Matthijs Oudkerk

..To evaluate whether mangafodipir trisodium (Mn-DPDP)-enhanced magnetic resonance (MR) imaging surpasses dual-phase spiral computed tomography (CT) in differentiating focal liver lesions...

..We aimed to assess the diagnostic accuracy of magnetic resonance angiography (MRA) for the diagnosis of pulmonary embolism, using conventional pulmonary angiography as a reference method...

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..96 and 0.29. In patients with an inconclusive diagnosis of myocardial ischemia a MDCT CAC score of less than 11 reliably rules out myocardial ischemia detected by dobutamine CMR...

..To evaluate prospectively the value of size, shape, margin and density in discriminating between benign and malignant CT screen detected solid non-calcified pulmonary nodules...

..This study compared CAC and TAC as independent predictors of all-cause mortality and cardiovascular events in a population of heavy smokers using low-dose, non-gated CT...

..In conclusion, the quantitative analysis together with the qualitative analysis rules out artefact-induced stenosis...

..To retrospectively evaluate the performance of consensus double reading compared with single reading at baseline screening of a lung cancer computed tomography (CT) screening trial...

..We investigated the association between Lp-PLA2 activity and coronary calcification assessed by electron-beam computed tomography (EBT) in a population of older participants...

..It is shown that for both general and special populations a zero score excludes most clinically relevant coronary artery disease. The importance of standardization of coronary artery calcium measurements by multidetector CT is discussed...

..This fast examination can play an important role in the evaluation of patients without prior myocardial infarctions and a necessity to exclude ischemia...

..In conclusion, the concentrations of Cho, Cr and NAA are reduced in PPMS/SPMS patients, especially in GM and in WML. Despite contrary observations in previous studies, increases in the concentrations of Cr and/or Cho were not observed...

..Furthermore, for all systems significant differences were found between mass scores and the physical calcium mass; however, the differences were relatively small and consistent...

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..If a bronchoscopic evaluation could be eliminated, the cost-effectiveness of a screening program could be enhanced and the potential harms of bronchoscopy avoided...

..Consequently, early onset of calcification in coronary plaque will remain invisible when using CT and a zero calcium score can not exclude the presence of coronary calcification...

..The purpose of this study was to investigate the noninvasive quantification of coronary artery stenosis using cardiac software packages and vessel phantoms with known stenosis severity...

..Smoking is a major risk factor for both cancer and chronic obstructive pulmonary disease (COPD). Computed tomography (CT)-based lung cancer screening may provide an opportunity to detect additional individuals with COPD at an early stage...

..70, P<.00001; correlation across four subjects, 144 data pairs). This is the first association of neuron metabolite contents in volunteers with structure as indicated by DTI...

..Remarkably, it is absent in the aorta and the lower-extremity vessels. Factors causing this site-specific gender difference require further investigation...

..To determine the optimal cutoff of choline (Cho) concentration in quantitative multivoxel magnetic resonance (MR) spectroscopic data to safely prove benignancy in breast lesions...

..To assess volumetric measurement variability in pulmonary nodules detected at low-dose chest CT with three reconstruction settings...

..In the Kreeftenberg method combining the results of three suboptimal sequences, leads to underestimation of the liver iron concentration...

..The aim was to demonstrate that mono-exponential diffusion in the liver is contaminated by microperfusion and that the bi-exponential model is required...

..88; P<0.00001) than in GM (r=-0.69, P<0.01). The demonstrated relationship between DTI parameters and water content in multiple sclerosis patients suggests a potential for therapy monitoring in normal-appearing brain tissue...

..This is clearly shown by the successful VA in all patients. Potential clinical value of VA should be determined in the near future...

..These preliminary results provide evidence of a neuroprotective effect of fluoxetine in MS by the observed partial normalization of the structure-related MRS parameter N-acetylaspartate in white matter lesions...

..In computed tomography lung cancer screening programs, up to 30% of all resections are futile...

..To evaluate performance of computer-aided detection (CAD) beyond double reading for pulmonary nodules on low-dose computed tomography (CT) by nodule volume...

..We investigated the association of CRP with extent and progression of atherosclerosis in multiple vessel beds in a large, population-based cohort study...

..Evaluation of the image quality of coronary artery stents at various heart rates using Multi Detector Computed Tomography (MDCT)...

..To retrospectively assess volume measurement variability in solid pulmonary nodules (volume, 15-500 mm(3)) detected at lung cancer screening and to quantify the independent effects of nodule morphology, size, and location...

