Dirk J van Veldhuisen

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint [The nurse practitioner in the treatment of cardiac patients: successful job reallocation within health care]
    D J van Veldhuisen
    Universitair Medisch Centrum Groningen, afd Cardiologie, Postbus 30 001, 9700 RB Groningen
    Ned Tijdschr Geneeskd 150:2528-9. 2006
  2. ncbi request reprint Randomized, double-blind, placebo-controlled study to evaluate the effect of two dosing regimens of darbepoetin alfa in patients with heart failure and anaemia
    Dirk J van Veldhuisen
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur Heart J 28:2208-16. 2007
  3. doi request reprint Implementation of device therapy (cardiac resynchronization therapy and implantable cardioverter defibrillator) for patients with heart failure in Europe: changes from 2004 to 2008
    Dirk J van Veldhuisen
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Heart Fail 11:1143-51. 2009
  4. ncbi request reprint Presence and development of atrial fibrillation in chronic heart failure. Experiences from the MERIT-HF Study
    Dirk J van Veldhuisen
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur J Heart Fail 8:539-46. 2006
  5. doi request reprint Anemia and iron deficiency in heart failure: mechanisms and therapeutic approaches
    Dirk J van Veldhuisen
    Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700RB Groningen, The Netherlands
    Nat Rev Cardiol 8:485-93. 2011
  6. doi request reprint Beta-blockade with nebivolol in elderly heart failure patients with impaired and preserved left ventricular ejection fraction: Data From SENIORS (Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors With Heart Failure)
    Dirk J van Veldhuisen
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    J Am Coll Cardiol 53:2150-8. 2009
  7. pmc Treatment of heart failure with ACE inhibitors and beta-blockers: what is next? Aldosterone receptor antagonists?
    Iwan C C van der Horst
    Thoraxcenter, Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Clin Res Cardiol 96:193-5. 2007
  8. pmc Prognostic value of galectin-3, a novel marker of fibrosis, in patients with chronic heart failure: data from the DEAL-HF study
    Dirk J A Lok
    Deventer Hospital, Deventer, The Netherlands
    Clin Res Cardiol 99:323-8. 2010
  9. pmc Renal dysfunction is associated with shorter telomere length in heart failure
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Clin Res Cardiol 98:629-34. 2009
  10. doi request reprint Myocardial perfusion reserve after a PET-driven revascularization procedure: a strong prognostic factor
    Riemer H J A Slart
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands
    J Nucl Med 52:873-9. 2011

Collaborators

Detail Information

Publications74

  1. ncbi request reprint [The nurse practitioner in the treatment of cardiac patients: successful job reallocation within health care]
    D J van Veldhuisen
    Universitair Medisch Centrum Groningen, afd Cardiologie, Postbus 30 001, 9700 RB Groningen
    Ned Tijdschr Geneeskd 150:2528-9. 2006
    ..These findings are important and need confirmation in larger studies and in other patient populations...
  2. ncbi request reprint Randomized, double-blind, placebo-controlled study to evaluate the effect of two dosing regimens of darbepoetin alfa in patients with heart failure and anaemia
    Dirk J van Veldhuisen
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur Heart J 28:2208-16. 2007
    ..This randomized, double-blind, placebo-controlled study evaluated the effect of two darbepoetin alfa dosing regimens on haemoglobin (Hb) rate of rise and clinical effects in patients with CHF and anaemia...
  3. doi request reprint Implementation of device therapy (cardiac resynchronization therapy and implantable cardioverter defibrillator) for patients with heart failure in Europe: changes from 2004 to 2008
    Dirk J van Veldhuisen
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Heart Fail 11:1143-51. 2009
    ..However, epidemiological data on the use of device therapy in Europe are limited...
  4. ncbi request reprint Presence and development of atrial fibrillation in chronic heart failure. Experiences from the MERIT-HF Study
    Dirk J van Veldhuisen
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur J Heart Fail 8:539-46. 2006
    ..Atrial fibrillation is common in heart failure, but data regarding beta-blockade in these patients and its ability to prevent new occurrence of atrial fibrillation are scarce...
