Nick H T ten Hacken

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. pmc Reticular basement membrane in asthma and COPD: similar thickness, yet different composition
    Jeroen J W Liesker
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 4:127-35. 2009
  2. doi request reprint Physical inactivity and obesity: relation to asthma and chronic obstructive pulmonary disease?
    Nick H T ten Hacken
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, The Netherlands
    Proc Am Thorac Soc 6:663-7. 2009
  3. ncbi request reprint [Pedometers for monitoring and improvement of the level of physical activity]
    N H T ten Hacken
    Universitair Medisch Centrum Groningen, afd Longziekten, Postbus 0 001, 9700 RB Groningen
    Ned Tijdschr Geneeskd 152:193-7. 2008
  4. pmc Treatment of bronchiectasis in adults
    Nick H T ten Hacken
    Pulmonary Department, University Medical Centre Groningen, University of Groningen, Postbox 30001, 9700 RB Groningen, Netherlands
    BMJ 335:1089-93. 2007
  5. ncbi request reprint [Efficacy of combined treatment with corticosteroids and beta2 agonists in adults with asthma]
    N H T ten Hacken
    Universitair Medisch Centrum Groningen, afd Longziekten, Postbus 30 001, 9700 RB Groningen
    Ned Tijdschr Geneeskd 150:892-7. 2006
  6. doi request reprint Clinical control of asthma associates with measures of airway inflammation
    Franke Volbeda
    Department of Pulmonology, University Medical Centre Groningen, Groningen and University of Groningen, The Netherlands
    Thorax 68:19-24. 2013
  7. ncbi request reprint Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial
    Thérèse S Lapperre
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 151:517-27. 2009
  8. pmc Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics
    Eef D Telenga
    Department of Pulmonary Diseases, University Medical Center Groningen, Groningen, Netherlands
    BMC Pulm Med 13:58. 2013
  9. ncbi request reprint Repeated sputum inductions induce a transient neutrophilic and eosinophilic response
    Hester van der Vaart
    University Medical Centre Groningen, Pulmonology, Hanzeplein 1, Groningen 9713 RB, The Netherlands
    Chest 130:1157-64. 2006
  10. doi request reprint Airway epithelial changes in smokers but not in ex-smokers with asthma
    Martine Broekema
    Dept of Pathology, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Am J Respir Crit Care Med 180:1170-8. 2009

Detail Information

Publications50

  1. pmc Reticular basement membrane in asthma and COPD: similar thickness, yet different composition
    Jeroen J W Liesker
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 4:127-35. 2009
    ..Reticular basement membrane (RBM) thickening has been variably associated with asthma and chronic obstructive pulmonary disease (COPD). Even if RBM thickness is similar in both diseases, its composition might still differ...
  2. doi request reprint Physical inactivity and obesity: relation to asthma and chronic obstructive pulmonary disease?
    Nick H T ten Hacken
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, The Netherlands
    Proc Am Thorac Soc 6:663-7. 2009
    ..To elucidate the independent relation of physical inactivity and obesity with systemic inflammation, performance-based studies of physical inactivity in asthma and COPD are highly needed...
  3. ncbi request reprint [Pedometers for monitoring and improvement of the level of physical activity]
    N H T ten Hacken
    Universitair Medisch Centrum Groningen, afd Longziekten, Postbus 0 001, 9700 RB Groningen
    Ned Tijdschr Geneeskd 152:193-7. 2008
    ..Pedometers combined with existing effective counseling methods may be an effective strategy for many health care providers for adoption and enhancement of healthy lifestyles by sedentary patients...
  4. pmc Treatment of bronchiectasis in adults
    Nick H T ten Hacken
    Pulmonary Department, University Medical Centre Groningen, University of Groningen, Postbox 30001, 9700 RB Groningen, Netherlands
    BMJ 335:1089-93. 2007
  5. ncbi request reprint [Efficacy of combined treatment with corticosteroids and beta2 agonists in adults with asthma]
    N H T ten Hacken
    Universitair Medisch Centrum Groningen, afd Longziekten, Postbus 30 001, 9700 RB Groningen
    Ned Tijdschr Geneeskd 150:892-7. 2006
    ..A well-founded choice between the two strategies cannot be made, if only due to the lack of knowledge regarding the effects of these strategies on treatment compliance, airway remodelling, side effects and costs...
