Dirkje S Postma

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. pmc Genetic variation in TIMP1 but not MMPs predict excess FEV1 decline in two general population-based cohorts
    C C van Diemen
    Department of Epidemiology, University of Groningen, Groningen, The Netherlands
    Respir Res 12:57. 2011
  2. doi request reprint I have taken my umbrella, so of course it does not rain
    D S Postma
    Department of Pulmonology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Thorax 67:88-9. 2012
  3. doi request reprint Asthma and chronic obstructive pulmonary disease: common genes, common environments?
    Dirkje S Postma
    Department of Pulmonology, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands
    Am J Respir Crit Care Med 183:1588-94. 2011
  4. ncbi request reprint Persisting remodeling and less airway wall eosinophil activation in complete remission of asthma
    Martine Broekema
    Department of Pulmonology, University Medical Center Groningen, RB Groningen, The Netherlands
    Am J Respir Crit Care Med 183:310-6. 2011
  5. doi request reprint A new perspective on optimal care for patients with COPD
    Dirkje Postma
    Department of Pulmonary Medicine and Tuberculosis, University Medical Center Groningen, University of Groningen, The Netherlands
    Prim Care Respir J 20:205-9. 2011
  6. ncbi request reprint Comparison of the effect of low-dose ciclesonide and fixed-dose fluticasone propionate and salmeterol combination on long-term asthma control
    Dirkje S Postma
    Department of Pulmonary Diseases, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Chest 139:311-8. 2011
  7. pmc Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD
    Simona E Budulac
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Respir Res 11:60. 2010
  8. doi request reprint Clinical control of asthma associates with measures of airway inflammation
    Franke Volbeda
    Department of Pulmonology, University Medical Centre Groningen, Groningen and University of Groningen, The Netherlands
    Thorax 68:19-24. 2013
  9. ncbi request reprint Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial
    Thérèse S Lapperre
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 151:517-27. 2009
  10. ncbi request reprint Anti-inflammatory effects of combined budesonide/formoterol in COPD exacerbations
    Erik Bathoorn
    Groningen Research Institute for Asthma and COPD, Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    COPD 5:282-90. 2008

Detail Information

Publications102 found, 100 shown here

  1. pmc Genetic variation in TIMP1 but not MMPs predict excess FEV1 decline in two general population-based cohorts
    C C van Diemen
    Department of Epidemiology, University of Groningen, Groningen, The Netherlands
    Respir Res 12:57. 2011
    ..Longitudinal studies investigating Single Nucleotide Polymorphisms (SNPs) in MMPs and TIMPs with respect to COPD development and lung function decline in the general population are lacking...
  2. doi request reprint I have taken my umbrella, so of course it does not rain
    D S Postma
    Department of Pulmonology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Thorax 67:88-9. 2012
    ..Therefore, the authors throw down the gauntlet: spirometry is an essential tool in patient evaluation but dangerous for disease diagnosis, and the term COPD should only be used in the appropriate clinical (diagnostic) context...
  3. doi request reprint Asthma and chronic obstructive pulmonary disease: common genes, common environments?
    Dirkje S Postma
    Department of Pulmonology, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands
    Am J Respir Crit Care Med 183:1588-94. 2011
    ..The genetic predisposition to the derailment of certain pathways may further help to define subgroups of asthma and COPD. In the end this may lead to stratification of patients by their genetic make-up and open new therapeutic prospects...
  4. ncbi request reprint Persisting remodeling and less airway wall eosinophil activation in complete remission of asthma
    Martine Broekema
    Department of Pulmonology, University Medical Center Groningen, RB Groningen, The Netherlands
    Am J Respir Crit Care Med 183:310-6. 2011
    ..It is uncertain whether this associates with remission of all inflammatory and remodeling asthma features...
  5. doi request reprint A new perspective on optimal care for patients with COPD
    Dirkje Postma
    Department of Pulmonary Medicine and Tuberculosis, University Medical Center Groningen, University of Groningen, The Netherlands
    Prim Care Respir J 20:205-9. 2011
    ..This broader approach to disease management should result in improved care for every COPD patient now and into the future...
  6. ncbi request reprint Comparison of the effect of low-dose ciclesonide and fixed-dose fluticasone propionate and salmeterol combination on long-term asthma control
    Dirkje S Postma
    Department of Pulmonary Diseases, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Chest 139:311-8. 2011
    ..We compared benefits of first-line treatment with ciclesonide and a combination of fluticasone and salmeterol in patients with mild asthma...
  7. pmc Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD
    Simona E Budulac
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Respir Res 11:60. 2010
    ..The aim of our study was to assess the associations of MRP1 SNPs with FEV1 level, MRP1 protein levels and inflammatory markers in bronchial biopsies and sputum of COPD patients...
