Research Topics
| Willem A NolenSummaryAffiliation: University of Groningen Country: The Netherlands Publications
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Detail Information
Publications
Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar NetworkWillem A Nolen
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
Am J Psychiatry 161:1447-54. 2004..The purpose of the study was to examine potential correlates of outcome in patients treated for bipolar disorder...
Genetic and environmental influences on focal brain density in bipolar disorderAstrid C van der Schot
Department of Psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
Brain 133:3080-92. 2010....- Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorderRalph W Kupka
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
Bipolar Disord 9:531-5. 2007..To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder... - Lithium augmentation compared with phenelzine in treatment-resistant depression in the elderly: an open, randomized, controlled trialRob M Kok
Department of Old Age Psychiatry, Altrecht Institute of Mental Health Care, Utrecht, The Netherlands
J Clin Psychiatry 68:1177-85. 2007.... - Are the vulnerability effects of personality and psychosocial functioning on depression accounted for by subthreshold symptoms?Jan Spijker
Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands
Depress Anxiety 24:472-8. 2007..This suggests that a depressive episode is interwoven in a long-standing and enduring pattern of mild personality deviance and limitations in psychosocial functioning... - Five-year prospective outcome of psychopathology in the adolescent offspring of bipolar parentsManon Hj Hillegers
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
Bipolar Disord 7:344-50. 2005..The purpose of this study was to determine the prevalence of psychopathology, specifically mood disorders, in adolescents and young adults with a bipolar parent... - Signs of a higher prevalence of autoimmune thyroiditis in female offspring of bipolar parentsManon H J Hillegers
University Medical Centre Utrecht Department of Child and Adolescent Psychiatry, Utrecht, The Netherlands
Eur Neuropsychopharmacol 17:394-9. 2007..Studies are inconsistent as to whether patients with bipolar disorder are more frequently affected by autoimmune thyroiditis... - Long-term response to successful acute pharmacological treatment of psychotic depressionJaap Wijkstra
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
J Affect Disord 123:238-42. 2010..Data about follow-up after acute pharmacological treatment of psychotic depression are scarce... - Impact of stressful life events, familial loading and their interaction on the onset of mood disorders: study in a high-risk cohort of adolescent offspring of parents with bipolar disorderManon H J Hillegers
Altrecht Institute for Mental Health Care, Lange Nieuwstraat 119, 3512 PG Utrecht, The Netherlands
Br J Psychiatry 185:97-101. 2004..Stressful life events are established as risk factors for the onset of mood disorders, but few studies have investigated their impact on the development of mood disorders in adolescents... - Treatment of unipolar psychotic depression: the use of evidence in practice guidelinesJaap Wijkstra
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
World J Biol Psychiatry 10:409-15. 2009..However, most current guidelines recommend the combination over an antidepressant alone... - Haloperidol dose when used as active comparator in randomized controlled trials with atypical antipsychotics in schizophrenia: comparison with officially recommended dosesGerard W K Hugenholtz
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
J Clin Psychiatry 67:897-903. 2006..Therefore, it is probable that the results of the RCTs were affected by the high dose of haloperidol, hampering the interpretation of the effects of atypical anti-psychotics in their comparison with haloperidol... - Rapid and non-rapid cycling bipolar disorder: a meta-analysis of clinical studiesRalph W Kupka
Altrecht Institute for Mental Health Care and University Medical Center Utrecht, Utrecht, The Netherlands
J Clin Psychiatry 64:1483-94. 2003..Several risk factors have been suggested to be associated with rapid cycling. The purpose of this meta-analysis was to compare clinical studies for the evidence of discriminating factors between rapid and non-rapid cycling... - The impact of environmental temperature on lithium serum levelsIngeborg Wilting
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
Bipolar Disord 9:603-8. 2007..Three studies have reported a seasonal variation in lithium serum levels, with higher levels during summer. Our objective was to investigate the impact of actual environmental temperature on lithium serum levels... - Lithium use and the risk of fracturesIngeborg Wilting
Utrecht University, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht, The Netherlands
Bone 40:1252-8. 2007..Our results support the role of the underlying mental disorders in the aetiology of fractures and do not support a pharmacological effect of lithium based on lack of an association with cumulative duration of use... - Evaluation of available treatment guidelines for the management of lithium intoxicationIngeborg Wilting
Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Faculty of Science, Utrecht Institute for Pharmaceutical Sciencest, Utrecht, The Netherlands
