Willem A Nolen

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. ncbi The association of the effect of lithium in the maintenance treatment of bipolar disorder with lithium plasma levels: a post hoc analysis of a double-blind study comparing switching to lithium or placebo in patients who responded to quetiapine (Trial 144)
    Willem A Nolen
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Bipolar Disord 15:100-9. 2013
  2. doi Course and risk factors of functional impairment in subthreshold depression and anxiety
    Julie Karsten
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Depress Anxiety 30:386-94. 2013
  3. doi Genetic and environmental influences on focal brain density in bipolar disorder
    Astrid C van der Schot
    Department of Psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Brain 133:3080-92. 2010
  4. doi Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder
    Astrid C van der Schot
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Arch Gen Psychiatry 66:142-51. 2009
  5. doi Long-term outcome of bipolar depressed patients receiving lamotrigine as add-on to lithium with the possibility of the addition of paroxetine in nonresponders: a randomized, placebo-controlled trial with a novel design
    Marc L M van der Loos
    Department of Psychiatry, Isala Klinieken Location Sophia, Zwolle, The Netherlands
    Bipolar Disord 13:111-7. 2011
  6. ncbi Insight in bipolar disorder: associations with cognitive and emotional processing and illness characteristics
    Marieke J van der Werf-Eldering
    Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands
    Bipolar Disord 13:343-54. 2011
  7. pmc Can variation in hypothalamic-pituitary-adrenal (HPA)-axis activity explain the relationship between depression and cognition in bipolar patients?
    Marieke J van der Werf-Eldering
    Department of Psychiatry, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e37119. 2012
  8. doi Long-term response to successful acute pharmacological treatment of psychotic depression
    Jaap Wijkstra
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 123:238-42. 2010
  9. doi One-year severity of depressive symptoms: results from the NESDA study
    Femke Lamers
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Psychiatry Res 190:226-31. 2011
  10. ncbi Gender differences in major depressive disorder: results from the Netherlands study of depression and anxiety
    Jérôme J J Schuch
    Department of Psychiatry and Interdisciplinary Center Psychopathology and Emotion regulation, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands Electronic address
    J Affect Disord 156:156-63. 2014