  5. doi request reprint Anemia and iron deficiency in heart failure: mechanisms and therapeutic approaches
    Dirk J van Veldhuisen
    Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700RB Groningen, The Netherlands
    Nat Rev Cardiol 8:485-93. 2011
    ..Therefore, this treatment approach is likely to become an attractive option for patients with HF and iron deficiency, both with and without anemia...
  6. doi request reprint Beta-blockade with nebivolol in elderly heart failure patients with impaired and preserved left ventricular ejection fraction: Data From SENIORS (Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors With Heart Failure)
    Dirk J van Veldhuisen
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    J Am Coll Cardiol 53:2150-8. 2009
    ....
  7. pmc Treatment of heart failure with ACE inhibitors and beta-blockers: what is next? Aldosterone receptor antagonists?
    Iwan C C van der Horst
    Thoraxcenter, Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Clin Res Cardiol 96:193-5. 2007
  8. pmc Prognostic value of galectin-3, a novel marker of fibrosis, in patients with chronic heart failure: data from the DEAL-HF study
    Dirk J A Lok
    Deventer Hospital, Deventer, The Netherlands
    Clin Res Cardiol 99:323-8. 2010
    ..Galectin-3 is a recently developed biomarker associated with fibrosis and inflammation, and it may play a role in cardiac remodeling in HF. We determined its prognostic value in patients with chronic HF...
  9. pmc Renal dysfunction is associated with shorter telomere length in heart failure
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Clin Res Cardiol 98:629-34. 2009
    ..We explored the association between leukocyte telomere length, a marker for biological age, and renal function in patients with CHF...
  10. doi request reprint Myocardial perfusion reserve after a PET-driven revascularization procedure: a strong prognostic factor
    Riemer H J A Slart
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands
    J Nucl Med 52:873-9. 2011
    ..In the present study, we investigated whether MPR is related to survival in ischemic heart disease (IHD) patients after a PET-driven intervention...
  11. doi request reprint Erythropoietin stimulates normal endothelial progenitor cell-mediated endothelial turnover, but attributes to neovascularization only in the presence of local ischemia
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, P O Box 30001, 9700 RB Groningen, The Netherlands
    Cardiovasc Drugs Ther 22:265-74. 2008
    ..We aimed to evaluate whether ischemia is required for erythropoietin (EPO) induced stimulation of endothelial progenitor cells (EPCs) and their related effects on endothelial and cardiac function...
  12. ncbi request reprint High prevalence of microalbuminuria in chronic heart failure patients
    Ruud M A van de Wal
    Department of Cardiology, St Antonius Hospital, Nieuwegein, The Netherlands
    J Card Fail 11:602-6. 2005
    ..In this cross-sectional study, we aim to evaluate the prevalence of microalbuminuria and the association with neurohormonal parameters in severe chronic heart failure patients...
  13. ncbi request reprint Vascular endothelial growth factor is crucial for erythropoietin-induced improvement of cardiac function in heart failure
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, Groningen 9700 RB, The Netherlands
    Cardiovasc Res 87:30-9. 2010
    ..We intended to delineate the mechanisms of erythropoietin (EPO)-induced cardiac vascular endothelial growth factor (VEGF) production and to establish if VEGF is crucial for EPO-induced improvement of cardiac performance...
  14. doi request reprint Differential associations between renal function and "modifiable" risk factors in patients with chronic heart failure
    Tom D J Smilde
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Res Cardiol 98:121-9. 2009
    ..Our aim was to determine different pathophysiologic markers that are associated with reduced renal function in CHF...
  15. doi request reprint Effects of rosuvastatin on coronary flow reserve and metabolic mismatch in patients with heart failure (from the CORONA Study)
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 105:517-21. 2010
    ....
  16. doi request reprint Advanced glycation end-products, anti-hypertensive treatment and diastolic function in patients with hypertension and diastolic dysfunction
    Jasper W L Hartog
    Department of Cardiology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Eur J Heart Fail 12:397-403. 2010
    ..To investigate the relationship between advanced glycation end-products (AGEs) and diastolic function and the response to blood pressure treatment in patients with hypertension and diastolic dysfunction...
