Marten P Smidt

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi Homeobox gene Pitx3 and its role in the development of dopamine neurons of the substantia nigra
    Marten P Smidt
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Cell Tissue Res 318:35-43. 2004
  2. ncbi Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3
    Marten P Smidt
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Development 131:1145-55. 2004
  3. ncbi Molecular mechanisms underlying midbrain dopamine neuron development and function
    Marten P Smidt
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Eur J Pharmacol 480:75-88. 2003
  4. doi Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons
    Frank M J Jacobs
    Rudolf Magnus Institute, Department of Neuroscience and Pharmacology, UMC Utrecht, Utrecht, The Netherlands
    Development 138:5213-22. 2011
  5. doi Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression
    Frank M J Jacobs
    Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Development 136:531-40. 2009
  6. pmc Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Development 136:2363-73. 2009
  7. ncbi Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Development 134:2673-84. 2007
  8. ncbi Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons
    Simone M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Eur J Neurosci 18:1731-8. 2003
  9. ncbi Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain
    Patrick J E C Wijchers
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Brain Res 1068:23-33. 2006
  10. ncbi Molecular and cellular alterations in the Pitx3-deficient midbrain dopaminergic system
    Simone M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Mol Cell Neurosci 30:352-63. 2005

Collaborators

Detail Information

Publications42

  1. ncbi Homeobox gene Pitx3 and its role in the development of dopamine neurons of the substantia nigra
    Marten P Smidt
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Cell Tissue Res 318:35-43. 2004
    ..Molecular analysis of the underlying mechanisms might provide new insights for understanding the selective degeneration observed in Parkinson patients...
  2. ncbi Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3
    Marten P Smidt
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Development 131:1145-55. 2004
    ..However, an overall lower activity was observed. The results suggest that Pitx3 is specifically required for the formation of the SNc subfield at the onset of dopaminergic neuron differentiation...
  3. ncbi Molecular mechanisms underlying midbrain dopamine neuron development and function
    Marten P Smidt
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Eur J Pharmacol 480:75-88. 2003
    ..Finally, we analyse the potential of the mesencephalic dopaminergic system to adapt to gene dysfunction...
  4. doi Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons
    Frank M J Jacobs
    Rudolf Magnus Institute, Department of Neuroscience and Pharmacology, UMC Utrecht, Utrecht, The Netherlands
    Development 138:5213-22. 2011
    ..In conclusion, our data reveal several RA-dependent and -independent aspects of the Pitx3-regulated gene cascade, suggesting that Pitx3 acts on multiple levels in the molecular subset-specification of mdDA neurons...
  5. doi Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression
    Frank M J Jacobs
    Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Development 136:531-40. 2009
    ....
  6. pmc Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Development 136:2363-73. 2009
    ....
  7. ncbi Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Development 134:2673-84. 2007
    ..Here, we propose a novel mechanism in which RA is involved in mdDA neuronal development and maintenance, providing new insights into subset-specific vulnerability in PD...
  8. ncbi Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons
    Simone M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Eur J Neurosci 18:1731-8. 2003
    ..5 and 14.5. Here we demonstrate that induction of VMAT2 and DAT specifically in mesDA neurons requires Nurr1 expression, whereas AADC expression in mesDA neurons is induced independently of Nurr1 function...
  9. ncbi Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain
    Patrick J E C Wijchers
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Brain Res 1068:23-33. 2006
    ..These forkhead transcription factors may play a role in maintenance and survival of developing and adult neurons...
  10. ncbi Molecular and cellular alterations in the Pitx3-deficient midbrain dopaminergic system
    Simone M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Mol Cell Neurosci 30:352-63. 2005
    ..In conclusion, ak mice display specific molecular and cellular alterations in the mDA system that provide new insights in compensatory mechanisms present in mDA-associated disorders such as PD...
  11. ncbi Phenotypic segregation of aphakia and Pitx3-null mutants reveals that Pitx3 deficiency increases consolidation of specific movement components
    Martien J H Kas
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Behav Brain Res 186:208-14. 2008
    ..Thus, Pitx3 is not involved in the expression of nighttime motor activity levels, but is critical for selective mdDA neuronal activity and associated with increased consolidation of movement...
  12. ncbi Developmental origin and fate of meso-diencephalic dopamine neurons
