Roel A Ophoff

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc Gene expression profiling in C57BL/6J and A/J mouse inbred strains reveals gene networks specific for brain regions independent of genetic background
    Simone de Jong
    Department of Medical Genetics and Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    BMC Genomics 11:20. 2010
  2. pmc Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients
    Christiaan G J Saris
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands
    BMC Genomics 10:405. 2009
  3. doi request reprint Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis
    Michael A van Es
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Nat Genet 41:1083-7. 2009
  4. ncbi request reprint Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
    Michael A van Es
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands
    Nat Genet 40:29-31. 2008
  5. doi request reprint FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands
    Ewout J N Groen
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands
    Arch Neurol 67:224-30. 2010
  6. pmc Hippocampal gene expression analysis highlights Ly6a/Sca-1 as candidate gene for previously mapped novelty induced behaviors in mice
    Simone de Jong
    Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 6:e20716. 2011
  7. pmc Genome-wide analysis shows increased frequency of copy number variation deletions in Dutch schizophrenia patients
    Jacobine E Buizer-Voskamp
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 70:655-62. 2011
  8. doi request reprint Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis
    Michael A van Es
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Ann Neurol 70:964-73. 2011
  9. pmc Gene-network analysis identifies susceptibility genes related to glycobiology in autism
    Bert van der Zwaag
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 4:e5324. 2009
  10. doi request reprint Do mood symptoms subdivide the schizophrenia phenotype? Association of the GMP6A gene with a depression subgroup
    Marco P M Boks
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:707-11. 2008

Detail Information

Publications18

  1. pmc Gene expression profiling in C57BL/6J and A/J mouse inbred strains reveals gene networks specific for brain regions independent of genetic background
    Simone de Jong
    Department of Medical Genetics and Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    BMC Genomics 11:20. 2010
    ..We performed a whole-genome gene expression experiment and applied a systems biology approach using weighted gene co-expression network analysis...
  2. pmc Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients
    Christiaan G J Saris
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands
    BMC Genomics 10:405. 2009
    ..Since access to spinal cord tissue is not possible at disease onset, we investigated changes in gene expression profiles in whole blood of ALS patients...
  3. doi request reprint Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis
    Michael A van Es
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Nat Genet 41:1083-7. 2009
    ..01 x 10(-8)) in the combined analysis of both stages. These SNPs are located at chromosome 9p21.2, in a linkage region for familial ALS with frontotemporal dementia found previously in several large pedigrees...
  4. ncbi request reprint Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
    Michael A van Es
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands
    Nat Genet 40:29-31. 2008
    ..30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies...
  5. doi request reprint FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands
    Ewout J N Groen
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands
    Arch Neurol 67:224-30. 2010
    ..To assess the frequency of FUS mutations in 52 probands with familial amyotrophic lateral sclerosis (FALS) and to provide careful documentation of clinical characteristics...
  6. pmc Hippocampal gene expression analysis highlights Ly6a/Sca-1 as candidate gene for previously mapped novelty induced behaviors in mice
    Simone de Jong
    Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 6:e20716. 2011
    ..This study shows that gene expression profiling can be used to narrow down a previously identified behavioral QTL in mice, providing support for Ly6a as a candidate gene for functional involvement in novelty responsiveness...
  7. pmc Genome-wide analysis shows increased frequency of copy number variation deletions in Dutch schizophrenia patients
    Jacobine E Buizer-Voskamp
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 70:655-62. 2011
    ....
  8. doi request reprint Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis
    Michael A van Es
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Ann Neurol 70:964-73. 2011
    ..We therefore investigated whether ANG variants could predispose to both ALS and PD...
  9. pmc Gene-network analysis identifies susceptibility genes related to glycobiology in autism
    Bert van der Zwaag
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 4:e5324. 2009
    ..Our findings suggest that the occurrence of genomic gains and losses of genes associated with glycobiology are important contributors to the development of ASD...
  10. doi request reprint Do mood symptoms subdivide the schizophrenia phenotype? Association of the GMP6A gene with a depression subgroup
    Marco P M Boks
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:707-11. 2008
    ..Overall, these finding suggests that investigating subgroups of schizophrenia based symptoms profile and particularly mood symptoms can facilitate genetic studies of schizophrenia...
  11. doi request reprint Finding suitable phenotypes for genetic studies of schizophrenia: heritability and segregation analysis
    Maartje F Aukes
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 64:128-36. 2008
    ..Intermediate phenotypes or endophenotypes may facilitate genetic research if they display a simpler mode of transmission than schizophrenia itself, i.e., if they reflect more closely the underlying genetic effects...
  12. ncbi request reprint [Genetic variation with increased risk of schizophrenia]
    Steven C Bakker
    Universitair Medisch Centrum Utrecht, Afdeling Psychiatrie, Rudolf Magnus Instituut, Utrecht, The Netherlands
    Ned Tijdschr Geneeskd 154:A1909. 2010
    ..Genetic testing of family members of patients may become feasible in the near future. For other clinical applications additional variants need to be identified first...
  13. pmc Association of the PIK4CA schizophrenia-susceptibility gene in adults with the 22q11.2 deletion syndrome
    Jacob A S Vorstman
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 150:430-3. 2009
    ..Second, the results of this study indicate that variation at PIK4CA may be a relevant factor influencing the risk of schizophrenia in individuals with 22q11DS...
  14. doi request reprint Genetic overlap among intelligence and other candidate endophenotypes for schizophrenia
    Maartje F Aukes
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 65:527-34. 2009
    ..Several cognitive endophenotypes, including intelligence, are likely to be modulated by overlapping genetic influences...
  15. pmc The relationship of DNA methylation with age, gender and genotype in twins and healthy controls
    Marco P Boks
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 4:e6767. 2009
    ..The identification of CpG loci of which DNA methylation levels are under genetic control or are related to age or gender will facilitate further studies into the role of DNA methylation and disease...
  16. pmc Paternal age and psychiatric disorders: findings from a Dutch population registry
    Jacobine E Buizer-Voskamp
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Res 129:128-32. 2011
    ..We measured the association between paternal age and schizophrenia (SCZ), autism spectrum disorders (ASD), major depressive disorder (MDD), and bipolar disorder (BPD) in the Dutch population...
  17. doi request reprint A common variant in DRD3 receptor is associated with autism spectrum disorder
    Mariken de Krom
    Department of Neuroscience and Pharmacology and Department of Child and Adolescent Psychiatry, Rudolph Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Biol Psychiatry 65:625-30. 2009
    ..The presence of specific and common genetic etiologies for autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) was investigated for 132 candidate genes in a two-stage design-association study...
  18. ncbi request reprint ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study
    Michael A van Es
    Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
    Lancet Neurol 6:869-77. 2007
    ..ALS is thought to be multifactorial, with both environmental and genetic causes. Our aim was to identify genetic variants that predispose for sporadic ALS...