  6. doi request reprint Clinical control of asthma associates with measures of airway inflammation
    Franke Volbeda
    Department of Pulmonology, University Medical Centre Groningen, Groningen and University of Groningen, The Netherlands
    Thorax 68:19-24. 2013
    ..We investigated whether clinical asthma control reflects eosinophilic inflammation in a broad population...
  7. ncbi request reprint Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial
    Thérèse S Lapperre
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 151:517-27. 2009
    ..Inhaled corticosteroids (ICSs) and long-acting beta(2)-agonists (LABAs) are used to treat moderate to severe chronic obstructive pulmonary disease (COPD)...
  8. pmc Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics
    Eef D Telenga
    Department of Pulmonary Diseases, University Medical Center Groningen, Groningen, Netherlands
    BMC Pulm Med 13:58. 2013
    ..We investigated differences in blood and sputum inflammatory profiles between ex-, current-, and never-smokers and assessed their ICS treatment response after 2-week and 1-year treatment...
  9. ncbi request reprint Repeated sputum inductions induce a transient neutrophilic and eosinophilic response
    Hester van der Vaart
    University Medical Centre Groningen, Pulmonology, Hanzeplein 1, Groningen 9713 RB, The Netherlands
    Chest 130:1157-64. 2006
    ..Sputum induction is a tool to monitor airway inflammation, yet it may induce by itself a neutrophilic response when repeated within 24 to 48 h. This limits its repeated use in clinical trials...
  10. doi request reprint Airway epithelial changes in smokers but not in ex-smokers with asthma
    Martine Broekema
    Dept of Pathology, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Am J Respir Crit Care Med 180:1170-8. 2009
    ..This results in accelerated lung function decline. The underlying pathological process of smoke-induced deterioration of asthma is unknown...
  11. doi request reprint Persisting remodeling and less airway wall eosinophil activation in complete remission of asthma
    Martine Broekema
    Department of Pulmonology, University Medical Center Groningen, RB Groningen, The Netherlands
    Am J Respir Crit Care Med 183:310-6. 2011
    ..Objectives: To compare the pathologic phenotype of individuals with asthma with CoR and clinical remission (ClinR) and those with active asthma, with and without the use of inhaled corticosteroids (ICS)...
  12. ncbi request reprint Functional and psychological variables both affect daily physical activity in COPD: a structural equations model
    Wytske A Altenburg
    University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, P O Box 30001, Internal mail address AA11, 9700 RB Groningen, The Netherlands University of Groningen, University Medical Center Groningen, Center for Rehabilitation, Groningen, P O Box 30002, Internal Mail Address CD24, 9750 RA Haren, The Netherlands University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, P O Box 30001, Internal Mail Address FA40, 9700RB Groningen, The Netherlands Electronic address
    Respir Med 107:1740-7. 2013
    ..Daily physical activity (DPA) level is reduced in patients with COPD. The aim of this study was to investigate the association of DPA with functional and psychological variables in these patients...
  13. pmc Can AMP induce sputum eosinophils, even in subjects with complete asthma remission?
    Franke Volbeda
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, The Netherlands
    Respir Res 11:106. 2010
    ....
  14. doi request reprint Consequences of physical inactivity in chronic obstructive pulmonary disease
    Jorine E Hartman
    Department of Pulmonary Medicine, University Medical Centre Groningen, University of Groningen, The Netherlands
    Expert Rev Respir Med 4:735-45. 2010
    ..This article aims to discuss in more detail the possible role of regular physical activity for a number of well-known outcome parameters in COPD...
  15. pmc Inhaled corticosteroids and long-acting beta-agonists in adult asthma: a winning combination in all?
    Dirkje S Postma
    Department of Pulmonology, University Medical Center, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 378:203-15. 2008
    ..Clinical effectiveness in the real world now has to be established, since this approach likely improves compliance with regular maintenance therapy...
  16. pmc Association of mast cells with lung function in chronic obstructive pulmonary disease
    Margot M E Gosman
    Department of Pulmonology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Respir Res 9:64. 2008
    ..We compared MC-T and MC-C distributions in COPD and controls without airflow limitation, and determined their relation with lung function...
