Arie P Otte

Summary

Affiliation: University of Amsterdam
Country: The Netherlands

Publications

  1. ncbi request reprint Gene repression by Polycomb group protein complexes: a distinct complex for every occasion?
    Arie P Otte
    Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands
    Curr Opin Genet Dev 13:448-54. 2003
  2. pmc Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene
    Frank M Raaphorst
    Department of Pathology, VU University Medical Center, BioCentrum Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    Neoplasia 5:481-8. 2003
  3. pmc Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome
    Kathrin Plath
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    J Cell Biol 167:1025-35. 2004
  4. ncbi request reprint Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3
    Tai Lung Cha
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Science 310:306-10. 2005
  5. ncbi request reprint Various expression-augmenting DNA elements benefit from STAR-Select, a novel high stringency selection system for protein expression
    Arie P Otte
    ChromaGenics, Kruislaan 406, 1098 SM, Amsterdam, The Netherlands
    Biotechnol Prog 23:801-7. 2007
  6. ncbi request reprint Distinct expression patterns of polycomb oncoproteins and their binding partners during the germinal center reaction
    Joost C van Galen
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    Eur J Immunol 34:1870-81. 2004
  7. pmc Increased expression of the EZH2 polycomb group gene in BMI-1-positive neoplastic cells during bronchial carcinogenesis
    Roderick H J Breuer
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    Neoplasia 6:736-43. 2004
  8. ncbi request reprint A panel of monoclonal antibodies against human polycomb group proteins
    Karien M Hamer
    Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, 1018 TV Amsterdam, The Netherlands
    Hybrid Hybridomics 21:245-52. 2002
  9. ncbi request reprint Identification of anti-repressor elements that confer high and stable protein production in mammalian cells
    Ted H J Kwaks
    Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands
    Nat Biotechnol 21:553-8. 2003
  10. ncbi request reprint Biochemical analysis of mammalian polycomb group protein complexes and the identification of genetic elements that block polycomb-mediated gene repression
    Richard G Sewalt
    Swammerdam Institute for Life Sciences, University of Amsterdam, 1018 TV Amsterdam, The Netherlands
    Methods Enzymol 377:282-96. 2004