  8. doi request reprint Clinical control of asthma associates with measures of airway inflammation
    Franke Volbeda
    Department of Pulmonology, University Medical Centre Groningen, Groningen and University of Groningen, The Netherlands
    Thorax 68:19-24. 2013
    ..We investigated whether clinical asthma control reflects eosinophilic inflammation in a broad population...
  9. ncbi request reprint Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial
    Thérèse S Lapperre
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 151:517-27. 2009
    ..Inhaled corticosteroids (ICSs) and long-acting beta(2)-agonists (LABAs) are used to treat moderate to severe chronic obstructive pulmonary disease (COPD)...
  10. ncbi request reprint Anti-inflammatory effects of combined budesonide/formoterol in COPD exacerbations
    Erik Bathoorn
    Groningen Research Institute for Asthma and COPD, Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    COPD 5:282-90. 2008
    ..50). In conclusion, budesonide/formoterol reduces sputum eosinophils and improves symptoms in the treatment of out-patient COPD exacerbations...
  11. ncbi request reprint Airway epithelial changes in smokers but not in ex-smokers with asthma
    Martine Broekema
    Dept of Pathology, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Am J Respir Crit Care Med 180:1170-8. 2009
    ..This results in accelerated lung function decline. The underlying pathological process of smoke-induced deterioration of asthma is unknown...
  12. pmc Heme oxygenase-1 prevents smoke induced B-cell infiltrates: a role for regulatory T cells?
    Corry Anke Brandsma
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, P, O, Box 30, 001, 9700 RB, Groningen, The Netherlands
    Respir Res 9:17. 2008
    ..The effects of HO-1 modulation on cigarette smoke induced inflammation and emphysema were tested in a smoking mouse model...
  13. ncbi request reprint Nitrogen dioxide exposure attenuates cigarette smoke-induced cytokine production in mice
    Corry Anke Brandsma
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Inhal Toxicol 20:183-9. 2008
    ..The next step is to translate these findings of combined, controlled exposure in animals to the human situation...
  14. doi request reprint Gene-gene interaction in regulatory T-cell function in atopy and asthma development in childhood
    Renske W B Bottema
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 126:338-46, 346.e1-10. 2010
    ..Therefore, we hypothesized that single nucleotide polymorphisms in genes involved in the development and function of regulatory T cells are associated with atopy and asthma development...
  15. pmc Change in inflammation in out-patient COPD patients from stable phase to a subsequent exacerbation
    Erik Bathoorn
    Department of Pulmonology, Groningen Research Institute for Asthma and COPD GRIAC, University Medical Center Groningen, University of Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 4:101-9. 2009
    ..Better identification of these changes will increase our knowledge and potentially guide therapy, for instance by helping with quicker distinction of bacterially induced exacerbations from other causes...
  16. ncbi request reprint Repeated sputum inductions induce a transient neutrophilic and eosinophilic response
    Hester van der Vaart
    University Medical Centre Groningen, Pulmonology, Hanzeplein 1, Groningen 9713 RB, The Netherlands
    Chest 130:1157-64. 2006
    ..Sputum induction is a tool to monitor airway inflammation, yet it may induce by itself a neutrophilic response when repeated within 24 to 48 h. This limits its repeated use in clinical trials...
  17. pmc Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics
    Eef D Telenga
    Department of Pulmonary Diseases, University Medical Center Groningen, Groningen, Netherlands
    BMC Pulm Med 13:58. 2013
    ..We investigated differences in blood and sputum inflammatory profiles between ex-, current-, and never-smokers and assessed their ICS treatment response after 2-week and 1-year treatment...
  18. pmc Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD
    Lisette I Z Kunz
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Respir Res 12:34. 2011
    ..Our aim was to study macrophage heterogeneity using the M2-marker CD163 and selected pro- and anti-inflammatory mediators in bronchoalveolar lavage (BAL) fluid and induced sputum from current smokers and ex-smokers with COPD...
  19. pmc Can AMP induce sputum eosinophils, even in subjects with complete asthma remission?
    Franke Volbeda
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, The Netherlands
    Respir Res 11:106. 2010
    ....
  20. ncbi request reprint Feasibility of sputum induction in lung transplant recipients
    Jan W K van den Berg
    Department of Pulmonary Diseases and Lung Transplantation, University Hospital Groningen, Groningen, The Netherlands
    Clin Transplant 18:605-12. 2004
    ..Induced sputum may be a useful tool to study inflammatory changes of the airways after LTX, and because of the large quantity of neutrophils sampled, especially for further studies on the pathogenesis of bronchiolitis obliterans...
  21. ncbi request reprint Skin-blanching is associated with FEV(1), allergy, age and gender in asthma families
    Eef D Telenga
    Department of Pulmonology, Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Respir Med 106:1376-82. 2012
    ..Finally, we assessed which clinical and inflammatory parameters influence the variability in skin-blanching response...
