Daniel B F Saris

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. doi request reprint Matrix-Applied Characterized Autologous Cultured Chondrocytes Versus Microfracture: Two-Year Follow-up of a Prospective Randomized Trial
    Daniël Saris
    University Medical Center Utrecht, Utrecht, the Netherlands Reconstructive Medicine, Tissue Regeneration, MIRA Institute, University of Twente, Enschede, The Netherlands
    Am J Sports Med 42:1384-94. 2014
  2. doi request reprint Treatment of symptomatic cartilage defects of the knee: characterized chondrocyte implantation results in better clinical outcome at 36 months in a randomized trial compared to microfracture
    Daniel B F Saris
    Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Sports Med 37:10S-19S. 2009
  3. doi request reprint Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture
    Daniel B F Saris
    Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Sports Med 36:235-46. 2008
  4. pmc Concise review: unraveling stem cell cocultures in regenerative medicine: which cell interactions steer cartilage regeneration and how?
    Tommy S de Windt
    Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands CellCoTec, Bilthoven, The Netherlands Laboratory of Musculoskeletal Tissue Engineering, Department of Orthopaedic Surgery, and Division of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands MIRA Institute for Biotechnology and Technical Medicine, University Twente, Enschede, The Netherlands
    Stem Cells Transl Med 3:723-33. 2014
  5. doi request reprint Single-stage cell-based cartilage regeneration using a combination of chondrons and mesenchymal stromal cells: comparison with microfracture
    Joris E J Bekkers
    Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Sports Med 41:2158-66. 2013
  6. doi request reprint Direct Cell-Cell Contact with Chondrocytes Is a Key Mechanism in Multipotent Mesenchymal Stromal Cell-Mediated Chondrogenesis
    Tommy S de Windt
    1 Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands
    Tissue Eng Part A 21:2536-47. 2015
  7. pmc Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection
    Marijn Rutgers
    Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arthritis Res Ther 12:R114. 2010
  8. doi request reprint Articular cartilage evaluation after TruFit plug implantation analyzed by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC)
    Joris E J Bekkers
    Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Sports Med 41:1290-5. 2013
  9. doi request reprint Cartilage damage caused by metal implants applied for the treatment of established localized cartilage defects in a rabbit model
    Roel J H Custers
    Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands
    J Orthop Res 27:84-90. 2009
  10. doi request reprint Joint injury and osteoarthritis: soluble mediators in the course and treatment of cartilage pathology
    Marijn Rutgers
    University Medical Center Utrecht, Department of Orthopaedics, Heidelberglaan 100, Utrecht, The Netherlands
    Immunotherapy 1:435-45. 2009

