Willem A Nolen

Summary

Affiliation: University of Groningen
Country: The Netherlands

Publications

  1. ncbi Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network
    Willem A Nolen
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Am J Psychiatry 161:1447-54. 2004
  2. doi Genetic and environmental influences on focal brain density in bipolar disorder
    Astrid C van der Schot
    Department of Psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Brain 133:3080-92. 2010
  3. ncbi Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Bipolar Disord 9:531-5. 2007
  4. ncbi Lithium augmentation compared with phenelzine in treatment-resistant depression in the elderly: an open, randomized, controlled trial
    Rob M Kok
    Department of Old Age Psychiatry, Altrecht Institute of Mental Health Care, Utrecht, The Netherlands
    J Clin Psychiatry 68:1177-85. 2007
  5. ncbi Five-year prospective outcome of psychopathology in the adolescent offspring of bipolar parents
    Manon Hj Hillegers
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Bipolar Disord 7:344-50. 2005
  6. ncbi Are the vulnerability effects of personality and psychosocial functioning on depression accounted for by subthreshold symptoms?
    Jan Spijker
    Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands
    Depress Anxiety 24:472-8. 2007
  7. ncbi Signs of a higher prevalence of autoimmune thyroiditis in female offspring of bipolar parents
    Manon H J Hillegers
    University Medical Centre Utrecht Department of Child and Adolescent Psychiatry, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 17:394-9. 2007
  8. doi Long-term response to successful acute pharmacological treatment of psychotic depression
    Jaap Wijkstra
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 123:238-42. 2010
  9. ncbi Impact of stressful life events, familial loading and their interaction on the onset of mood disorders: study in a high-risk cohort of adolescent offspring of parents with bipolar disorder
    Manon H J Hillegers
    Altrecht Institute for Mental Health Care, Lange Nieuwstraat 119, 3512 PG Utrecht, The Netherlands
    Br J Psychiatry 185:97-101. 2004
  10. ncbi Treatment of unipolar psychotic depression: the use of evidence in practice guidelines
    Jaap Wijkstra
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    World J Biol Psychiatry 10:409-15. 2009

Detail Information

Publications78

  1. ncbi Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network
    Willem A Nolen
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Am J Psychiatry 161:1447-54. 2004
    ..The purpose of the study was to examine potential correlates of outcome in patients treated for bipolar disorder...
  2. doi Genetic and environmental influences on focal brain density in bipolar disorder
    Astrid C van der Schot
    Department of Psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Brain 133:3080-92. 2010
    ....
  3. ncbi Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Bipolar Disord 9:531-5. 2007
    ..To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder...
  4. ncbi Lithium augmentation compared with phenelzine in treatment-resistant depression in the elderly: an open, randomized, controlled trial
    Rob M Kok
    Department of Old Age Psychiatry, Altrecht Institute of Mental Health Care, Utrecht, The Netherlands
    J Clin Psychiatry 68:1177-85. 2007
    ....
  5. ncbi Five-year prospective outcome of psychopathology in the adolescent offspring of bipolar parents
    Manon Hj Hillegers
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Bipolar Disord 7:344-50. 2005
    ..The purpose of this study was to determine the prevalence of psychopathology, specifically mood disorders, in adolescents and young adults with a bipolar parent...
  6. ncbi Are the vulnerability effects of personality and psychosocial functioning on depression accounted for by subthreshold symptoms?
    Jan Spijker
    Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands
    Depress Anxiety 24:472-8. 2007
    ..This suggests that a depressive episode is interwoven in a long-standing and enduring pattern of mild personality deviance and limitations in psychosocial functioning...
  7. ncbi Signs of a higher prevalence of autoimmune thyroiditis in female offspring of bipolar parents
    Manon H J Hillegers
    University Medical Centre Utrecht Department of Child and Adolescent Psychiatry, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 17:394-9. 2007
    ..Studies are inconsistent as to whether patients with bipolar disorder are more frequently affected by autoimmune thyroiditis...
  8. doi Long-term response to successful acute pharmacological treatment of psychotic depression
    Jaap Wijkstra
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 123:238-42. 2010
    ..Data about follow-up after acute pharmacological treatment of psychotic depression are scarce...
