Joost P G Sluijter

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. doi request reprint MicroRNA-1 and -499 regulate differentiation and proliferation in human-derived cardiomyocyte progenitor cells
    Joost P G Sluijter
    University Medical Center Utrecht, Department of Cardiology, Division of Heart and Lungs, Heidelberglaan 100, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 30:859-68. 2010
  2. pmc Concise review: heart regeneration and the role of cardiac stem cells
    Stefan Koudstaal
    Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Stem Cells Transl Med 2:434-43. 2013
  3. doi request reprint Hyperpolarization induces differentiation in human cardiomyocyte progenitor cells
    Patrick van Vliet
    Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    Stem Cell Rev 6:178-85. 2010
  4. doi request reprint Foetal and adult cardiomyocyte progenitor cells have different developmental potential
    Patrick van Vliet
    Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cell Mol Med 14:861-70. 2010
  5. doi request reprint Sequential use of human-derived medium supplements favours cardiovascular tissue engineering
    Paul W Riem Vis
    Department of Cardio Thoracic Surgery, University Medical Center, Utrecht, The Netherlands
    J Cell Mol Med 16:730-9. 2012
  6. doi request reprint Human cardiomyocyte progenitor cell-derived cardiomyocytes display a maturated electrical phenotype
    Teun P De Boer
    Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM Utrecht, The Netherlands
    J Mol Cell Cardiol 48:254-60. 2010
  7. doi request reprint Transendocardial cell injection is not superior to intracoronary infusion in a porcine model of ischaemic cardiomyopathy: a study on delivery efficiency
    Tycho I G van der Spoel
    Division Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cell Mol Med 16:2768-76. 2012
  8. ncbi request reprint TGF-beta1 induces efficient differentiation of human cardiomyocyte progenitor cells into functional cardiomyocytes in vitro
    Marie Jose Goumans
    Laboratory of Experimental Cardiology, Department of Cardiology, Division of Heart and Lung, University Medical Center, Heidelberglaan 100, Utrecht, The Netherlands
    Stem Cell Res 1:138-49. 2007
  9. doi request reprint Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia-reperfusion in vivo
    Martinus I F J Oerlemans
    Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Basic Res Cardiol 107:270. 2012
  10. doi request reprint Cardiac tissue engineering using tissue printing technology and human cardiac progenitor cells
    Roberto Gaetani
    Dept of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands
    Biomaterials 33:1782-90. 2012

Collaborators

Detail Information

Publications35

  1. doi request reprint MicroRNA-1 and -499 regulate differentiation and proliferation in human-derived cardiomyocyte progenitor cells
    Joost P G Sluijter
    University Medical Center Utrecht, Department of Cardiology, Division of Heart and Lungs, Heidelberglaan 100, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 30:859-68. 2010
    ..We hypothesize that miRNAs are also involved in proliferation/differentiation of the human CMPCs in vitro...
  2. pmc Concise review: heart regeneration and the role of cardiac stem cells
    Stefan Koudstaal
    Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Stem Cells Transl Med 2:434-43. 2013
    ..In particular, we summarize the current knowledge of CSCs as the regenerative substrate in the adult heart and their use in preclinical and clinical studies to repair the injured myocardium...
  3. doi request reprint Hyperpolarization induces differentiation in human cardiomyocyte progenitor cells
    Patrick van Vliet
    Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    Stem Cell Rev 6:178-85. 2010
    ..Thus, hyperpolarization is sufficient to induce differentiation of CMPCs, thereby revealing a novel mechanism for cardiomyogenic differentiation of heart-derived progenitor cells...
  4. doi request reprint Foetal and adult cardiomyocyte progenitor cells have different developmental potential
    Patrick van Vliet
    Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cell Mol Med 14:861-70. 2010
    ..The potential of adult CMPCs to form mature cardiomyocytes and smooth muscle cells may be essential for cardiac repair after transplantation into the injured heart...
  5. doi request reprint Sequential use of human-derived medium supplements favours cardiovascular tissue engineering
    Paul W Riem Vis
    Department of Cardio Thoracic Surgery, University Medical Center, Utrecht, The Netherlands
    J Cell Mol Med 16:730-9. 2012
    ....
