Isabelle C Van Gelder

Summary

Affiliation: University Hospital Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint Current treatment recommendations in antiarrhythmic therapy
    I C Van Gelder
    Department of Cardiology, Thoraxcenter, University Hospital Groningen, The Netherlands
    Drugs 55:331-46. 1998
  2. ncbi request reprint Alterations in gene expression of proteins involved in the calcium handling in patients with atrial fibrillation
    I C Van Gelder
    Department of Cardiology, Thoraxcenter, University Hospital Groningen, The Netherlands
    J Cardiovasc Electrophysiol 10:552-60. 1999
  3. ncbi request reprint A comparison of rate control and rhythm control in patients with recurrent persistent atrial fibrillation
    Isabelle C Van Gelder
    Department of Cardiology, Thoraxcenter, University Hospital, Groningen, The Netherlands
    N Engl J Med 347:1834-40. 2002
  4. ncbi request reprint Persistent atrial fibrillation is associated with appropriate shocks and heart failure in patients with left ventricular dysfunction treated with an implantable cardioverter defibrillator
    Michiel Rienstra
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am Heart J 153:120-6. 2007
  5. doi request reprint The effect of rate control on quality of life in patients with permanent atrial fibrillation: data from the RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) study
    Hessel F Groenveld
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 58:1795-803. 2011
  6. ncbi request reprint Verapamil versus digoxin and acute versus routine serial cardioversion for the improvement of rhythm control for persistent atrial fibrillation
    Martin E W Hemels
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 48:1001-9. 2006
  7. ncbi request reprint Rate control versus rhythm control for patients with persistent atrial fibrillation with mild to moderate heart failure: results from the RAte Control versus Electrical cardioversion (RACE) study
    Vincent E Hagens
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Am Heart J 149:1106-11. 2005
  8. ncbi request reprint Right ventricular pacing and the risk of heart failure in implantable cardioverter-defibrillator patients
    Marcelle D Smit
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Heart Rhythm 3:1397-403. 2006
  9. doi request reprint Importance of heart rate during exercise for response to cardiac resynchronization therapy
    Alexander H Maass
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Cardiovasc Electrophysiol 20:773-80. 2009
  10. doi request reprint Right atrial preventive and antitachycardia pacing for prevention of paroxysmal atrial fibrillation in patients without bradycardia: a randomized study
    Martin E W Hemels
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Europace 10:306-13. 2008

Detail Information

Publications69

  1. ncbi request reprint Current treatment recommendations in antiarrhythmic therapy
    I C Van Gelder
    Department of Cardiology, Thoraxcenter, University Hospital Groningen, The Netherlands
    Drugs 55:331-46. 1998
    ..This may imply that an increasing number of patients will be candidates for such a device. However, it will be necessary to await publication of data involving these devices from current ongoing studies...
  2. ncbi request reprint Alterations in gene expression of proteins involved in the calcium handling in patients with atrial fibrillation
    I C Van Gelder
    Department of Cardiology, Thoraxcenter, University Hospital Groningen, The Netherlands
    J Cardiovasc Electrophysiol 10:552-60. 1999
    ..Abnormalities in the calcium handling in response to tachycardia-induced intracellular calcium overload play a pivotal role in these processes...
  3. ncbi request reprint A comparison of rate control and rhythm control in patients with recurrent persistent atrial fibrillation
    Isabelle C Van Gelder
    Department of Cardiology, Thoraxcenter, University Hospital, Groningen, The Netherlands
    N Engl J Med 347:1834-40. 2002
    ..We hypothesized that ventricular rate control is not inferior to the maintenance of sinus rhythm for the treatment of atrial fibrillation...
  4. ncbi request reprint Persistent atrial fibrillation is associated with appropriate shocks and heart failure in patients with left ventricular dysfunction treated with an implantable cardioverter defibrillator
    Michiel Rienstra
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am Heart J 153:120-6. 2007
    ....
  5. doi request reprint The effect of rate control on quality of life in patients with permanent atrial fibrillation: data from the RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) study
    Hessel F Groenveld
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 58:1795-803. 2011
    ..The aim of this study was to investigate the influence of rate control on quality of life (QOL)...
  6. ncbi request reprint Verapamil versus digoxin and acute versus routine serial cardioversion for the improvement of rhythm control for persistent atrial fibrillation
    Martin E W Hemels
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 48:1001-9. 2006
    ....