  17. pmc A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology
    Margot M E Gosman
    Department of Pulmonology, University Medical Centre Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Thorax 62:242-7. 2007
    ..Single-nucleotide polymorphisms (SNPs) in a disintegrin and metalloprotease 33 (ADAM33) gene have been associated with AHR and COPD...
  18. doi request reprint Enhancement of daily physical activity increases physical fitness of outclinic COPD patients: results of an exercise counseling program
    Gieneke Hospes
    Rehabilitation Department, University Medical Center Groningen, Groningen, The Netherlands
    Patient Educ Couns 75:274-8. 2009
    ....
  19. doi request reprint Small airway disease in asthma and COPD: clinical implications
    Maarten van den Berge
    Department of Pulmonary, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Chest 139:412-23. 2011
    ..The first studies in COPD are promising, and results from new studies are eagerly awaited...
  20. pmc Development, validity and responsiveness of the Clinical COPD Questionnaire
    Thys van der Molen
    Department of General Practice, University of Groningen, Groningen, The Netherlands
    Health Qual Life Outcomes 1:13. 2003
    ..So far no validated questionnaires are available to measure symptom and functional state in daily clinical practice. The aim of this study was to develop and validate the Clinical COPD Questionnaire (CCQ)...
  21. doi request reprint Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD
    Maarten van den Berge
    Dept of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Eur Respir J 40:1098-105. 2012
    ..Our findings indicate that BHR is an independent trait in COPD and provides important information on phenotype heterogeneity and disease activity...
  22. doi request reprint Localization and quantification of regional and segmental air trapping in asthma
    Judith Cohen
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, The Netherlands
    J Comput Assist Tomogr 32:562-9. 2008
    ..To assess the feasibility of volumetric and densitometric software to localize and quantify signs of regional air trapping after methacholine bronchoprovocations in asthma...
  23. ncbi request reprint First study of infliximab treatment in patients with chronic obstructive pulmonary disease
    Hester van der Vaart
    Department of Pulmonology, University Medical Center Groningen, P O Box 30 001, NL 9700 RB, Groningen, The Netherlands
    Am J Respir Crit Care Med 172:465-9. 2005
    ..Tumor necrosis factor-alpha is believed to be important in the induction and maintenance of airway inflammation in chronic obstructive pulmonary disease...
  24. doi request reprint Smoking and nonsmoking asthma: differences in clinical outcome and pathogenesis
    Fatemeh Fattahi
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Expert Rev Respir Med 5:93-105. 2011
    ..Possible pathogenetic mechanisms that may explain the links between cigarette smoking and changes in the clinical expression of asthma will be discussed, as well as the beneficial effects of smoking cessation...
  25. doi request reprint Daily physical activity in patients with chronic obstructive pulmonary disease: a systematic review
    Linda Bossenbroek
    University Medical Center Groningen, University of Groningen, Pulmonary Department, The Netherlands
    COPD 8:306-19. 2011
    ..It demonstrates that reduced daily physical activity frequently occurs in COPD patients, yet with a large variation. Methods of measuring and reporting daily physical activity should be more standardized...
  26. ncbi request reprint Asthma and chronic obstructive pulmonary disease: similarities and differences
    Dirkje S Postma
    University of Groningen, Department of Pulmonology, GRIAC Research Institute, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands Electronic address
    Clin Chest Med 35:143-56. 2014
    ....
  27. pmc Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers
    Brigitte W M Willemse
    Department of Pathology, University Medical Centre Groningen, Groningen, The Netherlands
    Respir Res 6:38. 2005
    ..The exact role of smoking as promoting factor of inflammation in chronic obstructive pulmonary disease is not clear, partly because studies often do not distinguish between current and ex-smokers...
  28. doi request reprint Determinants of overweight and obesity in lung transplant recipients
    Linda Bossenbroek
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands l bossenbroek long umcg nl
    Respiration 82:28-35. 2011
    ..Obesity-related diseases have been shown to affect post-lung transplantation survival. An estimated 30% of lung transplant recipients develop overweight...
  29. doi request reprint Cross-sectional assessment of daily physical activity in chronic obstructive pulmonary disease lung transplant patients
    Linda Bossenbroek
    Department of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands
    J Heart Lung Transplant 28:149-55. 2009
    ....
