Leo S Price

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi request reprint Rap1 regulates E-cadherin-mediated cell-cell adhesion
    Leo S Price
    Department of Physiological Chemistry and the Centre for Biomedical Genetics, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    J Biol Chem 279:35127-32. 2004
  2. pmc Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction
    Jurgen A Riedl
    Department of Physiological Chemistry, Centre for Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Biochem J 389:465-9. 2005
  3. pmc Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor
    Savithri Rangarajan
    Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Center Utrecht, Netherlands
    J Cell Biol 160:487-93. 2003
  4. ncbi request reprint The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin
    Jorrit M Enserink
    Biotechnology Centre of Oslo, University of Oslo, Blindern, N 0317 Oslo, Norway
    J Biol Chem 279:44889-96. 2004
  5. ncbi request reprint RAPL: taking the Rap in immunity
    Leo S Price
    Nat Immunol 5:1007-8. 2004
  6. ncbi request reprint AF6 negatively regulates Rap1-induced cell adhesion
    Zhongchun Zhang
    Department of Physiological Chemistry and Centre of Biomedical Genetics, University Medical Centre, Utrecht 3508 AB, The Netherlands
    J Biol Chem 280:33200-5. 2005
  7. doi request reprint Renal expression of exchange protein directly activated by cAMP (Epac) 1 and 2
    Yuedan Li
    Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Physiol Renal Physiol 295:F525-33. 2008

Collaborators

  • Johannes L Bos
  • Jun Zhao
  • Jorrit M Enserink
  • Yuedan Li
  • Jurgen A Riedl
  • Zhongchun Zhang
  • Savithri Rangarajan
  • Peter M T Deen
  • Emile De Heer
  • Irene B M Konings
  • Holger Rehmann
  • Dominique T Brandt
  • Jurgen Riedl
  • Eduard Batlle
  • Hans Clevers
  • Trond Methi
  • Arnoud Sonnenberg
  • Milada Mahic
  • Kjetil Tasken
  • Frank Schwede
  • Johan de Rooij
  • H Bea Kuiperij

Detail Information

Publications7

  1. ncbi request reprint Rap1 regulates E-cadherin-mediated cell-cell adhesion
    Leo S Price
    Department of Physiological Chemistry and the Centre for Biomedical Genetics, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    J Biol Chem 279:35127-32. 2004
    ..Our results imply that Rap may function in a broader manner to regulate the function of cell-surface adhesion receptors...
  2. pmc Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction
    Jurgen A Riedl
    Department of Physiological Chemistry, Centre for Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Biochem J 389:465-9. 2005
    ..From these results, we conclude that down-regulation of Rap1 is a prerequisite for ephrin-induced cell retraction in colon cells...
  3. pmc Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor
    Savithri Rangarajan
    Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Center Utrecht, Netherlands
    J Cell Biol 160:487-93. 2003
    ..From these results we conclude that cAMP mediates receptor-induced integrin-mediated cell adhesion to fibronectin through the Epac-Rap1 signaling pathway...
  4. ncbi request reprint The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin
    Jorrit M Enserink
    Biotechnology Centre of Oslo, University of Oslo, Blindern, N 0317 Oslo, Norway
    J Biol Chem 279:44889-96. 2004
    ..They also define different roles for the laminin-binding integrins in regulated cell adhesion and subsequent cell spreading...
  5. ncbi request reprint RAPL: taking the Rap in immunity
    Leo S Price
    Nat Immunol 5:1007-8. 2004
  6. ncbi request reprint AF6 negatively regulates Rap1-induced cell adhesion
    Zhongchun Zhang
    Department of Physiological Chemistry and Centre of Biomedical Genetics, University Medical Centre, Utrecht 3508 AB, The Netherlands
    J Biol Chem 280:33200-5. 2005
    ..Thus, AF6 may buffer RapGTP in resting T cells and maintain them in a non-adherent state...
  7. doi request reprint Renal expression of exchange protein directly activated by cAMP (Epac) 1 and 2
    Yuedan Li
    Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Physiol Renal Physiol 295:F525-33. 2008
    ..A similar distribution for Epac1/2 was found in the human kidney. The observed expression in different tubular segments suggests a major role for Epac 1/2 in tubular transport physiology and cellular proliferation...