  9. ncbi Impact of stressful life events, familial loading and their interaction on the onset of mood disorders: study in a high-risk cohort of adolescent offspring of parents with bipolar disorder
    Manon H J Hillegers
    Altrecht Institute for Mental Health Care, Lange Nieuwstraat 119, 3512 PG Utrecht, The Netherlands
    Br J Psychiatry 185:97-101. 2004
    ..Stressful life events are established as risk factors for the onset of mood disorders, but few studies have investigated their impact on the development of mood disorders in adolescents...
  10. ncbi Treatment of unipolar psychotic depression: the use of evidence in practice guidelines
    Jaap Wijkstra
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    World J Biol Psychiatry 10:409-15. 2009
    ..However, most current guidelines recommend the combination over an antidepressant alone...
  11. ncbi Haloperidol dose when used as active comparator in randomized controlled trials with atypical antipsychotics in schizophrenia: comparison with officially recommended doses
    Gerard W K Hugenholtz
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    J Clin Psychiatry 67:897-903. 2006
    ....
  12. ncbi Rapid and non-rapid cycling bipolar disorder: a meta-analysis of clinical studies
    Ralph W Kupka
    Altrecht Institute for Mental Health Care and University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 64:1483-94. 2003
    ..Several risk factors have been suggested to be associated with rapid cycling. The purpose of this meta-analysis was to compare clinical studies for the evidence of discriminating factors between rapid and non-rapid cycling...
  13. ncbi The impact of environmental temperature on lithium serum levels
    Ingeborg Wilting
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Bipolar Disord 9:603-8. 2007
    ..Three studies have reported a seasonal variation in lithium serum levels, with higher levels during summer. Our objective was to investigate the impact of actual environmental temperature on lithium serum levels...
  14. doi Evaluation of available treatment guidelines for the management of lithium intoxication
    Ingeborg Wilting
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Faculty of Science, Utrecht Institute for Pharmaceutical Sciencest, Utrecht, The Netherlands
    Ther Drug Monit 31:247-60. 2009
    ....
  15. ncbi Lithium use and the risk of fractures
    Ingeborg Wilting
    Utrecht University, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht, The Netherlands
    Bone 40:1252-8. 2007
    ..Our results support the role of the underlying mental disorders in the aetiology of fractures and do not support a pharmacological effect of lithium based on lack of an association with cumulative duration of use...
  16. doi Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder
    Astrid C van der Schot
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Arch Gen Psychiatry 66:142-51. 2009
    ..Structural neuroimaging studies suggest the presence of subtle abnormalities in the brains of patients with bipolar disorder. The influence of genetic and/or environmental factors on these brain abnormalities is unknown...
  17. ncbi Psychosocial disability before, during, and after a major depressive episode: a 3-wave population-based study of state, scar, and trait effects
    Johan Ormel
    Department of Psychiatry and the Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, Groningen, The Netherlands
    Arch Gen Psychiatry 61:387-92. 2004
    ....
  18. ncbi Urine osmolality, cyclic AMP and aquaporin-2 in urine of patients under lithium treatment in response to water loading followed by vasopressin administration
    Ingeborg Wilting
    Utrecht University, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht, and Department of Clinical Pharmacy, TweeSteden Hospital, Tilburg, The Netherlands
    Eur J Pharmacol 566:50-7. 2007
    ..It remains to be elucidated whether principal cells, G-proteins or adenylate cyclase e.g. are the major targets for the mechanism underlying lithium-induced NDI in man...
  19. ncbi Pharmacological treatment for unipolar psychotic depression: Systematic review and meta-analysis
    Jaap Wijkstra
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, HP B01 206, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Br J Psychiatry 188:410-5. 2006
    ..The optimal pharmacological treatment of unipolar psychotic depression is uncertain...
  20. ncbi Drug-drug interactions as a determinant of elevated lithium serum levels in daily clinical practice
    Ingeborg Wilting
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Bipolar Disord 7:274-80. 2005
    ..We conducted a multicentre retrospective case-control study with the aim of investigating lithium-related drug interactions as determinants of elevated lithium serum levels in daily clinical practice...
  21. ncbi Determinants of persistence of major depressive episodes in the general population. Results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS)
    Jan Spijker
    Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands
    J Affect Disord 81:231-40. 2004
    ..Data on determinants of persistence of major depressive episodes (MDE) are inconsistent due to methodological shortcomings of the studies involved...
