Research Topics
Genomes and Genes
| Marten P SmidtSummaryAffiliation: University Medical Center Utrecht Country: The Netherlands Publications
| Collaborators
|
Detail Information
Publications
Homeobox gene Pitx3 and its role in the development of dopamine neurons of the substantia nigraMarten P Smidt
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
Cell Tissue Res 318:35-43. 2004..Molecular analysis of the underlying mechanisms might provide new insights for understanding the selective degeneration observed in Parkinson patients...- Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3Marten P Smidt
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Development 131:1145-55. 2004..However, an overall lower activity was observed. The results suggest that Pitx3 is specifically required for the formation of the SNc subfield at the onset of dopaminergic neuron differentiation... - Molecular mechanisms underlying midbrain dopamine neuron development and functionMarten P Smidt
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
Eur J Pharmacol 480:75-88. 2003..Finally, we analyse the potential of the mesencephalic dopaminergic system to adapt to gene dysfunction... 
Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neuronsFrank M J Jacobs
Rudolf Magnus Institute, Department of Neuroscience and Pharmacology, UMC Utrecht, Utrecht, The Netherlands
Development 138:5213-22. 2011..In conclusion, our data reveal several RA-dependent and -independent aspects of the Pitx3-regulated gene cascade, suggesting that Pitx3 acts on multiple levels in the molecular subset-specification of mdDA neurons...- Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repressionFrank M J Jacobs
Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
Development 136:531-40. 2009.... 
Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neuronsFrank M J Jacobs
Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
Development 136:2363-73. 2009....- Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiencyFrank M J Jacobs
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Development 134:2673-84. 2007..Here, we propose a novel mechanism in which RA is involved in mdDA neuronal development and maintenance, providing new insights into subset-specific vulnerability in PD... - Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neuronsSimone M Smits
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Eur J Neurosci 18:1731-8. 2003..5 and 14.5. Here we demonstrate that induction of VMAT2 and DAT specifically in mesDA neurons requires Nurr1 expression, whereas AADC expression in mesDA neurons is induced independently of Nurr1 function... - Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brainPatrick J E C Wijchers
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Brain Res 1068:23-33. 2006..These forkhead transcription factors may play a role in maintenance and survival of developing and adult neurons... - Molecular and cellular alterations in the Pitx3-deficient midbrain dopaminergic systemSimone M Smits
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Mol Cell Neurosci 30:352-63. 2005..In conclusion, ak mice display specific molecular and cellular alterations in the mDA system that provide new insights in compensatory mechanisms present in mDA-associated disorders such as PD... - Phenotypic segregation of aphakia and Pitx3-null mutants reveals that Pitx3 deficiency increases consolidation of specific movement componentsMartien J H Kas
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Behav Brain Res 186:208-14. 2008..Thus, Pitx3 is not involved in the expression of nighttime motor activity levels, but is critical for selective mdDA neuronal activity and associated with increased consolidation of movement... - Developmental origin and fate of meso-diencephalic dopamine neuronsSimone M Smits
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Prog Neurobiol 78:1-16. 2006..The data indicate that these specific subsets may explain the specific response of these neurons to toxins and genetic ablation... - FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttlingLars P van der Heide
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Biochem J 391:623-9. 2005..In summary, FoxO6 is not a constitutively active transcription factor and can be regulated by growth factors in a Thr26- and Ser184-dependent manner, independent of shuttling to the cytosol... - CNS expression pattern of Lmx1b and coexpression with ptx genes suggest functional cooperativity in the development of forebrain motor control systemsCeriel H J Asbreuk
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
Mol Cell Neurosci 21:410-20. 2002..These data point to a combinatorial gene network that allows Lmx1b to diversify its regulatory actions by cooperation with specific Ptx genes... - Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targetingSharon M Kolk