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Gene repression by Polycomb group protein complexes: a distinct complex for every occasion?
    Arie P Otte
    Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands
    Curr Opin Genet Dev 13:448-54. 2003
    ..Because of these dynamic changes, we argue that speaking of a definitive core PRC can be misleading...
  2. pmc Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene
    Frank M Raaphorst
    Department of Pathology, VU University Medical Center, BioCentrum Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    Neoplasia 5:481-8. 2003
    ..These observations suggest that deregulated expression of EZH2 is associated with loss of differentiation and development of poorly differentiated breast cancer in humans...
  3. pmc Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome
    Kathrin Plath
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    J Cell Biol 167:1025-35. 2004
    ..Our results implicate mPRC1 in X inactivation and suggest that the regulated assembly of PcG protein complexes on the Xi contributes to this multistep process...
  4. ncbi request reprint Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3
    Tai Lung Cha
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Science 310:306-10. 2005
    ..Our results imply that Akt regulates the methylation activity, through phosphorylation of EZH2, which may contribute to oncogenesis...
  5. ncbi request reprint Various expression-augmenting DNA elements benefit from STAR-Select, a novel high stringency selection system for protein expression
    Arie P Otte
    ChromaGenics, Kruislaan 406, 1098 SM, Amsterdam, The Netherlands
    Biotechnol Prog 23:801-7. 2007
    ..Our results also show that the novel STAR-Select selection system, which was developed in the context of STAR elements, is also very beneficial for the use of MAR elements...
  6. ncbi request reprint Distinct expression patterns of polycomb oncoproteins and their binding partners during the germinal center reaction
    Joost C van Galen
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    Eur J Immunol 34:1870-81. 2004
    ..We propose that these cells reflect a transitional stage between resting and dividing follicular B lymphocytes, and that they possibly represent the healthy precursors of nodal large B cell lymphomas...
  7. pmc Increased expression of the EZH2 polycomb group gene in BMI-1-positive neoplastic cells during bronchial carcinogenesis
    Roderick H J Breuer
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    Neoplasia 6:736-43. 2004
    ..Because PcG complexes are normally involved in the maintenance of cell characteristics, abnormal PcG expression may contribute to loss of cell identity...
  8. ncbi request reprint A panel of monoclonal antibodies against human polycomb group proteins
    Karien M Hamer
    Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, 1018 TV Amsterdam, The Netherlands
    Hybrid Hybridomics 21:245-52. 2002
    ..The novel MAbs are therefore valuable tools for the cell biological, biochemical, and pathological analysis of human PcG proteins...
  9. ncbi request reprint Identification of anti-repressor elements that confer high and stable protein production in mammalian cells
    Ted H J Kwaks
    Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands
    Nat Biotechnol 21:553-8. 2003
    ..Our results demonstrate the existence of a class of genetic elements that can readily be applied to more efficient transgenic protein production in mammalian cells...
  10. ncbi request reprint Biochemical analysis of mammalian polycomb group protein complexes and the identification of genetic elements that block polycomb-mediated gene repression
    Richard G Sewalt
    Swammerdam Institute for Life Sciences, University of Amsterdam, 1018 TV Amsterdam, The Netherlands
    Methods Enzymol 377:282-96. 2004
  11. pmc The use of a stringent selection system allows the identification of DNA elements that augment gene expression
    Femke Hoeksema
    Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098XH Amsterdam, The Netherlands
    Mol Biotechnol 48:19-29. 2011
    ..Functional analysis showed that the Rb1 DNA fragments contained no enhancer, promoter, or STAR activity. Our data show the potential of a methodology to identify novel gene expression augmenting DNA elements in an unbiased manner...
  12. pmc Expression of the polycomb-group gene BMI1 is related to an unfavourable prognosis in primary nodal DLBCL
    Joost C van Galen
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Clin Pathol 60:167-72. 2007
    ..The BMI1 proto-oncogene was identified as one of the genes present in the signature of the ABC type of DLBCL, associated with a poor prognosis...
  13. pmc Unique polycomb gene expression pattern in Hodgkin's lymphoma and Hodgkin's lymphoma-derived cell lines
    Danny F Dukers
    Department of Pathology, Vrije Universiteit University Medical Center VUMC, Amsterdam, The Netherlands
    Am J Pathol 164:873-81. 2004
    ..We propose that abnormal expression of BMI-1 and its binding partners in H/RS cells contributes to development of HL. However, abnormal expression of BMI-1 in HL is not necessarily associated with down-regulation of p16INK4a...
  14. pmc Site-specific expression of polycomb-group genes encoding the HPC-HPH/PRC1 complex in clinically defined primary nodal and cutaneous large B-cell lymphomas
    Frank M Raaphorst
    Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Am J Pathol 164:533-42. 2004
    ..We propose that distinct expression profiles of PcG genes results in abnormal formation of HPC-HPH/PRC1 PcG complexes, and that this contributes to lymphomagenesis and different clinical behavior of clinically defined LBCLs...
  15. ncbi request reprint Employing epigenetics to augment the expression of therapeutic proteins in mammalian cells
    Ted H J Kwaks
    ChromaGenics, Kruislaan 406, 1098 SM, Amsterdam, The Netherlands
    Trends Biotechnol 24:137-42. 2006
    ..We conclude that employing epigenetic gene regulation tools, in combination with further process optimization, might represent the next step forward in the production of therapeutic proteins...
  16. pmc Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins
    Richard G A B Sewalt
    Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands
    Mol Cell Biol 22:5539-53. 2002
    ..Our findings suggest a role for the SUV39H1 HMTase and histone H3-K9 methylation in the targeting of human HPC/HPH PcG proteins to modified chromatin structures...
  17. ncbi request reprint Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer
    Michele J Hoffmann
    1Department of Urology Heinrich Heine University Düsseldorf, Germany
    Cancer Biol Ther 6:1403-12. 2007
    ..SIRT1 appears to be generally increased in prostate cancers. Intriguingly, our data suggest a direct influence of increased EZH2 on altered DNA methylation patterns in prostate cancer...
  18. doi request reprint PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos
    Mareike Puschendorf
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nat Genet 40:411-20. 2008
    ..Parental epigenetic asymmetry, also observed along cleavage chromosomes, is resolved by the end of the 8-cell stage--concurrent with blastomere polarization--marking the end of the maternal-to-embryonic transition...
  19. ncbi request reprint X chromosome reactivation and regulation in cloned embryos
    Leisha D Nolen
    Department of Cell and Developmental Biology, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104 6148, USA
    Dev Biol 279:525-40. 2005
