C D Stehouwer

Summary

Affiliation: University Hospital Vrije Universiteit
Country: The Netherlands

Publications

  1. ncbi request reprint Hyperhomocysteinemia, vascular pathology, and endothelial dysfunction
    C van Guldener
    Department of Internal Medicine, University Hospital and Institute for Cardiovascular Research Vrije Universiteit, Amsterdam, The Netherlands
    Semin Thromb Hemost 26:281-9. 2000
  2. ncbi request reprint Internal medicine in the next millennium: whither vascular medicine?
    C D Stehouwer
    Department of Internal Medicine, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Neth J Med 55:261-4. 1999
  3. ncbi request reprint Clinical relevance of hyperhomocysteinaemia in atherothrombotic disease
    D A Stehouwer
    Department of Internal Medicine, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Drugs Aging 16:251-60. 2000
  4. ncbi request reprint Serum homocysteine and risk of coronary heart disease and cerebrovascular disease in elderly men: a 10-year follow-up
    C D Stehouwer
    Institute for Cardiovascular Research, Vrije Universiteit and the Department of Medicine Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 18:1895-901. 1998
  5. ncbi request reprint [Hormonal supplements for postmenopausal women: no evidence of protection against cardiovascular disease]
    C D Stehouwer
    Academisch Ziekenhuis Vrije Universiteit, Afd Algemene Inwendige Geneeskunde, De Boelelaan 1117, 1081 HV Amsterdam
    Ned Tijdschr Geneeskd 145:61-4. 2001
  6. ncbi request reprint Heterogeneity of the association between plasma homocysteine and atherothrombotic disease: insights from studies of vascular structure and function
    C D Stehouwer
    Department of Medicine, Institute for Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Clin Chem Lab Med 39:705-9. 2001
  7. ncbi request reprint Cardiovascular autonomic function is associated with (micro-)albuminuria in elderly Caucasian sujects with impaired glucose tolerance or type 2 diabetes: the Hoorn Study
    Y M Smulders
    Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Diabetes Care 23:1369-74. 2000
  8. ncbi request reprint Serum homocysteine level and protein intake are related to risk of microalbuminuria: the Hoorn Study
    E K Hoogeveen
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Kidney Int 54:203-9. 1998
  9. ncbi request reprint Serum homocysteine levels are associated with the development of (micro)albuminuria: the Hoorn study
    A Jager
    Institute for Research in Extramural Medicine, Vrije Universiteit, Department of Clinical Epidemiology, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 21:74-81. 2001
  10. ncbi request reprint Hyperhomocysteinemia increases risk of death, especially in type 2 diabetes : 5-year follow-up of the Hoorn Study
    E K Hoogeveen
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Circulation 101:1506-11. 2000

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Hyperhomocysteinemia, vascular pathology, and endothelial dysfunction
    C van Guldener
    Department of Internal Medicine, University Hospital and Institute for Cardiovascular Research Vrije Universiteit, Amsterdam, The Netherlands
    Semin Thromb Hemost 26:281-9. 2000
    ..The precise mechanisms (if any) by which homocysteine mediates its adverse vascular effects are in fact unknown but may relate to impaired endothelial and smooth muscle cell function...
  2. ncbi request reprint Internal medicine in the next millennium: whither vascular medicine?
    C D Stehouwer
    Department of Internal Medicine, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Neth J Med 55:261-4. 1999
    ..Academic and large community hospitals should consider the founding of multidisciplinary centres for vascular medicine. General internists should play a coordinating role in such centres...
  3. ncbi request reprint Clinical relevance of hyperhomocysteinaemia in atherothrombotic disease
    D A Stehouwer
    Department of Internal Medicine, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Drugs Aging 16:251-60. 2000
    ..Such a policy should be reassessed as the results of randomised trials become available...
  4. ncbi request reprint Serum homocysteine and risk of coronary heart disease and cerebrovascular disease in elderly men: a 10-year follow-up
    C D Stehouwer
    Institute for Cardiovascular Research, Vrije Universiteit and the Department of Medicine Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 18:1895-901. 1998
    ..It is a strong predictive factor for fatal cerebrovascular disease in men without hypertension but less so for coronary heart disease...
  5. ncbi request reprint [Hormonal supplements for postmenopausal women: no evidence of protection against cardiovascular disease]
    C D Stehouwer
    Academisch Ziekenhuis Vrije Universiteit, Afd Algemene Inwendige Geneeskunde, De Boelelaan 1117, 1081 HV Amsterdam
    Ned Tijdschr Geneeskd 145:61-4. 2001
    ..Hormonal replacement may affect the pathophysiology of atherothrombosis in several ways, both positive and negative. Progress in this field requires the isolation of the positive effects...