  22. doi Electroconvulsive therapy has acute immunological and neuroendocrine effects in patients with major depressive disorder
    Sjoerd B A H A Fluitman
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 131:388-92. 2011
    ..Major depressive disorder is associated with alterations in the neuroendocrine as well as immune system. Few studies examined the impact of electroconvulsive therapy (ECT) on these systems in patients with major depressive disorder (MDD)...
  23. ncbi Venlafaxine versus nortriptyline in the treatment of elderly depressed inpatients: a randomised, double-blind, controlled trial
    Rob M Kok
    Department of Old Age Psychiatry, Altrecht Institute of Mental Health Care, Utrecht, The Netherlands
    Int J Geriatr Psychiatry 22:1247-54. 2007
    ..Consequently information is lacking about the more complex cases of elderly depressed patients, as found in inpatient wards...
  24. ncbi Risk of hip/femur fractures in patients using antipsychotics
    Gerard W K Hugenholtz
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Bone 37:864-70. 2005
    ..We conclude that there is a small increased risk of hip/femur fractures associated with the use of antipsychotics. This risk increases with long-term use...
  25. pmc Treatment of bipolar disorder in the Netherlands and concordance with treatment guidelines: study protocol of an observational, longitudinal study on naturalistic treatment of bipolar disorder in everyday clinical practice
    Joannes W Renes
    Altrecht Institute for Mental Health Care, Lange Nieuwstraat 119, 3512 PG Utrecht, The Netherlands
    BMC Psychiatry 14:58. 2014
    ....
  26. ncbi Multiple dimensions of familial psychopathology affect risk of mood disorder in children of bipolar parents
    Marjolein Wals
    Altrecht, Institute for Mental Health Care, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 127:35-41. 2004
    ..8 (95% CI = 1.3-2.4) for FL of substance use disorder. Expression of mood disorders in children of bipolar parents varies with the degree of additional FL of unipolar disorder and substance use disorder in the extended family...
  27. ncbi Successful maintenance electroconvulsive therapy for more than seven years
    Jaap Wijkstra
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    J ECT 21:171-3. 2005
    ..Thus M-ECT does not appear to cause cognitive deterioration. M-ECT is being continued on the patient's request...
  28. ncbi Selective prescribing of atypical antipsychotics
    Nancy S Breekveldt-Postma
    PHARMO Institute, Institute for Pharmacology and Outcomes Research, Utrecht, The Netherlands
    Pharmacoepidemiol Drug Saf 14:25-30. 2005
    ....
  29. ncbi Impact of birth weight and genetic liability on psychopathology in children of bipolar parents
    Marjolein Wals
    Altrecht, Institute for Mental Health Care, Utrecht, The Netherlands
    J Am Acad Child Adolesc Psychiatry 42:1116-21. 2003
    ..To test different models for ways in which birth weight and familial loading influence the risk for psychopathology in bipolar offspring...
  30. ncbi Bipolar disorder in the general population in The Netherlands (prevalence, consequences and care utilisation): results from The Netherlands Mental Health Survey and Incidence Study (NEMESIS)
    Margreet Ten Have
    Netherlands Institute of Mental Health and Addiction, P O Box 725, 3500 AS, Utrecht, The Netherlands
    J Affect Disord 68:203-13. 2002
    ..Little is known about the prevalence of bipolar disorder in the general population, what proportion is receiving care and what factors motivate people to seek help...
  31. ncbi Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon
    Trisha Suppes
    Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
    Arch Gen Psychiatry 62:1089-96. 2005
    ..The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved...
  32. ncbi Is autoimmune thyroiditis part of the genetic vulnerability (or an endophenotype) for bipolar disorder?
    Ronald Vonk
    Reinier van Arkel group, s Hertogenbosch, Department of Psychiatry, University Medical Centre Utrecht, The Netherlands
    Biol Psychiatry 62:135-40. 2007
    ..This study was intended to examine whether autoimmune thyroiditis is related to the disease itself, to the (genetic) vulnerability to develop bipolar disorder, or both...
  33. ncbi Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, PO Box 670559, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Clin Psychiatry 66:617-24. 2005
    ..The response of 62 outpatients with DSM-IV bipolar disorders to open-label adjunctive zonisamide was evaluated in a prospective 8-week acute trial, followed by a 48-week continuation trial, conducted from June 2001 through May 2002...
