Carla H van Gils

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study
    Rebecca Ritte
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld TP4, Heidelberg, 69120, Germany
    Breast Cancer Res 14:R76. 2012
  2. pmc A bead-based multiplexed immunoassay to evaluate breast cancer biomarkers for early detection in pre-diagnostic serum
    Annemieke W J Opstal-van Winden
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Int J Mol Sci 13:13587-604. 2012
  3. ncbi request reprint [Tailored breast cancer screening with ultrasound and MRI?]
    Carla H van Gils
    Universitair Medisch Centrum Utrecht, Julius Centrum voor Gezondheidswetenschappen en Eerstelijns Geneeskunde, Utrecht, The Netherlands
    Ned Tijdschr Geneeskd 156:A5313. 2012
  4. pmc High-dose intensity-modulated radiotherapy for prostate cancer using daily fiducial marker-based position verification: acute and late toxicity in 331 patients
    Irene M Lips
    Department of Radiation Oncology, University Medical Center Utrecht, The Netherlands
    Radiat Oncol 3:15. 2008
  5. pmc No relationship between circulating levels of sex steroids and mammographic breast density: the Prospect-EPIC cohort
    Martijn Verheus
    Julius Center for Health Sciences and Primary Care, Room Str 6, 131, PO Box 85500, University Medical Center Utrecht, Utrecht 3508 GA, The Netherlands
    Breast Cancer Res 9:R53. 2007
  6. pmc Mammographic density, breast cancer risk and risk prediction
    Celine M Vachon
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Breast Cancer Res 9:217. 2007
  7. pmc Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    Federico Canzian
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 9:257. 2009
  8. pmc The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk
    Daniele Campa
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 10:563. 2010
  9. ncbi request reprint Influence of estrogen receptor alpha and progesterone receptor polymorphisms on the effects of hormone therapy on mammographic density
    Franzel J B van Duijnhoven
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Mail drop Str 6 131, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 15:462-7. 2006
  10. ncbi request reprint Plasma phytoestrogens and subsequent breast cancer risk
    Martijn Verheus
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Clin Oncol 25:648-55. 2007

Detail Information

Publications58

  1. pmc Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study
    Rebecca Ritte
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld TP4, Heidelberg, 69120, Germany
    Breast Cancer Res 14:R76. 2012
    ....
  2. pmc A bead-based multiplexed immunoassay to evaluate breast cancer biomarkers for early detection in pre-diagnostic serum
    Annemieke W J Opstal-van Winden
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Int J Mol Sci 13:13587-604. 2012
    ..Our findings indicate that this panel of selected tumor markers cannot be used for diagnosis of early breast cancer...
  3. ncbi request reprint [Tailored breast cancer screening with ultrasound and MRI?]
    Carla H van Gils
    Universitair Medisch Centrum Utrecht, Julius Centrum voor Gezondheidswetenschappen en Eerstelijns Geneeskunde, Utrecht, The Netherlands
    Ned Tijdschr Geneeskd 156:A5313. 2012
    ..If additional imaging is implemented too hastily it will be hard to turn it back, and impossible to assess it in a randomized study...
  4. pmc High-dose intensity-modulated radiotherapy for prostate cancer using daily fiducial marker-based position verification: acute and late toxicity in 331 patients
    Irene M Lips
    Department of Radiation Oncology, University Medical Center Utrecht, The Netherlands
    Radiat Oncol 3:15. 2008
    ..The low grade > or = 3 toxicity allows further dose escalation if the same dose constraints for the organs at risk will be used...
  5. pmc No relationship between circulating levels of sex steroids and mammographic breast density: the Prospect-EPIC cohort
    Martijn Verheus
    Julius Center for Health Sciences and Primary Care, Room Str 6, 131, PO Box 85500, University Medical Center Utrecht, Utrecht 3508 GA, The Netherlands
    Breast Cancer Res 9:R53. 2007
    ..The objective of the present study was to study the relation between circulating oestrogens and androgens as well as sex hormone binding globulin (SHBG) in relation to breast density...
