Iris E Sommer

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc Healthy individuals with auditory verbal hallucinations; who are they? Psychiatric assessments of a selected sample of 103 subjects
    Iris E C Sommer
    Neuroscience Division University Medical Center Utrecht, B01 206, Rudolf Magnus School for Neuroscience, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Bull 36:633-41. 2010
  2. ncbi request reprint Effects of cross-sex hormones on cerebral activation during language and mental rotation: An fMRI study in transsexuals
    I E C Sommer
    Rudolf Magnus Institute of Neuroscience, Brain Division, University Medical Center Utrecht, The Netherlands
    Eur Neuropsychopharmacol 18:215-21. 2008
  3. pmc Efficacy of Anti-inflammatory Agents to Improve Symptoms in Patients With Schizophrenia: An Update
    Iris E Sommer
    To whom correspondence should be addressed Department of Psychiatry, University Medical Centre Utrecht, Room A01 161 A01 126, Heidelberglaan 100, 3508GA Utrecht, The Netherlands tel 31 887556365, fax 31 887556543, E mail
    Schizophr Bull 40:181-91. 2014
  4. pmc How frequent are radiological abnormalities in patients with psychosis? A review of 1379 MRI scans
    Iris E Sommer
    Psychiatry Department, University Medical Center Utrecht and Rudolf Magnus Institute for Neuroscience, The Netherlands
    Schizophr Bull 39:815-9. 2013
  5. pmc Resting state functional connectivity in patients with chronic hallucinations
    Iris E Sommer
    Psychiatry Department, University Medical Center Utrecht and Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands
    PLoS ONE 7:e43516. 2012
  6. pmc Pharmacological augmentation strategies for schizophrenia patients with insufficient response to clozapine: a quantitative literature review
    Iris E Sommer
    Neuroscience Department of the University Medical Center Utrecht and Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands
    Schizophr Bull 38:1003-11. 2012
  7. pmc The treatment of hallucinations in schizophrenia spectrum disorders
    Iris E C Sommer
    Neuroscience Division, Psychiatry Department, University Medical Centre Utrecht and Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Schizophr Bull 38:704-14. 2012
  8. doi request reprint Nonsteroidal anti-inflammatory drugs in schizophrenia: ready for practice or a good start? A meta-analysis
    Iris E Sommer
    Neuroscience Department, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 73:414-9. 2012
  9. doi request reprint Formal thought disorder in non-clinical individuals with auditory verbal hallucinations
    Iris E Sommer
    The Neuroscience Division University Medical Center Utrecht, Rudolf Magnus School for Neuroscience, Netherlands
    Schizophr Res 118:140-5. 2010
  10. doi request reprint Auditory verbal hallucinations predominantly activate the right inferior frontal area
    Iris E C Sommer
    Neuroscience Division, University Medical Center Utrecht and Rudolf Magnus Institute for Neuroscience, Heidelberglaan, Netherlands
    Brain 131:3169-77. 2008

Detail Information

Publications22

  1. pmc Healthy individuals with auditory verbal hallucinations; who are they? Psychiatric assessments of a selected sample of 103 subjects
    Iris E C Sommer
    Neuroscience Division University Medical Center Utrecht, B01 206, Rudolf Magnus School for Neuroscience, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Bull 36:633-41. 2010
    ..Our data suggest that AVH in otherwise healthy individuals are not an isolated phenomenon but part of a general vulnerability for schizophrenia...
  2. ncbi request reprint Effects of cross-sex hormones on cerebral activation during language and mental rotation: An fMRI study in transsexuals
    I E C Sommer
    Rudolf Magnus Institute of Neuroscience, Brain Division, University Medical Center Utrecht, The Netherlands
    Eur Neuropsychopharmacol 18:215-21. 2008
    ..54, p=0.34), but post-treatment testosterone levels correlated to total activation during mental rotation (rho=0.64, p=0.01). Findings suggest that sex steroids may influence cerebral activation, but lateralization remains stable...