  7. ncbi request reprint Rate control versus rhythm control for patients with persistent atrial fibrillation with mild to moderate heart failure: results from the RAte Control versus Electrical cardioversion (RACE) study
    Vincent E Hagens
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Am Heart J 149:1106-11. 2005
    ..Rate control is not inferior to rhythm control in preventing mortality and morbidity in patients with AF. In CHF, this issue is still unsettled...
  8. ncbi request reprint Right ventricular pacing and the risk of heart failure in implantable cardioverter-defibrillator patients
    Marcelle D Smit
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Heart Rhythm 3:1397-403. 2006
    ..Right ventricular (RV) pacing in implantable cardioverter-defibrillator (ICD) patients may have detrimental effects on morbidity and mortality, in particular by inducing heart failure (HF)...
  9. doi request reprint Importance of heart rate during exercise for response to cardiac resynchronization therapy
    Alexander H Maass
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Cardiovasc Electrophysiol 20:773-80. 2009
    ..Cardiac resynchronization therapy (CRT) is an established therapy for patients with severe heart failure and mechanical dyssynchrony. Response is only achieved in 60-70% of patients...
  10. doi request reprint Right atrial preventive and antitachycardia pacing for prevention of paroxysmal atrial fibrillation in patients without bradycardia: a randomized study
    Martin E W Hemels
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Europace 10:306-13. 2008
    ..To investigate the efficacy of preventive and antitachycardia pacing (ATP) in patients with symptomatic paroxysmal atrial fibrillation (AF) without bradyarrhythmias...
  11. ncbi request reprint Effect of rate and rhythm control on left ventricular function and cardiac dimensions in patients with persistent atrial fibrillation: results from the RAte Control versus Electrical Cardioversion for Persistent Atrial Fibrillation (RACE) study
    Vincent E Hagens
    Department of Cardiology, University Hospital, Groningen, The Netherlands
    Heart Rhythm 2:19-24. 2005
    ..The purpose of this study was to evaluate left ventricular function and atrial and ventricular diameters in patients with persistent atrial fibrillation (AF) treated with rate or rhythm control...
  12. ncbi request reprint Mending the rhythm does not improve prognosis in patients with persistent atrial fibrillation: a subanalysis of the RACE study
    Michiel Rienstra
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur Heart J 27:357-64. 2006
    ..To compare outcome of AF patients with effective rhythm control with patients treated with rate control...
  13. ncbi request reprint Favorable long-term outcome of Maze surgery in patients with lone atrial fibrillation
    Martin E W Hemels
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Ann Thorac Surg 81:1773-9. 2006
    ..We investigated the long-term outcome of Cox maze III surgery in patients with symptomatic lone AF refractory to antiarrhythmic drug therapy...
  14. doi request reprint Effect of lenient versus strict rate control on cardiac remodeling in patients with atrial fibrillation data of the RACE II (RAte Control Efficacy in permanent atrial fibrillation II) study
    Marcelle D Smit
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 58:942-9. 2011
    ..The aim of this study was to evaluate echocardiographic remodeling in permanent atrial fibrillation (AF) patients treated with either lenient or strict rate control...
  15. ncbi request reprint Outcome of pharmacological rhythm control for new-onset persistent atrial fibrillation in patients with systolic heart failure: a comparison with patients with normal left ventricular function
    Martin E W Hemels
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Europace 9:239-45. 2007
    ..To compare outcome of a serial cardioversion strategy in atrial fibrillation (AF) patients with and without systolic heart failure (HF)...
  16. ncbi request reprint Implication from randomized trials of rate and rhythm controls on management of patients with persistent atrial fibrillation
    Vincent E Hagens
    Department of Cardiology, University Medical Center Groningen, The Netherlands
    Ann Noninvasive Electrocardiol 11:170-86. 2006
    ..As with antiarrhythmic therapy, the search for new and safer anticoagulant therapy is underway. This review will focus on the key aspects we have learned from the randomized trials on rate and rhythm controls for patients with AF...
  17. ncbi request reprint Determinants of sudden cardiac death in patients with persistent atrial fibrillation in the rate control versus electrical cardioversion (RACE) study
    Vincent E Hagens
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 98:929-32. 2006
    ..In conclusion, the treatment of underlying disease, rather than the heart rhythm, seems essential to prevent mortality...
  18. doi request reprint Continuous vs episodic prophylactic treatment with amiodarone for the prevention of atrial fibrillation: a randomized trial
    Sheba Ahmed
    Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    JAMA 300:1784-92. 2008
    ..Amiodarone effectively suppresses atrial fibrillation but causes many adverse events...