  34. ncbi An imbalance in the production of IL-1beta and IL-6 by monocytes of bipolar patients: restoration by lithium treatment
    Esther M Knijff
    Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
    Bipolar Disord 9:743-53. 2007
    ..To study the ex vivo interleukin (IL)-1beta and IL-6 production of monocytes in bipolar disorder (BD) patients in the absence/presence of lithium...
  35. ncbi Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study
    Lori L Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
    J Clin Psychiatry 67:1551-60. 2006
    ..Research examining this relationship in persons with bipolar disorder is rare. This study sought to evaluate the association between subsyndromal depressive symptoms and role functioning in subjects with bipolar disorder...
  36. ncbi Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Tolsteegsingel 2A, 3582 AC Utrecht, Netherlands
    Am J Psychiatry 162:1273-80. 2005
    ..To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective...
  37. ncbi Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:370-4. 2005
    ..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness...
  38. ncbi Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illness
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Compr Psychiatry 44:263-9. 2003
    ..The lack of observable prognostic impact may have been, in part, due to the relatively high morbidity and poor functional outcome of a substantial portion of the total cohort...
  39. ncbi Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Clin Psychiatry 64:506-15. 2003
    ..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder...
  40. ncbi Early physical and sexual abuse associated with an adverse course of bipolar illness
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network and the Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3S 239, Bethesda, MD 20892 1272, USA
    Biol Psychiatry 51:288-97. 2002
    ..There is growing awareness of the association between physical and sexual abuse and subsequent development of psychopathology, but little is known, however, about their relationship to the longitudinal course of bipolar disorder...
  41. ncbi Duration of major depressive episodes in the general population: results from The Netherlands Mental Health Survey and Incidence Study (NEMESIS)
    Jan Spijker
    Netherlands Institute of Mental Health and Addiction Trimbos institute, PO Box 725, 3500 AS Utrecht, The Netherlands
    Br J Psychiatry 181:208-13. 2002
    ..Data on the duration of major depressive episodes (MDE) in the general population are sparse...
  42. ncbi Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, UCLA Bipolar Research Program, University of California Los Angeles School of Medicine, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:883-9. 2003
    ..This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study...
  43. ncbi Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart method
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 12723, USA
    J Clin Psychiatry 64:680-90; quiz 738-9. 2003
    ..The detailed course and pattern of illness emerging despite comprehensive treatment with mood stabilizers and adjunctive agents have previously not been well delineated...
  44. ncbi Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network
    Trisha Suppes
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
    Int Clin Psychopharmacol 22:376-81. 2007
    ..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted...
  45. ncbi A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network
    Robert M Post
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:396-406. 2003
    ..This paper reviews new data on: (1) depression in bipolar illness, (2) switch rates on ADs and (3) risks of AD discontinuation that are pertinent to the ongoing discussion and recommendations...
  46. ncbi Impact of antidepressant discontinuation after acute bipolar depression remission on rates of depressive relapse at 1-year follow-up
    Lori Altshuler
    Stanley Bipolar Treatment Network, USA
    Am J Psychiatry 160:1252-62. 2003
    ..This study examined the effect of antidepressant discontinuation or continuation on depressive relapse risk among bipolar subjects successfully treated for an acute depressive episode...
  47. ncbi Lithium-associated psoriasis and omega-3 fatty acids
    Grad W Akkerhuis
    Am J Psychiatry 160:1355. 2003
  48. ncbi Prophylactic efficacy of lithium versus carbamazepine in treatment-naive bipolar patients
    Erwin G Th M Hartong
    Institute for Clinical Psychiatric Research IPPO, The Hague, Nijmegen, The Netherlands
    J Clin Psychiatry 64:144-51. 2003
    ..Alternatives to lithium for prophylactic treatment of patients with bipolar affective disorders are increasingly being advocated. However, trials comparing lithium with alternatives are scarce and often biased...
  49. ncbi High numbers of circulating activated T cells and raised levels of serum IL-2 receptor in bipolar disorder
    M Nadine Breunis
    Department of Immunology, Erasmus University Rotterdam MNB, HAD, Rotterdam, The Netherlands
    Biol Psychiatry 53:157-65. 2003
    ..In the present study, we investigated other signs of immune activation in bipolar patients, in particular an activation of the T cell system...
  50. doi Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects
    Dorret I Boomsma
    Netherlands Twin Register, Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands
    Eur J Hum Genet 16:335-42. 2008
    ..Genome-wide association results are open-access and can be viewed at the dbGAP web portal (http://www.ncbi.nlm.nih.gov). Approved users can download the genotype and phenotype data, which have been made available as of 9 October 2007...
