Ronald P Stolk

..These studies show that there are gender differences in the standard predictors of the decline in renal function...

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..LifeLines will contribute to the understanding of how universal risk factors are modified to influence the individual susceptibility to multifactorial diseases, not only at one stage of life but cumulatively over time: the lifeline...

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..73 m² during follow-up were defined as having progressive CKD. Possible predictors for progressive CKD were selected on the basis of univariable logistic regression analyses...

..However, the models need to be corrected for intercept and slope to acquire good calibration for application in a different setting...

..Providers of diabetes care should be attentive to patients with lower educational level...

..Therefore, the aim of this study was to investigate whether besides the baseline values of these risk factors, changes in risk factors are associated with subsequent rate of renal function loss...

..To identify existing prediction models for the risk of development of type 2 diabetes and to externally validate them in a large independent cohort...

..This study aims to investigate the occurrence of polypharmacy and non-adherence in general practice, their mutual relationship and the association between adherence and the intermediate outcomes of diabetes care...

..To assess and correlate the lipid content of various organs in obese subjects and in persons with a normal body weight...

..We aimed to investigate the associations of parental history of T2D with cardiometabolic biomarkers and to subsequently investigate to what extent these putative associations were explained by modifiable factors...

..We hypothesized that these effects differ according to expected priority of the conditions...

..Our aim was to determine the extent of health care utilization and provision in primary care and to evaluate the risk of cardiovascular disease in persons with an elevated risk score in a stepwise diabetes screening programme...

..To investigate whether Escherichia coli bacteriuria is associated with the development of hypertension during a long-term follow-up...

..In this study, we investigated whether the use of antipsychotic drugs in patients with diabetes leads to worsening of glycemic control...

..Women with diabetes have a high incidence and complication rate of urinary tract infections (UTIs). Our aims were to compare current treatment strategies with respect to recurrence rates in women with diabetes with those without diabetes...

..These findings suggest that the presence of insulin resistance in Type 1 diabetes or "double diabetes" plays a key role in determining daily insulin need...

..A growing body of evidence suggests that earlier diagnosis and treatment of diabetes may be beneficial; however, definitive evidence is lacking...

..The low overall action rates observed for blood pressure and especially lipid management cannot sufficiently be explained by the use of treatment thresholds higher than those indicated by guidelines...

..The goal of this work was to assess whether high dietary glycemic load and glycemic index are associated with an increased risk of cardiovascular disease (CVD)...

..To examine whether BMI is an effect modifier regarding the relation between level of glucose regulation and cardiovascular risk factors...

..Overweight is a complex trait in which both environmental and genetic factors play a role...

..Although adherence problems are often mentioned in surveys as a reason for not intensifying treatment, observational studies have shown inconclusive results...

..This is largely unexplored in renal transplant recipients (RTRs). We studied whether PA is associated with cardiovascular and all-cause mortality in a prospective cohort of RTR...

..Liver function tests might predict the risk of type 2 diabetes. An independent study evaluating utility of these markers compared with an existing prediction model is yet lacking...

..The cholesteryl ester transfer protein (CETP) plays a key role in the remodeling of triglyceride (TG)-rich and HDL particles. Sequence variations in the CETP gene may interfere with the effect of lipid-lowering treatment in type 2 diabetes...

..Procalcitonin, a well-known biomarker of sepsis and bacterial infections, is produced by adipose tissue and has potential as a marker for chronic low-grade inflammation...

..5; 95% confidence interval, 0.7-3.6). CONCLUSION: Women with DM (type 1 or type 2) with ASB do not have an increased risk for a faster decline in renal function or the development of hypertension after 6 years of follow-up...

..No data are available on the estimation of total body fat in non-obese children. The aim of this study is to compare total body fat, assessed by different methods in non-obese children...

..We subsequently examined the incremental value of Prx4 for the risk prediction of CVD compared with the Framingham risk score (FRS)...

..Increased dependence on motorized transportation may contribute to obesity. Countries in rapid socioeconomic transitions, such as China, provide an opportunity to investigate such an association...

..In conclusion, we identified common allelic variants specifically associated with distinctly different eating patterns, namely extreme snacking behavior or excessive portion size...

..In summary, in the general population, high protein intake does not promote accelerated decline of renal function but does associate with an increased risk for cardiovascular events...

..CONCLUSIONS: Our findings support the evidence of a decreased risk of type 2 diabetes with moderate alcohol consumption and expand this to a population of older women...

