J Roose

Summary

Affiliation: University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint The Sox-13 gene: structure, promoter characterization, and chromosomal localization
    J Roose
    Department of Immunology, University Hospital Utrecht, Utrecht, 3508 GA, The Netherlands
    Genomics 57:301-5. 1999
  2. pmc High expression of the HMG box factor sox-13 in arterial walls during embryonic development
    J Roose
    Department of Immunology, University Hospital, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Nucleic Acids Res 26:469-76. 1998
  3. pmc All Tcf HMG box transcription factors interact with Groucho-related co-repressors
    H Brantjes
    Department of Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Nucleic Acids Res 29:1410-9. 2001
  4. ncbi request reprint TCF transcription factors: molecular switches in carcinogenesis
    J Roose
    Department of Immunology, Center for Biomedical Genetics, University Medical Center Utrecht, 3508 GA, Utrecht, The Netherlands
    Biochim Biophys Acta 1424:M23-37. 1999
  5. ncbi request reprint Differential expression of the HMG box transcription factors XTcf-3 and XLef-1 during early xenopus development
    M Molenaar
    NIOB Hubrecht Laboratory, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Mech Dev 75:151-4. 1998
  6. ncbi request reprint The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
    J Roose
    Department of Immunology, University Hospital, Utrecht, The Netherlands
    Nature 395:608-12. 1998
  7. pmc Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse
    V Korinek
    Department of Immunology, University Hospital, Utrecht, The Netherlands
    Mol Cell Biol 18:1248-56. 1998
  8. ncbi request reprint The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes
    W Korver
    Department of Immunology, University Hospital Utrecht, The Netherlands
    Immunobiology 198:157-61. 1997
  9. ncbi request reprint The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization
    W Korver
    Department of Immunology, University Hospital Utrecht, The Netherlands
    Genomics 46:435-42. 1997
  10. ncbi request reprint Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis
    M Molenaar
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Mech Dev 91:311-5. 2000

Collaborators

Detail Information

Publications14

  1. ncbi request reprint The Sox-13 gene: structure, promoter characterization, and chromosomal localization
    J Roose
    Department of Immunology, University Hospital Utrecht, Utrecht, 3508 GA, The Netherlands
    Genomics 57:301-5. 1999
    ..To determine the chromosomal localization of the human gene, a human SOX13 cDNA was isolated with 75% homology to the mouse Sox-13. FISH analysis mapped the human SOX13 gene to chromosome 1 band q32...
  2. pmc High expression of the HMG box factor sox-13 in arterial walls during embryonic development
    J Roose
    Department of Immunology, University Hospital, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Nucleic Acids Res 26:469-76. 1998
    ..The Sox-13 protein binds to the consensus HMG box motif, AACAAAG, but does not transactivate transcription through a concatamer of this motif. Sox-13, like other members of the Sox family likely plays an important role in development...
  3. pmc All Tcf HMG box transcription factors interact with Groucho-related co-repressors
    H Brantjes
    Department of Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Nucleic Acids Res 29:1410-9. 2001
    ..Although Grg-5 contains the GP homology domain that mediates HDAC binding in long Grg proteins, Grg-5 fails to bind this co-repressor, explaining how it can de-repress transcription...
  4. ncbi request reprint TCF transcription factors: molecular switches in carcinogenesis
    J Roose
    Department of Immunology, Center for Biomedical Genetics, University Medical Center Utrecht, 3508 GA, Utrecht, The Netherlands
    Biochim Biophys Acta 1424:M23-37. 1999
    ..We will discuss Tcf signaling upon interaction with different partners, resulting in activator and repressor roles of Tcf factors in the light of carcinogenic events...
  5. ncbi request reprint Differential expression of the HMG box transcription factors XTcf-3 and XLef-1 during early xenopus development
    M Molenaar
    NIOB Hubrecht Laboratory, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Mech Dev 75:151-4. 1998
    ..The expression pattern of Lef-1 during later stages of development is evolutionarily conserved...
  6. ncbi request reprint The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
    J Roose
    Department of Immunology, University Hospital, Utrecht, The Netherlands
    Nature 395:608-12. 1998
    ..These data indicate that expression of Tcf target genes is regulated by a balance between Armadillo and Groucho...
  7. pmc Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse
    V Korinek
    Department of Immunology, University Hospital, Utrecht, The Netherlands
    Mol Cell Biol 18:1248-56. 1998
    ..These data demonstrate a direct link between Wnt stimulation and beta-catenin/Tcf transcriptional activation and imply a role for mTcf-3 and -4 in early Wnt-driven developmental decisions in the mouse embryo...
  8. ncbi request reprint The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes
    W Korver
    Department of Immunology, University Hospital Utrecht, The Netherlands
    Immunobiology 198:157-61. 1997
    ..In peripheral blood lymphocytes, expression of Trident mRNA was absent, but could be induced upon stimulation with mitogens in vitro. These observations imply a function for Trident in dividing lymphocytes...
  9. ncbi request reprint The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization
    W Korver
    Department of Immunology, University Hospital Utrecht, The Netherlands
    Genomics 46:435-42. 1997
    ..The winged-helix DNA-binding domain is encoded on three exons. Analysis of the promoter in synchronized Rat-1 fibroblasts revealed a fragment of 300 bases responsible for the cell cycle-specific expression of the TRIDENT gene...
  10. ncbi request reprint Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis
    M Molenaar
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Mech Dev 91:311-5. 2000
    ..Differences in the expression of XGrg-4 and XGrg-5 were found in the CNS, cranial ganglia, olfactory placodes, stomodeal-pharyngeal anlage, cement gland, head mesenchyme and ectoderm...
  11. pmc The winged-helix transcription factor Trident is expressed in cycling cells
    W Korver
    Department of Immunology, University Hospital Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Nucleic Acids Res 25:1715-9. 1997
    ..PCR-mediated selection of optimal binding sites yielded a consensus motif resembling that of other family members. These results identify Trident as a transcription factor, which is likely involved in cell cycle-specific gene regulation...
  12. ncbi request reprint Drosophila Tcf and Groucho interact to repress Wingless signalling activity
    R A Cavallo
    Department of Biology, University of North Carolina, Chapel Hill 27599, USA
    Nature 395:604-8. 1998
    ..Finally, mutations in the Drosophila groucho gene also suppress wingless and armadillo mutant phenotypes as Groucho physically interacts with dTcf and is required for its full repressor activity...
  13. ncbi request reprint Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1
    J Roose
    Department of Immunology and Center for Biomedical Genetics, Department of Pathology, University Medical Center Utrecht, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 285:1923-6. 1999
    ..Tcf1 may act as a feedback repressor of beta-catenin-Tcf4 target genes and thus may cooperate with APC to suppress malignant transformation of epithelial cells...
  14. ncbi request reprint XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
    M Molenaar
    Department of Immunology University Hospital, Utrecht The Netherlands
    Cell 86:391-9. 1996
    ..We propose that signaling by beta-catenin involves complex formation with XTcf-3, followed by nuclear translocation and activation of specific XTcf-3 target genes...