  6. doi request reprint Human cardiomyocyte progenitor cell-derived cardiomyocytes display a maturated electrical phenotype
    Teun P De Boer
    Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM Utrecht, The Netherlands
    J Mol Cell Cardiol 48:254-60. 2010
    ..In the context of cardiac repair, their properties may translate into a reduced pro-arrhythmic risk and enhanced electrical integration upon transplantation...
  7. doi request reprint Transendocardial cell injection is not superior to intracoronary infusion in a porcine model of ischaemic cardiomyopathy: a study on delivery efficiency
    Tycho I G van der Spoel
    Division Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cell Mol Med 16:2768-76. 2012
    ..In addition, no differences in safety profile were observed. These results are important in view of the choice of percutaneous cell delivery modality in future clinical stem cell trials...
  8. ncbi request reprint TGF-beta1 induces efficient differentiation of human cardiomyocyte progenitor cells into functional cardiomyocytes in vitro
    Marie Jose Goumans
    Laboratory of Experimental Cardiology, Department of Cardiology, Division of Heart and Lung, University Medical Center, Heidelberglaan 100, Utrecht, The Netherlands
    Stem Cell Res 1:138-49. 2007
    ..Their scalability and homogeneity are unique and provide an excellent basis for developing physiological, pharmacological, and toxicological assays on human heart cells in vitro...
  9. doi request reprint Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia-reperfusion in vivo
    Martinus I F J Oerlemans
    Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Basic Res Cardiol 107:270. 2012
    ..The cardioprotective effect of Nec-1 highlights the importance of necrotic cell death in the ischemic heart, thereby opening a new direction for therapy in patients with myocardial infarction...
  10. doi request reprint Cardiac tissue engineering using tissue printing technology and human cardiac progenitor cells
    Roberto Gaetani
    Dept of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands
    Biomaterials 33:1782-90. 2012
    ..This indicated that printing can be used for defined cell delivery, while retaining functional properties...
  11. pmc Active Wnt signaling in response to cardiac injury
    Martinus I F J Oerlemans
    Department of Cardiology, University Medical Centre Utrecht, The Netherlands
    Basic Res Cardiol 105:631-41. 2010
    ..Given its broad role during the healing phase after cardiac injury, additional research seems warranted before a therapeutic approach on Wnt to enhance cardiac regeneration can be carried out safely...
  12. doi request reprint Human relevance of pre-clinical studies in stem cell therapy: systematic review and meta-analysis of large animal models of ischaemic heart disease
    Tycho I G van der Spoel
    Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Rm E03 511, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Cardiovasc Res 91:649-58. 2011
    ..Meta-analysis of available pre-clinical data of ischaemic heart disease could provide important clues to design human clinical trials...
  13. doi request reprint Environmental regulation of valvulogenesis: implications for tissue engineering
    Paul W Riem Vis
    University Medical Center Utrecht, Department of Cardio Thoracic Surgery, E 03 511, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    Eur J Cardiothorac Surg 39:8-17. 2011
    ..The combined efforts from clinicians, cell biologists and engineers are required to implement and evaluate these approaches to achieve optimised protocols for heart-valve tissue engineering...
  14. pmc Early assessment of acute coronary syndromes in the emergency department: the potential diagnostic value of circulating microRNAs
    Martinus I F J Oerlemans
    Department of Cardiology, University Medical Center Utrecht, The Netherlands
    EMBO Mol Med 4:1176-85. 2012
    ..94 than hs-troponin T (0.89). Circulating microRNAs hold great potential as novel early biomarkers for the management of suspected ACS patients...
  15. doi request reprint Human cardiomyocyte progenitor cells: a short history of nearly everything
    Patrick van Vliet
    Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cell Mol Med 16:1669-73. 2012
    ..Here, we aim to provide a comprehensive summary of the past findings and present challenges for future therapeutic potential of CMPCs...
  16. doi request reprint Increased expression of the transforming growth factor-beta signaling pathway, endoglin, and early growth response-1 in stable plaques
    Pieter T G Bot
    Department of Cardiology, AMC Amsterdam, The Netherlands
    Stroke 40:439-47. 2009
    ..In atherosclerotic lesions, it is mainly expressed by SMCs. Therefore, we studied the TGFbeta, endoglin, and EGR-1 pathway in advanced atherosclerotic plaques in relation to plaque phenotype...
