Timothy Rdj Radstake
Affiliation: University Medical Center Utrecht
Country: The Netherlands
Silva Cardoso S, Affandi A, Spel L, Cossu M, van Roon J, Boes M, et al
. CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells. J Immunol. 2017;199:253-262 pubmed publisher
..Together our data support that increased levels of circulating CXCL4 may contribute to immune dysregulation through the modulation of DC differentiation. ..
van der Kroef M, Castellucci M, Mokry M, Cossu M, Garonzi M, Bossini Castillo L, et al
. Histone modifications underlie monocyte dysregulation in patients with systemic sclerosis, underlining the treatment potential of epigenetic targeting. Ann Rheum Dis. 2019;78:529-538 pubmed publisher
..SSc monocytes have altered chromatin marks correlating with their IFN signature. Enzymes modulating these reversible marks may provide interesting therapeutic targets to restore monocyte homeostasis to treat or even prevent SSc. ..
Angiolilli C, Marut W, van der Kroef M, Chouri E, Reedquist K, Radstake T. New insights into the genetics and epigenetics of systemic sclerosis. Nat Rev Rheumatol. 2018;14:657-673 pubmed publisher
..This knowledge will be of paramount importance for the development of medicines that are effective in treating or even reversing tissue fibrosis. ..
Chouri E, Servaas N, Bekker C, Affandi A, Cossu M, Hillen M, et al
. Serum microRNA screening and functional studies reveal miR-483-5p as a potential driver of fibrosis in systemic sclerosis. J Autoimmun. 2018;89:162-170 pubmed publisher
..Our findings showed that miR-483-5p is up-regulated in the serum of SSc patients, from the early stages of the disease onwards, and indicated its potential function as a fine regulator of fibrosis in SSc. ..
Van Bijnen S, Cossu M, Roeven M, Jansen T, Preijers F, Spanholtz J, et al
. Functionally active NKG2A-expressing natural killer cells are elevated in rheumatoid arthritis patients compared to psoriatic arthritis patients and healthy donors. Clin Exp Rheumatol. 2015;33:795-804 pubmed
..Together with an elevated frequency of NKR-expressing T cells, these changes may reflect differential pathogenetic involvement. ..
Cossu M, Beretta L, Mosterman P, de Hair M, Radstake T. Unmet Needs in Systemic Sclerosis Understanding and Treatment: the Knowledge Gaps from a Scientist's, Clinician's, and Patient's Perspective. Clin Rev Allergy Immunol. 2018;55:312-331 pubmed publisher
van Bon L, Cossu M, Scharstuhl A, Pennings B, Vonk M, Vreman H, et al
. Low heme oxygenase-1 levels in patients with systemic sclerosis are associated with an altered Toll-like receptor response: another role for CXCL4?. Rheumatology (Oxford). 2016;55:2066-2073 pubmed
..Since CXCL4 blocks the induction of HO-1 expression, neutralization of CXCL4 in SSc patients could have clinical benefits by diminishing overactivation of immune cells and other anti-inflammatory effects of HO-1. ..
Moret F, Hack C, van der Wurff Jacobs K, de Jager W, Radstake T, Lafeber F, et al
. Intra-articular CD1c-expressing myeloid dendritic cells from rheumatoid arthritis patients express a unique set of T cell-attracting chemokines and spontaneously induce Th1, Th17 and Th2 cell activity. Arthritis Res Ther. 2013;15:R155 pubmed publisher
..This study suggests that increased numbers of CD1c+?mDCs in SF are involved in the inflammatory cascade intra-articularly by the secretion of specific T cell-attracting chemokines and the activation of self-reactive T cells. ..