..Risk stratification by assessment of coronary calcification may have an important role in the primary prevention of coronary heart disease events in the elderly...

..The importance of standardization of coronary artery calcium measurements by multi-detector CT is discussed...

..The purpose of this study was to investigate the influence of heart rate, slice thickness, and calcification density on absolute value and variability of calcium score using 64-slice multidetector computed tomography (MDCT)...

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..To assess the sensitivity of detection and accuracy of volumetry by manual and semi-automated quantification of artificial pulmonary nodules in an anthropomorphic thoracic phantom on low-dose CT...

..Whether newer risk markers for coronary heart disease (CHD) improve CHD risk prediction remains unclear...

..To evaluate the additional value of computer-aided detection (CAD) in breast MRI by assessing radiologists' accuracy in discriminating benign from malignant breast lesions...

..The purpose of this study was to determine the association of coronary artery calcification (CAC) with incident heart failure in the elderly and examine its independence of overt coronary heart disease (CHD)...

..The authors believe that volume rendering of the whole heart is useful for anatomic evaluation of the coronary arteries. For more detailed observation of specific lesions, slab imaging with volume rendering or MIP is required...

..Best results were obtained at TE=135 ms, relating to the fact that at that particular TE, the visibility of a compound with a T2 of 215 ms still is good, while interfering signals from short-TE compounds are negligible...

..We compared nodule volumes measured with iterative reconstruction and FBP at different CT parameters...

..To determine the correlation between CT measurements of emphysema or peripheral airways and airflow obstruction in chronic obstructive pulmonary disease (COPD)...

..The purpose of this study was to assess the feasibility of noninvasive thermometry using high-resolution computer tomography (CT) for the monitoring of bovine liver during radiofrequency (RF) ablation...

..Successful treatment of hypertension may reduce this risk; however, a potential negative effect of decreasing diastolic blood pressure level on the occurrence of severe periventricular white matter lesions should be taken into account...

..67%) and almost no effect on the Agatston score. Parameter settings in software for quantification for coronary calcification affect the calcium score outcome. Therefore, parameter settings for calcium scoring should be standardized...

..Evolution in techniques and increase in sensitivity and specificity are clearly seen in all imaging modalities, thus increasing the clinical relevance and the ability to replace conventional coronary angiography...

..In this study long-term reproducibility of STIR image intensity was assessed under clinical conditions and the required image intensity nonuniformity correction was improved by using phantom scans obtained at multiple positions...

..These factors may be crucial in the differentiation between benign and malignant lesions...

..Age >70 years, prior myocardial infarction and rest wall motion abnormalities showed no significant differences with side effects (P>0.05). Dobutamine CMR is safe and feasible in patients with suspicion of myocardial ischemia...

..53 units, 0.05-1.02). Both high and declining diastolic blood pressure levels are associated with more global brain atrophy on MRI...

..Furthermore, the quality assurance measures and the NELSON management system (NMS) are presented...

..To prospectively assess the short inversion time inversion-recovery (STIR) magnetic resonance (MR) signal intensity changes of denervated and reinnervated skeletal muscle over time in clinical patients...

..We aimed to determine the diagnostic performance of human observers to visually evaluate COPD presence on CT images, in comparison to automated evaluation using quantitative CT measures...

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..Since renal function diminishes with aging we examined the association between GFR and CAC in the Rotterdam Study, a population-based study of elderly individuals...

..5 to 5.0) to 4.6% for SV (limits of agreement -7.2 to 15.0). Analysis of every second slice for quantification of global LV function is time-saving and as accurate as analysis of consecutive slices...

..The risk of extensive coronary calcification was 50% lower in individuals who consumed 1 to 2 alcoholic drinks per day than in nondrinkers...

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..To calculate the sensitivity and specificity of computed tomographic (CT) angiography in the diagnosis of cerebral aneurysms in patients with acute subarachnoid hemorrhage (SAH) at presentation...

..79; n=13; P=.001). It is concluded that in patients without inflammation and in patients with hematologic disease, the content of ferritin in blood is a better predictor of liver iron content than in other patient categories...

..To assess the effect of aging on the proportions of choline (Cho), creatine, and N-acetylaspartate (NAA) in the brains of elderly women and men...

..MDCT offers an accurate diagnostic modality to visualize the origin and course of anomalous coronary arteries by a three-dimensional display of anatomy. Shortcomings in CAG can be overcome by the use of contrast-enhanced MDCT...