Ther Drug Monit 31:247-60. 2009.... - Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorderAstrid C van der Schot
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Arch Gen Psychiatry 66:142-51. 2009..Structural neuroimaging studies suggest the presence of subtle abnormalities in the brains of patients with bipolar disorder. The influence of genetic and/or environmental factors on these brain abnormalities is unknown... - Psychosocial disability before, during, and after a major depressive episode: a 3-wave population-based study of state, scar, and trait effectsJohan Ormel
Department of Psychiatry and the Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, Groningen, The Netherlands
Arch Gen Psychiatry 61:387-92. 2004.... - Pharmacological treatment for unipolar psychotic depression: Systematic review and meta-analysisJaap Wijkstra
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, HP B01 206, PO Box 85500, 3508 GA, Utrecht, The Netherlands
Br J Psychiatry 188:410-5. 2006..The optimal pharmacological treatment of unipolar psychotic depression is uncertain... - Urine osmolality, cyclic AMP and aquaporin-2 in urine of patients under lithium treatment in response to water loading followed by vasopressin administrationIngeborg Wilting
Utrecht University, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht, and Department of Clinical Pharmacy, TweeSteden Hospital, Tilburg, The Netherlands
Eur J Pharmacol 566:50-7. 2007..It remains to be elucidated whether principal cells, G-proteins or adenylate cyclase e.g. are the major targets for the mechanism underlying lithium-induced NDI in man... - Drug-drug interactions as a determinant of elevated lithium serum levels in daily clinical practiceIngeborg Wilting
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
Bipolar Disord 7:274-80. 2005..14 (95% CI 1.15-8.61) for irregularity in lithium dispensing pattern. CONCLUSION: Use of co-medication, especially antibiotics, tends to be associated with elevated lithium serum levels... - Determinants of persistence of major depressive episodes in the general population. Results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS)Jan Spijker
Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands
J Affect Disord 81:231-40. 2004..Data on determinants of persistence of major depressive episodes (MDE) are inconsistent due to methodological shortcomings of the studies involved... - Electroconvulsive therapy has acute immunological and neuroendocrine effects in patients with major depressive disorderSjoerd B A H A Fluitman
The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
J Affect Disord 131:388-92. 2011..Major depressive disorder is associated with alterations in the neuroendocrine as well as immune system. Few studies examined the impact of electroconvulsive therapy (ECT) on these systems in patients with major depressive disorder (MDD)... - Venlafaxine versus nortriptyline in the treatment of elderly depressed inpatients: a randomised, double-blind, controlled trialRob M Kok
Department of Old Age Psychiatry, Altrecht Institute of Mental Health Care, Utrecht, The Netherlands
Int J Geriatr Psychiatry 22:1247-54. 2007..Consequently information is lacking about the more complex cases of elderly depressed patients, as found in inpatient wards... - Risk of hip/femur fractures in patients using antipsychoticsGerard W K Hugenholtz
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
Bone 37:864-70. 2005..We conclude that there is a small increased risk of hip/femur fractures associated with the use of antipsychotics. This risk increases with long-term use... - Successful maintenance electroconvulsive therapy for more than seven yearsJaap Wijkstra
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
J ECT 21:171-3. 2005..Thus M-ECT does not appear to cause cognitive deterioration. M-ECT is being continued on the patient's request... - Multiple dimensions of familial psychopathology affect risk of mood disorder in children of bipolar parentsMarjolein Wals
Altrecht, Institute for Mental Health Care, Utrecht, The Netherlands
Am J Med Genet B Neuropsychiatr Genet 127:35-41. 2004..8 (95% CI = 1.3-2.4) for FL of substance use disorder. Expression of mood disorders in children of bipolar parents varies with the degree of additional FL of unipolar disorder and substance use disorder in the extended family... - Selective prescribing of atypical antipsychoticsNancy S Breekveldt-Postma
PHARMO Institute, Institute for Pharmacology and Outcomes Research, Utrecht, The Netherlands
Pharmacoepidemiol Drug Saf 14:25-30. 2005.... - Bipolar disorder in the general population in The Netherlands (prevalence, consequences and care utilisation): results from The Netherlands Mental Health Survey and Incidence Study (NEMESIS)Margreet Ten Have
Netherlands Institute of Mental Health and Addiction, P O Box 725, 3500 AS, Utrecht, The Netherlands
J Affect Disord 68:203-13. 2002..Little is known about the prevalence of bipolar disorder in the general population, what proportion is receiving care and what factors motivate people to seek help... - Impact of birth weight and genetic liability on psychopathology in children of bipolar parentsMarjolein Wals
Altrecht, Institute for Mental Health Care, Utrecht, The Netherlands
