Research Topics
Genomes and Genes | Isabelle C Van GelderSummaryAffiliation: University Hospital Groningen Country: The Netherlands Publications
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Publications
Current treatment recommendations in antiarrhythmic therapyI C Van Gelder
Department of Cardiology, Thoraxcenter, University Hospital Groningen, The Netherlands
Drugs 55:331-46. 1998..This may imply that an increasing number of patients will be candidates for such a device. However, it will be necessary to await publication of data involving these devices from current ongoing studies...- Alterations in gene expression of proteins involved in the calcium handling in patients with atrial fibrillationI C Van Gelder
Department of Cardiology, Thoraxcenter, University Hospital Groningen, The Netherlands
J Cardiovasc Electrophysiol 10:552-60. 1999..Abnormalities in the calcium handling in response to tachycardia-induced intracellular calcium overload play a pivotal role in these processes... - A comparison of rate control and rhythm control in patients with recurrent persistent atrial fibrillationIsabelle C Van Gelder
Department of Cardiology, Thoraxcenter, University Hospital, Groningen, The Netherlands
N Engl J Med 347:1834-40. 2002..We hypothesized that ventricular rate control is not inferior to the maintenance of sinus rhythm for the treatment of atrial fibrillation... - Persistent atrial fibrillation is associated with appropriate shocks and heart failure in patients with left ventricular dysfunction treated with an implantable cardioverter defibrillatorMichiel Rienstra
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Am Heart J 153:120-6. 2007.... 
The effect of rate control on quality of life in patients with permanent atrial fibrillation: data from the RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) studyHessel F Groenveld
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
J Am Coll Cardiol 58:1795-803. 2011..The aim of this study was to investigate the influence of rate control on quality of life (QOL)...- Verapamil versus digoxin and acute versus routine serial cardioversion for the improvement of rhythm control for persistent atrial fibrillationMartin E W Hemels
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
J Am Coll Cardiol 48:1001-9. 2006..CONCLUSIONS: An acute serial cardioversion strategy does not improve long-term rhythm control in comparison with a routine serial cardioversion strategy. Furthermore, verapamil has no beneficial effect in a serial cardioversion strategy... - Rate control versus rhythm control for patients with persistent atrial fibrillation with mild to moderate heart failure: results from the RAte Control versus Electrical cardioversion (RACE) studyVincent E Hagens
Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
Am Heart J 149:1106-11. 2005..However, if sinus rhythm can be maintained, outcome may be improved. A prospective randomized trial is necessary to confirm these results... - Importance of heart rate during exercise for response to cardiac resynchronization therapyAlexander H Maass
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
J Cardiovasc Electrophysiol 20:773-80. 2009..Cardiac resynchronization therapy (CRT) is an established therapy for patients with severe heart failure and mechanical dyssynchrony. Response is only achieved in 60-70% of patients... - Right ventricular pacing and the risk of heart failure in implantable cardioverter-defibrillator patientsMarcelle D Smit
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Heart Rhythm 3:1397-403. 2006..50; 95% CI 1.02-2.20; P = .04). CONCLUSION: RV pacing was associated with an increased risk of HF in asymptomatic ICD patients, particularly in those with preexistent left ventricular dysfunction... - Mending the rhythm does not improve prognosis in patients with persistent atrial fibrillation: a subanalysis of the RACE studyMichiel Rienstra
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
Eur Heart J 27:357-64. 2006..CONCLUSION: Among patients who remained on warfarin, those who mostly were maintained in sinus rhythm under a rhythm-control strategy did not have a superior prognosis compared to those who remained in AF under a rate-control strategy... - Effect of rate and rhythm control on left ventricular function and cardiac dimensions in patients with persistent atrial fibrillation: results from the RAte Control versus Electrical Cardioversion for Persistent Atrial Fibrillation (RACE) studyVincent E Hagens
Department of Cardiology, University Hospital, Groningen, The Netherlands
Heart Rhythm 2:19-24. 2005..CONCLUSIONS: Routine rate control prevents deterioration of left ventricular function. Maintenance of sinus rhythm is associated with improvement of left ventricular function and reduction of atrial sizes... - Right atrial preventive and antitachycardia pacing for prevention of paroxysmal atrial fibrillation in patients without bradycardia: a randomized studyMartin E W Hemels
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
