R Jeroen Pasterkamp

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi request reprint MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat
    R Jeroen Pasterkamp
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell Neurosci 31:52-69. 2006
  2. pmc Semaphorins in axon regeneration: developmental guidance molecules gone wrong?
    R Jeroen Pasterkamp
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Philos Trans R Soc Lond B Biol Sci 361:1499-511. 2006
  3. pmc Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting
    Sharon M Kolk
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    J Neurosci 29:12542-57. 2009
  4. doi request reprint Screening for rare variants in the coding region of ALS-associated genes at 9p21.2 and 19p13.3
    Max Koppers
    Rudolf Magnus Institute of Neuroscience, Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurobiol Aging 34:1518.e5-7. 2013
  5. doi request reprint ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN
    Ewout J N Groen
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Hum Mol Genet 22:3690-704. 2013
  6. doi request reprint CGG-repeat expansion in FMR1 is not associated with amyotrophic lateral sclerosis
    Ewout J N Groen
    Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurobiol Aging 33:1852.e1-3. 2012
  7. pmc MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis
    Yeping Zhou
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Mol Cell Biol 31:3603-15. 2011
  8. pmc Expression patterns of semaphorin7A and plexinC1 during rat neural development suggest roles in axon guidance and neuronal migration
    R Jeroen Pasterkamp
    Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 1001 PCTB, 725 North Wolfe Street, Baltimore, MD 21205, USA
    BMC Dev Biol 7:98. 2007
  9. pmc Spatiotemporal expression of repulsive guidance molecules (RGMs) and their receptor neogenin in the mouse brain
    Dianne M A Van den Heuvel
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e55828. 2013
  10. pmc Protein aggregation in amyotrophic lateral sclerosis
    Anna M Blokhuis
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Acta Neuropathol 125:777-94. 2013