  6. ncbi request reprint Heterogeneity of the association between plasma homocysteine and atherothrombotic disease: insights from studies of vascular structure and function
    C D Stehouwer
    Department of Medicine, Institute for Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Clin Chem Lab Med 39:705-9. 2001
    ..This concept could account for some of the observed heterogeneity. Identifying these factors would be of major clinical importance and would provide crucial mechanistic insights...
  7. ncbi request reprint Cardiovascular autonomic function is associated with (micro-)albuminuria in elderly Caucasian sujects with impaired glucose tolerance or type 2 diabetes: the Hoorn Study
    Y M Smulders
    Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Diabetes Care 23:1369-74. 2000
    ....
  8. ncbi request reprint Serum homocysteine level and protein intake are related to risk of microalbuminuria: the Hoorn Study
    E K Hoogeveen
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Kidney Int 54:203-9. 1998
    ..It is not known whether hyperhomocysteinemia is associated with MA, and thus could be a possible cause of microalbuminuria...
  9. ncbi request reprint Serum homocysteine levels are associated with the development of (micro)albuminuria: the Hoorn study
    A Jager
    Institute for Research in Extramural Medicine, Vrije Universiteit, Department of Clinical Epidemiology, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 21:74-81. 2001
    ..These data suggest that homocysteine may play a pathophysiological role in the development of (micro)albuminuria...
  10. ncbi request reprint Hyperhomocysteinemia increases risk of death, especially in type 2 diabetes : 5-year follow-up of the Hoorn Study
    E K Hoogeveen
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Circulation 101:1506-11. 2000
    ..We therefore prospectively investigated the combined effect of hyperhomocysteinemia and type 2 diabetes on mortality...
  11. ncbi request reprint The 1997 American Diabetes Association criteria versus the 1985 World Health Organization criteria for the diagnosis of abnormal glucose tolerance: poor agreement in the Hoorn Study
    F de Vegt
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Diabetes Care 21:1686-90. 1998
    ..We compared the 1997 ADA criteria with the 1985 World Health Organization (WHO) criteria with respect to the prevalence of diabetes and the cardiovascular risk profile in the population of the Hoorn Study..
  12. ncbi request reprint Normohomocysteinaemia and vitamin-treated hyperhomocysteinaemia are associated with similar risks of cardiovascular events in patients with premature atherothrombotic cerebrovascular disease. A prospective cohort study
    E G Vermeulen
    Department of Surgery, Vascular Surgical Unit, University Hospital Vrije Universiteit, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Neth J Med 56:138-46. 2000
    ..We investigated the clinical efficacy with regard to the incidence of cardiovascular events of treatment of mild HHC with vitamin B(6) plus folic acid...
  13. ncbi request reprint Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in non-insulin-dependent diabetes mellitus: a population-based study
    E K Hoogeveen
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 18:133-8. 1998
    ..High serum tHcy may be a stronger (1.6-fold) risk factor for cardiovascular disease in subjects with non-insulin-dependent diabetes mellitus than in nondiabetic subjects...
  14. ncbi request reprint Hyperhomocysteinaemia is not related to risk of distal somatic polyneuropathy: the Hoorn Study
    E K Hoogeveen
    Institute for Resaerch in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    J Intern Med 246:561-6. 1999
    ..Both metabolic and vascular abnormalities may contribute to the development of impaired nerve function. We therefore assessed the association between hyperhomocysteinaemia, a risk factor for cardiovascular disease, and polyneuropathy...
  15. ncbi request reprint Hyperhomocysteinaemia is not associated with isolated crural arterial occlusive disease: The Hoorn Study
    E K Hoogeveen
    Institute for Research in Extramural Medicine, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Intern Med 247:442-8. 2000
    ..The aim of the study was to investigate whether the strength of the association between hyperhomocysteinaemia and peripheral arterial disease differs according to the localization of the anatomical obstruction...
  16. doi request reprint Greater arterial stiffness in polycystic ovary syndrome (PCOS) is an obesity--but not a PCOS-associated phenomenon
    I J Ketel
    Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Vrije Universiteit Medical Centre VU, Amsterdam, The Netherlands
    J Clin Endocrinol Metab 95:4566-75. 2010
    ..Polycystic ovary syndrome (PCOS) and obesity are associated with cardiovascular disease, but it is unclear to what extent they contribute independently. Arterial stiffness might link obesity and PCOS to cardiovascular diseases...
  17. ncbi request reprint Does metformin increase the serum total homocysteine level in non-insulin-dependent diabetes mellitus?
    E K Hoogeveen
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    J Intern Med 242:389-94. 1997
    ..An elevated serum total homocysteine level is a risk factor for atherosclerosis. Metformin decreases serum vitamin B12, and may thereby indirectly increase the serum total homocysteine level...