  30. ncbi request reprint A systematic review of the effects of bronchodilators on exercise capacity in patients with COPD
    Jeroen J W Liesker
    Department of Pulmonary Diseases, University Hospital Groningen, Groningen, The Netherlands
    Chest 121:597-608. 2002
    ..The majority of studies reporting a measure of dyspnea found improvements, even in the absence of improvement in exercise capacity...
  31. pmc Steroid resistance in COPD? Overlap and differential anti-inflammatory effects in smokers and ex-smokers
    Susan J M Hoonhorst
    University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands
    PLoS ONE 9:e87443. 2014
    ..The literature suggests that cigarette smoking causes ICS insensitivity. The aim of this study is to compare anti-inflammatory effects of ICS in persistent smokers and persistent ex-smokers in a post-hoc analysis of the GLUCOLD study...
  32. pmc Atopy is a risk factor for respiratory symptoms in COPD patients: results from the EUROSCOP study
    Fatemeh Fattahi
    Department of Pulmonology, University of Groningen, University Medical Center Groningen, PO Box 196 9700 AD, Groningen, The Netherlands
    Respir Res 14:10. 2013
    ..So far effects of atopy on the long-term course of COPD have not been elucidated...
  33. doi request reprint Self-efficacy for physical activity and insight into its benefits are modifiable factors associated with physical activity in people with COPD: a mixed-methods study
    Jorine E Hartman
    Department of Pulmonary Diseases, University of Groningen, Groningen, The Netherlands
    J Physiother 59:117-24. 2013
    ..What are the perceived reasons for people with chronic obstructive pulmonary disease (COPD) to be physically active or sedentary? Are those reasons related to the actual measured level of physical activity?..
  34. doi request reprint Small-airways dysfunction associates with respiratory symptoms and clinical features of asthma: a systematic review
    Erica van der Wiel
    Department of Pulmonary Medicine and Tuberculosis and the GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 131:646-57. 2013
    ..It is important to develop simpler and more reliable tools (eg, questionnaires or bronchial provocation tests with small-particle stimuli) to assess the presence and extent of small-airways dysfunction in daily clinical practice...
  35. ncbi request reprint Cognitive performance in patients with COPD
    Jeroen J W Liesker
    Department of Pulmonary Diseases, University Hospital Groningen, Hanzeplein 1, Postbox 30001 NL 9700 RB, Groningen, The Netherlands
    Respir Med 98:351-6. 2004
    ..These neuropsychological impairments are related to the degree of hypoxemia. So far, cognitive performance has not been tested in non-hypoxemic patients with COPD...
  36. pmc Lower corticosteroid skin blanching response is associated with severe COPD
    Susan J M Hoonhorst
    University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands
    PLoS ONE 9:e91788. 2014
    ..The underlying mechanisms are yet unclear. This study aimed to assess whether skin corticosteroid insensitivity is associated with COPD and COPD severity using the corticosteroid skin blanching test...
  37. doi request reprint The minimal important difference for residual volume in patients with severe emphysema
    Jorine E Hartman
    Dept of Pulmonary Diseases AA11, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Eur Respir J 40:1137-41. 2012
    ..8 and -4.0% for RV/TLC. These MID estimates are useful for sample size determination in new studies on interventions aimed at reducing RV and for interpreting the results from clinical trials in severe emphysema patients...
  38. ncbi request reprint FVC to slow inspiratory vital capacity ratio: a potential marker for small airways obstruction
    Judith Cohen
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Chest 132:1198-203. 2007
    ....
  39. doi request reprint Expression of ADAMs ("a disintegrin and metalloprotease") in the human lung
    Antoon Dijkstra
    Department of Pulmonology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Virchows Arch 454:441-9. 2009
    ..As most ADAMs are involved in release of (pro-) inflammatory mediators and growth factors, they may play an important role in the first line of defense and in initiation of repair events in the airways...
  40. ncbi request reprint The effects of a lifestyle physical activity counseling program with feedback of a pedometer during pulmonary rehabilitation in patients with COPD: a pilot study
    Bertine M J de Blok
    Institute of Human Movement Sciences, University of Groningen, Anton Deusinglaan 1, P O Box 196, 9700 AD Groningen, The Netherlands
    Patient Educ Couns 61:48-55. 2006
    ..To study the effects of a lifestyle physical activity counseling program with feedback of a pedometer during pulmonary rehabilitation...
