Research Topics
Genomes and Genes
| R Jeroen PasterkampSummaryAffiliation: University Medical Center Utrecht Country: The Netherlands Publications
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Detail Information
Publications
Semaphorins in axon regeneration: developmental guidance molecules gone wrong?R Jeroen Pasterkamp
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Philos Trans R Soc Lond B Biol Sci 361:1499-511. 2006....
MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the ratR Jeroen Pasterkamp
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Mol Cell Neurosci 31:52-69. 2006..These results implicate MICALs in neuronal regeneration and support the possibility of employing EGCG to attenuate Sema3-mediated axon repulsion in the injured spinal cord...- Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targetingSharon M Kolk
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
J Neurosci 29:12542-57. 2009..In all, this study provides a framework for additional dissection of the molecular basis of mdDA pathway development and disease... 
CGG-repeat expansion in FMR1 is not associated with amyotrophic lateral sclerosisEwout J N Groen
Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
Neurobiol Aging 33:1852.e1-3. 2012..The present investigation involves screening FMR1 repeat length in 742 sporadic ALS patients and 792 matched controls. Our conclusion is that FMR1 repeat expansions are not associated with ALS...- MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosisYeping Zhou
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Mol Cell Biol 31:3603-15. 2011..Our findings unveil a previously unknown biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling... - Expression patterns of semaphorin7A and plexinC1 during rat neural development suggest roles in axon guidance and neuronal migrationR Jeroen Pasterkamp
Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 1001 PCTB, 725 North Wolfe Street, Baltimore, MD 21205, USA
BMC Dev Biol 7:98. 2007..To gain further insight into the function(s) of Sema7A and plexinC1 during neural development, we present here a detailed analysis of Sema7A and plexinC1 expression in the developing rat nervous system... - Screening for rare variants in the coding region of ALS-associated genes at 9p21.2 and 19p13.3Max Koppers
Rudolf Magnus Institute of Neuroscience, Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
Neurobiol Aging 34:1518.e5-7. 2013..None of the genes showed significant enrichment of rare variants in the coding sequence. Rare variants in the coding region of UNC13a, IFNK, MOBKL2b, and C9ORF72 are unlikely to be a genetic cause of ALS... - Getting neural circuits into shape with semaphorinsR Jeroen Pasterkamp
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Nat Rev Neurosci 13:605-18. 2012..This Review discusses recent advances in semaphorin research, focusing on novel aspects of neuronal semaphorin receptor regulation and previously unexplored cellular functions of semaphorins in the nervous system... - NIPA1 polyalanine repeat expansions are associated with amyotrophic lateral sclerosisHylke M Blauw
Department of Neurology, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands
Hum Mol Genet 21:2497-502. 2012..6 years earlier. Our data show that NIPA1 polyalanine repeat expansions are a common risk factor for ALS and modulate disease course... - VCP mutations in familial and sporadic amyotrophic lateral sclerosisMax Koppers
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Neurobiol Aging 33:837.e7-13. 2012..Conservation analysis and protein prediction software indicate the p.I114V mutation to be a rare benign polymorphism. VCP mutations are a rare cause of familial ALS. The role of VCP mutations in sporadic ALS, if present, appears limited... - Semaphorin signaling: progress made and promises aheadYeping Zhou
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, Utrecht, The Netherlands
Trends Biochem Sci 33:161-70. 2008..These discoveries could lead to therapeutic advances in axonal regeneration, cancer and other diseases... - MICALs in control of the cytoskeleton, exocytosis, and cell deathYeping Zhou
Department of Neuroscience and Pharmacology, University Medical Center Utrecht, STR 4 229, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Cell Mol Life Sci 68:4033-44. 2011..These discoveries could lead to therapeutic advances in neural regeneration, cancer, and other diseases... - Semaphorin function in neural plasticity and diseaseR Jeroen Pasterkamp
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Curr Opin Neurobiol 19:263-74. 2009..A detailed understanding of how semaphorins function beyond initial phases of neural network assembly is revealing novel insights into key aspects of nervous system physiology and pathology... - Axon guidance in the dopamine systemAsheeta A Prasad
Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
Adv Exp Med Biol 651:91-100. 2009.... - MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsionJonathan R Terman
Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Cell 109:887-900. 2002..These results suggest a novel role for oxidoreductases in repulsive neuronal guidance... - MeCP2 deficiency disrupts axonal guidance, fasciculation, and targeting by altering Semaphorin 3F functionAlicia L Degano
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Mol Cell Neurosci 42:243-54. 2009..These findings have broad implications for the role of MECP2 in neurodevelopment and RTT, given the critical role of the semaphorins in the formation of neural circuits... - MICAL flavoprotein monooxygenases: structure, function and role in semaphorin signalingSharon M Kolk
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Adv Exp Med Biol 600:38-51. 2007..This review summarizes our current understanding of MICALs, with an emphasis on their role in semaphorin signaling... - Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune responseAnne A Kan
Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
Cell Mol Life Sci 69:3127-45. 2012..Overall, this work extends the current concepts of human mTLE pathogenesis to the level of miRNA-mediated gene regulation... - Axon guidance proteins: novel therapeutic targets for ALS?Ewoud R E Schmidt
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Prog Neurobiol 88:286-301. 2009..Finally, we discuss the therapeutic potential of axon guidance proteins in understanding and treating the changes in motor neuron connectivity that underlie this debilitating disease... - Getting connected in the dopamine systemDianne M A Van den Heuvel
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Prog Neurobiol 85:75-93. 2008.... - Semaphorin signaling: molecular switches at the midlineAlwin A H A Derijck
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Trends Cell Biol 20:568-76. 2010.... - Semaphorin junction: making tracks toward neural connectivityR Jeroen Pasterkamp
Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
Curr Opin Neurobiol 13:79-89. 2003..Our understanding of the intracellular signal transduction machinery linking semaphorins to actin dynamics is limited; however, recent advances provide a more comprehensive view of the molecular basis of neuronal semaphorin signaling... - Semaphorin 7A promotes axon outgrowth through integrins and MAPKsR Jeroen Pasterkamp
Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
Nature 424:398-405. 2003.... - Spatiotemporal expression of repulsive guidance molecules (RGMs) and their receptor neogenin in the mouse brainDianne M A Van den Heuvel
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
PLoS ONE 8:e55828. 2013..Overall, the results presented here will serve as a framework for further dissection of the role of RGM-Neogenin signaling during neural development... - Endocannabinoids in amygdala and nucleus accumbens mediate social play reward in adolescent ratsViviana Trezza
Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
J Neurosci 32:14899-908. 2012.... - UNC13A is a modifier of survival in amyotrophic lateral sclerosisFrank P Diekstra
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
Neurobiol Aging 33:630.e3-8. 2012..In both cohorts, the minor allele of rs12608932 in UNC13A was not only associated with susceptibility but also with shorter survival of ALS patients. Our results further corroborate the role of UNC13A in ALS pathogenesis... - Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretionMarijke W A de Backer
Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, Utrecht University Medical Centre Utrecht, Utrecht, The Netherlands
BMC Neurosci 11:94. 2010..To study the roles of the different neuropeptides encoded by one large precursor we developed a method to overexpress minigenes and establish local secretion... - R-Ras fills another GAP in semaphorin signallingR Jeroen Pasterkamp
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Trends Cell Biol 15:61-4. 2005..These results indicate that plexins not only bind to but also regulate directly the activity of some of their downstream effectors... - Soluble CD100 functions on human monocytes and immature dendritic cells require plexin C1 and plexin B1, respectivelyIsabelle Chabbert-de Ponnat
INSERM U448, Faculty of Medicine, 8 rue du General Sarrail, 94010 Creteil Cedex, France
Int Immunol 17:439-47. 2005..Together these results suggest that sCD100 plays a critical role in the regulation of antigen-presenting cell migration and functions via a tightly regulated process of receptor expression... - High-resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling moleculeChristian Siebold
Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, University of Oxford, UK
Proc Natl Acad Sci U S A 102:16836-41. 2005.... - Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrinKazuhiro Suzuki
Department of Molecular Immunology and CREST Program of JST, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
Nature 446:680-4. 2007..These findings not only identify a function of Sema7A as an effector molecule in T-cell-mediated inflammation, but also reveal a mechanism of integrin-mediated immune regulation...