  18. ncbi request reprint Leptin and variables of body adiposity, energy balance, and insulin resistance in a population-based study. The Hoorn Study
    J B Ruige
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Diabetes Care 22:1097-104. 1999
    ..We therefore explored, in a large population-based study of 2,484 Caucasian subjects aged 50-74 years, the relationship between leptin and variables of body adiposity, energy balance, and insulin resistance...
  19. ncbi request reprint Hormone replacement therapy in postmenopausal women with specific risk factors for coronary artery disease
    M J van der Mooren
    Department of Obstetrics and Gynaecology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Maturitas 30:27-36. 1998
    ..Although clinical trials still need to demonstrate the impact of lowering concentrations of Lp(a) and homocysteine, HRT appears to be a promising risk reduction strategy in this respect...
  20. ncbi request reprint Amadori albumin in type 1 diabetic patients: correlation with markers of endothelial function, association with diabetic nephropathy, and localization in retinal capillaries
    C G Schalkwijk
    Department of Clinical Chemistry, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Diabetes 48:2446-53. 1999
    ..06 [1.01-1.11]) per U/ml increase. Our results are consistent with a proposed pathophysiological role of Amadori albumin in microvascular complications of type 1 diabetic patients...
  21. ncbi request reprint Brachial artery pulse pressure and common carotid artery diameter: mutually independent associations with mortality in subjects with a recent history of impaired glucose tolerance
    R A van Dijk
    Institute for Cardiovascular Research Vrije Universiteit and Department of Internal Medicine, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Eur J Clin Invest 31:756-63. 2001
    ....
  22. ncbi request reprint Determinants of the limits of agreement between the sphygmomanometer and the SpaceLabs 90207 device for blood pressure measurement in health volunteers and insulin-dependent diabetic patients
    F J van Ittersum
    Institute for Cardiovascular Research, Vrije Universiteit Amsterdam, Department of Medicine, The Netherlands
    J Hypertens 16:1125-30. 1998
    ..To compare the limits of agreement between the SpaceLabs 90207 oscillometric blood pressure measurement device and the sphygmomanometer for patients with insulin-dependent diabetes mellitus (IDDM) versus healthy control subjects...
  23. ncbi request reprint No net renal extraction of homocysteine in fasting humans
    C van Guldener
    Department of Nephrology, Vrije Universiteit, Amsterdam, The Netherlands
    Kidney Int 54:166-9. 1998
    ..We studied homocysteine extraction in the normal human kidney...
  24. ncbi request reprint Homocysteine and methionine metabolism in ESRD: A stable isotope study
    C van Guldener
    Department of Internal Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Kidney Int 56:1064-71. 1999
    ..The cause of hyperhomocysteinemia in renal failure is unknown, and therapies have not been able to normalize plasma homocysteine levels. Insight into methionine-homocysteine metabolism in ESRD is therefore necessary...
  25. ncbi request reprint ACE-inhibition modulates some endothelial functions in healthy subjects and in normotensive type 1 diabetic patients
    C G Schalkwijk
    Department of Clinical Chemistry, Academisch Ziekenhuis Vrije Universiteit, and Institute for Cardiovascular Research ICaR, Vrije Universiteit, Amsterdam, The Netherlands
    Eur J Clin Invest 30:853-60. 2000
    ..We investigated whether ACE-inhibition improves endothelial function in such patients and compared the responses to those in healthy subjects...
  26. ncbi request reprint Decreased smooth muscle cell/extracellular matrix ratio of media of femoral artery in patients with atherosclerosis and hyperhomocysteinemia
    E G Vermeulen
    Department of General Surgery, Vascular Surgical Unit, The Institute for Cardiovascular Research, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 21:573-7. 2001
    ..Further investigations should concentrate on the cause of this newly discovered phenomenon and its impact on vascular compliance...
  27. doi request reprint BclI Glucocorticoid Receptor Polymorphism Is Associated With Greater Body Fatness: The Hoorn and CODAM Studies
    C C Geelen
    MD, PhD, Department of Internal Medicine, Division of Endocrinology, Maastricht University Medical Center, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Clin Endocrinol Metab 98:E595-9. 2013
    ..04 (-0.04 to 0.11)]. Conclusion: Homozygous carriers of the BclI polymorphism of the GR gene have significantly greater total body fatness, contributing to higher HOMA2-IR, compared with heterozygous carriers and noncarriers...
  28. ncbi request reprint Homocysteine metabolism in renal failure
    C van Guldener
    Department of Internal Medicine, Academic Hospital, and Institute for Cardiovascular Research, Vrije Universiteit, Amsterdam, The Netherlands
    Kidney Int Suppl 78:S234-7. 2001
    ..This should lead to optimal treatment and, ultimately, to the prevention of cardiovascular complications in this vulnerable patient group...