  22. ncbi request reprint Small airways dysfunction and neutrophilic inflammation in bronchial biopsies and BAL in COPD
    Thérèse S Lapperre
    Department of Pulmonology, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, NL 2300 RC Leiden, The Netherlands
    Chest 131:53-9. 2007
    ..We investigated whether uneven ventilation and airway closure are associated with specific markers of airway inflammation as obtained by bronchial biopsies, BAL, and induced sputum in patients with manifest COPD...
  23. ncbi request reprint Down-regulation of E-cadherin in human bronchial epithelial cells leads to epidermal growth factor receptor-dependent Th2 cell-promoting activity
    Irene H Heijink
    Department of Allergology, University Medical Center, University of Groningen, Groningen, The Netherlands
    J Immunol 178:7678-85. 2007
    ..Thus, disruption of intercellular epithelial contacts may specifically promote Th2 cell recruitment in allergic asthma...
  24. pmc A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology
    Margot M E Gosman
    Department of Pulmonology, University Medical Centre Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Thorax 62:242-7. 2007
    ..Single-nucleotide polymorphisms (SNPs) in a disintegrin and metalloprotease 33 (ADAM33) gene have been associated with AHR and COPD...
  25. ncbi request reprint Detrimental effects of beta-blockers in COPD: a concern for nonselective beta-blockers
    Hanneke J van der Woude
    Department of Pulmonary Diseases, Martini Hospital, Van Ketwich Verschuurlaan 82, 9721 SW Groningen, The Netherlands
    Chest 127:818-24. 2005
    ..beta-Blockers are known to worsen FEV(1) and airway hyperresponsiveness (AHR) in patients with asthma. Both characteristics determine the outcome of COPD, a disease with frequent cardiac comorbidity requiring beta-blocker treatment...
  26. ncbi request reprint Inhaled corticosteroids in chronic obstructive pulmonary disease: a review
    Eef D Telenga
    University Medical Center Groningen, University of Groningen, Department of Pulmonology PO Box 30 001, 9700 RB Groningen, The Netherlands
    Expert Opin Pharmacother 11:405-21. 2010
    ..Although widely used, the efficacy of inhaled corticosteroids (ICS) in the treatment of COPD remains a matter of debate...
  27. pmc Acute effects of cigarette smoking on inflammation in healthy intermittent smokers
    Hester van der Vaart
    Department of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands
    Respir Res 6:22. 2005
    ..Knowledge on the response to the initial smoke exposures might enhance the understanding of changes due to chronic smoking, since repetitive acute smoke effects may cumulate and lead to irreversible lung damage...
  28. ncbi request reprint Transient early wheeze and lung function in early childhood associated with chronic obstructive pulmonary disease genes
    Marjan Kerkhof
    Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands GRIAC Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Electronic address
    J Allergy Clin Immunol 133:68-76.e1-4. 2014
    ..Little is known about whether subjects genetically predisposed to COPD show their first symptoms or reduced lung function in childhood...
  29. pmc Inhaled steroids modulate extracellular matrix composition in bronchial biopsies of COPD patients: a randomized, controlled trial
    Lisette I Z Kunz
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e63430. 2013
    ..We hypothesized that inhaled corticosteroids and current smoking modulate bronchial extracellular matrix components in COPD...
  30. doi request reprint Characterization of protocadherin-1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation
    Henk Koning
    Beatrix Children s Hospital, University Medical Center Groningen, Groningen, The Netherlands
    FASEB J 26:439-48. 2012
    ..In summary, PCDH1 transcripts display remarkable variability in expression of conserved intracellular signaling domains. Enhanced PCDH1 expression levels strongly correlate with differentiation of bronchial epithelial cells...
  31. pmc Effect of COPD treatments on MRP1-mediated transport in bronchial epithelial cells
    Margaretha van der Deen
    Department of Medical Oncology, University Medical Center Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 3:469-75. 2008
    ..We questioned whether MRP1-mediated transport is influenced by pulmonary drugs that are commonly prescribed in COPD...
  32. ncbi request reprint Effect of ciclesonide treatment on allergen-induced changes in T cell regulation in asthma
    Irene H Heijink
    Department of Allergology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Int Arch Allergy Immunol 145:111-21. 2008
    ....
  33. ncbi request reprint Protocadherin-1 polymorphisms are associated with eczema in two Dutch birth cohorts
    Henk Koning
    Pediatric Pulmonology and Pediatric Allergology, Beatrix Children s Hospital, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Pediatr Allergy Immunol 23:270-7. 2012
    ..We determined whether PCDH1 polymorphisms, previously associated with asthma or BHR, also associated with questionnaire and UK Working Party (UKWP) defined eczema...
  34. pmc Increased levels of (class switched) memory B cells in peripheral blood of current smokers
    Corry Anke Brandsma
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, 9700 RB, Groningen, The Netherlands
    Respir Res 10:108. 2009
    ..Future studies focusing on the presence of these (class switched) memory B cells in the lung, their antigen specificity and their interaction with Tregs are necessary to further elucidate the specific B-cell response in COPD...