Collaborators

Detail Information

Publications36

  1. ncbi request reprint MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat
    R Jeroen Pasterkamp
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell Neurosci 31:52-69. 2006
    ..These results implicate MICALs in neuronal regeneration and support the possibility of employing EGCG to attenuate Sema3-mediated axon repulsion in the injured spinal cord...
  2. pmc Semaphorins in axon regeneration: developmental guidance molecules gone wrong?
    R Jeroen Pasterkamp
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Philos Trans R Soc Lond B Biol Sci 361:1499-511. 2006
    ....
  3. pmc Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting
    Sharon M Kolk
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    J Neurosci 29:12542-57. 2009
    ..In all, this study provides a framework for additional dissection of the molecular basis of mdDA pathway development and disease...
  4. doi request reprint Screening for rare variants in the coding region of ALS-associated genes at 9p21.2 and 19p13.3
    Max Koppers
    Rudolf Magnus Institute of Neuroscience, Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurobiol Aging 34:1518.e5-7. 2013
    ..None of the genes showed significant enrichment of rare variants in the coding sequence. Rare variants in the coding region of UNC13a, IFNK, MOBKL2b, and C9ORF72 are unlikely to be a genetic cause of ALS...
  5. doi request reprint ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN
    Ewout J N Groen
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Hum Mol Genet 22:3690-704. 2013
    ....
  6. doi request reprint CGG-repeat expansion in FMR1 is not associated with amyotrophic lateral sclerosis
    Ewout J N Groen
    Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurobiol Aging 33:1852.e1-3. 2012
    ..The present investigation involves screening FMR1 repeat length in 742 sporadic ALS patients and 792 matched controls. Our conclusion is that FMR1 repeat expansions are not associated with ALS...
  7. pmc MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis
    Yeping Zhou
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Mol Cell Biol 31:3603-15. 2011
    ..Our findings unveil a previously unknown biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling...
  8. pmc Expression patterns of semaphorin7A and plexinC1 during rat neural development suggest roles in axon guidance and neuronal migration
    R Jeroen Pasterkamp
    Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 1001 PCTB, 725 North Wolfe Street, Baltimore, MD 21205, USA
    BMC Dev Biol 7:98. 2007
    ..To gain further insight into the function(s) of Sema7A and plexinC1 during neural development, we present here a detailed analysis of Sema7A and plexinC1 expression in the developing rat nervous system...
  9. pmc Spatiotemporal expression of repulsive guidance molecules (RGMs) and their receptor neogenin in the mouse brain
    Dianne M A Van den Heuvel
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e55828. 2013
    ..Overall, the results presented here will serve as a framework for further dissection of the role of RGM-Neogenin signaling during neural development...
  10. pmc Protein aggregation in amyotrophic lateral sclerosis
    Anna M Blokhuis
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Acta Neuropathol 125:777-94. 2013
    ..Further insight into protein aggregation will not only deepen our understanding of ALS pathogenesis but also may provide novel avenues for therapeutic intervention...
  11. doi request reprint Semaphorin7A and its receptors: pleiotropic regulators of immune cell function, bone homeostasis, and neural development
    Bart C Jongbloets
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Utrecht, The Netherlands
    Semin Cell Dev Biol 24:129-38. 2013
    ..Furthermore, we discuss a potential role for Sema7A in disease and provide directions for further research...
  12. doi request reprint Getting neural circuits into shape with semaphorins
    R Jeroen Pasterkamp
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Nat Rev Neurosci 13:605-18. 2012
    ..This Review discusses recent advances in semaphorin research, focusing on novel aspects of neuronal semaphorin receptor regulation and previously unexplored cellular functions of semaphorins in the nervous system...
  13. doi request reprint VCP mutations in familial and sporadic amyotrophic lateral sclerosis
    Max Koppers
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurobiol Aging 33:837.e7-13. 2012
    ..Conservation analysis and protein prediction software indicate the p.I114V mutation to be a rare benign polymorphism. VCP mutations are a rare cause of familial ALS. The role of VCP mutations in sporadic ALS, if present, appears limited...
  14. doi request reprint NIPA1 polyalanine repeat expansions are associated with amyotrophic lateral sclerosis
    Hylke M Blauw
    Department of Neurology, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands
    Hum Mol Genet 21:2497-502. 2012
    ..6 years earlier. Our data show that NIPA1 polyalanine repeat expansions are a common risk factor for ALS and modulate disease course...
  15. pmc MICALs in control of the cytoskeleton, exocytosis, and cell death
    Yeping Zhou
    Department of Neuroscience and Pharmacology, University Medical Center Utrecht, STR 4 229, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Cell Mol Life Sci 68:4033-44. 2011
    ..These discoveries could lead to therapeutic advances in neural regeneration, cancer, and other diseases...
  16. pmc Semaphorin function in neural plasticity and disease
    R Jeroen Pasterkamp
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Opin Neurobiol 19:263-74. 2009
    ..A detailed understanding of how semaphorins function beyond initial phases of neural network assembly is revealing novel insights into key aspects of nervous system physiology and pathology...
  17. doi request reprint Semaphorin signaling: progress made and promises ahead
    Yeping Zhou
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, Utrecht, The Netherlands
    Trends Biochem Sci 33:161-70. 2008