Europace 10:306-13. 2008..To investigate the efficacy of preventive and antitachycardia pacing (ATP) in patients with symptomatic paroxysmal atrial fibrillation (AF) without bradyarrhythmias... - Effect of lenient versus strict rate control on cardiac remodeling in patients with atrial fibrillation data of the RACE II (RAte Control Efficacy in permanent atrial fibrillation II) studyMarcelle D Smit
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
J Am Coll Cardiol 58:942-9. 2011..The aim of this study was to evaluate echocardiographic remodeling in permanent atrial fibrillation (AF) patients treated with either lenient or strict rate control... - Favorable long-term outcome of Maze surgery in patients with lone atrial fibrillationMartin E W Hemels
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Ann Thorac Surg 81:1773-9. 2006..CONCLUSIONS: Cox maze III surgery is a highly effective therapy for drug-refractory lone AF, and therefore remains an alternative to transvenous pulmonary vein ablation... - Continuous vs episodic prophylactic treatment with amiodarone for the prevention of atrial fibrillation: a randomized trialSheba Ahmed
Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
JAMA 300:1784-92. 2008..Amiodarone effectively suppresses atrial fibrillation but causes many adverse events... - Effect of rate or rhythm control on quality of life in persistent atrial fibrillation. Results from the Rate Control Versus Electrical Cardioversion (RACE) StudyVincent E Hagens
Department of Cardiology, University Hospital, Groningen, Netherlands
J Am Coll Cardiol 43:241-7. 2004..Treatment strategy does not affect QoL. Patients with complaints related to AF, however, may benefit from rhythm control if SR can be maintained... - Implication from randomized trials of rate and rhythm controls on management of patients with persistent atrial fibrillationVincent E Hagens
Department of Cardiology, University Medical Center Groningen, The Netherlands
Ann Noninvasive Electrocardiol 11:170-86. 2006..As with antiarrhythmic therapy, the search for new and safer anticoagulant therapy is underway. This review will focus on the key aspects we have learned from the randomized trials on rate and rhythm controls for patients with AF... - Beta-blockers prevent subacute recurrences of persistent atrial fibrillation only in patients with hypertensionTrudeke Van Noord
University Hospital Groningen, Cardiology, The Netherlands
Europace 6:343-50. 2004.... - Determinants of sudden cardiac death in patients with persistent atrial fibrillation in the rate control versus electrical cardioversion (RACE) studyVincent E Hagens
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Am J Cardiol 98:929-32. 2006..In conclusion, the treatment of underlying disease, rather than the heart rhythm, seems essential to prevent mortality... - Effect of continuous versus episodic amiodarone treatment on quality of life in persistent atrial fibrillationSheba Ahmed
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
Europace 12:785-91. 2010..We hypothesized that episodic amiodarone treatment would be associated with better quality of life (QoL) compared with continuous treatment in the prevention of recurrent atrial fibrillation (AF)... - Outcome of pharmacological rhythm control for new-onset persistent atrial fibrillation in patients with systolic heart failure: a comparison with patients with normal left ventricular functionMartin E W Hemels
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
Europace 9:239-45. 2007..To compare outcome of a serial cardioversion strategy in atrial fibrillation (AF) patients with and without systolic heart failure (HF)... - Clustering of RR intervals predicts effective electrical cardioversion for atrial fibrillationMaarten P van den Berg
Department of Cardiology, Thoraxcenter, University Hospital Groningen, Groningen, The Netherlands
J Cardiovasc Electrophysiol 15:1027-33. 2004..It was hypothesized that electrical cardioversion (ECV) would be more effective in AF patients with clustering, because clustering might reflect a higher degree of organization of atrial fibrillatory activity... - Lenient versus strict rate control in patients with atrial fibrillationIsabelle C Van Gelder
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
N Engl J Med 362:1363-73. 2010..We hypothesized that lenient rate control is not inferior to strict rate control for preventing cardiovascular morbidity and mortality in patients with permanent atrial fibrillation... - A family with Andersen-Tawil syndrome and dilated cardiomyopathyBas A Schoonderwoerd
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Heart Rhythm 3:1346-50. 2006 - Natriuretic peptides in patients with atrial fibrillation and advanced chronic heart failure: determinants and prognostic value of (NT-)ANP and (NT-pro)BNPMichiel Rienstra
Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
Europace 8:482-7. 2006..CONCLUSION: In advanced CHF patients, AF affects (NT-)ANP levels, but not (NT-pro)BNP levels. NT-proBNP is an independent determinant of prognosis in advanced CHF, irrespective of the rhythm, AF, or sinus rhythm... - New risk factors for atrial fibrillation: causes of 'not-so-lone atrial fibrillation'Bas A Schoonderwoerd
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