  19. ncbi request reprint Beta-blockers prevent subacute recurrences of persistent atrial fibrillation only in patients with hypertension
    Trudeke Van Noord
    University Hospital Groningen, Cardiology, The Netherlands
    Europace 6:343-50. 2004
    ....
  20. doi request reprint Effect of continuous versus episodic amiodarone treatment on quality of life in persistent atrial fibrillation
    Sheba Ahmed
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Europace 12:785-91. 2010
    ..We hypothesized that episodic amiodarone treatment would be associated with better quality of life (QoL) compared with continuous treatment in the prevention of recurrent atrial fibrillation (AF)...
  21. ncbi request reprint Effect of rate or rhythm control on quality of life in persistent atrial fibrillation. Results from the Rate Control Versus Electrical Cardioversion (RACE) Study
    Vincent E Hagens
    Department of Cardiology, University Hospital, Groningen, Netherlands
    J Am Coll Cardiol 43:241-7. 2004
    ..We studied the influence of rate control or rhythm control in patients with persistent atrial fibrillation (AF) on quality of life (QoL)...
  22. ncbi request reprint Clustering of RR intervals predicts effective electrical cardioversion for atrial fibrillation
    Maarten P van den Berg
    Department of Cardiology, Thoraxcenter, University Hospital Groningen, Groningen, The Netherlands
    J Cardiovasc Electrophysiol 15:1027-33. 2004
    ..It was hypothesized that electrical cardioversion (ECV) would be more effective in AF patients with clustering, because clustering might reflect a higher degree of organization of atrial fibrillatory activity...
  23. doi request reprint Lenient versus strict rate control in patients with atrial fibrillation
    Isabelle C Van Gelder
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    N Engl J Med 362:1363-73. 2010
    ..We hypothesized that lenient rate control is not inferior to strict rate control for preventing cardiovascular morbidity and mortality in patients with permanent atrial fibrillation...
  24. doi request reprint Rate control efficacy in permanent atrial fibrillation: successful and failed strict rate control against a background of lenient rate control: data from RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation)
    Hessel F Groenveld
    Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 61:741-8. 2013
    ..This study sought to investigate differences in outcome between patients treated with successful strict, failed strict, and lenient rate control...
  25. ncbi request reprint A family with Andersen-Tawil syndrome and dilated cardiomyopathy
    Bas A Schoonderwoerd
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Heart Rhythm 3:1346-50. 2006
  26. ncbi request reprint Atrial fibrillation predicts appropriate shocks in primary prevention implantable cardioverter-defibrillator patients
    Marcelle D Smit
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Europace 8:566-72. 2006
    ..The purpose of this study was to investigate whether AF is associated with appropriate shocks and cardiovascular mortality in primary prevention ICD patients with left ventricular dysfunction...
  27. ncbi request reprint Natriuretic peptides in patients with atrial fibrillation and advanced chronic heart failure: determinants and prognostic value of (NT-)ANP and (NT-pro)BNP
    Michiel Rienstra
    Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Europace 8:482-7. 2006
    ....
  28. ncbi request reprint Right atrial overdrive pacing for prevention of symptomatic refractory atrial fibrillation
    Martin E W Hemels
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, The Netherlands
    Europace 8:107-12. 2006
    ..Our aim was to investigate whether right atrial overdrive pacing is effective for the prevention of atrial fibrillation (AF) in patients without bradyarrhythmias...
  29. doi request reprint New risk factors for atrial fibrillation: causes of 'not-so-lone atrial fibrillation'
    Bas A Schoonderwoerd
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Europace 10:668-73. 2008
    ..In this review, we address these 'new risk factors' (i.e. as opposed to the classical risk factors) and the mechanisms by which they lead to AF...
  30. ncbi request reprint Gender-related differences in rhythm control treatment in persistent atrial fibrillation: data of the Rate Control Versus Electrical Cardioversion (RACE) study
    Michiel Rienstra
    Department of Cardiology, University Medical Center, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 46:1298-306. 2005
    ..This study sought to compare whether gender affects the outcome of rate versus rhythm control treatment in patients with persistent atrial fibrillation (AF)...