  6. pmc Mammographic density, breast cancer risk and risk prediction
    Celine M Vachon
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Breast Cancer Res 9:217. 2007
    ..Promising new measures of mammographic density, including volumetric density, which can be standardized using full-field digital mammography, will likely result in a stronger risk factor and improve accuracy of risk prediction models...
  7. pmc Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    Federico Canzian
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 9:257. 2009
    ..We studied the association between breast cancer risk and polymorphisms in genes that code for GNRH1 and its receptor (GNRHR) in the large National Cancer Institute Breast and Prostate Cancer Cohort Consortium (NCI-BPC3)...
  8. pmc The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk
    Daniele Campa
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 10:563. 2010
    ..BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC)...
  9. ncbi request reprint Influence of estrogen receptor alpha and progesterone receptor polymorphisms on the effects of hormone therapy on mammographic density
    Franzel J B van Duijnhoven
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Mail drop Str 6 131, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 15:462-7. 2006
    ..In conclusion, our results suggest that specific polymorphisms in the ESR1 and PGR genes may make women more susceptible to the effects of hormone therapy use on mammographic density...
  10. ncbi request reprint Plasma phytoestrogens and subsequent breast cancer risk
    Martijn Verheus
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Clin Oncol 25:648-55. 2007
    ..We investigated the association between plasma phytoestrogen levels and breast cancer risk in a prospective manner...
  11. doi request reprint Common genetic variation of insulin-like growth factor-binding protein 1 (IGFBP-1), IGFBP-3, and acid labile subunit in relation to serum IGF-I levels and mammographic density
    Cornelia W Taverne
    Julius Center for Health Sciences and Primary Care, University Medical Center, Room Str 6 131, PO Box 85500, Utrecht, 3508, GA, The Netherlands
    Breast Cancer Res Treat 123:843-55. 2010
    ..These findings suggest that common genetic variation in the IGFBP1 gene is weakly related to IGF-I levels and mammographic density. Our results do not provide support for such a role of genetic variants in the IGFBP3 and ALS genes...
  12. pmc Lifetime cumulative number of menstrual cycles and serum sex hormone levels in postmenopausal women
    Mariana Chavez-MacGregor
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Breast Cancer Res Treat 108:101-12. 2008
    ..Lifetime cumulative number of menstrual cycles is related to breast cancer risk. The aim of this study is to investigate the relation between this index and serum sex hormone levels in postmenopausal women...
  13. ncbi request reprint Polymorphisms in the estrogen receptor alpha gene and mammographic density
    Franzel J B van Duijnhoven
    Julius Center for Health Sciences and Primary Care University Medical Center, Utrecht Mail Drop Str 6 131, 3508 GA Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 14:2655-60. 2005
    ..01, respectively). Similar associations were found with absolute density (P(trend) < 0.01). The findings of this study support the view that ESR1 polymorphisms may affect breast cancer risk through differences in breast density...
  14. ncbi request reprint The estrogen receptor alpha gene and breast cancer risk (The Netherlands)
    N Charlotte Onland-Moret
    Julius Center for Health Sciences and Primary Care, UMC Utrecht, Room St 6 131, PO Box 85500, 3508, GA Utrecht, The Netherlands
    Cancer Causes Control 16:1195-202. 2005
    ..The selection of these polymorphisms was based on previously published associations with osteoporosis and spontaneous abortions...
  15. ncbi request reprint Cyp17, urinary sex steroid levels and breast cancer risk in postmenopausal women
    N Charlotte Onland-Moret
    Julius Center for Health Sciences and Primary Care, UMC Utrecht, 3508 GA Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 14:815-20. 2005
    ..However, these increased sex steroid levels are not translated into an increased breast cancer risk in these women...