  17. ncbi request reprint Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27
    Rudolf A de Boer
    Thoraxcenter, Department of Cardiology, University Hospital Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands
    J Mol Med (Berl) 82:678-87. 2004
    ..This process is prevented by both AT1 receptor blockade and TYR, and therefore inhibition of either pathway is equally efficacious in restoring LV function and architecture...
  18. ncbi request reprint Right ventricular pacing and the risk of heart failure in implantable cardioverter-defibrillator patients
    Marcelle D Smit
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Heart Rhythm 3:1397-403. 2006
    ..Right ventricular (RV) pacing in implantable cardioverter-defibrillator (ICD) patients may have detrimental effects on morbidity and mortality, in particular by inducing heart failure (HF)...
  19. pmc Effects of eprosartan on diastolic function and neurohormones in patients with hypertension and diastolic dysfunction
    Adriaan A Voors
    Department of Cardiology, University Medical Centre Groningen, RB, The Netherlands
    Cardiovasc Drugs Ther 24:33-40. 2010
    ..To compare the effects of an angiotensin receptor blocker(ARB)-based regimen versus a non-ARB based regimen on diastolic function and neurohormones in patients with hypertension and diastolic dysfunction...
  20. doi request reprint Inflammation and anaemia in a broad spectrum of patients with heart failure
    Lennaert Kleijn
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Heart 98:1237-41. 2012
    ..Although inflammation is assumed to be an important cause of anaemia, the association between anaemia and inflammatory markers in patients with HF has not been well established...
  21. ncbi request reprint Renal function dependent association of AGTR1 polymorphism (A1166C) and electrocardiographic left-ventricular hypertrophy
    Tom D J Smilde
    Thorax Center, Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Am J Hypertens 20:1097-103. 2007
    ..We studied whether renal function modulates the association between RAS polymorphisms and LVH in a cross-sectional study of 8592 inhabitants of Groningen...
  22. doi request reprint Functional and hemodynamic cardiac determinants of exercise capacity in patients with systolic heart failure
    Yoran M Hummel
    Department of Cardiology, University Medical Center of Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 110:1336-41. 2012
    ..Of all echocardiographic parameters at rest, right ventricular function and E/e' were independently and significantly associated with pVo(2), whereas LV ejection fraction at rest was not...
  23. doi request reprint Anaemia is associated with shorter leucocyte telomere length in patients with chronic heart failure
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Eur J Heart Fail 12:348-53. 2010
    ..We hypothesize that short telomere length contributes to the susceptibility to develop anaemia in patients with CHF...
  24. ncbi request reprint Caregiver burden in partners of Heart Failure patients; limited influence of disease severity
    Marie Louise Luttik
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Heart Fail 9:695-701. 2007
    ..However providing care may cause burden and affect the health of these partners. The aim of this study was to investigate determinants of caregiver burden in order to identify caregivers who are at risk...
  25. doi request reprint Galectin-3 is an independent marker for ventricular remodeling and mortality in patients with chronic heart failure
    Dirk J Lok
    Deventer Hospital, Nico Bolkesteinlaan 75, 7415 CM, Deventer, The Netherlands
    Clin Res Cardiol 102:103-10. 2013
    ..Therefore, we determined the utility of Gal-3 as a novel biomarker for left ventricular remodeling and long-term outcome in patients with severe chronic HF...
  26. ncbi request reprint Determinants of depressive symptoms in hospitalised men and women with heart failure
    Ivonne Lesman-Leegte
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur J Cardiovasc Nurs 7:121-6. 2008
    ..Depressive symptoms are prominent and related to an increased risk on cardiovascular disease outcomes and all cause mortality in HF patients...
  27. doi request reprint Importance of heart rate during exercise for response to cardiac resynchronization therapy
    Alexander H Maass
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Cardiovasc Electrophysiol 20:773-80. 2009
    ..Cardiac resynchronization therapy (CRT) is an established therapy for patients with severe heart failure and mechanical dyssynchrony. Response is only achieved in 60-70% of patients...