  3. pmc Efficacy of Anti-inflammatory Agents to Improve Symptoms in Patients With Schizophrenia: An Update
    Iris E Sommer
    To whom correspondence should be addressed Department of Psychiatry, University Medical Centre Utrecht, Room A01 161 A01 126, Heidelberglaan 100, 3508GA Utrecht, The Netherlands tel 31 887556365, fax 31 887556543, E mail
    Schizophr Bull 40:181-91. 2014
    ..These 3 agents are all very broadly active substances, and it has to be investigated if the beneficial effects on symptom severity are indeed mediated by their anti-inflammatory aspects. ..
  4. pmc How frequent are radiological abnormalities in patients with psychosis? A review of 1379 MRI scans
    Iris E Sommer
    Psychiatry Department, University Medical Center Utrecht and Rudolf Magnus Institute for Neuroscience, The Netherlands
    Schizophr Bull 39:815-9. 2013
    ..Some of these underlying organic disorders can be identified on magnetic resonance imaging (MRI) scans. Whether routine screening for all psychotic patients should therefore include MRI scans is still a matter of debate...
  5. pmc Resting state functional connectivity in patients with chronic hallucinations
    Iris E Sommer
    Psychiatry Department, University Medical Center Utrecht and Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands
    PLoS ONE 7:e43516. 2012
    ..Moreover, we found decreased connectivity between language-related areas, indicating aberrant integration in this system potentially including corollary discharge mechanisms...
  6. pmc Pharmacological augmentation strategies for schizophrenia patients with insufficient response to clozapine: a quantitative literature review
    Iris E Sommer
    Neuroscience Department of the University Medical Center Utrecht and Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands
    Schizophr Bull 38:1003-11. 2012
    ..This meta-analysis summarizes available evidence on efficacy of pharmacological augmentation of clozapine treatment in schizophrenia spectrum disorder...
  7. pmc The treatment of hallucinations in schizophrenia spectrum disorders
    Iris E C Sommer
    Neuroscience Division, Psychiatry Department, University Medical Centre Utrecht and Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Schizophr Bull 38:704-14. 2012
    ..Electroconvulsive therapy (ECT) is considered a last resort for treatment-resistant psychosis. Although several studies showed clinical improvement, a specific reduction in hallucination severity has never been demonstrated...
  8. doi request reprint Nonsteroidal anti-inflammatory drugs in schizophrenia: ready for practice or a good start? A meta-analysis
    Iris E Sommer
    Neuroscience Department, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 73:414-9. 2012
    ..This article quantitatively summarizes the efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) to augment antipsychotic treatment to reduce schizophrenia symptom severity...
  9. doi request reprint Formal thought disorder in non-clinical individuals with auditory verbal hallucinations
    Iris E Sommer
    The Neuroscience Division University Medical Center Utrecht, Rudolf Magnus School for Neuroscience, Netherlands
    Schizophr Res 118:140-5. 2010
    ..The hypothesis of a shared neurobiological basis would be strengthened by the presence of FTD in individuals who frequently experience AVH, but do not meet DSM-IV criteria for a psychotic disorder...
  10. doi request reprint Auditory verbal hallucinations predominantly activate the right inferior frontal area
    Iris E C Sommer
    Neuroscience Division, University Medical Center Utrecht and Rudolf Magnus Institute for Neuroscience, Heidelberglaan, Netherlands
    Brain 131:3169-77. 2008
    ..The predominant engagement of the right inferior frontal area during AVH may be related to the typical low semantic complexity and negative emotional content...
  11. doi request reprint Sex differences in handedness, asymmetry of the planum temporale and functional language lateralization
    Iris E Sommer
    Neuroscience Division of the University Medical Center Utrecht, The Netherlands
    Brain Res 1206:76-88. 2008
    ..In conclusion, males are more frequently non-right handed than females, but there is no sex difference in asymmetries of the Planum Temporale, dichotic listening or functional imaging findings during language tasks...
  12. doi request reprint Aberrations in the arcuate fasciculus are associated with auditory verbal hallucinations in psychotic and in non-psychotic individuals
    Antoin D de Weijer
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Hum Brain Mapp 34:626-34. 2013
    ..As increased MTR in the arcuate fasciculus was present in both hallucinating groups, a specific association with AVH seems plausible. Decreases in FA, on the other hand, seem to be related to other disease processes of schizophrenia...