  16. ncbi request reprint Long term consequences of the 1944-1945 Dutch famine on the insulin-like growth factor axis
    Sjoerd G Elias
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Int J Cancer 108:628-30. 2004
    ..These results are opposite to immediate responses seen under starvation and we hypothesize that this could indicate a permanent overshoot upon improvement of nutritional status after the famine...
  17. ncbi request reprint Physical activity in relation to mammographic density in the dutch prospect-European prospective investigation into cancer and nutrition cohort
    Karijn P M Suijkerbuijk
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 15:456-60. 2006
    ..The study aim was to investigate the association between physical activity and breast density because mammographic density is strongly associated with breast cancer risk...
  18. ncbi request reprint Weight change later in life and colon and rectal cancer risk in participants in the EPIC-PANACEA study
    Charlotte N Steins Bisschop
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands CNSB, CHvG, EMM, PHMP, and AMM the National Institute for Public Health and the Environment, Bilthoven, Netherlands HBB d M the Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, Netherlands HBB d M the Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany HB and KA the International Agency for Research on Cancer, WHO, Lyon, France MJ, HF, and PF the Division of Epidemiology, Public Health and Primary Care, Imperial College, London, United Kingdom HBB d M, TN, ER, and PHMP INSERM, Centre for research in Epidemiology and Population Health, Nutrition, Hormones and Women s Health Team, Villejuif, France MB R, GF, and AR University of Paris, Sud, Villejuif, France MB R, McGaw Park
    Am J Clin Nutr 99:139-47. 2014
    ..A moderate association exists between body mass index (BMI) and colorectal cancer. Less is known about the effect of weight change...
  19. ncbi request reprint Cumulative genetic defects in carcinogen metabolism may increase breast cancer risk (The Netherlands)
    Olga L van der Hel
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Cancer Causes Control 16:675-81. 2005
    ..45 (95% CI 1.24-4.86), compared to women with zero putative at risk genotypes. In conclusion, the results of this study suggest that presence of three or more putative at risk genotypes increases breast cancer risk...
  20. ncbi request reprint Analysis of case-cohort data: a comparison of different methods
    N Charlotte Onland-Moret
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Epidemiol 60:350-5. 2007
    ..However, adaptation of the model is necessary because of the sampling. We compared three methods that were proposed in the literature, which differ in weighting of study subjects: Prentice's, Barlow's, and Self and Prentice's method...
  21. ncbi request reprint Postmenopausal hormone therapy and changes in mammographic density
    Franzel J B van Duijnhoven
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Oncol 25:1323-8. 2007
    ..We explored the underlying mechanism further by determining the effects of HT on mammographic density, a measure of dense tissue in the breast and a consistent breast cancer risk factor...
  22. ncbi request reprint Premenopausal insulin-like growth factor-I serum levels and changes in breast density over menopause
    Martijn Verheus
    Julius Center for Health Sciences and Primary Care, University Medical Center, Room Str 6 131, P O Box 85500, Utrecht 3508 GA, The Netherlands
    Cancer Epidemiol Biomarkers Prev 16:451-7. 2007
    ..Insulin-like growth factor-I (IGF-I) is hypothesized to influence breast cancer risk by increasing breast density...
  23. ncbi request reprint Common genetic variation in the IGF-1 gene, serum IGF-I levels and breast density
    Martijn Verheus
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA, Utrecht, The Netherlands
    Breast Cancer Res Treat 112:109-22. 2008
    ..Insulin-like growth factor I (IGF-I) is a strong mitogen and has been suggested to increase breast cancer risk by increasing the amount of dense tissue in the female breast...
  24. doi request reprint A double-blind placebo-controlled randomized clinical trial with magnesium oxide to reduce intrafraction prostate motion for prostate cancer radiotherapy
    Irene M Lips
    Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Int J Radiat Oncol Biol Phys 83:653-60. 2012
    ..To investigate whether magnesium oxide during external-beam radiotherapy for prostate cancer reduces intrafraction prostate motion in a double-blind, placebo-controlled randomized trial...