  17. doi request reprint Stem cells from in- or outside of the heart: isolation, characterization, and potential for myocardial tissue regeneration
    Willy A Noort
    Division of Heart and Lungs, Department of Cardiology, Laboratory of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaan 100, Mailboxnr G 02 523, 3584 CX Utrecht, The Netherlands
    Pediatr Cardiol 30:699-709. 2009
    ..For future research, it will be a challenge to isolate the most potent therapeutic cell with an intrinsic capacity to stimulate regeneration in the heart, by direct participation or by producing paracrine factors...
  18. ncbi request reprint Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction
    Leo Timmers
    Department of Cardiology, University Medical Center, Utrecht, The Netherlands
    Circ Res 102:257-64. 2008
    ..TLR4 may therefore constitute a novel target in the treatment of ischemic heart failure...
  19. doi request reprint Impaired recruitment of HHT-1 mononuclear cells to the ischaemic heart is due to an altered CXCR4/CD26 balance
    Simone Post
    Department of Cardiology, Division Heart and Lung, UMCU, Utrecht, The Netherlands
    Cardiovasc Res 85:494-502. 2010
    ..Stromal cell-derived factor-1alpha (SDF-1alpha) and the chemokine receptor CXCR4 are crucial for homing and negatively influenced by CD26. The aim of this study was to gain insight into the impaired homing of HHT1-MNCs...
  20. doi request reprint Advanced measurement techniques of regional myocardial function to assess the effects of cardiac regenerative therapy in different models of ischaemic cardiomyopathy
    Frebus J van Slochteren
    Department of Cardiology, University Medical Centre Utrecht, F02 324, PO Box 85500, GA 3508 Utrecht, The Netherlands
    Eur Heart J Cardiovasc Imaging 13:808-18. 2012
    ..This approach provides information about local tissue contractility, stiffness, and thereby remodelling. We recommend that researchers use this comprehensive approach in future studies...
  21. doi request reprint MicroRNA-214 inhibits angiogenesis by targeting Quaking and reducing angiogenic growth factor release
    Alain van Mil
    Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, Room G02 523, 3584 CX Utrecht, The Netherlands
    Cardiovasc Res 93:655-65. 2012
    ..Previously, we have observed that miR-214 is differentially expressed in compensatory arteriogenesis. Here, we investigated the potential role of miR-214 in the process of angiogenesis...
  22. ncbi request reprint Isolation and expansion of resident cardiac progenitor cells
    Patrick van Vliet
    The Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands
    Expert Rev Cardiovasc Ther 5:33-43. 2007
    ....
  23. pmc Non-surgical stem cell delivery strategies and in vivo cell tracking to injured myocardium
    Tycho I G van der Spoel
    Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Rm E03 511, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Int J Cardiovasc Imaging 27:367-83. 2011
    ..This review will provide a comprehensive overview on the various cell tracking and non-surgical cell delivery techniques, which are highly important in view of experimental and clinical studies...
  24. doi request reprint Layer-specific radiofrequency ultrasound-based strain analysis in a porcine model of ischemic cardiomyopathy validated by a geometric model
    Frebus J van Slochteren
    Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands Electronic address
    Ultrasound Med Biol 40:378-88. 2014
    ..Although the relationship between tissue stiffness and tissue strain is not strictly local, this novel technique provides a valuable way to assess layer-specific regional cardiac function in a variety of myocardial diseases. ..
  25. doi request reprint Post-transcriptional regulation of α-1-antichymotrypsin by microRNA-137 in chronic heart failure and mechanical support
    Sjoukje I Lok
    Department of Cardiology, University Medical Center, Utrecht, The Netherlands
    Circ Heart Fail 6:853-61. 2013
    ..In the present study, proteomics identified significant changes in α-1-antichymotrypsin (ACT) levels during LVAD support. Moreover, the potential role of ACT in reverse remodeling was studied in detail...