  29. pmc Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress
    O Brouwers
    Department of Internal Medicine, University Hospital Maastricht, P Debyelaan 25, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Diabetologia 53:989-1000. 2010
    ..We investigated the effect of hyperglycaemia on impaired vasoreactivity and a putative role therein of the AGE precursor methylglyoxal...
  30. ncbi request reprint Rapid progression of albumin excretion is an independent predictor of cardiovascular mortality in patients with type 2 diabetes and microalbuminuria
    A M Spoelstra-de Man
    Department of Internal Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Diabetes Care 24:2097-101. 2001
    ..The purpose of this study was to determine the prognostic significance of rate of progression of microalbuminuria for cardiovascular end points and renal function...
  31. ncbi request reprint Long-term homocysteine-lowering treatment with folic acid plus pyridoxine is associated with decreased blood pressure but not with improved brachial artery endothelium-dependent vasodilation or carotid artery stiffness: a 2-year, randomized, placebo-contr
    R A van Dijk
    Institute for Cardiovascular Research Vrije Universiteit, Department of Internal Medicine, University Hospital Vrije Universiteit, Netherlands
    Arterioscler Thromb Vasc Biol 21:2072-9. 2001
    ....
  32. ncbi request reprint Prognostic implications of retinopathy and a high plasma von Willebrand factor concentration in type 2 diabetic subjects with microalbuminuria
    A Jager
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Nephrol Dial Transplant 16:529-36. 2001
    ....
  33. ncbi request reprint Evidence for genetic factors explaining the association between birth weight and low-density lipoprotein cholesterol and possible intrauterine factors influencing the association between birth weight and high-density lipoprotein cholesterol: analysis in t
    R G Ijzerman
    Department of Internal Medicine and Institute for Cardiovascular Research-Vrije Universiteit, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Clin Endocrinol Metab 86:5479-84. 2001
    ....
  34. ncbi request reprint Homocysteine-lowering treatment: an overview
    C van Guldener
    Department of Internal Medicine, University Hospital and Institute of Cardiovascular Research, Vrije Universiteit, Amsterdam, The Netherlands
    Expert Opin Pharmacother 2:1449-60. 2001
    ..In view of the effective, cheap and safe character of therapy with folic acid and pyridoxine, a policy can be accepted to screen and treat high-risk patients until these trials have been concluded...
  35. ncbi request reprint Ambulatory--not office--blood pressures decline during hormone replacement therapy in healthy postmenopausal women
    F J van Ittersum
    Institute for Cardiovascular Research Vrije Universiteit Amsterdam, Department of Medicine, The Netherlands
    Am J Hypertens 11:1147-52. 1998
    ..33 [-0.69 to +7.35]/+1.67 [-1.75 to +5.09] mm Hg; P [HRT v control group] = .001/.005). We conclude that HRT may have blood pressure lowering properties in healthy, normotensive postmenopausal women...
  36. ncbi request reprint Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease: the Hoorn Study
    J Gerritsen
    Department of Clinical Physics and Informatics, Vrije Universiteit, Amsterdam, The Netherlands
    Diabetes Care 24:1793-8. 2001
    ..Moreover, the results of the present study suggest that cardiac autonomic dysfunction in patients already at risk (diabetes, hypertension, or history of cardiovascular disease) may be especially hazardous...
  37. ncbi request reprint Intra-uterine and genetic influences on the relationship between size at birth and height in later life: analysis in twins
    R G Ijzerman
    Department of Internal Medicine, Institute for Cardiovascular Research-Vrije Universiteit, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Twin Res 4:337-43. 2001
    ..These data suggest that the association between size at birth and height in later life is influenced by non-genetic intra-uterine and by genetic factors...
  38. ncbi request reprint [Diastolic heart failure]
    Y M Smulders
    afd Inwendige Geneeskunde, VU Medisch Centrum, De Boelelaan 1117, 1081 HV Amsterdam
    Ned Tijdschr Geneeskd 147:2467-70. 2003
    ..Angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, and (non-dihydropyridine) calcium antagonists have therapeutic potential. Digoxin may be contraindicated...
  39. ncbi request reprint Impaired skin capillary recruitment in essential hypertension is caused by both functional and structural capillary rarefaction
    E H Serne
    Department of Medicine, Academic Hospital, Vrije Universiteit, Amsterdam, The Netherlands
    Hypertension 38:238-42. 2001
    ..In conclusion, in patients with essential hypertension, recruitment of perfused capillaries is impaired, which can be explained by both functional and structural rarefaction...