  28. ncbi request reprint Prediction of functional recovery after revascularization in patients with coronary artery disease and left ventricular dysfunction by gated FDG-PET
    Riemer H J A Slart
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands
    J Nucl Cardiol 13:210-9. 2006
    ....
  29. ncbi request reprint Persistent atrial fibrillation is associated with appropriate shocks and heart failure in patients with left ventricular dysfunction treated with an implantable cardioverter defibrillator
    Michiel Rienstra
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am Heart J 153:120-6. 2007
    ....
  30. doi request reprint B-type natriuretic peptide and prognosis in heart failure patients with preserved and reduced ejection fraction
    Dirk J van Veldhuisen
    Department of Cardiology, University Medical Center, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 61:1498-506. 2013
    ....
  31. doi request reprint Both in- and out-hospital worsening of renal function predict outcome in patients with heart failure: results from the Coordinating Study Evaluating Outcome of Advising and Counseling in Heart Failure (COACH)
    Kevin Damman
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Eur J Heart Fail 11:847-54. 2009
    ..The effect of worsening renal function (WRF) after discharge on outcome in patients with heart failure is unknown...
  32. ncbi request reprint Effect of rate and rhythm control on left ventricular function and cardiac dimensions in patients with persistent atrial fibrillation: results from the RAte Control versus Electrical Cardioversion for Persistent Atrial Fibrillation (RACE) study
    Vincent E Hagens
    Department of Cardiology, University Hospital, Groningen, The Netherlands
    Heart Rhythm 2:19-24. 2005
    ..The purpose of this study was to evaluate left ventricular function and atrial and ventricular diameters in patients with persistent atrial fibrillation (AF) treated with rate or rhythm control...
  33. ncbi request reprint Vascular function and mild renal impairment in stable coronary artery disease
    Pim van der Harst
    Department of Cardiology, Medical Center Groningen, University of Groningen, The Netherlands
    Arterioscler Thromb Vasc Biol 26:379-84. 2006
    ....
  34. pmc Heart failure-associated anemia: bone marrow dysfunction and response to erythropoietin
    Willem Peter T Ruifrok
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Mol Med (Berl) 89:377-87. 2011
    ..Altogether, these results suggest that BM dysfunction is an important contributor to HF-associated anemia and that EPO is not an effective agent to treat HF-associated anemia...
  35. doi request reprint Plasma renin and outcome in the community: data from PREVEND
    Rudolf A de Boer
    Department of Cardiology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, Groningen 9713GZ, The Netherlands
    Eur Heart J 33:2351-9. 2012
    ..The renin-angiotensin system plays a central role in patients with established cardiovascular (CV) disease, but the prognostic effect of plasma renin in the community is unclear...
  36. ncbi request reprint Pregnancy after biventricular repair for pulmonary atresia with ventricular septal defect
    Willem Drenthen
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Am J Cardiol 98:262-6. 2006
    ..Infertility and menstrual cycle disorders do not appear to be more prevalent, except for a high incidence of primary amenorrhea...
  37. ncbi request reprint Verapamil versus digoxin and acute versus routine serial cardioversion for the improvement of rhythm control for persistent atrial fibrillation
    Martin E W Hemels
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 48:1001-9. 2006
    ....
  38. doi request reprint Telomere length and psychological well-being in patients with chronic heart failure
    Jardi Huzen
    Department of Cardiology, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Age Ageing 39:223-7. 2010
    ..Shorter telomere length indicates a more advanced biological age. It is unknown whether psychological well-being is associated with telomere length in patients with the somatic condition of chronic heart failure (CHF)...
  39. ncbi request reprint Fertility, pregnancy and delivery in women after biventricular repair for double outlet right ventricle
    Willem Drenthen
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Cardiology 109:105-9. 2008
    ..To investigate outcome of pregnancy and fertility in women with double outlet right ventricle (DORV)...
  40. doi request reprint Continuous vs episodic prophylactic treatment with amiodarone for the prevention of atrial fibrillation: a randomized trial
    Sheba Ahmed
    Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    JAMA 300:1784-92. 2008
    ..Amiodarone effectively suppresses atrial fibrillation but causes many adverse events...