J Am Acad Child Adolesc Psychiatry 42:1116-21. 2003..To test different models for ways in which birth weight and familial loading influence the risk for psychopathology in bipolar offspring... - Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatientsRalph W Kupka
Altrecht Institute for Mental Health Care, Tolsteegsingel 2A, 3582 AC Utrecht, Netherlands
Am J Psychiatry 162:1273-80. 2005..To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective... - Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite studyLori L Altshuler
Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
J Clin Psychiatry 67:1551-60. 2006..Research examining this relationship in persons with bipolar disorder is rare. This study sought to evaluate the association between subsyndromal depressive symptoms and role functioning in subjects with bipolar disorder... - Is autoimmune thyroiditis part of the genetic vulnerability (or an endophenotype) for bipolar disorder?Ronald Vonk
Reinier van Arkel group, s Hertogenbosch, Department of Psychiatry, University Medical Centre Utrecht, The Netherlands
Biol Psychiatry 62:135-40. 2007..This study was intended to examine whether autoimmune thyroiditis is related to the disease itself, to the (genetic) vulnerability to develop bipolar disorder, or both... - Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenonTrisha Suppes
Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
Arch Gen Psychiatry 62:1089-96. 2005..The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved... - Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorderRobert M Post
Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Clin Psychiatry 66:370-4. 2005..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness... - Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trialSusan L McElroy
Psychopharmacology Research Program, Department of Psychiatry, PO Box 670559, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
J Clin Psychiatry 66:617-24. 2005..The response of 62 outpatients with DSM-IV bipolar disorders to open-label adjunctive zonisamide was evaluated in a prospective 8-week acute trial, followed by a 48-week continuation trial, conducted from June 2001 through May 2002... - Early physical and sexual abuse associated with an adverse course of bipolar illnessGabriele S Leverich
Stanley Foundation Bipolar Treatment Outcome Network and the Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3S 239, Bethesda, MD 20892-1272, USA
Biol Psychiatry 51:288-97. 2002.... - Duration of major depressive episodes in the general population: results from The Netherlands Mental Health Survey and Incidence Study (NEMESIS)Jan Spijker
Netherlands Institute of Mental Health and Addiction Trimbos institute, PO Box 725, 3500 AS Utrecht, The Netherlands
Br J Psychiatry 181:208-13. 2002..Data on the duration of major depressive episodes (MDE) in the general population are sparse... - Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorderMark A Frye
Department of Psychiatry and Biobehavioral Sciences, UCLA Bipolar Research Program, University of California Los Angeles School of Medicine, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, CA 90095, USA
Am J Psychiatry 160:883-9. 2003..This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study... - Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart methodRobert M Post
Stanley Foundation Bipolar Network and Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 12723, USA
J Clin Psychiatry 64:680-90; quiz 738-9. 2003..The detailed course and pattern of illness emerging despite comprehensive treatment with mood stabilizers and adjunctive agents have previously not been well delineated... - Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illnessPaul E Keck
Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267-0559, USA
Compr Psychiatry 44:263-9. 2003..The lack of observable prognostic impact may have been, in part, due to the relatively high morbidity and poor functional outcome of a substantial portion of the total cohort... - Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar NetworkGabriele S Leverich
Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
J Clin Psychiatry 64:506-15. 2003..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder... - An imbalance in the production of IL-1beta and IL-6 by monocytes of bipolar patients: restoration by lithium treatmentEsther M Knijff
Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
Bipolar Disord 9:743-53. 2007..To study the ex vivo interleukin (IL)-1beta and IL-6 production of monocytes in bipolar disorder (BD) patients in the absence/presence of lithium... - Are bipolar mood symptoms affected by the phase of the menstrual cycle?Geetha Shivakumar
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
J Womens Health (Larchmt) 17:473-8. 2008..We sought to examine the relationship between bipolar disorder and menstrual cycle-related mood changes. To our knowledge, this is one of the largest samples in the literature addressing this issue... - Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment NetworkTrisha Suppes
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
Int Clin Psychopharmacol 22:376-81. 2007..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted... - The poor prognosis of childhood-onset bipolar disorderGabriele S Leverich
Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