  35. doi request reprint Sputum inflammation predicts exacerbations after cessation of inhaled corticosteroids in COPD
    Jeroen J W Liesker
    Department of Respiratory Diseases and Tuberculosis, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Respir Med 105:1853-60. 2011
    ..Unfortunately, physicians do not know in which patients they can stop ICS treatment safely...
  36. pmc Decorin and TGF-beta1 polymorphisms and development of COPD in a general population
    Cleo C van Diemen
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Respir Res 7:89. 2006
    ..Interestingly, they act as each other's feedback regulator. We investigated whether single nucleotide polymorphisms (SNPs) in decorin and TGF-beta1 underlie accelerated decline in FEV1 and development of COPD in the general population...
  37. pmc Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity
    Maarten van den Berge
    Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Thorax 69:14-23. 2014
    ....
  38. ncbi request reprint Cigarette smoke-induced emphysema: A role for the B cell?
    Barry W A van der Strate
    Department of Respiratory Medicine, University Medical Center Groningen, Postbox 30 001, NL 9700 RB Groningen, The Netherlands
    Am J Respir Crit Care Med 173:751-8. 2006
    ..Little is known about what drives the inflammatory reaction in the development of chronic obstructive lung disease. B cells have been found...
  39. doi request reprint Differential effects of fluticasone on extracellular matrix production by airway and parenchymal fibroblasts in severe COPD
    Corry Anke Brandsma
    Dept of Pathology and Medical Biology, Univ Medical Center Groningen, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 305:L582-9. 2013
    ..More research is needed to further disentangle these differential effects of steroid treatment on the different lung compartments and its impact on tissue repair and remodeling in COPD. ..
  40. doi request reprint Multidrug resistance-associated protein 1 and lung function decline with or without long-term corticosteroids treatment in COPD
    Simona E Budulac
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands
    Eur J Pharmacol 696:136-42. 2012
    ..None of the variants was associated with FEV(1) decline. Our unique study suggests a role of MRP1 protein expression in bronchial biopsies in FEV(1) decline occurring selectively in COPD patients with long-term (30-month) ICS therapy...
  41. doi request reprint Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD
    Maarten van den Berge
    Dept of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Eur Respir J 40:1098-105. 2012
    ..Our findings indicate that BHR is an independent trait in COPD and provides important information on phenotype heterogeneity and disease activity...
  42. pmc Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease
    Simona E Budulac
    Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 7:e43124. 2012
    ....
  43. pmc Induction of autoantibodies against lung matrix proteins and smoke-induced inflammation in mice
    Corry Anke Brandsma
    Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    BMC Pulm Med 10:64. 2010
    ..Whether the presence of these autoantibodies contributes to the pathogenesis of COPD is unclear...
  44. doi request reprint Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer
    Mirjam C Boelens
    Department of Pathology, University Medical Centre Groningen, Groningen, The Netherlands
    J Pathol 218:182-91. 2009
    ..Our data indicate that smoking-related changes in normal bronchial epithelial cells persist in malignant transformed squamous cells...
  45. pmc Association of mast cells with lung function in chronic obstructive pulmonary disease
    Margot M E Gosman
    Department of Pulmonology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Respir Res 9:64. 2008
    ..We compared MC-T and MC-C distributions in COPD and controls without airflow limitation, and determined their relation with lung function...
  46. pmc Inhaled corticosteroids and long-acting beta-agonists in adult asthma: a winning combination in all?
    Dirkje S Postma
    Department of Pulmonology, University Medical Center, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 378:203-15. 2008
    ..Clinical effectiveness in the real world now has to be established, since this approach likely improves compliance with regular maintenance therapy...
  47. ncbi request reprint First study of infliximab treatment in patients with chronic obstructive pulmonary disease
    Hester van der Vaart
    Department of Pulmonology, University Medical Center Groningen, P O Box 30 001, NL 9700 RB, Groningen, The Netherlands
    Am J Respir Crit Care Med 172:465-9. 2005
    ..Tumor necrosis factor-alpha is believed to be important in the induction and maintenance of airway inflammation in chronic obstructive pulmonary disease...
  48. ncbi request reprint Risk factors for chronic mucus hypersecretion in individuals with and without COPD: influence of smoking and job exposure on CMH
    Akkelies E Dijkstra
    Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Occup Environ Med 71:346-52. 2014
    ..Several risk factors contribute to CMH and to COPD. It is, however, unknown if risk factors for CMH are similar in persons with and without COPD...
  49. ncbi request reprint Bronchoalveolar lavage fluid characteristics in acute and chronic lung transplant rejection
    Dirk Jan Slebos
    Department of Pulmonary Diseases and Lung Transplantation, University Hospital Groningen, Groningen, The Netherlands
    J Heart Lung Transplant 23:532-40. 2004
    ..The detection of graft rejection by bronchoalveolar lavage remains controversial...