  26. doi request reprint Increasing short-term cardiomyocyte progenitor cell (CMPC) survival by necrostatin-1 did not further preserve cardiac function
    Dries Feyen
    Division Heart and Lungs, Department of Cardiology, Experimental Cardiology Laboratory, University Medical Center Utrecht, Heidelberglaan 100, Room G02 523, Utrecht 3584 CX, The Netherlands
    Cardiovasc Res 99:83-91. 2013
    ..In the present study, we investigated the utilization of necrostatin-1 (Nec-1) as a possible attenuator of cell death in cardiomyocyte progenitor cells (CMPCs)...
  27. doi request reprint MiR-155 inhibits cell migration of human cardiomyocyte progenitor cells (hCMPCs) via targeting of MMP-16
    Jia Liu
    Department of Endocrinology, Provincial Hospital affiliated to Shandong University, Jinan, China
    J Cell Mol Med 16:2379-86. 2012
    ..By directly targeting MMP-16, miR-155 efficiently inhibits cell migration via a reduction in MMP-2 and -9 activities. Our study shows that miR-155 might be used to improve local retention of hCMPCs after intramyocardial delivery...
  28. doi request reprint Platelet-lysate as an autologous alternative for fetal bovine serum in cardiovascular tissue engineering
    Paul W Riem Vis
    Department of Cardio Thoracic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Tissue Eng Part A 16:1317-27. 2010
    ..This could lead to production of strong tissue with properly organized collagen fibers, which is important for heart valve tissue engineering...
  29. ncbi request reprint The potential of modulating small RNA activity in vivo
    Alain van Mil
    University Medical Center Utrecht, Department of Cardiology, DH and L, Heidelberglaan 100, Room G02 523, 3584 CX Utrecht, The Nederlands
    Mini Rev Med Chem 9:235-48. 2009
    ..A variety of small RNA formulations and modifications will be reviewed for their improvement on stability and half-life, their safety and off-target effects, and their efficiency and specificity of gene silencing...
  30. doi request reprint Cardiospheres and tissue engineering for myocardial regeneration: potential for clinical application
    Roberto Gaetani
    Department of Experimental Medicine, Cenci Bolognetti Foundation, Pasteur Institute, University of Rome Sapienza, Rome, Italy
    J Cell Mol Med 14:1071-7. 2010
    ..This review will focus on the applications and advantages that CTE application could offer compared to conventional cell therapy...
  31. doi request reprint Targeting cell death in the reperfused heart: pharmacological approaches for cardioprotection
    Martinus I F J Oerlemans
    Department of Cardiology, University Medical Center Utrecht, The Netherlands
    Int J Cardiol 165:410-22. 2013
    ....
  32. doi request reprint Balance between angiopoietin-1 and angiopoietin-2 is in favor of angiopoietin-2 in atherosclerotic plaques with high microvessel density
    Simone Post
    University Medical Center, Utrecht, The Netherlands
    J Vasc Res 45:244-50. 2008
    ..Ang-1 induces formation of stable vessels, whereas Ang-2 destabilizes the interaction between endothelial cells and their support cells. We studied the expression patterns of Ang-1 and -2 in relation to plaque microvessels...
  33. ncbi request reprint Cyclooxygenase-2 inhibition increases mortality, enhances left ventricular remodeling, and impairs systolic function after myocardial infarction in the pig
    Leo Timmers
    Department of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Circulation 115:326-32. 2007
    ..In murine models of MI, COX-2 inhibition preserves left ventricular dimensions and function. We studied the effect of selective COX-2 inhibition on left ventricular remodeling and function after MI in a pig model...
  34. ncbi request reprint Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions: a study in human endarterectomy specimen pointing to a role for different extracellular matrix metalloproteinase in
    Joost P G Sluijter
    Experimental Cardiology Laboratory, University Medical Center, Utrecht, The Netherlands
    Stroke 37:235-9. 2006
    ..We studied matrix metalloproteinases (MMP) 2, 8, and 9 and extracellular matrix metalloproteinase inducer (EMMPRIN) levels in relation to carotid atherosclerotic plaque characteristics...
  35. ncbi request reprint Involvement of furin-like proprotein convertases in the arterial response to injury
    Joost P G Sluijter
    Experimental Cardiology Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands
    Cardiovasc Res 68:136-43. 2005
    ..We also investigated the effect of an inhibitor of furin-like PCs, alpha1-antitrypsin Portland (alpha1-PDX), on arterial injury following balloon dilation...