J Pediatr 150:485-90. 2007..We examined age of onset of bipolar disorder as a potential course-of-illness modifier with the hypothesis that early onset will engender more severe illness... - A relative resistance of T cells to dexamethasone in bipolar disorderEsther M Knijff
Department of Immunology, Erasmus MC, 3000 DR Rotterdam, The Netherlands
Bipolar Disord 8:740-50. 2006..In this study, we investigated the in vitro responsiveness of T cells to dexamethasone (DEX) of patients with bipolar disorder (BD)... - Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projectsDorret I Boomsma
Netherlands Twin Register, Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands
Eur J Hum Genet 16:335-42. 2008..Genome-wide association results are open-access and can be viewed at the dbGAP web portal (http://www.ncbi.nlm.nih.gov). Approved users can download the genotype and phenotype data, which have been made available as of 9 October 2007... - ECNP consensus meeting. Bipolar depression. Nice, March 2007Guy M Goodwin
University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
Eur Neuropsychopharmacol 18:535-49. 2008..Assay sensitivity and patient acceptability are enhanced if the outcome in long-term studies is 'time to intervention for a new episode' for discontinuation designs... - Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholismEric Levander
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
J Affect Disord 101:211-7. 2007..This study was undertaken to evaluate the prevalence rate of anxiety comorbidity in bipolar subjects with and without alcohol use disorders (AUD)... - Incidence of childhood-onset bipolar illness in the USA and EuropeRobert M Post
Department of Psychiatry, George Washington University, Washington, DC, USA
Br J Psychiatry 192:150-1. 2008..In the USA there was also twice the incidence of childhood adversity and genetic/familial risk for affective disorder. The findings deserve replication and further exploration... - Treatment with low doses of tranylcypromine resulted in a disappointing remission rateWillem A Nolen
Am J Psychiatry 164:524; author reply 524. 2007 - A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytesRoos C Padmos
Department of Immunology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
Arch Gen Psychiatry 65:395-407. 2008..Mood disturbances are associated with an activated inflammatory response system... - New findings from the Bipolar Collaborative Network: clinical implications for therapeuticsRobert M Post
Penn State College of Medicine, Hershey, PA, USA
Curr Psychiatry Rep 8:489-97. 2006..Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss... - Social functioning of bipolar offspringCatrien G Reichart
Erasmus Medical Center Rotterdam Department of Child and Adolescent Psychiatry, Sophia Children s Hospital, Rotterdam, The Netherlands
J Affect Disord 98:207-13. 2007..The objective of this study was to compare social functioning of adolescent and young adult offspring of bipolar parents with social functioning of adolescents and young adults in the general population... - The use of the GBI in a population of adolescent offspring of parents with a bipolar disorderCatrien G Reichart
Department of Child and Adolescent Psychiatry, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GH Rotterdam, The Netherlands
J Affect Disord 80:263-7. 2004..To assess the psychometric properties and the usefulness of the General Behavior Inventory (GBI) in the adolescent age range... - Earlier onset of bipolar disorder in children by antidepressants or stimulants? An hypothesisCatrien G Reichart
Department of Child and Adolescent Psychiatry, Sophia Children s Hospital Erasmus University of Rotterdam, Dr Molewaterplein 40, Rotterdam 3015 GD, The Netherlands
J Affect Disord 78:81-4. 2004..In those children who are genetically at risk to develop BD, these drugs may lead to a switch into mania... - Psychopathology in the adolescent offspring of bipolar parentsCatrien G Reichart
Department of Child and Adolescent Psychiatry, Sophia Children s Hospital Erasmus University Rotterdam, Dr Molewaterplein 60, 3015 GH Rotterdam, The Netherlands
J Affect Disord 78:67-71. 2004..The aim of this study was to determine the prevalence and 14-months incidence of psychopathology in adolescent offspring of a bipolar parent... - A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar NetworkRobert M Post
Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
Bipolar Disord 5:396-406. 2003..This paper reviews new data on: (1) depression in bipolar illness, (2) switch rates on ADs and (3) risks of AD discontinuation that are pertinent to the ongoing discussion and recommendations... - An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)Robert M Post
Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
Bipolar Disord 5:310-9. 2003..Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed... - Lithium-associated psoriasis and omega-3 fatty acidsGrad W Akkerhuis
Am J Psychiatry 160:1355. 2003 - Impact of antidepressant discontinuation after acute bipolar depression remission on rates of depressive relapse at 1-year follow-upLori Altshuler
Stanley Bipolar Treatment Network, USA
Am J Psychiatry 160:1252-62. 2003..This study examined the effect of antidepressant discontinuation or continuation on depressive relapse risk among bipolar subjects successfully treated for an acute depressive episode... - Prophylactic efficacy of lithium versus carbamazepine in treatment-naive bipolar patientsErwin G Th M Hartong