Europace 10:668-73. 2008..In this review, we address these 'new risk factors' (i.e. as opposed to the classical risk factors) and the mechanisms by which they lead to AF... - Atrial fibrillation predicts appropriate shocks in primary prevention implantable cardioverter-defibrillator patientsMarcelle D Smit
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Europace 8:566-72. 2006..CONCLUSION: Our study demonstrates that history of AF is associated with increased risk of appropriate shocks and cardiovascular mortality in primary prevention ICD patients with left ventricular dysfunction... - Right atrial overdrive pacing for prevention of symptomatic refractory atrial fibrillationMartin E W Hemels
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, The Netherlands
Europace 8:107-12. 2006..CONCLUSION: Right atrial overdrive pacing in combination with antiarrhythmic drugs seems an attractive treatment option in drug refractory symptomatic AF patients... - Rate control is more cost-effective than rhythm control for patients with persistent atrial fibrillation--results from the RAte Control versus Electrical cardioversion (RACE) studyVincent E Hagens
Department of Cardiology, Thoraxcenter, University Hospital Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
Eur Heart J 25:1542-9. 2004..Conclusions Rate control is more cost-effective than rhythm control for treatment of persistent atrial fibrillation. Underlying heart disease but not heart rhythm largely accounts for costs... - Clinical characteristics of persistent lone atrial fibrillation in the RACE studyMichiel Rienstra
Department of Cardiology, Northern Center of Healthcare Research, University Hospital, Groningen, The Netherlands
Am J Cardiol 94:1486-90. 2004..Despite the absence of demonstrable cardiovascular and cerebrovascular disease, lone AF is associated with bleeding and thromboembolism... 
Pretreatment with ACE inhibitors improves acute outcome of electrical cardioversion in patients with persistent atrial fibrillationTrudeke Van Noord
Department of Cardiology, Thoraxcenter, University Hospital Groningen, P O Box 30, 001, 9700RB Groningen, The Netherlands
BMC Cardiovasc Disord 5:3. 2005..The renin-angiotensin system may play a important role in this. The aim of this study was to investigate the role of angiotensin-converting enzyme (ACE) inhibitor use on efficacy of ECV, and occurrence of subacute recurrences...- Gender-related differences in rhythm control treatment in persistent atrial fibrillation: data of the Rate Control Versus Electrical Cardioversion (RACE) studyMichiel Rienstra
Department of Cardiology, University Medical Center, University of Groningen, Groningen, The Netherlands
J Am Coll Cardiol 46:1298-306. 2005..Because treatment strategy did not influence QoL in female patients, a rate control approach may be considered in these patients... - Enhanced cardiovascular morbidity and mortality during rhythm control treatment in persistent atrial fibrillation in hypertensives: data of the RACE studyMichiel Rienstra
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Eur Heart J 28:741-51. 2007..To investigate the influence of hypertension on morbidity and mortality during rate and rhythm control in patients with persistent atrial fibrillation (AF)... - Prognostic importance of natriuretic peptides and atrial fibrillation in patients receiving cardiac resynchronization therapyMarcelle D Smit
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Eur J Heart Fail 13:543-50. 2011..The aim of this study was to investigate the prognostic value of natriuretic peptides and atrial fibrillation (AF) on response to cardiac resynchronization therapy (CRT) and mortality... - Case of the month by the EHRA Education committee: exercise-related arrhythmiasIsabelle C Van Gelder
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
Europace 10:235-7, 256. 2008..This case describes two nephews with exercise-related arrhythmias... - Does intensity of rate-control influence outcome in atrial fibrillation? An analysis of pooled data from the RACE and AFFIRM studiesIsabelle C Van Gelder
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
Europace 8:935-42. 2006..The AFFIRM and RACE studies showed that rate control is an acceptable treatment strategy for atrial fibrillation (AF). We examined whether strict rate control offers benefit over more lenient rate control... - Electrical and structural remodeling: role in the genesis and maintenance of atrial fibrillationBas A Schoonderwoerd
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, RB Groningen, The Netherlands
Prog Cardiovasc Dis 48:153-68. 2005..Primary and secondary prevention programs should tailor treatment to the various types of remodeling... - A comparison of low versus high heart rate in patients with atrial fibrillation and advanced chronic heart failure: effects on clinical profile, neurohormones and survivalMichiel Rienstra
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Int J Cardiol 109:95-100. 2006..Not higher heart rates at baseline but, on the contrary, lower heart rates seem associated with a worse outcome... - Role of inflammation in early atrial fibrillation recurrenceMarcelle D Smit
