R E G Schutgens

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. doi request reprint Anticoagulation therapy in haemophilia. Managing the unknown
    R E G Schutgens
    Roger EG Schutgens, MD, PhD, University Medical Center Utrecht, Van Creveldkliniek Department of Haematology, Room C01 425, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands, Tel 31 88 755 55 55, Fax 31 88 755 54 38, E mail
    Hamostaseologie 33:299-304. 2013
  2. ncbi request reprint The role of fibrin monomers in optimizing the diagnostic work-up of deep vein thrombosis
    Roger E G Schutgens
    Department of Haematology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Thromb Haemost 97:807-13. 2007
  3. doi request reprint Treatment of ischaemic heart disease in haemophilia patients: an institutional guideline
    R E G Schutgens
    Van Creveldkliniek Department of Haematology, University Medical Center Utrecht, Heidelberglaan 100, PO Box 85500, Utrecht 3508 GA, The Netherlands
    Haemophilia 15:952-8. 2009
  4. ncbi request reprint Rituximab-induced serum sickness
    Roger E G Schutgens
    Department of Haematology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Br J Haematol 135:147. 2006
  5. doi request reprint Quality of life in patients with no-option critical limb ischemia underlines the need for new effective treatment
    Ralf W Sprengers
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    J Vasc Surg 52:843-9, 849.e1. 2010
  6. doi request reprint Risk of inhibitor development in mild haemophilia A increases with age
    E P Mauser-Bunschoten
    Van Creveldkliniek, Department of Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Haemophilia 18:263-7. 2012
  7. doi request reprint Identification and expression of iron regulators in human synovium: evidence for upregulation in haemophilic arthropathy compared to rheumatoid arthritis, osteoarthritis, and healthy controls
    L Nieuwenhuizen
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Haemophilia 19:e218-27. 2013
  8. doi request reprint Clinical severity of haemophilia A: does the classification of the 1950s still stand?
    I E M den Uijl
    Van Creveldkliniek, Department of Haematology, UMC Utrecht, The Netherlands
    Haemophilia 17:849-53. 2011
  9. doi request reprint Cardiac catheterization and intervention in haemophilia patients: prospective evaluation of the 2009 institutional guideline
    A Tuinenburg
    Van Creveldkliniek Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Haemophilia 19:370-7. 2013
  10. doi request reprint Unfavourable cardiovascular disease risk profiles in a cohort of Dutch and British haemophilia patients
    Dietje E Fransen van de Putte
    Van Creveldkliniek, Department of Haematology, Postzone C01 425, University Medical Center Utrecht, POBox 85500, 3508 GA Utrecht, The Netherlands
    Thromb Haemost 109:16-23. 2013