  41. doi request reprint A better response in exercise capacity after pulmonary rehabilitation in more severe COPD patients
    Wytske A Altenburg
    Department of Pulmonary Diseases, University Medical Centre Groningen, University of Groningen, P O Box 30001, Internal mail address AA11, 9700 RB Groningen, The Netherlands
    Respir Med 106:694-700. 2012
    ..However, not all COPD patients benefit from PR to the same extent. We investigated whether there is a patient profile, which is associated with the improvement in endurance exercise capacity...
  42. doi request reprint Characterization of protocadherin-1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation
    Henk Koning
    Beatrix Children s Hospital, University Medical Center Groningen, Groningen, The Netherlands
    FASEB J 26:439-48. 2012
    ..In summary, PCDH1 transcripts display remarkable variability in expression of conserved intracellular signaling domains. Enhanced PCDH1 expression levels strongly correlate with differentiation of bronchial epithelial cells...
  43. ncbi request reprint Changes in personal control as a predictor of quality of life after pulmonary rehabilitation
    Rosemarie Arnold
    Northern Centre for Healthcare Research, NCH, University of Groningen Medical Center, Antonius Deusinglaan 1, P O Box 196, 9700 AD Groningen, The Netherlands
    Patient Educ Couns 61:99-108. 2006
    ....
  44. ncbi request reprint The relationship between self-efficacy and self-reported physical functioning in chronic obstructive pulmonary disease and chronic heart failure
    Rosemarie Arnold
    Northern Centre for Healthcare Research, Department of Health Sciences, University of Groningen Medical Center, The Netherlands
    Behav Med 31:107-15. 2005
    ..Therefore, important aims in the treatment of patients with COPD and CHF should be not only improving physical functioning but also enhancing self-efficacy...
  45. ncbi request reprint Third-line chemotherapy for small cell lung cancer
    Wouter K de Jong
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, P O Box 30 001, NL 9700 RB, Groningen, The Netherlands
    Lung Cancer 52:339-42. 2006
    ..001), had a better performance score (p<0.001), and had a better response to first-line treatment (p=0.004). In conclusion, third-line chemotherapy is still active in one in four SCLC patients...
  46. pmc Acute effects of cigarette smoking on inflammation in healthy intermittent smokers
    Hester van der Vaart
    Department of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands
    Respir Res 6:22. 2005
    ..Knowledge on the response to the initial smoke exposures might enhance the understanding of changes due to chronic smoking, since repetitive acute smoke effects may cumulate and lead to irreversible lung damage...
  47. ncbi request reprint Airway remodeling and long-term decline in lung function in asthma
    Nick H T ten Hacken
    Department of Pulmonology, University Hospital Groningen, The Netherlands
    Curr Opin Pulm Med 9:9-14. 2003
    ....
  48. ncbi request reprint Quantification of free and total desmosine and isodesmosine in human urine by liquid chromatography tandem mass spectrometry: a comparison of the surrogate-analyte and the surrogate-matrix approach for quantitation
    Sara Ongay
    University of Groningen, Department of Pharmacy, Analytical Biochemistry, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Chromatogr A 1326:13-9. 2014
    ..Results indicate that the presented methods have the necessary quality and level of validation to assess the potential of urinary DES and IDS levels as biomarkers for the progression of COPD and the effect of therapeutic interventions. ..
  49. doi request reprint Adenosine dry powder inhalation for bronchial challenge testing, part 1: inhaler and formulation development and in vitro performance testing
    Anne J Lexmond
    Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands Electronic address
    Eur J Pharm Biopharm 86:105-14. 2014
    ..The new test concept allows for more consistent aerosol delivery over the entire dose range with narrower size distributions than nebulisation and thus may improve adenosine administration in bronchial challenge testing. ..
  50. pmc Morphological measurements in computed tomography correlate with airflow obstruction in chronic obstructive pulmonary disease: systematic review and meta-analysis
    Xueqian Xie
    Center for Medical Imaging North East Netherlands CMI NEN, Department of Radiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P O Box 30 001, 9700, RB, Groningen, The Netherlands
    Eur Radiol 22:2085-93. 2012
    ..To determine the correlation between CT measurements of emphysema or peripheral airways and airflow obstruction in chronic obstructive pulmonary disease (COPD)...