthy individuals from 64 studies was determined...
  39. ncbi request reprint Volume changes in gray matter in patients with schizophrenia
    Hilleke E Hulshoff Pol
    Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Am J Psychiatry 159:244-50. 2002
    ..Although structural brain abnormalities, particularly decrements in gray matter volume, are considered important to the pathology of schizophrenia, it is not resolved whether the brain abnormalities become more prominent over time...
  40. ncbi request reprint No evidence for structural brain changes in young adolescents at ultra high risk for psychosis
    Tim B Ziermans
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Schizophr Res 112:1-6. 2009
    ..However, the timing of these changes has not been established. We investigated structural brain changes in a sample of young adolescents (12-18 years) at ultra high-risk for psychosis (UHR)...
  41. doi request reprint Human brain changes across the life span: a review of 56 longitudinal magnetic resonance imaging studies
    Anna M Hedman
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, The Netherlands
    Hum Brain Mapp 33:1987-2002. 2012
    ..Hum Brain Mapp, 2012. © 2011 Wiley Periodicals, Inc...
  42. ncbi request reprint Twin-singleton differences in brain structure using structural equation modelling
    H E Hulshoff Pol
    Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands
    Brain 125:384-90. 2002
    ..Since other brain volume measures were comparable between the groups, twin studies can provide reliable estimates of heritabilities in brain volume measures and these can be generalized to the singleton population...