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
Europace 14:810-7. 2012..Differences in timing of AF recurrence may depend on different types of mechanisms. The aim of this study was to assess the mechanisms involved in early AF recurrence in patients with short-lasting AF... - Does intensity of rate control influence outcome in persistent atrial fibrillation? Data of the RACE studyHessel F Groenveld
Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
Am Heart J 158:785-91. 2009..However, optimal heart rate during atrial fibrillation (AF) remains unknown. Aim of this analysis was to compare outcome between rate control > or =80 and <80 beat/min in patients with persistent atrial fibrillation... - Impact of interventricular lead distance and the decrease in septal-to-lateral delay on response to cardiac resynchronization therapySandra Buck
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, RB Groningen, The Netherlands
Europace 10:1313-9. 2008..Despite application of established selection criteria, 20-40% of the patients do not respond to CRT... - Determinants and outcome of amiodarone-associated thyroid dysfunctionSheba Ahmed
Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
Clin Endocrinol (Oxf) 75:388-94. 2011..Amiodarone is frequently associated with thyroid dysfunction. Identifying predictors for amiodarone-associated thyroid dysfunction and assessing treatment outcome may aid clinicians in daily practice... - Cardiac resynchronization therapy in patients with heart failure and atrial fibrillation: importance of new-onset atrial fibrillation and total atrial conduction timeSandra Buck
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
Europace 10:558-65. 2008..The aim of our study was to investigate whether predictors for CRT success differ between patients with AF and SR and to study the influence of present or developing AF on response to CRT... - Long-term outcome of the atrioventricular node ablation and pacemaker implantation for symptomatic refractory atrial fibrillationEng S Tan
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
Europace 10:412-8. 2008.... - Clinical and prognostic effects of atrial fibrillation in heart failure patients with reduced and preserved left ventricular ejection fractionGerard C M Linssen
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen
Eur J Heart Fail 13:1111-20. 2011..We aimed to study the clinical impact of AF vs. sinus rhythm (SR) in stabilized HF patients with reduced left ventricular ejection fraction (HF-REF) and in those with preserved left ventricular ejection fraction (HF-PEF)... - Severe cardiac phenotype with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES geneJ Peter van Tintelen
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Heart Rhythm 6:1574-83. 2009..Mutations in the gene encoding desmin (DES), a major intermediate filament protein, can underlie this phenotype... - Feasibility and outcome of epicardial pulmonary vein isolation for lone atrial fibrillation using minimal invasive surgery and high intensity focused ultrasoundTheo J Klinkenberg
Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Europace 11:1624-31. 2009..Success and complications rates are, however, still not optimal. New techniques and energy sources are therefore being developed... - The RACE study in perspective of randomized studies on management of persistent atrial fibrillationVincent E Hagens
Department of Cardiology, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
Card Electrophysiol Rev 7:118-21. 2003..Therefore, one of the main lesson learned from the randomized studies is that anticoagulation must be continued if stroke risk factors are present even if patients maintain sinus rhythm... - Upstream therapy of atrial fibrillationMarcelle D Smit
Department of Cardiology, Thorax Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Expert Rev Cardiovasc Ther 7:763-78. 2009..e., secondary prevention). Larger clinical trials are required to further elucidate the position of upstream therapy in the primary and secondary prevention of atrial fibrillation... - The value and limitations of a wound inspection clinic after cardiac device implantationJ Han H Deuling
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Eur J Cardiovasc Nurs 8:288-92. 2009..Due to the growing number of cardiac device implantations it is important to develop methods to reduce device-implantation related complications... - Atrial ultrastructural changes during experimental atrial tachycardia depend on high ventricular rateBas A Schoonderwoerd
Department of Cardiology, Thoraxcenter, University Hospital Groningen, Groningen, The Netherlands
J Cardiovasc Electrophysiol 15:1167-74. 2004..Atrial structural and electrophysiologic changes occur during atrial tachycardia. The role of high ventricular rate in these processes remains to be established... - How to prevent ICD shocks: part IISandra Buck
1Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
Europace 10:1126-9. 2008 - Who, when and how to rate control for atrial fibrillationMichiel Rienstra