    Simone M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Prog Neurobiol 78:1-16. 2006
    ..The data indicate that these specific subsets may explain the specific response of these neurons to toxins and genetic ablation...
  13. pmc FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling
    Lars P van der Heide
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Biochem J 391:623-9. 2005
    ..In summary, FoxO6 is not a constitutively active transcription factor and can be regulated by growth factors in a Thr26- and Ser184-dependent manner, independent of shuttling to the cytosol...
  14. pmc Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting
    Sharon M Kolk
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    J Neurosci 29:12542-57. 2009
    ..In all, this study provides a framework for additional dissection of the molecular basis of mdDA pathway development and disease...
  15. ncbi CNS expression pattern of Lmx1b and coexpression with ptx genes suggest functional cooperativity in the development of forebrain motor control systems
    Ceriel H J Asbreuk
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Mol Cell Neurosci 21:410-20. 2002
    ..These data point to a combinatorial gene network that allows Lmx1b to diversify its regulatory actions by cooperation with specific Ptx genes...
  16. pmc LMX1B is part of a transcriptional complex with PSPC1 and PSF
    Elisa J Hoekstra
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e53122. 2013
    ..The identification of these proteins suggests that Lmx1b may act directly in the transcriptional activation of Nurr1 target genes and be involved in other processes like neurite outgrowth as well...
  17. doi Alterations in serotonin signalling are involved in the hyperactivity of Pitx3-deficient mice
    Simone M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Eur J Neurosci 27:388-95. 2008
    ..Taken together, our results indicate alterations in 5-HT signalling in Pitx3-deficient mice that underlie their spontaneous hyperactivity...
  18. ncbi Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain
    Marco F M Hoekman
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Gene Expr Patterns 6:134-40. 2006
    ..5 and E14. In summary, the presented data show FoxO factors to be expressed in the adult and developing mouse brain, in a spatially end temporally restricted manner...
  19. pmc Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development
    Koushik Chakrabarty
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    Biol Open 1:693-704. 2012
    ..Furthermore, we provide evidence of two divergent regulatory pathways resulting in the expression of Chrna6 and Chrnb3 respectively...
  20. doi Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons
    Elisa J Hoekstra
    Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Neurosci 37:23-32. 2013
    ..Taken together, microarray analysis of an LMX1A-overexpression cell system resulted in the identification of novel direct or indirect downstream targets of Lmx1a in mdDA neurons: Grb10, Rgs4 and Vmat2...
  21. ncbi Molecular programming of stem cells into mesodiencephalic dopaminergic neurons
    J Peter H Burbach
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, PO Box 85060, 3508 AB Utrecht, The Netherlands
    Trends Neurosci 29:601-3. 2006
    ..Lmx1a also initiated a developmental program that drove an mdDA phenotype in mouse embryonic stem cells. This indicates that these factors can be exploited in cell-replacement strategies for treatment of Parkinson's disease...
  22. ncbi Transcription factors in the development of midbrain dopamine neurons
    J Peter H Burbach
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann N Y Acad Sci 991:61-8. 2003
    ....
  23. ncbi Species differences in brain pre-pro-neurotensin/neuromedin N mRNA distribution: the expression pattern in mice resembles more closely that of primates than rats
    Simone M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, The Netherlands
    Brain Res Mol Brain Res 125:22-8. 2004
    ..Moreover, these data indicate that the distribution in mice resembles most that of primates than rats...
  24. pmc Phox2b influences the development of a caudal dopaminergic subset
    Elisa J Hoekstra
    Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e52118. 2012
    ..Our data suggest that Phox2b is, next to the known role in the development of the oculomotor complex, involved in the development of a specific caudal mdDA neuronal subset...
  25. ncbi Decreased thalamic expression of the homeobox gene DLX1 in psychosis
    Marjan Kromkamp
    Department of Pharmacology, Rudolf Magnus Institute for Neurosciences, University Medical Center, Utrecht, The Netherlands
    Arch Gen Psychiatry 60:869-74. 2003
    ..Homeobox genes involved in development and differentiation of the brain could play an important role in these disorders...
  26. ncbi Cloning and analysis of the murine Foxi2 transcription factor
    Patrick J E C Wijchers
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Biochim Biophys Acta 1731:133-8. 2005
    ..Since FoxI factors are thought to be implicated in the regulation of cell fate, the highly restricted expression pattern of Foxi2 suggestive of a possible role in controlling cellular identity...
  27. pmc A passport to neurotransmitter identity
    Marten P Smidt
    Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Genome Biol 10:229. 2009
    ..Comparison of a regulatory network that specifies dopaminergic neurons in Caenorhabditis elegans to the development of vertebrate dopamine systems in the mouse reveals a possible partial conservation of such a network...
  28. pmc In control of biology: of mice, men and Foxes
    Patrick J E C Wijchers
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Biochem J 397:233-46. 2006
    ..Finally, we will discuss how novel insights gained from involvement of 'Foxes' in the mechanisms underlying human pathology may create new opportunities for treatment strategies...
  29. ncbi Insulin signaling in the central nervous system: learning to survive
    Lars P van der Heide
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Prog Neurobiol 79:205-21. 2006
    ..Applying this knowledge may provide novel therapeutic approaches in the treatment of neurodegenerative diseases such as Alzheimer's disease...
  30. ncbi How to make a mesodiencephalic dopaminergic neuron
    Marten P Smidt
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3508 AB Utrecht corrected The Netherlands
    Nat Rev Neurosci 8:21-32. 2007
    ..Here, we follow the developmental path of these neurons with the goal of generating a molecular code that could be exploited in cell-replacement strategies to treat diseases such as Parkinson's disease...
  31. pmc The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation
    Lars P van der Heide
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Biochem J 380:297-309. 2004
    ..Description of the FoxO-shuttling mechanism contributes to the understanding of FoxO function in relation to signalling and gene regulation...
  32. ncbi Regulation of FoxO activity by CBP/p300-mediated acetylation
    Lars P van der Heide
    Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Trends Biochem Sci 30:81-6. 2005
    ..Therefore, acetylation shifts the function of FoxO from cell-cycle arrest and protection against oxidative stress towards cell death...
  33. ncbi FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics
    Frank M J Jacobs
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    J Biol Chem 278:35959-67. 2003
    ..In conclusion, the data presented here gives a new view on regulation of FoxO-function through multiple phosphorylation events and other mechanisms involved in the nuclear exclusion of FoxO-proteins...
  34. pmc En1 and Wnt signaling in midbrain dopaminergic neuronal development
    Maria T M Alves dos Santos
    Rudolf Magnus Institute of Neuroscience, Department of Neurosciences and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Neural Dev 6:23. 2011
    ....
  35. doi Morphine withdrawal enhances constitutive μ-opioid receptor activity in the ventral tegmental area
    Frank J Meye
    Rudolf Magnus Institute, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    J Neurosci 32:16120-8. 2012
    ....
  36. pmc Modulation of serotonin transporter function during fetal development causes dilated heart cardiomyopathy and lifelong behavioral abnormalities
    Cornelle W Noorlander
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 3:e2782. 2008
    ..The possible effects are the product of placental transfer efficiency, time of administration and dose of the respective SSRI...
  37. ncbi U-SPECT-I: a novel system for submillimeter-resolution tomography with radiolabeled molecules in mice
    Freek J Beekman
    Department of Nuclear Medicine, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Nucl Med 46:1194-200. 2005
    ..Here, we present a SPECT system (U-SPECT-I) dedicated to radionuclide imaging of murine organs at a submillimeter resolution...
  38. ncbi Modulation of cellular activity and synaptic transmission in the ventral tegmental area
    Daniel S Mathon
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Eur J Pharmacol 480:97-115. 2003
    ..Here, we will review the effects of neurotransmitter systems and drugs of abuse on cellular activity and synaptic transmission in the ventral tegmental area...
  39. ncbi Pitx3 deficiency in mice affects cholinergic modulation of GABAergic synapses in the nucleus accumbens
    Mischa De Rover
    Department of Experimental Neurophysiology, Centre for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    J Neurophysiol 96:2034-41. 2006
    ....
  40. pmc Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system
    Edgar R Kramer
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Martinsried, Germany
    PLoS Biol 5:e39. 2007
    ....
  41. ncbi The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta
    Sandrine Thuret
    Interdisciplinary Center for Neuroscience, Department of Neuroanatomy, University of Heidelberg, Heidelberg, Germany
    J Neurochem 91:1302-11. 2004
    ..Finally, an assessment of their motor function revealed no behavioral deficits. The apparent lack of any mutant phenotype suggests the presence of a strong compensatory mechanism...
  42. pmc Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice
    Paola Sgadò
    Interdisciplinary Center for Neuroscience, Department of Neuroanatomy, Ruprecht Karls Universitat Heidelberg, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 103:15242-7. 2006
    ..This genetic model may provide access to the molecular etiology for Parkinson's disease and could assist in the development of novel treatments for this neurodegenerative disorder...