  31. pmc Pretreatment with ACE inhibitors improves acute outcome of electrical cardioversion in patients with persistent atrial fibrillation
    Trudeke Van Noord
    Department of Cardiology, Thoraxcenter, University Hospital Groningen, P O Box 30, 001, 9700RB Groningen, The Netherlands
    BMC Cardiovasc Disord 5:3. 2005
    ..The renin-angiotensin system may play a important role in this. The aim of this study was to investigate the role of angiotensin-converting enzyme (ACE) inhibitor use on efficacy of ECV, and occurrence of subacute recurrences...
  32. ncbi request reprint Clinical characteristics of persistent lone atrial fibrillation in the RACE study
    Michiel Rienstra
    Department of Cardiology, Northern Center of Healthcare Research, University Hospital, Groningen, The Netherlands
    Am J Cardiol 94:1486-90. 2004
    ..Despite the absence of demonstrable cardiovascular and cerebrovascular disease, lone AF is associated with bleeding and thromboembolism...
  33. ncbi request reprint Rate control is more cost-effective than rhythm control for patients with persistent atrial fibrillation--results from the RAte Control versus Electrical cardioversion (RACE) study
    Vincent E Hagens
    Department of Cardiology, Thoraxcenter, University Hospital Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Eur Heart J 25:1542-9. 2004
    ..Conclusions Rate control is more cost-effective than rhythm control for treatment of persistent atrial fibrillation. Underlying heart disease but not heart rhythm largely accounts for costs...
  34. doi request reprint Prognostic importance of natriuretic peptides and atrial fibrillation in patients receiving cardiac resynchronization therapy
    Marcelle D Smit
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Heart Fail 13:543-50. 2011
    ..The aim of this study was to investigate the prognostic value of natriuretic peptides and atrial fibrillation (AF) on response to cardiac resynchronization therapy (CRT) and mortality...
  35. doi request reprint Case of the month by the EHRA Education committee: exercise-related arrhythmias
    Isabelle C Van Gelder
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Europace 10:235-7, 256. 2008
    ..This case describes two nephews with exercise-related arrhythmias...
  36. ncbi request reprint Enhanced cardiovascular morbidity and mortality during rhythm control treatment in persistent atrial fibrillation in hypertensives: data of the RACE study
    Michiel Rienstra
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur Heart J 28:741-51. 2007
    ..To investigate the influence of hypertension on morbidity and mortality during rate and rhythm control in patients with persistent atrial fibrillation (AF)...
  37. ncbi request reprint Does intensity of rate-control influence outcome in atrial fibrillation? An analysis of pooled data from the RACE and AFFIRM studies
    Isabelle C Van Gelder
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Europace 8:935-42. 2006
    ..The AFFIRM and RACE studies showed that rate control is an acceptable treatment strategy for atrial fibrillation (AF). We examined whether strict rate control offers benefit over more lenient rate control...
  38. ncbi request reprint A comparison of low versus high heart rate in patients with atrial fibrillation and advanced chronic heart failure: effects on clinical profile, neurohormones and survival
    Michiel Rienstra
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Int J Cardiol 109:95-100. 2006
    ..Long-term restoration of sinus rhythm is generally unsuccessful. It may be speculated that higher heart rates are unfavorable, since this may lead to tachycardiomyopathy, but there are no data which have examined this...
  39. ncbi request reprint Electrical and structural remodeling: role in the genesis and maintenance of atrial fibrillation
    Bas A Schoonderwoerd
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, RB Groningen, The Netherlands
    Prog Cardiovasc Dis 48:153-68. 2005
    ..Primary and secondary prevention programs should tailor treatment to the various types of remodeling...
  40. doi request reprint Role of inflammation in early atrial fibrillation recurrence
    Marcelle D Smit
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Europace 14:810-7. 2012
    ..Differences in timing of AF recurrence may depend on different types of mechanisms. The aim of this study was to assess the mechanisms involved in early AF recurrence in patients with short-lasting AF...
  41. doi request reprint Cardiac resynchronization therapy in patients with heart failure and atrial fibrillation: importance of new-onset atrial fibrillation and total atrial conduction time
    Sandra Buck
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Europace 10:558-65. 2008
    ..The aim of our study was to investigate whether predictors for CRT success differ between patients with AF and SR and to study the influence of present or developing AF on response to CRT...
  42. doi request reprint Determinants and outcome of amiodarone-associated thyroid dysfunction
    Sheba Ahmed
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Clin Endocrinol (Oxf) 75:388-94. 2011
    ..Amiodarone is frequently associated with thyroid dysfunction. Identifying predictors for amiodarone-associated thyroid dysfunction and assessing treatment outcome may aid clinicians in daily practice...