  50. pmc Low-dose CT measurements of airway dimensions and emphysema associated with airflow limitation in heavy smokers: a cross sectional study
    Akkelies E Dijkstra
    University of Groningen, Department of Pulmonary Diseases, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands
    Respir Res 14:11. 2013
    ..Advances in computed tomography (CT) post-processing imaging allow to quantify these features. The aim of this Dutch population study is to assess the relationships between AWT, lung function, emphysema and respiratory symptoms...
  51. doi request reprint Differential switching to IgG and IgA in active smoking COPD patients and healthy controls
    Corry Anke Brandsma
    Dept of Pathology and Medical Biology, University Medical Center Groningen and University of Groningen, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    Eur Respir J 40:313-21. 2012
    ....
  52. doi request reprint Small airway disease in asthma and COPD: clinical implications
    Maarten van den Berge
    Department of Pulmonary, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Chest 139:412-23. 2011
    ..The first studies in COPD are promising, and results from new studies are eagerly awaited...
  53. ncbi request reprint ABCC1 polymorphisms contribute to level and decline of lung function in two population-based cohorts
    Mateusz Siedlinski
    Departments of Epidemiology, University Medical Center, Groningen, The Netherlands
    Pharmacogenet Genomics 19:675-84. 2009
    ..In line with these results, we now aimed to assess effects of ABCC1 single nucleotide polymorphisms (SNPs) on both the level and the longitudinal course of lung function in the general population...
  54. ncbi request reprint Cigarette smoke extract affects functional activity of MRP1 in bronchial epithelial cells
    Margaretha van der Deen
    Department of Medical Oncology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
    J Biochem Mol Toxicol 21:243-51. 2007
    ..Inhibition of MRP1 in turn results in higher CSE toxicity. We propose that MRP1 may be a protective protein for COPD development...
  55. ncbi request reprint Exposure to TARC alters beta2-adrenergic receptor signaling in human peripheral blood T lymphocytes
    Irene H Heijink
    Department of Allergology, University Medical Center Groningen, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 289:L53-9. 2005
    ..We propose that aberrant T cell control in the presence of endogenous beta-agonists promotes T cell-mediated inflammation in asthma...
  56. doi request reprint House dust mite-promoted epithelial-to-mesenchymal transition in human bronchial epithelium
    Irene H Heijink
    Department of Allergology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Am J Respir Cell Mol Biol 42:69-79. 2010
    ..We propose that TGF-beta secretion and dysregulated EGFR signaling may increase epithelial vulnerability to allergens and trigger the induction of EMT, a hitherto unrecognized contributor to airway remodeling in asthma...
  57. ncbi request reprint Localization and quantification of regional and segmental air trapping in asthma
    Judith Cohen
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, The Netherlands
    J Comput Assist Tomogr 32:562-9. 2008
    ..To assess the feasibility of volumetric and densitometric software to localize and quantify signs of regional air trapping after methacholine bronchoprovocations in asthma...
  58. pmc Prediction and course of symptoms and lung function around an exacerbation in chronic obstructive pulmonary disease
    Maarten van den Berge
    Department of Respiratory Medicine, University Medical Center Groningen, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands
    Respir Res 13:44. 2012
    ..We investigated the course of exacerbations in the published COSMIC study that investigated the effects of 1-year withdrawal of fluticasone after a 3-month run-in treatment period with salmeterol/fluticasone in patients with COPD...
  59. pmc Nicotinic acetylcholine receptor variants are related to smoking habits, but not directly to COPD
    Simona E Budulac
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e33386. 2012
    ....
  60. doi request reprint A chronic obstructive pulmonary disease related signature in squamous cell lung cancer
    Mirjam C Boelens
    Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Lung Cancer 72:177-83. 2011
    ....
  61. ncbi request reprint Different modulation of decorin production by lung fibroblasts from patients with mild and severe emphysema
    Jacobien A Noordhoek
    Department of Pulmonology, University Medical Center Groningen, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    COPD 2:17-25. 2005
    ..This dysregulation of decorin production may contribute to the impaired lung tissue repair, present in patients with emphysema, since these alterations in the extracellular matrix may cause diminished cytokine binding and neutralization...
  62. ncbi request reprint Gender differences in asthma development and remission during transition through puberty: the TRacking Adolescents' Individual Lives Survey (TRAILS) study
    Nienke M Vink
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 126:498-504.e1-6. 2010
    ..During puberty, a gender shift in asthma prevalence occurs, with a preponderance of boys before puberty. The mechanisms underlying this gender shift are unclear...