Collaborators

Detail Information

Publications28

  1. doi request reprint Matrix-Applied Characterized Autologous Cultured Chondrocytes Versus Microfracture: Two-Year Follow-up of a Prospective Randomized Trial
    Daniël Saris
    University Medical Center Utrecht, Utrecht, the Netherlands Reconstructive Medicine, Tissue Regeneration, MIRA Institute, University of Twente, Enschede, The Netherlands
    Am J Sports Med 42:1384-94. 2014
    ..Randomized controlled trials studying the efficacy and safety of matrix-applied characterized autologous cultured chondrocytes (MACI) versus microfracture (MFX) for treating cartilage defects are limited...
  2. doi request reprint Treatment of symptomatic cartilage defects of the knee: characterized chondrocyte implantation results in better clinical outcome at 36 months in a randomized trial compared to microfracture
    Daniel B F Saris
    Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Sports Med 37:10S-19S. 2009
    ....
  3. doi request reprint Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture
    Daniel B F Saris
    Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Sports Med 36:235-46. 2008
    ..Characterized chondrocyte implantation uses an autologous cartilage cell therapy product that has been optimized for its biological potency to form stable cartilage tissue in vivo...
  4. pmc Concise review: unraveling stem cell cocultures in regenerative medicine: which cell interactions steer cartilage regeneration and how?
    Tommy S de Windt
    Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands CellCoTec, Bilthoven, The Netherlands Laboratory of Musculoskeletal Tissue Engineering, Department of Orthopaedic Surgery, and Division of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands MIRA Institute for Biotechnology and Technical Medicine, University Twente, Enschede, The Netherlands
    Stem Cells Transl Med 3:723-33. 2014
    ..It could serve as a basis for research groups and clinicians aiming at designing and implementing combined cellular technologies for single-stage cartilage repair and treatment or prevention of OA. ..
  5. doi request reprint Single-stage cell-based cartilage regeneration using a combination of chondrons and mesenchymal stromal cells: comparison with microfracture
    Joris E J Bekkers
    Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Sports Med 41:2158-66. 2013
    ..Chondrons have been shown to have higher regenerative capacities than chondrocytes without such a pericellular matrix...
  6. doi request reprint Direct Cell-Cell Contact with Chondrocytes Is a Key Mechanism in Multipotent Mesenchymal Stromal Cell-Mediated Chondrogenesis
    Tommy S de Windt
    1 Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands
    Tissue Eng Part A 21:2536-47. 2015
    ....
  7. pmc Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection
    Marijn Rutgers
    Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arthritis Res Ther 12:R114. 2010
    ..The current study aims to evaluate the in vitro effects of ACS on cartilage proteoglycan (PG) metabolism, its composition and the effects on synovial fluid (SF) cytokine levels following intraarticular ACS administration...
  8. doi request reprint Articular cartilage evaluation after TruFit plug implantation analyzed by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC)
    Joris E J Bekkers
    Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Sports Med 41:1290-5. 2013
    ..Quantitative MRI of articular cartilage has rapidly developed in recent years and provides the clinician with a noninvasive tool to determine the biological consequence of an intervention...
  9. doi request reprint Cartilage damage caused by metal implants applied for the treatment of established localized cartilage defects in a rabbit model
    Roel J H Custers
    Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands
    J Orthop Res 27:84-90. 2009
    ....
  10. doi request reprint Joint injury and osteoarthritis: soluble mediators in the course and treatment of cartilage pathology
    Marijn Rutgers
    University Medical Center Utrecht, Department of Orthopaedics, Heidelberglaan 100, Utrecht, The Netherlands
    Immunotherapy 1:435-45. 2009
    ....
  11. doi request reprint Chondrogenic potential of articular chondrocytes depends on their original location
    Joris E J Bekkers
    1 Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands
    Tissue Eng Part A 20:663-71. 2014
    ....
  12. pmc Strategies for patient profiling in articular cartilage repair of the knee: a prospective cohort of patients treated by one experienced cartilage surgeon
    Tommy S de Windt
    Department of Orthopaedics, University Medical Centre Utrecht, Utrecht, The Netherlands
    Knee Surg Sports Traumatol Arthrosc 20:2225-32. 2012
    ....
  13. doi request reprint Extracellular matrix scaffolds for cartilage and bone regeneration
    Kim E M Benders
    Department of Orthopedics, University Medical Center Utrecht, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    Trends Biotechnol 31:169-76. 2013
    ..This review describes the rationale for using ECM-based approaches for different regenerative purposes and details the application of ECM for cartilage or osteochondral repair...
  14. ncbi request reprint [Treatment of cartilaginous defects in the knee: recommendations from the Dutch Orthopaedic Association]
    Marleen H van der Linden
    UMC Utrecht, afd Orthopedie, Utrecht, The Netherlands
    Ned Tijdschr Geneeskd 157:A5719. 2013
    ..New second- and third-generation autologous chondrocyte implantation techniques seem to yield more sustainable tissue repair and better clinical long-term results for lesions larger than 4 cm2 in comparison to microfracture treatment...