  51. ncbi Correlates of overweight and obesity in 644 patients with bipolar disorder
    Susan L McElroy
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    J Clin Psychiatry 63:207-13. 2002
    ..Overweight and obesity are common clinical problems encountered in the treatment of bipolar disorder. We therefore assessed the prevalence and clinical correlates of overweight, obesity, and extreme obesity in 644 bipolar patients...
  52. doi Are bipolar mood symptoms affected by the phase of the menstrual cycle?
    Geetha Shivakumar
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    J Womens Health (Larchmt) 17:473-8. 2008
    ..We sought to examine the relationship between bipolar disorder and menstrual cycle-related mood changes. To our knowledge, this is one of the largest samples in the literature addressing this issue...
  53. doi A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes
    Roos C Padmos
    Department of Immunology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Arch Gen Psychiatry 65:395-407. 2008
    ..Mood disturbances are associated with an activated inflammatory response system...
  54. doi ECNP consensus meeting. Bipolar depression. Nice, March 2007
    Guy M Goodwin
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Eur Neuropsychopharmacol 18:535-49. 2008
    ..Assay sensitivity and patient acceptability are enhanced if the outcome in long-term studies is 'time to intervention for a new episode' for discontinuation designs...
  55. ncbi Tiagabine in treatment refractory bipolar disorder: a clinical case series
    Trisha Suppes
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Bipolar Disord 4:283-9. 2002
    ..We sought to evaluate the effectiveness of tiagabine added to ongoing medication regimens in patients with bipolar disorder inadequately responsive to or intolerant of usual treatments...
  56. ncbi High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposure
    Ralph W Kupka
    Altrecht Centre for Mental Health Care and University Medical Centre Utrecht, Vrouwjuttenhof 18, 3512 PZ Utrecht, The Netherlands
    Biol Psychiatry 51:305-11. 2002
    ..We assessed the prevalence of thyroperoxidase antibodies (TPO-Abs) and thyroid failure in outpatients with bipolar disorder compared with two control groups...
  57. doi Incidence of childhood-onset bipolar illness in the USA and Europe
    Robert M Post
    Department of Psychiatry, George Washington University, Washington, DC, USA
    Br J Psychiatry 192:150-1. 2008
    ..In the USA there was also twice the incidence of childhood adversity and genetic/familial risk for affective disorder. The findings deserve replication and further exploration...
  58. ncbi The poor prognosis of childhood-onset bipolar disorder
    Gabriele S Leverich
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Pediatr 150:485-90. 2007
    ..We examined age of onset of bipolar disorder as a potential course-of-illness modifier with the hypothesis that early onset will engender more severe illness...
  59. ncbi Treatment with low doses of tranylcypromine resulted in a disappointing remission rate
    Willem A Nolen
    Am J Psychiatry 164:524; author reply 524. 2007
  60. ncbi A high prevalence of organ-specific autoimmunity in patients with bipolar disorder
    Roos C Padmos
    Department of Immunology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Biol Psychiatry 56:476-82. 2004
    ..Here we report the prevalence of other organ-specific autoantibodies: H/K adenosine triphosphatase (ATPA), glutamic acid decarboxylase-65 (GAD65A), and GAD-67 (GAD67A)...
  61. ncbi Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants
    Lori L Altshuler
    Dept of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 1544, Box 957057, Los Angeles, CA 90095 7057
    Am J Psychiatry 163:313-5. 2006
    ..The authors compared the switch rate into hypomania/mania in depressed patients treated with second-generation antidepressants who had either bipolar I or bipolar II disorder...
  62. ncbi Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers
    Gabriele S Leverich
    Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    Am J Psychiatry 163:232-9. 2006
    ..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression...
  63. ncbi The use of the GBI as predictor of bipolar disorder in a population of adolescent offspring of parents with a bipolar disorder
    Catrien G Reichart
    Erasmus Medical Center Rotterdam Department of Child and Adolescent Psychiatry, Sophia Children s Hospital, Rotterdam, The Netherlands
    J Affect Disord 89:147-55. 2005
    ..To assess the usefulness of the General Behavior Inventory (GBI) to predict the development of mood disorders in the offspring of parents with bipolar disorder...