  41. doi request reprint The effect of rate control on quality of life in patients with permanent atrial fibrillation: data from the RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) study
    Hessel F Groenveld
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 58:1795-803. 2011
    ..The aim of this study was to investigate the influence of rate control on quality of life (QOL)...
  42. ncbi request reprint Low-dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit
    Erik Lipsic
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur J Heart Fail 10:22-9. 2008
    ..However, the increased haematocrit associated with EPO treatment might exert concomitant deleterious effects...
  43. ncbi request reprint Levels of hematopoiesis inhibitor N-acetyl-seryl-aspartyl-lysyl-proline partially explain the occurrence of anemia in heart failure
    Peter van der Meer
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Circulation 112:1743-7. 2005
    ..The aim of the present study was to determine possible mechanisms linking anemia to renin-angiotensin system activity in CHF patients...
  44. doi request reprint Incremental prognostic power of novel biomarkers (growth-differentiation factor-15, high-sensitivity C-reactive protein, galectin-3, and high-sensitivity troponin-T) in patients with advanced chronic heart failure
    Dirk J Lok
    Deventer Hospital, Deventer, The Netherlands
    Am J Cardiol 112:831-7. 2013
    ..In conclusion, in chronic HF, GDF-15, hs-CRP, and hs-TnT are independent prognostic markers, incremental to NT-proBNP, in predicting long-term mortality. In this study, GDF-15 is the most predictive marker, even stronger than NT-proBNP...
  45. ncbi request reprint Indium-111-labeled trastuzumab scintigraphy in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer
    Patrick J Perik
    Department of Medical Oncology, Hospital Pharmacy, Nuclear Medicine and Cardiology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    J Clin Oncol 24:2276-82. 2006
    ..In addition, we evaluated whether plasma markers for cardiac dysfunction can be used to predict cardiotoxicity...
  46. doi request reprint Comparison between the prognostic value of left ventricular function and myocardial perfusion reserve in patients with ischemic heart disease
    Rene A Tio
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    J Nucl Med 50:214-9. 2009
    ..In addition, MPR determines survival in patients with hypertrophic and dilated cardiomyopathies. In the present study, we evaluated whether MPR also determines survival in patients with IHD...
  47. doi request reprint The role of advanced glycation end-products and their receptor on outcome in heart failure patients with preserved and reduced ejection fraction
    Suzan Willemsen
    Department of Cardiology, University Medical Center Groningen, Groningen The Netherlands
    Am Heart J 164:742-749.e3. 2012
    ..We studied the predictive value of plasma AGEs N(ε)-(carboxymethyl)lysine (CML), pentosidine, and the soluble form of its receptor (sRAGE) in a large HF population...
  48. doi request reprint A single dose of erythropoietin in ST-elevation myocardial infarction
    Adriaan A Voors
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Eur Heart J 31:2593-600. 2010
    ..Clinical Trial Registration Information: NCT00449488; http://www.clinicaltrials.gov/ct2/show/NCT00449488?term=voors&rank=2...
  49. doi request reprint Tissue advanced glycation end products are associated with diastolic function and aerobic exercise capacity in diabetic heart failure patients
    Suzan Willemsen
    Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur J Heart Fail 13:76-82. 2011
    ..We therefore studied the association among tissue AGEs, diastolic function, and aerobic capacity in patients with HF with or without diabetes...
  50. ncbi request reprint RAte Control Efficacy in permanent atrial fibrillation: a comparison between lenient versus strict rate control in patients with and without heart failure. Background, aims, and design of RACE II
    Isabelle C Van Gelder
    University Medical Center Groningen, University of Groningen, The Netherlands
    Am Heart J 152:420-6. 2006
    ..Recent studies demonstrated that rate control is an acceptable alternative for rhythm control in patients with persistent atrial fibrillation (AF). However, optimal heart rate during AF is still unknown...
  51. doi request reprint Lenient versus strict rate control in patients with atrial fibrillation
    Isabelle C Van Gelder
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    N Engl J Med 362:1363-73. 2010
    ..We hypothesized that lenient rate control is not inferior to strict rate control for preventing cardiovascular morbidity and mortality in patients with permanent atrial fibrillation...