    ..We conclude that, although SCNT embryos can reactivate, count, and inactivate X chromosomes, they are not able to regulate XCI consistently. These results illustrate the heterogeneity of epigenetic changes found in cloned embryos...
  20. ncbi request reprint Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features
    Geert J L H van Leenders
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur Urol 52:455-63. 2007
    ..In this study, we evaluated the expression of eight members of both PcG complexes in clinicopathologically defined prostate cancer...
  21. pmc The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation
    Sundeep Kalantry
    Department of Genetics and the Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Nat Cell Biol 8:195-202. 2006
    ..Instead, PcG proteins seem to propagate cellular memory by preventing transcriptional activation of facultative heterochromatin during differentiation...
  22. ncbi request reprint Reactivation of the paternal X chromosome in early mouse embryos
    Winifred Mak
    X Inactivation Group, MRC Clinical Sciences Centre, ICSM, Hammersmith Hospital, London, W12 0NN, UK
    Science 303:666-9. 2004
    ..Our observations illustrate that an important component of genome plasticity in early development is the capacity to reverse heritable gene silencing decisions...
  23. ncbi request reprint The polycomb group protein EZH2 is involved in progression of prostate cancer
    Sooryanarayana Varambally
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nature 419:624-9. 2002
    ..Thus, dysregulated expression of EZH2 may be involved in the progression of prostate cancer, as well as being a marker that distinguishes indolent prostate cancer from those at risk of lethal progression...
  24. pmc EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
    Celina G Kleer
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:11606-11. 2003
    ..This study provides compelling evidence for a functional link between dysregulated cellular memory, transcriptional repression, and neoplastic transformation...
  25. ncbi request reprint Role of histone H3 lysine 27 methylation in X inactivation
    Kathrin Plath
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA
    Science 300:131-5. 2003
    ..Together, our results suggest a role for Eed-Ezh2-mediated H3-K27 methylation during initiation of both imprinted and random X inactivation and demonstrate that H3-K27 methylation is not sufficient for silencing of the Xi...
  26. ncbi request reprint Polycomb group gene silencing proteins are concentrated in the perichromatin compartment of the mammalian nucleus
    Dusan Cmarko
    Centre of Electron Microscopy, University of Lausanne, 27 Bugnon, CH 1005 Lausanne, Switzerland
    J Cell Sci 116:335-43. 2003
    ..Implications of these observations for higher order chromatin structure and for the mechanisms of PcG-mediated gene silencing are discussed...
  27. doi request reprint Loss of BMI-1 expression is associated with clinical progress of malignant melanoma
    Ingeborg M Bachmann
    Section for Pathology, The Gade Institute, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Mod Pathol 21:583-90. 2008
    ..Low BMI-1 expression was associated with low p14 and CDK4 but not with p16 expression. Low levels of BMI-1 expression were also significantly associated with decreased patient survival...
  28. doi request reprint Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity
    Mitsuhiro Endoh
    RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro, Tsurumi ku, Yokohama 230 0045, Japan
    Development 135:1513-24. 2008
    ..Collectively, these results indicate that Ring1A/B-mediated Polycomb silencing functions downstream of the core transcriptional regulatory circuitry to maintain ES cell identity...
  29. ncbi request reprint Mitotically stable association of polycomb group proteins eed and enx1 with the inactive x chromosome in trophoblast stem cells
    Winifred Mak
    X Inactivation Group, MRC Clinical Sciences Centre, ICSM, Hammersmith Hospital, London W12 0NN, United Kingdom
    Curr Biol 12:1016-20. 2002
    ..The association of Eed/Enx1 complexes is mitotically stable, suggesting a mechanism for the maintenance of imprinted X inactivation in these cells...
  30. ncbi request reprint Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes
    Jose Silva
    X Inactivation Group, MRC Clinical Sciences Centre, ICSM, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Dev Cell 4:481-95. 2003
    ..Functional analysis demonstrates that Eed-Enx1 is required to establish methylation of histone H3 at lysine 9 and/or lysine 27 on Xi and that this, in turn, is required to stabilize the Xi chromatin structure...
  31. pmc Control of developmental regulators by Polycomb in human embryonic stem cells
    Tong Ihn Lee
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 125:301-13. 2006
    ..These results indicate that PRC2 occupies a special set of developmental genes in ES cells that must be repressed to maintain pluripotency and that are poised for activation during ES cell differentiation...
  32. ncbi request reprint Polycomb complexes repress developmental regulators in murine embryonic stem cells
    Laurie A Boyer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 441:349-53. 2006
    ..Our results indicate that dynamic repression of developmental pathways by Polycomb complexes may be required for maintaining ES cell pluripotency and plasticity during embryonic development...
  33. ncbi request reprint Multiplex biomarker approach for determining risk of prostate-specific antigen-defined recurrence of prostate cancer
    Daniel R Rhodes
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA
    J Natl Cancer Inst 95:661-8. 2003
    ....
  34. ncbi request reprint EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
    Ingeborg M Bachmann
    Gade Institute, Section of Pathology, Bergen, Norway
    J Clin Oncol 24:268-73. 2006
    ..The purpose of this study was to validate previous findings in a population-based setting, also including tumors that have not been studied previously...
  35. ncbi request reprint Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice
    Ikuhiro Okamoto
    CNRS UMR218, Curie Institute, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nature 438:369-73. 2005
    ..We propose that expression of the paternal Xist gene at zygotic gene activation is sufficient to trigger cis-inactivation of the X chromosome, or of an autosome carrying a Xist transgene...
  36. ncbi request reprint Epigenetic dynamics of imprinted X inactivation during early mouse development
    Ikuhiro Okamoto
    CNRS UMR218, Curie Institute, 26 Rue d Ulm, Paris 75005, France
    Science 303:644-9. 2004
    ..This reveals the remarkable plasticity of the X-inactivation process during preimplantation development and underlines the importance of the ICM in global reprogramming of epigenetic marks in the early embryo...
  37. ncbi request reprint The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation
    Nathan D Montgomery
    Department of Genetics, University of North Carolina at Chapel Hill, Call Box 7264, Chapel Hill, North Carolina 27599, USA
    Curr Biol 15:942-7. 2005
    ..These results provide a functionally important distinction between PRC2 complex components and implicate Eed in PRC2-independent histone methylation...
  38. ncbi request reprint Correspondence re: S. Beá et al., BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas. Cancer Res., 61: 2409-2412, 2001
    Frank M Raaphorst
    Cancer Res 62:618-9. 2002