  64. ncbi Stressful life events and onset of mood disorders in children of bipolar parents during 14-month follow-up
    Marjolein Wals
    Erasmus Medical Center Rotterdam Department of Child and Adolescent Psychiatry, Sophia Children s Hospital, Rotterdam, The Netherlands
    J Affect Disord 87:253-63. 2005
    ....
  65. ncbi Monocyte-derived dendritic cells in bipolar disorder
    Esther M Knijff
    Department of Immunology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Biol Psychiatry 59:317-26. 2006
    ..Dendritic cells (DC) are key regulators of the immune system, which is compromised in patients with bipolar disorder. We sought to study monocyte-derived DC in bipolar disorder...
  66. ncbi Reproductive function and risk for PCOS in women treated for bipolar disorder
    Natalie L Rasgon
    Department of Psychiatry, Stanford School of Medicine, Palo Alto, CA, USA
    Bipolar Disord 7:246-59. 2005
    ..This study examined the reproductive function and prevalence of polycystic ovary syndrome (PCOS) in women with bipolar disorder taking antimanic medications...
  67. ncbi A European perspective on the Canadian guidelines for bipolar disorder
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    Bipolar Disord 7:73-6. 2005
  68. ncbi Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and the Mental Health Care Line, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 60:1020-2. 2006
    ..The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder...
  69. ncbi Antidepressants for bipolar depression: a systematic review of randomized, controlled trials
    Harm J Gijsman
    Department of Psychiatry, Warneford Hospital, Oxford, UK
    Am J Psychiatry 161:1537-47. 2004
    ..This study reviewed the evidence from randomized, controlled trials on the efficacy and safety of antidepressants in the short-term treatment of bipolar depression...
  70. ncbi An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:310-9. 2003
    ..Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed...
  71. ncbi Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism
    Eric Levander
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
    J Affect Disord 101:211-7. 2007
    ..This study was undertaken to evaluate the prevalence rate of anxiety comorbidity in bipolar subjects with and without alcohol use disorders (AUD)...
  72. ncbi New findings from the Bipolar Collaborative Network: clinical implications for therapeutics
    Robert M Post
    Penn State College of Medicine, Hershey, PA, USA
    Curr Psychiatry Rep 8:489-97. 2006
    ..Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss...
  73. ncbi A relative resistance of T cells to dexamethasone in bipolar disorder
    Esther M Knijff
    Department of Immunology, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    Bipolar Disord 8:740-50. 2006
    ..In this study, we investigated the in vitro responsiveness of T cells to dexamethasone (DEX) of patients with bipolar disorder (BD)...
  74. ncbi Psychopathology in the adolescent offspring of bipolar parents
    Catrien G Reichart
    Department of Child and Adolescent Psychiatry, Sophia Children s Hospital Erasmus University Rotterdam, Dr Molewaterplein 60, 3015 GH Rotterdam, The Netherlands
    J Affect Disord 78:67-71. 2004
    ..The aim of this study was to determine the prevalence and 14-months incidence of psychopathology in adolescent offspring of a bipolar parent...
  75. ncbi Earlier onset of bipolar disorder in children by antidepressants or stimulants? An hypothesis
    Catrien G Reichart
    Department of Child and Adolescent Psychiatry, Sophia Children s Hospital Erasmus University of Rotterdam, Dr Molewaterplein 40, Rotterdam 3015 GD, The Netherlands
    J Affect Disord 78:81-4. 2004
    ..In those children who are genetically at risk to develop BD, these drugs may lead to a switch into mania...
  76. ncbi The use of the GBI in a population of adolescent offspring of parents with a bipolar disorder
    Catrien G Reichart
    Department of Child and Adolescent Psychiatry, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GH Rotterdam, The Netherlands
    J Affect Disord 80:263-7. 2004
    ..To assess the psychometric properties and the usefulness of the General Behavior Inventory (GBI) in the adolescent age range...
  77. ncbi Social functioning of bipolar offspring
    Catrien G Reichart
    Erasmus Medical Center Rotterdam Department of Child and Adolescent Psychiatry, Sophia Children s Hospital, Rotterdam, The Netherlands
    J Affect Disord 98:207-13. 2007
    ..The objective of this study was to compare social functioning of adolescent and young adult offspring of bipolar parents with social functioning of adolescents and young adults in the general population...
  78. ncbi Evidence that the immunopathogenic mechanism of lithium-induced psoriasis differs from that of regular psoriasis
    Esther M Knijff
    Bipolar Disord 7:388-9. 2005