  52. doi request reprint Effects of alagebrium, an advanced glycation end-product breaker, in patients with chronic heart failure: study design and baseline characteristics of the BENEFICIAL trial
    Suzan Willemsen
    Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur J Heart Fail 12:294-300. 2010
    ..45...
  53. ncbi request reprint Effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria
    Folkert W Asselbergs
    Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    Circulation 110:2809-16. 2004
    ..We assessed whether therapeutic intervention aimed at lowering urinary albumin excretion would reduce cardiovascular events in microalbuminuric subjects (15 to 300 mg/24 hours)...
  54. ncbi request reprint The VEGF +405 CC promoter polymorphism is associated with an impaired prognosis in patients with chronic heart failure: a MERIT-HF substudy
    Peter van der Meer
    Department of Cardiology, University Hospital Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    J Card Fail 11:279-84. 2005
    ..We investigated the association between two VEGF polymorphisms and morbidity and mortality in patients with CHF...
  55. ncbi request reprint Rate control versus rhythm control for patients with persistent atrial fibrillation with mild to moderate heart failure: results from the RAte Control versus Electrical cardioversion (RACE) study
    Vincent E Hagens
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Am Heart J 149:1106-11. 2005
    ..Rate control is not inferior to rhythm control in preventing mortality and morbidity in patients with AF. In CHF, this issue is still unsettled...
  56. ncbi request reprint Hydrochlorothiazide increases plasma or tissue angiotensin-converting enzyme-inhibitor drug levels in rats with myocardial infarction: differential effects on lisinopril and zofenopril
    Bart Westendorp
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Eur J Pharmacol 527:141-9. 2005
    ..Whether combining different angiotensin-converting enzyme-inhibitors with hydrochlorothiazide translates into distinct clinical profiles requires further study...
  57. ncbi request reprint Prognostic value of plasma erythropoietin on mortality in patients with chronic heart failure
    Peter van der Meer
    Department of Cardiology, University Hospital Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 44:63-7. 2004
    ..This study aimed to investigate the prognostic importance of plasma erythropoietin (EPO) levels in chronic heart failure (CHF) patients...
  58. ncbi request reprint Outcome of pregnancy in women with congenital heart disease: a literature review
    Willem Drenthen
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 49:2303-11. 2007
    ..The offspring mortality was high throughout the spectrum and was related to the relatively high rate of premature delivery and recurrence of CHD...
  59. ncbi request reprint Erythropoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor mediated neovascularization
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands
    Eur Heart J 28:2018-27. 2007
    ..We studied the effects of EPO on homing and incorporation of endothelial progenitor cells (EPC) into the myocardial microvasculature and myocardial expression of angiogenic factors...
  60. pmc Ischemic patterns assessed by positron emission tomography predict adverse outcome in patients with idiopathic dilated cardiomyopathy
    Richard M de Jong
    Thoraxcenter, Department of Cardiology, University Medical Centre Groningen, Hanzeplein 1, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    J Nucl Cardiol 16:769-74. 2009
    ..Our aim was to assess the prognostic relevance of PET-mismatch between stress myocardial perfusion and glucose uptake on clinical outcome in DCM...
  61. ncbi request reprint Tolerability and dose-related effects of nebivolol in elderly patients with heart failure: data from the Study of the Effects of Nebivolol Intervention on Outcomes and Rehospitalisation in Seniors with Heart Failure (SENIORS) trial
    Daniela Dobre
    Department of Clinical Pharmacology, University Medical Centre Groningen, University of Groningen, The Netherlands
    Am Heart J 154:109-15. 2007
    ..We aimed to assess tolerability and dose-related effects of the beta-blocker nebivolol in elderly patients from the SENIORS trial...
  62. doi request reprint Urinary neutrophil gelatinase associated lipocalin (NGAL), a marker of tubular damage, is increased in patients with chronic heart failure
    Kevin Damman
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Heart Fail 10:997-1000. 2008
    ..In conclusion, renal impairment in CHF patients is not only characterised by decreased eGFR and increased UAE, but also by the presence of tubular damage, as measured by increased urinary NGAL concentrations...