Detail Information

Publications22

  1. doi request reprint Anticoagulation therapy in haemophilia. Managing the unknown
    R E G Schutgens
    Roger EG Schutgens, MD, PhD, University Medical Center Utrecht, Van Creveldkliniek Department of Haematology, Room C01 425, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands, Tel 31 88 755 55 55, Fax 31 88 755 54 38, E mail
    Hamostaseologie 33:299-304. 2013
    ..There is an absolute need for risk assessment tools and prospective validation of suggested anticoagulation management strategies in PWH. Until then, we are managing the unknown. ..
  2. ncbi request reprint The role of fibrin monomers in optimizing the diagnostic work-up of deep vein thrombosis
    Roger E G Schutgens
    Department of Haematology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Thromb Haemost 97:807-13. 2007
    ..In patients with abnormal D-dimer concentrations and a normal US, a normal FM test might be able to replace the second US...
  3. doi request reprint Treatment of ischaemic heart disease in haemophilia patients: an institutional guideline
    R E G Schutgens
    Van Creveldkliniek Department of Haematology, University Medical Center Utrecht, Heidelberglaan 100, PO Box 85500, Utrecht 3508 GA, The Netherlands
    Haemophilia 15:952-8. 2009
    ..As evidence-based guidelines are lacking, we developed a protocol on how we will treat haemophilia patients with ischaemic heart disease...
  4. ncbi request reprint Rituximab-induced serum sickness
    Roger E G Schutgens
    Department of Haematology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Br J Haematol 135:147. 2006
  5. doi request reprint Quality of life in patients with no-option critical limb ischemia underlines the need for new effective treatment
    Ralf W Sprengers
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    J Vasc Surg 52:843-9, 849.e1. 2010
    ..QoL serves as an important secondary endpoint in many of these trials, but solid reference QoL data for patients with no-option CLI are lacking...
  6. doi request reprint Risk of inhibitor development in mild haemophilia A increases with age
    E P Mauser-Bunschoten
    Van Creveldkliniek, Department of Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Haemophilia 18:263-7. 2012
    ..Especially patients with a change of arginine in cysteine at 593 are at risk for inhibitor development...
  7. doi request reprint Identification and expression of iron regulators in human synovium: evidence for upregulation in haemophilic arthropathy compared to rheumatoid arthritis, osteoarthritis, and healthy controls
    L Nieuwenhuizen
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Haemophilia 19:e218-27. 2013
    ....
  8. doi request reprint Clinical severity of haemophilia A: does the classification of the 1950s still stand?
    I E M den Uijl
    Van Creveldkliniek, Department of Haematology, UMC Utrecht, The Netherlands
    Haemophilia 17:849-53. 2011
    ..This study confirms the clinical distinction between severe and non-severe haemophilia A. However, the group of moderate haemophilia patients showed a wide variability, warranting close follow-up and individualized treatment...
  9. doi request reprint Cardiac catheterization and intervention in haemophilia patients: prospective evaluation of the 2009 institutional guideline
    A Tuinenburg
    Van Creveldkliniek Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Haemophilia 19:370-7. 2013
    ..Furthermore, based on the case series and developments in new guidelines for non-haemophilic patients with IHD, some adjustments on the 2009 guideline are proposed...
  10. doi request reprint Unfavourable cardiovascular disease risk profiles in a cohort of Dutch and British haemophilia patients
    Dietje E Fransen van de Putte
    Van Creveldkliniek, Department of Haematology, Postzone C01 425, University Medical Center Utrecht, POBox 85500, 3508 GA Utrecht, The Netherlands
    Thromb Haemost 109:16-23. 2013
    ..Our results indicate an increased prevalence of hypertension and overall more unfavourable CVD risk profiles in haemophilia patients compared with the general age-matched male population...
  11. doi request reprint Cardiovascular disease in patients with hemophilia
    A Tuinenburg
    Van Creveldkliniek Department of Haematology, University Medical Center Utrecht, The Netherlands
    J Thromb Haemost 7:247-54. 2009
    ..This review focuses on what is currently known about cardiovascular risk factors, atherosclerosis, arterial thrombosis and ischemic cardiovascular disease in hemophilia patients...
  12. ncbi request reprint Increased prevalence of hypertension in haemophilia patients
    Dietje E Fransen van de Putte
    Van Creveldkliniek, Department of Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Thromb Haemost 108:750-5. 2012
    ..The cause of this increased prevalence is unknown. Blood pressure measurements should be part of standard care in haemophilia patients aged 30 years or older...
  13. doi request reprint Stimulation of naïve monocytes and PBMCs with coagulation proteases results in thrombin-mediated and PAR-1-dependent cytokine release and cell proliferation in PBMCs only
    L Nieuwenhuizen
    Rheumatology and Clinical Immunology, University Medical Center, Utrecht, The Netherlands
    Scand J Immunol 77:339-49. 2013
    ..These data demonstrate that naïve monocytes are not triggered by coagulation proteases, whereas thrombin is able to elicit pro-inflammatory events in a PAR-1-dependent manner in PBMCs...
  14. doi request reprint Von Willebrand factor deficiency and atherosclerosis
    K P M van Galen
    Department of Haematology Van Creveldkliniek, University Medical Center Utrecht, The Netherlands
    Blood Rev 26:189-96. 2012
    ..In conclusion, VWF is probably a significant player in the multifaceted interaction between the haemostatic system and the atherosclerotic process which deserves further study...
  15. doi request reprint Factor VIII concentrate infusion in patients with haemophilia results in decreased von Willebrand factor and ADAMTS-13 activity
    E R van Bladel
    Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, the Netherlands Van Creveld Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands
    Haemophilia 20:92-8. 2014
    ..When treating severe haemophilia A patients with coagulation concentrate infusion, one should realize this does not merely correct FVIII levels but also may influence primary haemostasis. ..
  16. doi request reprint No firm association between N-terminal pro-brain natriuretic peptide and percentage of pulmonary vascular obstruction in patients with acute pulmonary embolism
    M J Agterof
    Department of Internal Medicine, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Thromb Res 127:547-50. 2011
    ..We postulated that NT-proBNP is associated with the amount of perfusion defects, expressed as the PVO, on perfusion scintigraphy...
  17. doi request reprint Rationale and design of the JUVENTAS trial for repeated intra-arterial infusion of autologous bone marrow-derived mononuclear cells in patients with critical limb ischemia
    Ralf W Sprengers
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    J Vasc Surg 51:1564-8. 2010
    ..Primary outcome is the incidence of major amputation at 6 months. Inclusion of patients is well underway. If BM-MNC cells therapy is beneficial, it could become a novel treatment to prevent amputation in patients with CLI...
  18. doi request reprint Co-morbidity in the ageing haemophilia patient: the down side of increased life expectancy
    E P Mauser-Bunschoten
    Department of Haematology, University Medical Center Utrecht, Postbox 85500, Utrecht 3508 GA, The Netherlands
    Haemophilia 15:853-63. 2009
    ..It can also result in complex treatment regimens, in which coordination between health care workers is essential...
  19. ncbi request reprint Reduced efficacy of clinical probability score and D-dimer assay in elderly subjects suspected of having deep vein thrombosis
    Roger E G Schutgens
    Haematology, University Hospital Utrecht, Utrecht, The Netherlands
    Br J Haematol 129:653-7. 2005
    ..8 years) versus 25% in younger patients (P = 0.00005). We therefore conclude that the combined strategy of a low/moderate PCP score with a normal D-dimer test is safe for excluding DVT in all age groups, but is less useful in the elderly...
  20. ncbi request reprint The predictive value of D-dimer measurement for cancer in patients with deep vein thrombosis
    Roger E G Schutgens
    Department of Hematology, University Hospital Utrecht, The Netherlands
    Haematologica 90:214-9. 2005
    ..The aim of this study was to evaluate the value of D-dimer concentration in predicting cancer in patients with DVT...
  21. ncbi request reprint Usefulness of a semiquantitative D-dimer test for the exclusion of deep venous thrombosis in outpatients
    Roger E G Schutgens
    Department of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
    Am J Med 112:617-21. 2002
    ..We studied several clinical and laboratory variables that might limit the accuracy of a semiquantitative D-dimer test...
  22. ncbi request reprint No influence of heparin plasma and other (pre)analytic variables on D-dimer determinations
    Roger E G Schutgens
    Department of Internal Medicine, St Antonius Hospital Koekoekslaan 1, PO Box 2500, 3430 EM Nieuwegein, The Netherlands
    Clin Chem 48:1611-3. 2002