..Thereafter, questions about the type of patients actually treated with RLAI in daily practice remain to be answered for making valid antipsychotic treatment comparisons involving RLAI in observational studies...

..Further studies using directly measured physical activity and percentage body fat to define adiposity are needed to draw more firm conclusions...

..To investigate whether the yield of population-based diabetes screening is influenced by characteristics of the general practitioner (GP) and the practice...

..We investigated the independent and joint association of adiposity and physical activity with fasting plasma glucose, impaired fasting glucose, and type 2 diabetes in a Chinese population...

..Little is known about normal values of HbA(1c) in infants. The aim of this study is to describe the distribution of HbA(1c) in 8- to 12-month-old nondiabetic infants...

..Detecting young children with high amount of body fat is important to intervene in the development of obesity. The aim of this study is to gain inside in the bioelectrical impedance vector analysis in healthy infants...

..We sought to investigate whether Escherichia coli bacteriuria is associated with a decline in renal function or with the development of end-stage renal failure after long-term follow-up...

..To present an overview of the association between depressive symptoms in childhood and adolescence and subsequent overweight in later life...

..To assess the period during infancy and childhood in which growth is most associated with adolescent adiposity and the metabolic syndrome (MS) and whether this differs depending on maternal smoking during pregnancy...

..To assess the effects of a multidisciplinary intervention program for 3-year-old to 5-year-old overweight and obese children compared with a usual-care program...

..Furthermore, this review clearly showed that results can differ depending on what method is used to assess interaction...

..After the recent success of lifestyle intervention to prevent diabetes, further research is needed to show the effects of lifestyle changes to prevent and reduce obesity-related morbidity, including chronic kidney disease...

..TRIAL REGISTRATION: Netherlands Trial Register (NTR): NTR2242...

..We hypothesize that the intervention will decrease the need for fertility treatment, diminish overweight-related pregnancy complications, and will improve perinatal outcome...

..001). This validation study shows that a combination of computer-assessed ultrasound measures from routine ultrasound images can be used to quantitatively assess hepatic fat content...

..To evaluate the effects of insulin 30/70 twice daily or bedtime isophane (NPH) insulin plus continued sulfonylurea and metformin in patients with type 2 diabetes in primary care...

..The explained phenotypic variance from this approach was comparable to that from a meta-analysis of GWAS data, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids...

..The objective of this study was to determine the association between different antihypertensive drug therapies and lower extremity amputations (LEAs) in type 2 diabetes patients...

..Further exploration of the multifaceted actions of vitamin D may pave the way for disease-overriding intervention strategies...

..We designed a trial to assess the (cost-)effectiveness of a screening program for Q fever in pregnant women living in risks areas in The Netherlands...

..This method is more accurate than measurement of waist and hip circumferences and is simpler and less expensive than computed tomography or magnetic resonance imaging...

..To determine parental, especially paternal factors associated with the weight of the placenta and offspring...

..In an effort to reach professional consensus on the concept, we end this paper with recommendations for further research...

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..This results in a model with sufficient accuracy (AUC > 0.75)...

..6% vs 8.0%, p = 0.25). In conclusion, undetected diabetics were shown to have an increased risk of PMI...

..Random effects models assume Missing At Random and do not take into account informative drop-out. We therefore aim to correct the bias due to informative drop-out...

..The quality of recording of clinical data in diabetes care in general practices is very variable. It has been suggested that better recording leads to improved glycaemic control...

..Aggressive lipid lowering by administration of atorvastatin, resulting in substantial improvement of the lipid profile, did not reverse endothelial dysfunction...

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..To assess whether switching to insulin therapy in patients with type 2 diabetes mellitus is associated with medication refill compliance of oral hypoglycemic agents...

..To address this issue, we decided to assess glucose metabolism in a population of patients with schizophrenia or schizoaffective disorder...

..Therefore our data provide evidence that retinal microvascular disease is of limited value in risk stratification for future cardiovascular events...

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..To assess prevalence, incidence and risk factors in The Netherlands we performed a prospective cohort study...

..Endothelial damage precedes atherosclerotic changes of the vascular wall. Therefore, several markers of endothelial dysfunction were examined in elderly subjects with IGT and elderly patients with type 2 diabetes...

..We have focused on patients with type 1 diabetes instead of type 2 diabetes to minimise the effect of insulin resistance as a potential confounder...

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..Therefore, we studied the effect of atorvastatin 10 mg (A10) and 80 mg (A80) on HL activity in 198 patients with type 2 diabetes...