  63. ncbi request reprint Skin-autofluorescence, a measure of tissue advanced glycation end-products (AGEs), is related to diastolic function in dialysis patients
    Jasper W L Hartog
    Department of Cardiology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    J Card Fail 14:596-602. 2008
    ..The aim of our study was to assess whether AGE accumulation in dialysis patients is related to the presence of diastolic dysfunction...
  64. doi request reprint Effect of fosinopril treatment on serum C-reactive protein levels in patients with microalbuminuria
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 102:223-5. 2008
    ..Male gender was associated with a significantly larger reduction in CRP compared to female gender. In conclusion, contrary to previous observational studies, no effect of angiotensin-converting enzyme inhibition on CRP levels was found...
  65. ncbi request reprint Predictors of angiotensin-converting enzyme inhibitor-induced reduction of urinary albumin excretion in nondiabetic patients
    Ruud M A van de Wal
    St Antonius Hospital, Department of Cardiology, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands
    Hypertension 48:870-6. 2006
    ....
  66. ncbi request reprint Usefulness of preoperative C-reactive protein and soluble intercellular adhesion molecule-1 level for predicting future cardiovascular events after coronary artery bypass grafting
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 97:1697-701. 2006
    ....
  67. pmc Comparison of the temporal release pattern of copeptin with conventional biomarkers in acute myocardial infarction
    Youlan L Gu
    Department of Cardiology, Thorax Center, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, 9700 RB, Groningen, The Netherlands
    Clin Res Cardiol 100:1069-76. 2011
    ....
  68. ncbi request reprint Mild renal dysfunction is associated with electrocardiographic left ventricular hypertrophy
    Tom D J Smilde
    Department of Cardiology, Thoraxcenter, University Hospital Groningen, Hanzeplein 1, P O Box 30001, 9700 RB Gronigen, The Netherlands
    Am J Hypertens 18:342-7. 2005
    ..We studied the relation between renal dysfunction and LVH in a cross-sectional study in 8592 inhabitants from Groningen, The Netherlands...
  69. ncbi request reprint Correlates of B-type natriuretic peptide and 6-min walk in heart failure patients
    Jochem Hogenhuis
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, PO Box 30 001, Groningen 9700 RB, The Netherlands
    Int J Cardiol 108:63-7. 2006
    ....
  70. ncbi request reprint Effect of intensive versus moderate lipid lowering on endothelial function and vascular responsiveness to angiotensin II in stable coronary artery disease
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 96:1361-4. 2005
    ..05). Endothelium improvement was accompanied by decreased vascular response to angiotensin II (p = 0.039). These findings suggest a mechanism for the clinical benefit of intensive lipid-lowering treatment in coronary heart disease...
  71. doi request reprint Circulating leukocyte and carotid atherosclerotic plaque telomere length: interrelation, association with plaque characteristics, and restenosis after endarterectomy
    Jardi Huzen
    University Medical Centre Groningen, Department of Cardiology, University of Groningen, Hanzeplein 1, PO Box 9700 RB Groningen, The Netherlands
    Arterioscler Thromb Vasc Biol 31:1219-25. 2011
    ..The goal of the present study was to determine whether leukocyte telomere length is related to atherosclerotic plaque telomere length and whether it is associated with plaque characteristics or recurrence of disease...
  72. ncbi request reprint Drawbacks and prognostic value of formulas estimating renal function in patients with chronic heart failure and systolic dysfunction
    Tom D J Smilde
    Department of Cardiology, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands
    Circulation 114:1572-80. 2006
    ..Furthermore, we compared the prognostic value of these formulas for cardiovascular outcome with that of true GFR during 12 months of follow-up...
  73. pmc Tubular damage in chronic systolic heart failure is associated with reduced survival independent of glomerular filtration rate
    Kevin Damman
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Heart 96:1297-302. 2010
    ..The prognostic impact of reduced glomerular filtration rate (GFR) in chronic heart failure (CHF) is increasingly recognised, but little is known about tubular damage in these patients...