  25. doi request reprint Physical activity and endogenous sex hormone levels in postmenopausal women: a cross-sectional study in the Prospect-EPIC Cohort
    Carla H van Gils
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 18:377-83. 2009
    ..In this study, we examined the association between usual physical activity and plasma levels of estrogens, androgens, dehydroepiandrosterone sulphate (DHEAS), and sex hormone binding globulin (SHBG) in postmenopausal women...
  26. doi request reprint The influence of a period of caloric restriction due to the Dutch famine on breast density
    Gerco Haars
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Int J Cancer 126:2211-5. 2010
    ..We observed no overall effect on breast density in women severely exposed to a short, intense caloric restriction. However, in women exposed before puberty, the non-dense area was smaller and density tended to be higher...
  27. pmc Mammographic density and breast cancer risk: the role of the fat surrounding the fibroglandular tissue
    Mariëtte Lokate
    Julius Center for Health Sciences and Primary Care, Str 6, 131, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Breast Cancer Res 13:R103. 2011
    ..In this study we investigated the independent effects of dense and fat tissue, as well as their combined effect on postmenopausal breast cancer risk...
  28. doi request reprint Soy protein containing isoflavones and mammographic density in a randomized controlled trial in postmenopausal women
    Martijn Verheus
    Julius Center for Health Sciences and Primary Care, University Medical Center, Room Str 6 131, P O Box 85500, Utrecht 3508 GA, Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 17:2632-8. 2008
    ..The aim of the present study was to determine the effect of daily soy supplementation on mammographic density, one of the strongest known risk factors for breast cancer...
  29. ncbi request reprint Postmenopausal breast cancer risk and cumulative number of menstrual cycles
    Mariana Chavez-MacGregor
    Julius Center for Health Sciences and Primary Care, University Medical Center, Room STR 6 1 31, P O Box 85060, 3508 BA Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 14:799-804. 2005
    ....
  30. ncbi request reprint Alcohol and endogenous sex steroid levels in postmenopausal women: a cross-sectional study
    N Charlotte Onland-Moret
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Endocrinol Metab 90:1414-9. 2005
    ..This finding supports the hypothesis that alcohol use may increase breast cancer risk at least partially through an effect on sex steroid levels...
  31. ncbi request reprint Early life factors and adult mammographic density
    Mariëtte Lokate
    Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Str 6 131, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Cancer Causes Control 24:1771-8. 2013
    ..Mammary gland development already starts in utero and early life factors might affect the number of mammary cells at risk. In this study, we investigated the association between early life factors and mammographic density in adulthood...
  32. ncbi request reprint Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study
    Vincent K Dik
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Int J Cancer 135:401-12. 2014
    ..This study shows that coffee and tea consumption is not likely to be associated with overall CRC. ..
  33. doi request reprint Fruit and vegetable consumption and mortality: European prospective investigation into cancer and nutrition
    Max Leenders
    Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands
    Am J Epidemiol 178:590-602. 2013
    ..Inverse associations were stronger for raw than for cooked vegetable consumption. These results support the evidence that fruit and vegetable consumption is associated with a lower risk of death. ..
  34. ncbi request reprint Serum IGF-I, its major binding protein (IGFBP-3) and epithelial ovarian cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Petra H M Peeters
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Endocr Relat Cancer 14:81-90. 2007
    ..Our results suggest that the circulating levels of IGF-I may play a potentially important role in the development of ovarian cancer in women of a pre- or perimenopausal age...
  35. ncbi request reprint Measurements of breast density: no ratio for a ratio
    Gerco Haars
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 14:2634-40. 2005
    ..Although relative density is a relevant prognostic factor, inferences about the etiology of breast density should be made on the basis of absolute measures...
  36. doi request reprint Early diagnostic protein biomarkers for breast cancer: how far have we come?
    Annemieke W J Opstal-van Winden
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Breast Cancer Res Treat 134:1-12. 2012
    ..Ultimately this may lead to the discovery of new and valid breast cancer specific biomarkers...