Institute for Clinical Psychiatric Research IPPO, The Hague, Nijmegen, The Netherlands
J Clin Psychiatry 64:144-51. 2003..Alternatives to lithium for prophylactic treatment of patients with bipolar affective disorders are increasingly being advocated. However, trials comparing lithium with alternatives are scarce and often biased... - High numbers of circulating activated T cells and raised levels of serum IL-2 receptor in bipolar disorderM Nadine Breunis
Department of Immunology, Erasmus University Rotterdam (MNB, HAD, Rotterdam, The Netherlands
Biol Psychiatry 53:157-65. 2003..CONCLUSION: The T cell system was found to be activated in both symptomatic and euthymic patients with bipolar disorder. The pathophysiological significance of these findings remains to be explored... - Tiagabine in treatment refractory bipolar disorder: a clinical case seriesTrisha Suppes
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
Bipolar Disord 4:283-9. 2002..We sought to evaluate the effectiveness of tiagabine added to ongoing medication regimens in patients with bipolar disorder inadequately responsive to or intolerant of usual treatments... - Antidepressants for bipolar depression: a systematic review of randomized, controlled trialsHarm J Gijsman
Department of Psychiatry, Warneford Hospital, Oxford, UK
Am J Psychiatry 161:1537-47. 2004..This study reviewed the evidence from randomized, controlled trials on the efficacy and safety of antidepressants in the short-term treatment of bipolar depression... - A high prevalence of organ-specific autoimmunity in patients with bipolar disorderRoos C Padmos
Department of Immunology, Erasmus Medical Centre, Rotterdam, The Netherlands
Biol Psychiatry 56:476-82. 2004..The level of TPOA was negatively correlated with the serum level of sIL-2R, a measure of T cell activation. CONCLUSION: Bipolar disorder is associated with organ-specific autoimmunity to the antigens TPO, H/K ATPase, and GAD65... - Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorderPaul E Keck
Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and the Mental Health Care Line, Cincinnati, Ohio 45267 0559, USA
Biol Psychiatry 60:1020-2. 2006..The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder... - Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressantsLori L Altshuler
Dept of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 1544, Box 957057, Los Angeles, CA 90095 7057
Am J Psychiatry 163:313-5. 2006..The authors compared the switch rate into hypomania/mania in depressed patients treated with second-generation antidepressants who had either bipolar I or bipolar II disorder... - Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizersGabriele S Leverich
Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
Am J Psychiatry 163:232-9. 2006..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression... - The use of the GBI as predictor of bipolar disorder in a population of adolescent offspring of parents with a bipolar disorderCatrien G Reichart
Erasmus Medical Center Rotterdam Department of Child and Adolescent Psychiatry, Sophia Children s Hospital, Rotterdam, The Netherlands
J Affect Disord 89:147-55. 2005..To assess the usefulness of the General Behavior Inventory (GBI) to predict the development of mood disorders in the offspring of parents with bipolar disorder... - Monocyte-derived dendritic cells in bipolar disorderEsther M Knijff
Department of Immunology, Erasmus Medical Centre, Rotterdam, The Netherlands
Biol Psychiatry 59:317-26. 2006..Dendritic cells (DC) are key regulators of the immune system, which is compromised in patients with bipolar disorder. We sought to study monocyte-derived DC in bipolar disorder... - Correlates of overweight and obesity in 644 patients with bipolar disorderSusan L McElroy
Stanley Foundation Bipolar Treatment Outcome Network, Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267-0559, USA
J Clin Psychiatry 63:207-13. 2002.... - Evidence that the immunopathogenic mechanism of lithium-induced psoriasis differs from that of regular psoriasisEsther M Knijff
Bipolar Disord 7:388-9. 2005 - Stressful life events and onset of mood disorders in children of bipolar parents during 14-month follow-upMarjolein Wals
Erasmus Medical Center Rotterdam Department of Child and Adolescent Psychiatry, Sophia Children s Hospital, Rotterdam, The Netherlands
J Affect Disord 87:253-63. 2005.... - A European perspective on the Canadian guidelines for bipolar disorderEduard Vieta
Bipolar Disorders Program, , University of Barcelona, IDIBAPS, Barcelona, Spain
Bipolar Disord 7:73-6. 2005 - Reproductive function and risk for PCOS in women treated for bipolar disorderNatalie L Rasgon
Department of Psychiatry, Stanford School of Medicine, Palo Alto, CA, USA
Bipolar Disord 7:246-59. 2005..This study examined the reproductive function and prevalence of polycystic ovary syndrome (PCOS) in women with bipolar disorder taking antimanic medications... - High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposureRalph W Kupka
Altrecht Centre for Mental Health Care and University Medical Centre Utrecht, Vrouwjuttenhof 18, 3512 PZ Utrecht, The Netherlands
Biol Psychiatry 51:305-11. 2002..These variables appear to be independent risk factors for the development of hypothyroidism, especially in women with bipolar disorder...