  43. doi request reprint Does intensity of rate control influence outcome in persistent atrial fibrillation? Data of the RACE study
    Hessel F Groenveld
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Am Heart J 158:785-91. 2009
    ..However, optimal heart rate during atrial fibrillation (AF) remains unknown. Aim of this analysis was to compare outcome between rate control > or =80 and <80 beat/min in patients with persistent atrial fibrillation...
  44. doi request reprint Long-term outcome of the atrioventricular node ablation and pacemaker implantation for symptomatic refractory atrial fibrillation
    Eng S Tan
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Europace 10:412-8. 2008
    ....
  45. doi request reprint Impact of interventricular lead distance and the decrease in septal-to-lateral delay on response to cardiac resynchronization therapy
    Sandra Buck
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, RB Groningen, The Netherlands
    Europace 10:1313-9. 2008
    ..Despite application of established selection criteria, 20-40% of the patients do not respond to CRT...
  46. ncbi request reprint Effect of nebivolol on outcome in elderly patients with heart failure and atrial fibrillation: insights from SENIORS
    Bart A Mulder
    Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherland
    Eur J Heart Fail 14:1171-8. 2012
    ..We evaluated the effect of nebivolol on cardiovascular outcomes in elderly patients with heart failure and AF...
  47. doi request reprint The importance of whether atrial fibrillation or heart failure develops first
    Marcelle D Smit
    Department of Cardiology, Thoraxcenter, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Heart Fail 14:1030-40. 2012
    ..We assessed the prognosis of AF patients hospitalized for heart failure based on the timing of AF and heart failure development...
  48. doi request reprint Clinical and prognostic effects of atrial fibrillation in heart failure patients with reduced and preserved left ventricular ejection fraction
    Gerard C M Linssen
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen
    Eur J Heart Fail 13:1111-20. 2011
    ..We aimed to study the clinical impact of AF vs. sinus rhythm (SR) in stabilized HF patients with reduced left ventricular ejection fraction (HF-REF) and in those with preserved left ventricular ejection fraction (HF-PEF)...
  49. ncbi request reprint The RACE study in perspective of randomized studies on management of persistent atrial fibrillation
    Vincent E Hagens
    Department of Cardiology, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Card Electrophysiol Rev 7:118-21. 2003
    ..Therefore, one of the main lesson learned from the randomized studies is that anticoagulation must be continued if stroke risk factors are present even if patients maintain sinus rhythm...
  50. ncbi request reprint Atrial ultrastructural changes during experimental atrial tachycardia depend on high ventricular rate
    Bas A Schoonderwoerd
    Department of Cardiology, Thoraxcenter, University Hospital Groningen, Groningen, The Netherlands
    J Cardiovasc Electrophysiol 15:1167-74. 2004
    ..Atrial structural and electrophysiologic changes occur during atrial tachycardia. The role of high ventricular rate in these processes remains to be established...
  51. doi request reprint Severe cardiac phenotype with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES gene
    J Peter van Tintelen
    Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Heart Rhythm 6:1574-83. 2009
    ..Mutations in the gene encoding desmin (DES), a major intermediate filament protein, can underlie this phenotype...
  52. doi request reprint Feasibility and outcome of epicardial pulmonary vein isolation for lone atrial fibrillation using minimal invasive surgery and high intensity focused ultrasound
    Theo J Klinkenberg
    Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Europace 11:1624-31. 2009
    ..Success and complications rates are, however, still not optimal. New techniques and energy sources are therefore being developed...
  53. doi request reprint Upstream therapy of atrial fibrillation
    Marcelle D Smit
    Department of Cardiology, Thorax Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Expert Rev Cardiovasc Ther 7:763-78. 2009
    ..e., secondary prevention). Larger clinical trials are required to further elucidate the position of upstream therapy in the primary and secondary prevention of atrial fibrillation...
  54. doi request reprint Who, when and how to rate control for atrial fibrillation
    Michiel Rienstra
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Curr Opin Cardiol 23:23-7. 2008
    ..This review emphasizes the indications for rate control, the optimal heart rate and the different treatment modalities...
  55. doi request reprint How to prevent ICD shocks: part II
    Sandra Buck
    1Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Europace 10:1126-9. 2008
  56. doi request reprint The value and limitations of a wound inspection clinic after cardiac device implantation
    J Han H Deuling
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Cardiovasc Nurs 8:288-92. 2009
    ..Due to the growing number of cardiac device implantations it is important to develop methods to reduce device-implantation related complications...