..CONCLUSIONS: Rose questionnaire angina pectoris is strongly associated with the amount of coronary calcification. Rose questionnaire angina pectoris corresponds better with the amount of coronary calcification in men than in women...

..The short T2 of choline in tumor and edema implies that short-echo-time 1H chemical shift imaging is most suited in the use of choline elevation as tumor marker...

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..To compare the accuracy of electron-beam computed tomography (CT) with 3.0- and 1.5-mm section thickness for calcium quantification and the prevalence of coronary calcifications with each...

..Therefore, this study proves that from the actual acquisition time per heart cycle one cannot determine an actual acquisition time, but only a mathematical acquisition time...

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..CONCLUSIONS: The incidence of silent brain infarcts on MRI in the general elderly population strongly increases with age. The cardiovascular risk factors for silent brain infarcts are similar to those for stroke...

..Given that each technique has its inherent strengths and weaknesses, the combination of the methods will result in improved diagnosis, staging, and treatment prediction and monitoring...

..Our purpose was to determine whether perfusion MR imaging can be used to differentiate benign and malignant meningiomas on the basis of the differences in perfusion of tumor parenchyma and/or peritumoral edema...

..17 (0.79-1.74), 1.58 (1.07-2.34) and 2.12 (1.40-3.20), respectively. CONCLUSIONS: In this large population-based study performed in elderly subjects aortic stiffness was strongly and independently associated with coronary atherosclerosis...

..This is of interest in view of previous reports in which Cho increases were associated with demyelination and the subsequent breakdown of neurons...

..The results suggest that coronary calcification as detected by electron-beam CT may be useful to identify subjects at high risk of stroke...

..In the current review, the design of the NELSON study including participant selection and the lung nodule management protocol, as well as results on validation of CT screening and first results on lung cancer screening are described...

..To retrospectively determine interobserver variability of semiautomated volume measurements of pulmonary nodules and the potential reasons for variability...

..20-0.36]) as the average (0.10 points/year [95% confidence interval, 0.09-0.11]). There was no independent relationship between severity of subcortical white matter lesions and rate of cognitive decline...

..The aim of this feasibility study was to assess the effect of a new blood pool contrast agent on magnetic resonance coronary angiography (MRCA) in patients suspected of having coronary artery disease...

..A nonlinear association was found between coronary calcification and the AAI...

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..Previous claims about changes in lactate levels in the visual cortex upon visual stimulation may have been based on such erroneous observations...

..The cardiovascular occurrence-free survival rate was 96.2%. In patients suspected of myocardial ischemia, dobutamine-CMR is able to assess risk levels for coronary events with high accuracy...

..Associations were stronger for risk factors measured at earlier age. Almost 30% of the men and 15% of the women without risk factors had extensive coronary calcification...

..85-0.93) for CCS was superior to 0.69 (95% CI: 0.61-0.78) for exercise testing (P<0.0001). In conclusion, measurement of CCS is an appropriate initial screening test in a well-defined low-risk population with suspected CAD...

..To assess the extent of hyperenhancement in hypertrophic cardiomyopathy (HCM) patients with nonsustained ventricular tachycardia (NSVT) in comparison to patients without NSVT...

..To evaluate 4 doses of gadobenate dimeglumine (Gd-BOPTA) for contrast-enhanced magnetic resonance angiography (CE-MRA) of the pelvic arteries and to compare CE-MRA with unenhanced time-of-flight MRA (2D-TOF-MRA)...

..However, it is not clear which test should be preferred as initial diagnostic test. We evaluated the prevalence of documented coronary artery disease (CAD) according to calcium scores and exercise test results...

..EBT appeared to be a valuable non-invasive method to measure the AVA. EBT measures the anatomical AVA, while with TTE the functional AVA is calculated, which explains the difference in results between the methods...

..84 at the end of the second week (p=0.007). These findings show evidence for a reversible axonal dysfunction in patients with MS and provide a rationale for investigating whether fluoxetine has neuroprotective effects in MS...

..To evaluate contrast-enhanced ultrasonography (CEUS) using SonoVue in the detection of liver metastases in patients with known extrahepatic primary tumors versus the combined gold standard comprising CT, MRI and clinical/histological data...

..As will be demonstrated, some of these techniques are now entering the clinical arena, and it is anticipated that MR imaging (MRI) will have an increasing role in the initial diagnosis and follow-up of patients with acute PE...

..In the present study, DISA SPECT was compared with positron emission tomography (PET) for the detection of myocardial viability in normal and dysfunctional left ventricular (LV) myocardium...