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Curr Opin Cardiol 23:23-7. 2008..This review emphasizes the indications for rate control, the optimal heart rate and the different treatment modalities... - Implantable cardioverter defibrillator therapy in adults with congenital heart disease: who is at risk of shocks?Zeliha Koyak
Department of Cardiology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
Circ Arrhythm Electrophysiol 5:101-10. 2012..We investigated the long-term outcome after ICD implantation and developed a simple risk stratification score for ICD therapy... - Genetic aspects of atrial fibrillationAns C P Wiesfeld
Thoraxcenter, Department of Cardiology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Cardiovasc Res 67:414-8. 2005..Understanding the molecular mechanisms underlying AF may provide insight into the pathogenesis of AF and eventually may lead to improved, patient-tailored rhythm control strategies... - Predictors of non-pharmacological intervention in patients with paroxysmal atrial fibrillation: Value of neuroticismMartin E W Hemels
Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
Int J Cardiol 111:75-9. 2006..We sought to investigate which factors play a role in the choice for non-pharmacological intervention with a particular focus on neuroticism... - How to prevent ICD shocks: part ISandra Buck
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
Europace 10:1110-1. 2008 - Atrial natriuretic peptides during experimental atrial tachycardia: role of developing tachycardiomyopathyBas A Schoonderwoerd
Department of Cardiology, Thoraxcenter, University Hospital Groningen, Groningen, The Netherlands
J Cardiovasc Electrophysiol 15:927-32. 2004..The aim of this study was to establish the contribution of elevated atrial rate and of high ventricular rate, resulting in CHF, on ANP and NT-ANP levels during chronic atrial tachycardia... - The importance of whether atrial fibrillation or heart failure develops firstMarcelle D Smit
Department of Cardiology, Thoraxcenter, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Eur J Heart Fail 14:1030-40. 2012..We assessed the prognosis of AF patients hospitalized for heart failure based on the timing of AF and heart failure development... - Rationale and current perspective for early rhythm control therapy in atrial fibrillationIsabelle C Van Gelder
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Europace 13:1517-25. 2011..In the present paper we describe the background of these studies and provide some information on their design... - Prognostic significance of atrial arrhythmias in a primary prevention ICD populationIsabelle C Van Gelder
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Pacing Clin Electrophysiol 34:1070-9. 2011.... - Sinus node function after cardiac surgery: is impairment specific for the maze procedure?Anton E Tuinenburg
Department of Cardiology, Thoraxcenter, University Hospital Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
Int J Cardiol 95:101-8. 2004..Maze surgery is a final solution for intractable atrial fibrillation (AF), but an adverse effect on postoperative sinus node function has been reported. Whether this also applies to other types of cardiac surgery is unclear... - Myocardial perfusion imaging does not adequately assess the risk of coronary artery disease in patients with atrial fibrillationMarcelle D Smit
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
Europace 12:643-8. 2010..This study investigated the value of myocardial perfusion single-photon emission computed tomography (SPECT) in the assessment of risk of CAD in patients with a history of AF... - How to enhance acute outcome of electrical cardioversion by drug therapy: importance of immediate reinitiation of atrial fibrillationTrudeke Van Noord
Department of Cardiology, Thoraxcenter, University Hospital Groningen, The Netherlands
J Cardiovasc Electrophysiol 13:822-5. 2002..Different antiarrhythmic drugs within the same Vaughan-Williams class have different effects on shock failure and IRAF... - Implementation of device therapy (cardiac resynchronization therapy and implantable cardioverter defibrillator) for patients with heart failure in Europe: changes from 2004 to 2008Dirk J van Veldhuisen
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Eur J Heart Fail 11:1143-51. 2009..However, epidemiological data on the use of device therapy in Europe are limited... - The progressive nature of atrial fibrillation: a rationale for early restoration and maintenance of sinus rhythmIsabelle C Van Gelder
Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
Europace 8:943-9. 2006..Although early intervention to limit the progression of this arrhythmia is hindered by the limitations of existing anti-arrhythmic therapies, it is nevertheless a critical goal... - Should aldosterone blockade be used beyond current indications in heart failure?Marcelle D Smit
Department of Cardiology, Thorax Center, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, The Netherlands
Curr Heart Fail Rep 6:117-25. 2009..It is hoped that the results of large randomized clinical trials further elucidate the indications of ARAs beyond current guidelines...