  57. doi request reprint Implantable cardioverter defibrillator therapy in adults with congenital heart disease: who is at risk of shocks?
    Zeliha Koyak
    Department of Cardiology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
    Circ Arrhythm Electrophysiol 5:101-10. 2012
    ..We investigated the long-term outcome after ICD implantation and developed a simple risk stratification score for ICD therapy...
  58. doi request reprint How to prevent ICD shocks: part I
    Sandra Buck
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Europace 10:1110-1. 2008
  59. ncbi request reprint Predictors of non-pharmacological intervention in patients with paroxysmal atrial fibrillation: Value of neuroticism
    Martin E W Hemels
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Int J Cardiol 111:75-9. 2006
    ..We sought to investigate which factors play a role in the choice for non-pharmacological intervention with a particular focus on neuroticism...
  60. ncbi request reprint Atrial natriuretic peptides during experimental atrial tachycardia: role of developing tachycardiomyopathy
    Bas A Schoonderwoerd
    Department of Cardiology, Thoraxcenter, University Hospital Groningen, Groningen, The Netherlands
    J Cardiovasc Electrophysiol 15:927-32. 2004
    ..The aim of this study was to establish the contribution of elevated atrial rate and of high ventricular rate, resulting in CHF, on ANP and NT-ANP levels during chronic atrial tachycardia...
  61. ncbi request reprint Genetic aspects of atrial fibrillation
    Ans C P Wiesfeld
    Thoraxcenter, Department of Cardiology, University Medical Center Groningen, University of Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Cardiovasc Res 67:414-8. 2005
    ..Understanding the molecular mechanisms underlying AF may provide insight into the pathogenesis of AF and eventually may lead to improved, patient-tailored rhythm control strategies...
  62. pmc Rationale and current perspective for early rhythm control therapy in atrial fibrillation
    Isabelle C Van Gelder
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Europace 13:1517-25. 2011
    ..In the present paper we describe the background of these studies and provide some information on their design...
  63. ncbi request reprint Should aldosterone blockade be used beyond current indications in heart failure?
    Marcelle D Smit
    Department of Cardiology, Thorax Center, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, The Netherlands
    Curr Heart Fail Rep 6:117-25. 2009
    ..It is hoped that the results of large randomized clinical trials further elucidate the indications of ARAs beyond current guidelines...
  64. ncbi request reprint How to enhance acute outcome of electrical cardioversion by drug therapy: importance of immediate reinitiation of atrial fibrillation
    Trudeke Van Noord
    Department of Cardiology, Thoraxcenter, University Hospital Groningen, The Netherlands
    J Cardiovasc Electrophysiol 13:822-5. 2002
    ..Relative prevalence of shock failure and IRAF are not well known because data on outcome of electrical cardioversion therapy mostly do not distinguish shock failure from IRAF...
  65. ncbi request reprint Sinus node function after cardiac surgery: is impairment specific for the maze procedure?
    Anton E Tuinenburg
    Department of Cardiology, Thoraxcenter, University Hospital Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Int J Cardiol 95:101-8. 2004
    ..Maze surgery is a final solution for intractable atrial fibrillation (AF), but an adverse effect on postoperative sinus node function has been reported. Whether this also applies to other types of cardiac surgery is unclear...
  66. doi request reprint Myocardial perfusion imaging does not adequately assess the risk of coronary artery disease in patients with atrial fibrillation
    Marcelle D Smit
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Europace 12:643-8. 2010
    ..This study investigated the value of myocardial perfusion single-photon emission computed tomography (SPECT) in the assessment of risk of CAD in patients with a history of AF...
  67. doi request reprint Implementation of device therapy (cardiac resynchronization therapy and implantable cardioverter defibrillator) for patients with heart failure in Europe: changes from 2004 to 2008
    Dirk J van Veldhuisen
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Heart Fail 11:1143-51. 2009
    ..However, epidemiological data on the use of device therapy in Europe are limited...
  68. ncbi request reprint The progressive nature of atrial fibrillation: a rationale for early restoration and maintenance of sinus rhythm
    Isabelle C Van Gelder
    Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Europace 8:943-9. 2006
    ..Although early intervention to limit the progression of this arrhythmia is hindered by the limitations of existing anti-arrhythmic therapies, it is nevertheless a critical goal...
  69. doi request reprint Prognostic significance of atrial arrhythmias in a primary prevention ICD population
    Isabelle C Van Gelder
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Pacing Clin Electrophysiol 34:1070-9. 2011
    ....