  13. pmc The relationship of DNA methylation with age, gender and genotype in twins and healthy controls
    Marco P Boks
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 4:e6767. 2009
    ..The identification of CpG loci of which DNA methylation levels are under genetic control or are related to age or gender will facilitate further studies into the role of DNA methylation and disease...
  14. doi request reprint Dissecting auditory verbal hallucinations into two components: audibility (Gedankenlautwerden) and alienation (thought insertion)
    Iris E Sommer
    UMC Utrecht, Utrecht, The Netherlands
    Psychopathology 43:137-40. 2010
    ..When alienation is not accompanied by audibility, it will result in the experience of thought insertion. The 2 hypothesized components are illustrated using case vignettes...
  15. ncbi request reprint Psychiatric morbidity and X-chromosomal origin in a Klinefelter sample
    Marco P M Boks
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, Utrecht, The Netherlands
    Schizophr Res 93:399-402. 2007
    ..Nevertheless, these findings provide further support for the role of the X-chromosome in the susceptibility to psychiatric disorders in general and psychotic disorders in particular...
  16. doi request reprint Initial evaluation of the effects of competitive memory training (COMET) on depression in schizophrenia-spectrum patients with persistent auditory verbal hallucinations: a randomized controlled trial
    Mark van der Gaag
    VU University and EMGO Institute, Amsterdam, The Netherlands
    Br J Clin Psychol 51:158-71. 2012
    ..Design.  A randomized controlled clinical trial comparing competitive memory training (COMET) with treatment as usual (TAU) in schizophrenia patients with persistent auditory hallucinations...
  17. doi request reprint Do mood symptoms subdivide the schizophrenia phenotype? Association of the GMP6A gene with a depression subgroup
    Marco P M Boks
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:707-11. 2008
    ..Overall, these finding suggests that investigating subgroups of schizophrenia based symptoms profile and particularly mood symptoms can facilitate genetic studies of schizophrenia...
  18. doi request reprint Estrogen augmentation in schizophrenia: a quantitative review of current evidence
    Marieke J H Begemann
    Neuroscience Division, University Medical Center Utrecht UMCU and Rudolf Magnus Institute for Neuroscience, Heidelberglaan 100, 3485CX Utrecht, Netherlands
    Schizophr Res 141:179-84. 2012
    ..This quantitative review summarizes available evidence on the efficacy of estrogens in the treatment of schizophrenia...
  19. pmc The Measurement of Language Lateralization with Functional Transcranial Doppler and Functional MRI: A Critical Evaluation
    Metten Somers
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht Utrecht, Netherlands
    Front Hum Neurosci 5:31. 2011
    ..Our results suggest that fTCD can be a valid alternative for fMRI to measure lateralization, particularly when costs or mobility are important factors in the study design...
  20. ncbi request reprint Language lateralization in female patients with schizophrenia: an fMRI study
    I E C Sommer
    Department of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands
    Schizophr Res 60:183-90. 2003
    ..These findings indicate that lower language lateralization in women is not likely to underlie gender differences in schizophrenia...
  21. ncbi request reprint Language lateralization in monozygotic twin pairs concordant and discordant for handedness
    I E C Sommer
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, Neuroscience Division, University Medical Centre Utrecht, The Netherlands
    Brain 125:2710-8. 2002
    ..Discordant language dominance may be caused by a relatively late time of splitting of the original embryo, which disrupts the normal development of left-right asymmetry...
  22. ncbi request reprint Efficacy of slow repetitive transcranial magnetic stimulation in the treatment of resistant auditory hallucinations in schizophrenia: a meta-analysis
    Andre Aleman
    BCN Neuroimaging Center, University Medical Center Groningen, University of Groningen, The Netherlands
    J Clin Psychiatry 68:416-21. 2007
    ..Several studies have now been reported regarding the efficacy of TMS treatment, but results were inconsistent. Therefore, meta-analytic integration of the published trials is needed to evaluate the prospects of this new treatment...