    ..These discoveries could lead to therapeutic advances in axonal regeneration, cancer and other diseases...
  18. pmc MeCP2 deficiency disrupts axonal guidance, fasciculation, and targeting by altering Semaphorin 3F function
    Alicia L Degano
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell Neurosci 42:243-54. 2009
    ..These findings have broad implications for the role of MECP2 in neurodevelopment and RTT, given the critical role of the semaphorins in the formation of neural circuits...
  19. ncbi request reprint Axon guidance in the dopamine system
    Asheeta A Prasad
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Adv Exp Med Biol 651:91-100. 2009
    ....
  20. ncbi request reprint MICAL flavoprotein monooxygenases: structure, function and role in semaphorin signaling
    Sharon M Kolk
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Adv Exp Med Biol 600:38-51. 2007
    ..This review summarizes our current understanding of MICALs, with an emphasis on their role in semaphorin signaling...
  21. ncbi request reprint MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion
    Jonathan R Terman
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Cell 109:887-900. 2002
    ..These results suggest a novel role for oxidoreductases in repulsive neuronal guidance...
  22. ncbi request reprint The intracellular redox protein MICAL-1 regulates the development of hippocampal mossy fibre connections
    Eljo Y van Battum
    1 Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands 2
    Nat Commun 5:4317. 2014
    ....
  23. pmc Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response
    Anne A Kan
    Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Cell Mol Life Sci 69:3127-45. 2012
    ..Overall, this work extends the current concepts of human mTLE pathogenesis to the level of miRNA-mediated gene regulation...
  24. doi request reprint Semaphorin signaling: molecular switches at the midline
    Alwin A H A Derijck
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Trends Cell Biol 20:568-76. 2010
    ....
  25. ncbi request reprint Semaphorin junction: making tracks toward neural connectivity
    R Jeroen Pasterkamp
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Curr Opin Neurobiol 13:79-89. 2003
    ..Our understanding of the intracellular signal transduction machinery linking semaphorins to actin dynamics is limited; however, recent advances provide a more comprehensive view of the molecular basis of neuronal semaphorin signaling...
  26. doi request reprint Axon guidance proteins: novel therapeutic targets for ALS?
    Ewoud R E Schmidt
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Prog Neurobiol 88:286-301. 2009
    ..Finally, we discuss the therapeutic potential of axon guidance proteins in understanding and treating the changes in motor neuron connectivity that underlie this debilitating disease...
  27. doi request reprint Getting connected in the dopamine system
    Dianne M A Van den Heuvel
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Prog Neurobiol 85:75-93. 2008
    ....
  28. ncbi request reprint Semaphorin 7A promotes axon outgrowth through integrins and MAPKs
    R Jeroen Pasterkamp
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Nature 424:398-405. 2003
    ....
  29. pmc Endocannabinoids in amygdala and nucleus accumbens mediate social play reward in adolescent rats
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    J Neurosci 32:14899-908. 2012
    ....
  30. doi request reprint UNC13A is a modifier of survival in amyotrophic lateral sclerosis
    Frank P Diekstra
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
    Neurobiol Aging 33:630.e3-8. 2012
    ..In both cohorts, the minor allele of rs12608932 in UNC13A was not only associated with susceptibility but also with shorter survival of ALS patients. Our results further corroborate the role of UNC13A in ALS pathogenesis...
  31. pmc Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretion
    Marijke W A de Backer
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, Utrecht University Medical Centre Utrecht, Utrecht, The Netherlands
    BMC Neurosci 11:94. 2010
    ..To study the roles of the different neuropeptides encoded by one large precursor we developed a method to overexpress minigenes and establish local secretion...
  32. pmc Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development
    Koushik Chakrabarty
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    Biol Open 1:693-704. 2012
    ..Furthermore, we provide evidence of two divergent regulatory pathways resulting in the expression of Chrna6 and Chrnb3 respectively...
  33. ncbi request reprint R-Ras fills another GAP in semaphorin signalling
    R Jeroen Pasterkamp
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Trends Cell Biol 15:61-4. 2005
    ..These results indicate that plexins not only bind to but also regulate directly the activity of some of their downstream effectors...
  34. pmc High-resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling molecule
    Christian Siebold
    Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, University of Oxford, UK
    Proc Natl Acad Sci U S A 102:16836-41. 2005
    ....
  35. ncbi request reprint Soluble CD100 functions on human monocytes and immature dendritic cells require plexin C1 and plexin B1, respectively
    Isabelle Chabbert-de Ponnat
    INSERM U448, Faculty of Medicine, 8 rue du General Sarrail, 94010 Creteil Cedex, France
    Int Immunol 17:439-47. 2005
    ..Together these results suggest that sCD100 plays a critical role in the regulation of antigen-presenting cell migration and functions via a tightly regulated process of receptor expression...
  36. ncbi request reprint Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin
    Kazuhiro Suzuki
    Department of Molecular Immunology and CREST Program of JST, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nature 446:680-4. 2007
    ..These findings not only identify a function of Sema7A as an effector molecule in T-cell-mediated inflammation, but also reveal a mechanism of integrin-mediated immune regulation...