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
J Neurosci 29:12542-57. 2009..In all, this study provides a framework for additional dissection of the molecular basis of mdDA pathway development and disease... - Alterations in serotonin signalling are involved in the hyperactivity of Pitx3-deficient miceSimone M Smits
Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Eur J Neurosci 27:388-95. 2008..Taken together, our results indicate alterations in 5-HT signalling in Pitx3-deficient mice that underlie their spontaneous hyperactivity... - Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brainMarco F M Hoekman
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Gene Expr Patterns 6:134-40. 2006..5 and E14. In summary, the presented data show FoxO factors to be expressed in the adult and developing mouse brain, in a spatially end temporally restricted manner... - Molecular programming of stem cells into mesodiencephalic dopaminergic neuronsJ Peter H Burbach
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, PO Box 85060, 3508 AB Utrecht, The Netherlands
Trends Neurosci 29:601-3. 2006..Lmx1a also initiated a developmental program that drove an mdDA phenotype in mouse embryonic stem cells. This indicates that these factors can be exploited in cell-replacement strategies for treatment of Parkinson's disease... - Transcription factors in the development of midbrain dopamine neuronsJ Peter H Burbach
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Utrecht, The Netherlands
Ann N Y Acad Sci 991:61-8. 2003.... - Species differences in brain pre-pro-neurotensin/neuromedin N mRNA distribution: the expression pattern in mice resembles more closely that of primates than ratsSimone M Smits
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, The Netherlands
Brain Res Mol Brain Res 125:22-8. 2004..Moreover, these data indicate that the distribution in mice resembles most that of primates than rats... - A passport to neurotransmitter identityMarten P Smidt
Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Genome Biol 10:229. 2009..Comparison of a regulatory network that specifies dopaminergic neurons in Caenorhabditis elegans to the development of vertebrate dopamine systems in the mouse reveals a possible partial conservation of such a network... - Insulin signaling in the central nervous system: learning to surviveLars P van der Heide
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Prog Neurobiol 79:205-21. 2006..Applying this knowledge may provide novel therapeutic approaches in the treatment of neurodegenerative diseases such as Alzheimer's disease... - Decreased thalamic expression of the homeobox gene DLX1 in psychosisMarjan Kromkamp
Department of Pharmacology, Rudolf Magnus Institute for Neurosciences, University Medical Center, Utrecht, The Netherlands
Arch Gen Psychiatry 60:869-74. 2003..CONCLUSION: Decreased thalamic expression of DLX1 in schizophrenia and bipolar disorder with psychosis suggests shared genetic deficits in expression of this homeobox gene... - In control of biology: of mice, men and FoxesPatrick J E C Wijchers
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Biochem J 397:233-46. 2006..Finally, we will discuss how novel insights gained from involvement of 'Foxes' in the mechanisms underlying human pathology may create new opportunities for treatment strategies... - Cloning and analysis of the murine Foxi2 transcription factorPatrick J E C Wijchers
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Biochim Biophys Acta 1731:133-8. 2005..Since FoxI factors are thought to be implicated in the regulation of cell fate, the highly restricted expression pattern of Foxi2 suggestive of a possible role in controlling cellular identity... - Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neuronsElisa J Hoekstra
Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands Center for NeuroScience, Swammerdam Institute for Life Sciences, University of Amsterdam, PO Box 94232, 1090 GE, Amsterdam, The Netherlands
Eur J Neurosci 37:23-32. 2013..Taken together, microarray analysis of an LMX1A-overexpression cell system resulted in the identification of novel direct or indirect downstream targets of Lmx1a in mdDA neurons: Grb10, Rgs4 and Vmat2... - Regulation of FoxO activity by CBP/p300-mediated acetylationLars P van der Heide
Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Trends Biochem Sci 30:81-6. 2005..Therefore, acetylation shifts the function of FoxO from cell-cycle arrest and protection against oxidative stress towards cell death... - How to make a mesodiencephalic dopaminergic neuronMarten P Smidt
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3508 AB Utrecht corrected The Netherlands
Nat Rev Neurosci 8:21-32. 2007..Here, we follow the developmental path of these neurons with the goal of generating a molecular code that could be exploited in cell-replacement strategies to treat diseases such as Parkinson's disease... - The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulationLars P van der Heide