  63. ncbi request reprint Der p, IL-4, and TGF-beta cooperatively induce EGFR-dependent TARC expression in airway epithelium
    Irene H Heijink
    Department of Allergology, Pulmonology, and Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, NL 9713 GZ, Groningen, The Netherlands
    Am J Respir Cell Mol Biol 36:351-9. 2007
    ..Interference with ADAM or EGFR activity may be a novel promising target to prevent TARC release and subsequent allergic inflammation...
  64. pmc Reticular basement membrane in asthma and COPD: similar thickness, yet different composition
    Jeroen J W Liesker
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 4:127-35. 2009
    ..Reticular basement membrane (RBM) thickening has been variably associated with asthma and chronic obstructive pulmonary disease (COPD). Even if RBM thickness is similar in both diseases, its composition might still differ...
  65. ncbi request reprint Lung function loss, smoking, vitamin C intake, and polymorphisms of the glutamate-cysteine ligase genes
    Mateusz Siedlinski
    Department of Epidemiology, University Medical Center Groningen, E3 29, PO Box 196, 9700 AD Groningen, The Netherlands
    Am J Respir Crit Care Med 178:13-9. 2008
    ....
  66. doi request reprint Interleukin 13 and interleukin 4 receptor-α polymorphisms in rhinitis and asthma
    Renske W B Bottema
    Department of Pulmonology, University Medical Center, University of Groningen, Groningen, The Netherlands
    Int Arch Allergy Immunol 153:259-67. 2010
    ..IL13 and IL4R polymorphisms are associated with asthma and show gene-gene interaction in asthma. Their role in rhinitis has not been extensively studied...
  67. doi request reprint Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response
    Judith M Vonk
    Department of Epidemiology, University Medical Center Groningen, The Netherlands
    Pharmacogenet Genomics 20:179-86. 2010
    ..Arginase probably plays an important role in asthma development, severity and progression. Polymorphisms in arginase 1 and arginase 2 genes have been associated with childhood asthma and FEV1 reversibility to beta2 agonists...
  68. ncbi request reprint Effects of IL-4 and IL-13 on adenosine receptor expression and responsiveness of the human mast cell line 1
    Mieke Versluis
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Int Immunopharmacol 8:866-73. 2008
    ..Bronchoconstriction upon AMP inhalation is thought to occur by histamine release and subsequent binding to receptors on airway smooth muscle cells...
  69. ncbi request reprint Bronchoalveolar lavage in a patient with recurrence of sarcoidosis after lung transplantation
    Dirk Jan Slebos
    Departments of Pulmonary Diseases and Lung Transplantation, University Hospital Groningen, 9700 RB Groningen, The Netherlands
    J Heart Lung Transplant 23:1010-3. 2004
    ..In this case report we show, for the first time, the utility of bronchoalveolar lavage fluid in diagnosing the recurrence of sarcoidosis in the transplanted allograft...
  70. doi request reprint Predicting who will have asthma at school age among preschool children
    Olga E M Savenije
    Department of Epidemiology, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 130:325-31. 2012
    ..In the future, biomarkers and genomic risk profiles to develop personalized medicine might further improve asthma prediction, treatment, and prevention...
  71. pmc Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD
    Irene H Heijink
    Laboratory of Allergology and Pulmonary Diseases, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, The Netherlands
    Respir Res 12:110. 2011
    ....
  72. ncbi request reprint Sensitivity of IL-5 production to the cAMP-dependent pathway in human T cells is reduced by exogenous IL-2 in a phosphoinositide 3-kinase-dependent way
    Irene H Heijink
    Department of Allergology, University Hospital Groningen, Groningen, The Netherlands
    Eur J Immunol 33:2206-15. 2003
    ..Together, our results indicate that increased IL-2-dependent PI3-K signaling leads to impaired negative feedback control of the production of Th2-type cytokine IL-5 by the cAMP-dependent pathway...
  73. ncbi request reprint Short-term smoke exposure attenuates ovalbumin-induced airway inflammation in allergic mice
    Barbro N Melgert
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    Am J Respir Cell Mol Biol 30:880-5. 2004
    ..This effect of smoking may be different for long-term smoking, in which remodeling effects of smoking can be expected to interrelate with remodeling changes caused by asthmatic disease...
  74. ncbi request reprint Localization and enhanced mRNA expression of the orphan chemokine receptor L-CCR in the lung in a murine model of ovalbumin-induced airway inflammation
    Jaap Oostendorp
    Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands
    J Histochem Cytochem 52:401-10. 2004
    ..Regarding the likely role of L-CCR as a chemokine receptor with the putative ligand monocyte chemotactic protein-1 (MCP-1, CCL2), this receptor may have an important function in the early phase of airway inflammation...
  75. ncbi request reprint Rationale for the Dutch hypothesis. Allergy and airway hyperresponsiveness as genetic factors and their interaction with environment in the development of asthma and COPD
    Dirkje S Postma
    Department of Pulmonology, University Hospital, University of Groningen, Postbus 30001, Hanseplein 1, 9700 RB Groningen, The Netherlands
    Chest 126:96S-104S; discussion 159S-161S. 2004
    ..Such studies must include subjects who have airway obstruction that does not necessarily meet the current strict definitions of asthma or COPD (ie, the extremes of these conditions) that are used in clinical studies...
