Research Topics
Genomes and Genes | J RooseSummaryAffiliation: University Medical Center Country: The Netherlands Publications
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Publications
The Sox-13 gene: structure, promoter characterization, and chromosomal localizationJ Roose
Department of Immunology, University Hospital Utrecht, Utrecht, 3508 GA, The Netherlands
Genomics 57:301-5. 1999..To determine the chromosomal localization of the human gene, a human SOX13 cDNA was isolated with 75% homology to the mouse Sox-13. FISH analysis mapped the human SOX13 gene to chromosome 1 band q32...
High expression of the HMG box factor sox-13 in arterial walls during embryonic developmentJ Roose
Department of Immunology, University Hospital, PO Box 85500, 3508 GA, Utrecht, The Netherlands
Nucleic Acids Res 26:469-76. 1998..The Sox-13 protein binds to the consensus HMG box motif, AACAAAG, but does not transactivate transcription through a concatamer of this motif. Sox-13, like other members of the Sox family likely plays an important role in development...- All Tcf HMG box transcription factors interact with Groucho-related co-repressorsH Brantjes
Department of Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
Nucleic Acids Res 29:1410-9. 2001..Although Grg-5 contains the GP homology domain that mediates HDAC binding in long Grg proteins, Grg-5 fails to bind this co-repressor, explaining how it can de-repress transcription... - TCF transcription factors: molecular switches in carcinogenesisJ Roose
Department of Immunology, Center for Biomedical Genetics, University Medical Center Utrecht, 3508 GA, Utrecht, The Netherlands
Biochim Biophys Acta 1424:M23-37. 1999..We will discuss Tcf signaling upon interaction with different partners, resulting in activator and repressor roles of Tcf factors in the light of carcinogenic events... - Differential expression of the HMG box transcription factors XTcf-3 and XLef-1 during early xenopus developmentM Molenaar
NIOB Hubrecht Laboratory, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
Mech Dev 75:151-4. 1998..The expression pattern of Lef-1 during later stages of development is evolutionarily conserved... - The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressorsJ Roose
Department of Immunology, University Hospital, Utrecht, The Netherlands
Nature 395:608-12. 1998..These data indicate that expression of Tcf target genes is regulated by a balance between Armadillo and Groucho... - Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouseV Korinek
Department of Immunology, University Hospital, Utrecht, The Netherlands
Mol Cell Biol 18:1248-56. 1998..These data demonstrate a direct link between Wnt stimulation and beta-catenin/Tcf transcriptional activation and imply a role for mTcf-3 and -4 in early Wnt-driven developmental decisions in the mouse embryo... - The winged-helix transcription factor Trident is expressed in actively dividing lymphocytesW Korver
Department of Immunology, University Hospital Utrecht, The Netherlands
Immunobiology 198:157-61. 1997..In peripheral blood lymphocytes, expression of Trident mRNA was absent, but could be induced upon stimulation with mitogens in vitro. These observations imply a function for Trident in dividing lymphocytes... - The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterizationW Korver
Department of Immunology, University Hospital Utrecht, The Netherlands
Genomics 46:435-42. 1997..The winged-helix DNA-binding domain is encoded on three exons. Analysis of the promoter in synchronized Rat-1 fibroblasts revealed a fragment of 300 bases responsible for the cell cycle-specific expression of the TRIDENT gene... - Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevisM Molenaar
Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
Mech Dev 91:311-5. 2000..Differences in the expression of XGrg-4 and XGrg-5 were found in the CNS, cranial ganglia, olfactory placodes, stomodeal-pharyngeal anlage, cement gland, head mesenchyme and ectoderm... - The winged-helix transcription factor Trident is expressed in cycling cellsW Korver
Department of Immunology, University Hospital Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
Nucleic Acids Res 25:1715-9. 1997..PCR-mediated selection of optimal binding sites yielded a consensus motif resembling that of other family members. These results identify Trident as a transcription factor, which is likely involved in cell cycle-specific gene regulation... - Drosophila Tcf and Groucho interact to repress Wingless signalling activityR A Cavallo
Department of Biology, University of North Carolina, Chapel Hill 27599, USA
Nature 395:604-8. 1998..Finally, mutations in the Drosophila groucho gene also suppress wingless and armadillo mutant phenotypes as Groucho physically interacts with dTcf and is required for its full repressor activity... - Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1J Roose
Department of Immunology and Center for Biomedical Genetics, Department of Pathology, University Medical Center Utrecht, Post Office Box 85500, 3508 GA Utrecht, Netherlands
Science 285:1923-6. 1999..Tcf1 may act as a feedback repressor of beta-catenin-Tcf4 target genes and thus may cooperate with APC to suppress malignant transformation of epithelial cells... - XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryosM Molenaar
Department of Immunology University Hospital, Utrecht The Netherlands
Cell 86:391-9. 1996..We propose that signaling by beta-catenin involves complex formation with XTcf-3, followed by nuclear translocation and activation of specific XTcf-3 target genes...