  15. doi request reprint Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: establishment and characterization of a long-term cartilage-synovium coculture
    Michiel Beekhuizen
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 63:1918-27. 2011
    ..The aim of this study was to develop an in vitro model that includes both the synovium and cartilage of patients with knee OA...
  16. pmc Osteoarthritis treatment using autologous conditioned serum after placebo
    Marijn Rutgers
    University Medical Center Utrecht, Department of Orthopaedics, Utrecht
    Acta Orthop 86:114-8. 2015
    ..We hypothesized that when given the opportunity, placebo-treated patients from that RCT would now opt for ACS treatment, which would result in a greater clinical improvement than placebo...
  17. doi request reprint Functional articular cartilage repair: here, near, or is the best approach not yet clear?
    Simon C Mastbergen
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Nat Rev Rheumatol 9:277-90. 2013
    ..Only with such rational and integrated assessment of outcomes will the promising results of these approaches be consolidated in clinical practice...
  18. doi request reprint Is magnetic resonance imaging reliable in predicting clinical outcome after articular cartilage repair of the knee? A systematic review and meta-analysis
    Tommy S de Windt
    Department of Orthopaedics, University Medical Center Utrecht, POB 85500, 3508 GA, Utrecht, The Netherlands
    Am J Sports Med 41:1695-702. 2013
    ..While MRI can provide a detailed morphological evaluation after articular cartilage repair, its additional value in determining clinical outcome has yet to be determined...
  19. doi request reprint Replacement of the medial tibial plateau by a metallic implant in a goat model
    Roel J H Custers
    Department of Orthopaedics, University Medical Center Utrecht, P O Box 85500 3508 GA Utrecht, The Netherlands
    J Orthop Res 28:429-35. 2010
    ....
  20. ncbi request reprint Intersurgeon variance in computer-assisted planning of anterior cruciate ligament reconstruction
    Niels W L Schep
    Department of Surgery, University Medical Center, Utrecht, The Netherlands
    Arthroscopy 21:942-7. 2005
    ....
  21. ncbi request reprint Suture anchors are superior to transglenoid sutures in arthroscopic shoulder stabilization
    Dirk P H van Oostveen
    Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands
    Arthroscopy 22:1290-7. 2006
    ..We retrospectively compared 2 groups of high-demand patients with post-traumatic anterior shoulder instability to determine whether arthroscopic stabilization was superior with transglenoid suture or suture anchors...
  22. doi request reprint Treatment selection in articular cartilage lesions of the knee: a systematic review
    Joris E J Bekkers
    Department of Orthopaedics, University Medical Centre, Utrecht, The Netherlands
    Am J Sports Med 37:148S-55S. 2009
    ..Several treatment options are available to repair articular cartilage lesions of the knee; however, evidence-based parameters for treatment selection are lacking...
  23. doi request reprint Autologous, allogeneic, induced pluripotent stem cell or a combination stem cell therapy? Where are we headed in cartilage repair and why: a concise review
    Lucienne A Vonk
    Department of Orthopaedics, University Medical Center Utrecht, HP G05 228, PO Box 85090, 3508 GA, Utrecht, The Netherlands
    Stem Cell Res Ther 6:94. 2015
    ..In this review, we discuss the different aspects of new stem cell-based treatments, including safety and ethical issues, as well as provide an overview of current clinical trials exploring these approaches and future perspectives. ..
  24. doi request reprint In vivo matrix production by bone marrow stromal cells seeded on PLGA scaffolds for ligament tissue engineering
    Floor van Eijk
    Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands
    Tissue Eng Part A 15:3109-17. 2009
    ..Moreover, using a goat-specific anti-collagen type III, donor-derived matrix could be demonstrated. We conclude that bone marrow stromal cells survived in vivo and at least partially differentiated after implantation...
  25. doi request reprint Patient profiling in cartilage regeneration: prognostic factors determining success of treatment for cartilage defects
    Tommy S de Windt
    Orthopaedic Surgeon, Department of Orthopaedics, University Medical Centre, Utrecht, The Netherlands
    Am J Sports Med 37:58S-62S. 2009
    ..What is still lacking, however, is analysis of patient characteristics to help improve outcome or select patients for specific treatment...
  26. doi request reprint Reconstruction of the medial patellofemoral ligament for treatment of patellofemoral instability: a systematic review
    Constantinus F M Buckens
    Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Sports Med 38:181-8. 2010
    ....
  27. doi request reprint A small molecule approach to engineering vascularized tissue
    Joyce Doorn
    MIRA Institute for Biomedical Technology and Technical Medicine, Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands
    Biomaterials 34:3053-63. 2013
    ..We showed that phenanthroline alone was sufficient to induce blood vessel formation in a Matrigel plug assay in vivo paving the way to its application in ischeamic-related diseases...
  28. doi request reprint The effect of timing of mechanical stimulation on proliferation and differentiation of goat bone marrow stem cells cultured on braided PLGA scaffolds
    Floor van Eijk
    Department of Orthopedics University Medical Center Utrecht, Utrecht, The Netherlands
    Tissue Eng Part A 14:1425-33. 2008
    ..Future research should be aimed at elucidating the biomechanical and biochemical characteristics of tissue formed by BMSCs on PLGA under mechanical stimulation...