  76. pmc Differential desensitization of homozygous haplotypes of the beta2-adrenergic receptor in lymphocytes
    Jaap Oostendorp
    Department of Molecular Pharmacology, University of Groningen, The Netherlands
    Am J Respir Crit Care Med 172:322-8. 2005
    ..This haplotype-related desensitization of the beta(2)-adrenergic receptor in lymphocytes might have consequences regarding the regulation of helper T-cell type 2 inflammatory responses...
  77. ncbi request reprint Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA
    Olga E Savenije
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 127:1505-12.e14. 2011
    ..It is unclear whether these phenotypes can be replicated in other birth cohorts...
  78. doi request reprint Smoking and nonsmoking asthma: differences in clinical outcome and pathogenesis
    Fatemeh Fattahi
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Expert Rev Respir Med 5:93-105. 2011
    ..Possible pathogenetic mechanisms that may explain the links between cigarette smoking and changes in the clinical expression of asthma will be discussed, as well as the beneficial effects of smoking cessation...
  79. doi request reprint Poly(ethylene glycol)-based stable isotope labeling reagents for the quantitative analysis of low molecular weight metabolites by LC-MS
    Nicolas Abello
    Department of Analytical Biochemistry, University of Groningen, Groningen, The Netherlands
    Anal Chem 80:9171-80. 2008
    ..g., glutathione) decreased although disulfide bond formation was not increased. These labeling reagents should also prove useful for the labeling of peptides and other compounds containing primary amine functionalities...
  80. pmc Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population
    Mateusz Siedlinski
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Respir Res 10:73. 2009
    ..We assessed the impact of Single Nucleotide Polymorphisms (SNPs) in both genes on the level and longitudinal course of Forced Expiratory Volume in 1 second (FEV1) in the general population...
  81. ncbi request reprint Relief of dyspnoea by beta2-agonists after methacholine-induced bronchoconstriction
    Hanneke J van der Woude
    Department of Pulmonary Diseases, Martini Hospital, PO Box 30033, RM Groningen 9728, The Netherlands
    Respir Med 98:816-20. 2004
    ..0 (1-75) min, respectively) than with placebo (33.6 (1-75 min). Formoterol and salbutamol act significantly faster than salmeterol in relieving dyspnoea induced by methacholine-induced bronchoconstriction, in patients with asthma...
  82. doi request reprint Beneficial effects of treatment with anti-IgE antibodies (Omalizumab) in a patient with severe asthma and negative skin-prick test results
    Maarten van den Berge
    Department of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands
    Chest 139:190-3. 2011
    ....
  83. ncbi request reprint Airway cellular response to two different immunosuppressive regimens in lung transplant recipients
    Dirk Jan Slebos
    Department of Pulmonary Diseases and Lung Transplantation, University Hospital Groningen, Groningen, The Netherlands
    Clin Transplant 19:243-9. 2005
    ..Airway lymphocyte subtypes are affected by the immunosuppressive protocol used. This observation should be taken into account when studying transplant recipients, and may contribute to our understanding of alloreactive airway disease...
  84. pmc Genomewide screen for pulmonary function in 200 families ascertained for asthma
    Dirkje S Postma
    Department of Pulmonology, University Hospital, Hanzeplein 3, 9731 GZ Groningen, The Netherlands
    Am J Respir Crit Care Med 172:446-52. 2005
    ..Thus, there may be multiple genes on chromosome 2q that are important in determining presence and degree of airflow limitation in families ascertained for obstructive airway disease...
  85. ncbi request reprint Airway remodeling and long-term decline in lung function in asthma
    Nick H T ten Hacken
    Department of Pulmonology, University Hospital Groningen, The Netherlands
    Curr Opin Pulm Med 9:9-14. 2003
    ....
  86. ncbi request reprint Dissociation of lung function and airway inflammation in chronic obstructive pulmonary disease
    Thérèse S Lapperre
    Lung Function Lab, C2 P, Department of Pulmonology, Leiden University Medical Center, Albinusdreef 2, P O Box 9600 2300 RC Leiden, The Netherlands
    Am J Respir Crit Care Med 170:499-504. 2004
    ..We conclude that airflow limitation, airway inflammation, and features commonly associated with asthma are separate and largely independent factors in the pathophysiology of COPD...
  87. pmc Development, validity and responsiveness of the Clinical COPD Questionnaire
    Thys van der Molen
    Department of General Practice, University of Groningen, Groningen, The Netherlands
    Health Qual Life Outcomes 1:13. 2003
    ..So far no validated questionnaires are available to measure symptom and functional state in daily clinical practice. The aim of this study was to develop and validate the Clinical COPD Questionnaire (CCQ)...