  37. ncbi request reprint Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns
    Mariken de Krom
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Diabetes 56:276-80. 2007
    ..In conclusion, we identified common allelic variants specifically associated with distinctly different eating patterns, namely extreme snacking behavior or excessive portion size...
  38. ncbi request reprint No association of estrogen receptor alpha and cytochrome P450c17alpha polymorphisms with age at menopause in a Dutch cohort
    Helen S Kok
    Julius Center for Health Sciences and Primary Care, Department of Medical Genetics, University Medical Center Utrecht, The Netherlands
    Hum Reprod 20:536-42. 2005
    ..This study aims to investigate whether PvuII, XbaI and B-variant polymorphisms of the ERalpha gene, and the MspAI polymorphism of the cytochrome P450c17alpha (CYP17) gene are associated with age at menopause in a Dutch cohort...
  39. ncbi request reprint The V89L polymorphism in the 5-alpha-reductase type 2 gene and risk of breast cancer
    Carla H van Gils
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 12:1194-9. 2003
    ..10). In conclusion, our findings do not provide evidence for an important role of the V89L polymorphism in the etiology of breast cancer. However, in breast cancer patients, the LL genotype may be associated with unfavorable prognosis...
  40. ncbi request reprint Variations in plasma phytoestrogen concentrations in European adults
    Petra H M Peeters
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Nutr 137:1294-300. 2007
    ..Despite the fact that plasma concentrations of phytoestrogens in Europe were low compared with Asian populations, they varied substantially among subjects from the 16 different regions...
  41. doi request reprint Age-related changes in mammographic density and breast cancer risk
    Mariëtte Lokate
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Mail Drop Strasse 6 131, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Am J Epidemiol 178:101-9. 2013
    ..Although no difference was seen in the average decline, we cannot exclude that large changes may influence breast cancer risk. ..
  42. pmc Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study
    Annemieke W J Opstal-van Winden
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    BMC Cancer 11:381. 2011
    ..We present for the first time pre-diagnostic serum protein profiles in relation to breast cancer, using the Prospect-EPIC (European Prospective Investigation into Cancer and nutrition) cohort...
  43. ncbi request reprint Use of hormones in the menopausal transition period in the Netherlands between 1993 and 1997
    Franzel J B van Duijnhoven
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Maturitas 53:462-75. 2006
    ..To describe the patterns and to assess the indicators of hormone use during the menopausal transition period in a Dutch population...
  44. pmc Single blind randomized phase III trial to investigate the benefit of a focal lesion ablative microboost in prostate cancer (FLAME-trial): study protocol for a randomized controlled trial
    Irene M Lips
    Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Trials 12:255. 2011
    ..The aim of this study is to investigate the benefit of an ablative microboost to the macroscopic tumor within the prostate in patients treated with external beam radiotherapy for prostate cancer...
  45. ncbi request reprint Heterozygosity for the Cys282Tyr mutation in the HFE gene and the risk of colorectal cancer (Netherlands)
    Daphne L van der A
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Cancer Causes Control 14:541-5. 2003
    ..Heterozygosity for the Cys282Tyr transition in the HFE-gene is associated with slightly increased iron levels and may therefore be a potential risk factor for colorectal cancer...
  46. doi request reprint Cigarette smoking and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study
    Anke M Leufkens
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Gastroenterol Hepatol 9:137-44. 2011
    ..We investigated the relationships between cigarette smoking and risk of CRC and tumor location...
  47. doi request reprint Volumetric breast density from full-field digital mammograms and its association with breast cancer risk factors: a comparison with a threshold method
    Mariëtte Lokate
    Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 19:3096-105. 2010
    ..We investigated whether volumetric density measurements on full-field digital mammography (FFDM) are more strongly related to breast cancer risk factors than measurements with a computer-assisted threshold method...
  48. doi request reprint Serum degradome markers for the detection of breast cancer
    Annemieke W J van Winden
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Proteome Res 9:3781-8. 2010
    ....