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
Biochem J 380:297-309. 2004..Description of the FoxO-shuttling mechanism contributes to the understanding of FoxO function in relation to signalling and gene regulation... - FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamicsFrank M J Jacobs
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
J Biol Chem 278:35959-67. 2003..In conclusion, the data presented here gives a new view on regulation of FoxO-function through multiple phosphorylation events and other mechanisms involved in the nuclear exclusion of FoxO-proteins... - En1 and Wnt signaling in midbrain dopaminergic neuronal developmentMaria T M Alves dos Santos
Rudolf Magnus Institute of Neuroscience, Department of Neurosciences and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Neural Dev 6:23. 2011.... - Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic developmentKoushik Chakrabarty
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
Biol Open 1:693-704. 2012..Furthermore, we provide evidence of two divergent regulatory pathways resulting in the expression of Chrna6 and Chrnb3 respectively... - Phox2b influences the development of a caudal dopaminergic subsetElisa J Hoekstra
Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands Center for NeuroScience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
PLoS ONE 7:e52118. 2012..Our data suggest that Phox2b is, next to the known role in the development of the oculomotor complex, involved in the development of a specific caudal mdDA neuronal subset... - Modulation of serotonin transporter function during fetal development causes dilated heart cardiomyopathy and lifelong behavioral abnormalitiesCornelle W Noorlander
Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
PLoS ONE 3:e2782. 2008..The possible effects are the product of placental transfer efficiency, time of administration and dose of the respective SSRI... - U-SPECT-I: a novel system for submillimeter-resolution tomography with radiolabeled molecules in miceFreek J Beekman
Department of Nuclear Medicine, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
J Nucl Med 46:1194-200. 2005..Here, we present a SPECT system (U-SPECT-I) dedicated to radionuclide imaging of murine organs at a submillimeter resolution... - Morphine Withdrawal Enhances Constitutive μ-Opioid Receptor Activity in the Ventral Tegmental AreaFrank J Meye
Rudolf Magnus Institute, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands, Master s Programme in Neuroscience and Cognition, Utrecht University, 3508 TC Utrecht, The Netherlands, and Swammerdam Institute of Life Sciences, University of Amsterdam, 1090 GE Amsterdam, The Netherlands
J Neurosci 32:16120-8. 2012.... - LMX1B Is Part of a Transcriptional Complex with PSPC1 and PSFElisa J Hoekstra
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands Molecular Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
PLoS ONE 8:e53122. 2013..The identification of these proteins suggests that Lmx1b may act directly in the transcriptional activation of Nurr1 target genes and be involved in other processes like neurite outgrowth as well... - Modulation of cellular activity and synaptic transmission in the ventral tegmental areaDaniel S Mathon
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
Eur J Pharmacol 480:97-115. 2003..Here, we will review the effects of neurotransmitter systems and drugs of abuse on cellular activity and synaptic transmission in the ventral tegmental area... - Pitx3 deficiency in mice affects cholinergic modulation of GABAergic synapses in the nucleus accumbensMischa De Rover
Department of Experimental Neurophysiology, Centre for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
J Neurophysiol 96:2034-41. 2006.... 
Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal systemEdgar R Kramer
Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Martinsried, Germany
PLoS Biol 5:e39. 2007....- The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compactaSandrine Thuret
Interdisciplinary Center for Neuroscience, Department of Neuroanatomy, University of Heidelberg, Heidelberg, Germany
J Neurochem 91:1302-11. 2004..Finally, an assessment of their motor function revealed no behavioral deficits. The apparent lack of any mutant phenotype suggests the presence of a strong compensatory mechanism... - Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant micePaola Sgadò
Interdisciplinary Center for Neuroscience, Department of Neuroanatomy, Ruprecht Karls Universitat Heidelberg, 69120 Heidelberg, Germany
Proc Natl Acad Sci U S A 103:15242-7. 2006..This genetic model may provide access to the molecular etiology for Parkinson's disease and could assist in the development of novel treatments for this neurodegenerative disorder...