  88. ncbi request reprint A disintegrin and metalloprotease 33 polymorphisms and lung function decline in the general population
    Cleo C van Diemen
    Department of Epidemiology and Bioinformatics, University of Groningen, The Netherlands
    Am J Respir Crit Care Med 172:329-33. 2005
    ....
  89. pmc Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness
    Gerard H Koppelman
    Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
    Am J Respir Crit Care Med 180:929-35. 2009
    ..Bronchial hyperresponsiveness (BHR) is a hallmark of asthma and results from increased sensitivity of the airways to physical or chemical stimulants. BHR and asthma are linked to chromosome 5q31-q33...
  90. doi request reprint Genetics of asthma: where are we and where do we go?
    Dirkje S Postma
    Department of Pulmonology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Proc Am Thorac Soc 6:283-7. 2009
    ..Only by collaborative efforts of many groups of researchers that join forces in DNA analyses will it be possible to help to develop preventive strategies for asthma...
  91. pmc Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD
    Andre Zandvoort
    Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Respir Res 9:83. 2008
    ..We address the following hypothesis: fibroblasts have abnormal expression of genes in the Smad pathway in COPD, resulting in abnormal proteoglycan modulation, the ground substance of ECM...
  92. ncbi request reprint Initial improvements in lung function and bronchial hyperresponsiveness are maintained during 5 years of treatment with inhaled beclomethasone dipropionate and terbutaline
    W Rob Douma
    Department of Pulmonology, University Hospital Groningen, Groningen, The Netherlands
    Chest 121:151-7. 2002
    ....
  93. ncbi request reprint Gender differences in asthma development and progression
    Dirkje S Postma
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Gend Med 4:S133-46. 2007
    ..Because of the complexity of the disease, no single straightforward mechanism can explain the gender differences found in asthma...
  94. pmc ATP-binding cassette (ABC) transporters in normal and pathological lung
    Margaretha van der Deen
    Department of Internal Medicine, Medical Oncology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Respir Res 6:59. 2005
    ..We especially focused on polymorphisms, knock-out mice models and in vitro results of pulmonary research. Insight in the function of ABC transporters in the lung may open new ways to facilitate treatment of lung diseases...
  95. pmc Bronchodilation improves endurance but not muscular efficiency in chronic obstructive pulmonary disease
    Hester van der Vaart
    University Medical Center, Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 6:229-35. 2011
    ..22]). In this small study, we were not able to demonstrate that bronchodilator therapy improved muscular efficiency. Apparently, reduced costs of breathing relative to total energy expenditure were too small to be detected...
  96. pmc A self-rating scale for patient-perceived side effects of inhaled corticosteroids
    Juliet M Foster
    Department of General Practice and Primary Care, University of Aberdeen, UK
    Respir Res 7:131. 2006
    ..In this research we aim to assess the construct validity and reliability of the ICQ and test its responsiveness to dose changes in adult asthma patients...
  97. ncbi request reprint Remodeling in asthma and chronic obstructive pulmonary disease
    Dirkje S Postma
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9731 GZ Groningen, The Netherlands
    Proc Am Thorac Soc 3:434-9. 2006
    ..The localization of this process is dependent on the etiology of the disease (i.e., allergen-driven in asthma and smoke-driven in COPD) and the local environment in which the pathologic process takes place...
  98. pmc Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers
    Brigitte W M Willemse
    Department of Pathology, University Medical Centre Groningen, Groningen, The Netherlands
    Respir Res 6:38. 2005
    ..The exact role of smoking as promoting factor of inflammation in chronic obstructive pulmonary disease is not clear, partly because studies often do not distinguish between current and ex-smokers...
  99. pmc Microarray amplification bias: loss of 30% differentially expressed genes due to long probe - poly(A)-tail distances
    Mirjam C Boelens
    Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    BMC Genomics 8:277. 2007
    ..Since amplification induces truncation of RNA molecules, we studied the impact of a second round of amplification on identification of differentially expressed genes in relation to the probe - poly(A)-tail distances...
  100. ncbi request reprint Universal risk factors for multifactorial diseases: LifeLines: a three-generation population-based study
    Ronald P Stolk
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Epidemiol 23:67-74. 2008
    ..LifeLines will contribute to the understanding of how universal risk factors are modified to influence the individual susceptibility to multifactorial diseases, not only at one stage of life but cumulatively over time: the lifeline...
  101. ncbi request reprint The role of endogenous and exogenous AMP in asthma and chronic obstructive pulmonary disease
    Maarten van den Berge
    Department of Pulmonology, University Hospital Groningen, The Netherlands
    J Allergy Clin Immunol 114:737-46. 2004
    ..The aim of this article was to review the literature assessing AMP's value in asthma and chronic obstructive pulmonary disease...