  49. ncbi request reprint Search for breast cancer biomarkers in fractionated serum samples by protein profiling with SELDI-TOF MS
    Annemieke W J Opstal-van Winden
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute Slotervaart Hospital, Amsterdam, The Netherlands
    J Clin Lab Anal 26:1-9. 2012
    ..However, they are unlikely to be specific for breast cancer. Cancer-specific biomarkers are thought to be among the lower abundant proteins...
  50. doi request reprint Influence of antiflatulent dietary advice on intrafraction motion for prostate cancer radiotherapy
    Irene M Lips
    Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Int J Radiat Oncol Biol Phys 81:e401-6. 2011
    ..To evaluate the effect of an antiflatulent dietary advice on the intrafraction prostate motion in patients treated with intensity-modulated radiotherapy (IMRT) for prostate cancer...
  51. ncbi request reprint Circulating levels of insulin-like growth factor I, its binding proteins -1,-2, -3, C-peptide and risk of postmenopausal breast cancer
    Lital Keinan-Boker
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht UMCU, Utrecht, The Netherlands
    Int J Cancer 106:90-5. 2003
    ..7; 3.5), for C-peptide, 1.3 (0.7; 2.7) and for IGF-I/IGFBP-3 ratio, 1.0 (0.5; 1.8). Our data do not support an association between postmenopausal circulating levels of IGF-I, IGFBP-1, -2, -3, C-peptide and postmenopausal breast cancer...
  52. doi request reprint Digital mammography: more microcalcifications, more columnar cell lesions without atypia
    Anoek H J Verschuur-Maes
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    Mod Pathol 24:1191-7. 2011
    ..In conclusion, since the implementation of full-field digital mammography, more microcalcifications are seen at mammography, more often resulting in core needle biopsies, which especially yields more columnar cell lesions without atypia...
  53. ncbi request reprint Consumption of vegetables and fruits and risk of breast cancer
    Carla H van Gils
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    JAMA 293:183-93. 2005
    ..Most of the evidence comes from case-control studies, but a recent pooled analysis of the relatively few published cohort studies suggests no significantly reduced breast cancer risk is associated with vegetable and fruit consumption...
  54. doi request reprint Prognostic value of estrogen receptor α and progesterone receptor conversion in distant breast cancer metastases
    Laurien D C Hoefnagel
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cancer 118:4929-35. 2012
    ..The purpose of this study was to evaluate the impact of receptor conversion for ERα and PR on survival in a large group of distant non-bone breast cancer metastases...
  55. doi request reprint Risk factors for idiopathic orbital inflammation: a case-control study
    Ward R Bijlsma
    Department of Ophthalmology, University Medical Center Utrecht, Heidelbergiaan 100, 3584 CX Utrecht, The Netherlands
    Br J Ophthalmol 95:360-4. 2011
    ..To identify risk factors involved in the development of idiopathic orbital inflammation (IOI)...
  56. ncbi request reprint Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases
    Niven Mehra
    Department of Medical Oncology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Cancer Res 12:4859-66. 2006
    ....
  57. ncbi request reprint [Cohort multiple randomized controlled trial: a solution for the evaluation of multiple interventions]
    H M Lenny Verkooijen
    Universitair Medisch Centrum Utrecht, Divisie Beeld, Utrecht, The Netherlands
    Ned Tijdschr Geneeskd 157:A5762. 2013
    ..Advantages include the ability to facilitate multiple simultaneous randomized evaluations, the improved comparability between trials and the patient-centered informed consent procedure...
  58. doi request reprint Large cohort dose-volume response analysis of parotid gland function after radiotherapy: intensity-modulated versus conventional radiotherapy
    Tim Dijkema
    Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Int J Radiat Oncol Biol Phys 72:1101-9. 2008
    ..To compare parotid gland dose-volume response relationships in a large cohort of patients treated with intensity-modulated (IMRT) and conventional radiotherapy (CRT)...