Collaborators

Detail Information

Publications38

  1. ncbi The association of the effect of lithium in the maintenance treatment of bipolar disorder with lithium plasma levels: a post hoc analysis of a double-blind study comparing switching to lithium or placebo in patients who responded to quetiapine (Trial 144)
    Willem A Nolen
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Bipolar Disord 15:100-9. 2013
    ..This analysis aimed to compare the effect of lithium within the presumed therapeutic range of 0.6-1.2 mEq/L and below 0.6 mEq/L with that of placebo...
  2. doi Course and risk factors of functional impairment in subthreshold depression and anxiety
    Julie Karsten
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Depress Anxiety 30:386-94. 2013
    ..Furthermore, we evaluate which illness, personal, and environmental risk factors influence its course...
  3. doi Genetic and environmental influences on focal brain density in bipolar disorder
    Astrid C van der Schot
    Department of Psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Brain 133:3080-92. 2010
    ....
  4. doi Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder
    Astrid C van der Schot
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Arch Gen Psychiatry 66:142-51. 2009
    ..Structural neuroimaging studies suggest the presence of subtle abnormalities in the brains of patients with bipolar disorder. The influence of genetic and/or environmental factors on these brain abnormalities is unknown...
  5. doi Long-term outcome of bipolar depressed patients receiving lamotrigine as add-on to lithium with the possibility of the addition of paroxetine in nonresponders: a randomized, placebo-controlled trial with a novel design
    Marc L M van der Loos
    Department of Psychiatry, Isala Klinieken Location Sophia, Zwolle, The Netherlands
    Bipolar Disord 13:111-7. 2011
    ..In this paper we describe the long-term (68 weeks) outcome of that study...
  6. ncbi Insight in bipolar disorder: associations with cognitive and emotional processing and illness characteristics
    Marieke J van der Werf-Eldering
    Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands
    Bipolar Disord 13:343-54. 2011
    ..To investigate the multifactorial relationship between illness insight, cognitive and emotional processes, and illness characteristics in bipolar disorder patients...
  7. pmc Can variation in hypothalamic-pituitary-adrenal (HPA)-axis activity explain the relationship between depression and cognition in bipolar patients?
    Marieke J van der Werf-Eldering
    Department of Psychiatry, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e37119. 2012
    ..This study examined whether variation in HPA axis activity underlies the association between mood symptoms and cognitive functioning...
  8. doi Long-term response to successful acute pharmacological treatment of psychotic depression
    Jaap Wijkstra
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 123:238-42. 2010
    ..Data about follow-up after acute pharmacological treatment of psychotic depression are scarce...
  9. doi One-year severity of depressive symptoms: results from the NESDA study
    Femke Lamers
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Psychiatry Res 190:226-31. 2011
    ..The findings indicate that the prediction of prognosis and identification of persons at risk of a poor outcome should not only be based on clinical characteristics, but on risk factors as well...
  10. ncbi Gender differences in major depressive disorder: results from the Netherlands study of depression and anxiety
    Jérôme J J Schuch
    Department of Psychiatry and Interdisciplinary Center Psychopathology and Emotion regulation, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands Electronic address
    J Affect Disord 156:156-63. 2014
    ..This study aims to identify gender differences in psychopathology, treatment, and public health consequences in patients with MDD...
  11. pmc Most antidepressant use in primary care is justified; results of the Netherlands Study of Depression and Anxiety
    Ellen Piek
    Department of General Practice, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 6:e14784. 2011
    ..The present study was designed to assess whether treatment with antidepressants in primary care is in accordance with current guidelines, with a special focus on overtreatment...
  12. ncbi The state effect of depressive and anxiety disorders on big five personality traits
    Julie Karsten
    Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Psychiatr Res 46:644-50. 2012
    ..Here, we aim to determine the extent of change in all five personality traits associated with the occurrence of or recovery from depressive and anxiety disorders...
  13. doi The Dutch bipolar offspring study: 12-year follow-up
    Esther Mesman
    Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Am J Psychiatry 170:542-9. 2013
    ..In a longitudinal study, the authors followed a bipolar offspring cohort from adolescence into adulthood to determine the onset, prevalence, and early course of mood disorders and other psychopathology...
  14. pmc Seasonality in depressive and anxiety symptoms among primary care patients and in patients with depressive and anxiety disorders; results from the Netherlands Study of Depression and Anxiety
    Wim H Winthorst
    Department of Psychiatry, University Medical Centre Groningen, University of Groningen, The Netherlands
    BMC Psychiatry 11:198. 2011
    ....
  15. pmc Preventing relapse in recurrent depression using mindfulness-based cognitive therapy, antidepressant medication or the combination: trial design and protocol of the MOMENT study
    Marloes J Huijbers
    Department of Psychiatry, Radboud University Nijmegen Medical Center, Reinier Postlaan 10, Nijmegen 6525 GC, The Netherlands
    BMC Psychiatry 12:125. 2012
    ..First, what is the effectiveness of MBCT in addition to mADM? Second, how large is the risk of relapse/recurrence in patients withdrawing from mADM after participating in MBCT, compared to those who continue to use mADM after MBCT?..
  16. ncbi Co-occurring manic symptomatology influences HPA axis alterations in depression
    Nienke Jabben
    Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, AJ Ernststraat 1187, 1081 HL Amsterdam, The Netherlands
    J Psychiatr Res 45:1208-13. 2011
    ....
  17. doi Determinants of (non-)recognition of depression by general practitioners: results of the Netherlands Study of Depression and Anxiety
    Ellen Piek
    Department of General Practice, University Medical Center Groningen, University of Groningen, Postbox 196, 9700 AD Groningen, The Netherlands
    J Affect Disord 138:397-404. 2012
    ..This study explores the determinants of (non-)recognition of depression by general practitioners (GPs), with a focus on specific depression symptoms as possible determinants...
  18. ncbi Self-attributed seasonality of mood and behavior: a report from the Netherlands study of depression and anxiety
    Wim H Winthorst
    Department of Psychiatry and Interdisciplinary Center Psychopathology and Emotion regulation, University of Groningen, University Medical Center Groningen, The Netherlands
    Depress Anxiety 31:517-23. 2014
    ....
  19. pmc Preventing mood and anxiety disorders in youth: a multi-centre RCT in the high risk offspring of depressed and anxious patients
    Maaike H Nauta
    Department of Clinical Psychology, University of Groningen, Grote Kruisstraat 2 1, 9712 TS Groningen, The Netherlands
    BMC Psychiatry 12:31. 2012
    ..Further, while the indication for preventive interventions is often elevated symptoms, offspring with other high risk profiles may also benefit from resilience-based prevention programs...
  20. doi Prevalence of autoimmune thyroid dysfunction in postpartum psychosis
    Veerle Bergink
    Department of Psychiatry, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Br J Psychiatry 198:264-8. 2011
    ..Although many studies have postulated an involvement of the immune and endocrine systems in the onset of postpartum psychosis, the specific aetiological factors have remained unknown...
  21. doi Psychiatric history and subthreshold symptoms as predictors of the occurrence of depressive or anxiety disorder within 2 years
    Julie Karsten
    University Medical Center Groningen, Department of Psychiatry, University of Groningen, The Netherlands
    Br J Psychiatry 198:206-12. 2011
    ..It is unclear to what extent the two factors interact or predict these disorders independently...
  22. ncbi Effect of alcohol use on the course of bipolar disorder: one-year follow-up study using the daily prospective Life Chart method
    Jan van Zaane
    Department of Psychiatry, EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Bipolar Disord 16:400-9. 2014
    ..The present study was a fine-grained analysis of the temporal relationship between alcohol use and short-term mood-switching probabilities...
  23. pmc Maintenance use of antidepressants in dutch general practice: non-guideline concordant
    Ellen Piek
    Department of General Practice, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 9:e97463. 2014
    ..This study explores the characteristics of patients on maintenance treatment with antidepressants in general practice, and compares these characteristics with guideline recommendations for maintenance treatment...
  24. pmc Referral of patients with depression to mental health care by Dutch general practitioners: an observational study
    Ellen Piek
    Department of General Practice, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    BMC Fam Pract 12:41. 2011
    ..We wanted to evaluate general practitioner's referral of depressed patients to mental health care and to what extent this is in agreement with (Dutch) guideline recommendations...
  25. doi Identifying depressive subtypes in a large cohort study: results from the Netherlands Study of Depression and Anxiety (NESDA)
    Femke Lamers
    Department of Psychiatry, VU University Medical Center Amsterdam, AJ Ernststraat 887, 1081 HL Amsterdam, The Netherlands
    J Clin Psychiatry 71:1582-9. 2010
    ..Data-driven techniques may help to come to a more empirically based classification. This study aimed to identify depressive subtypes within a large cohort of subjects with depression...
  26. ncbi Neuroinflammation in bipolar disorder - A [(11)C]-(R)-PK11195 positron emission tomography study
    Bartholomeus C M Benno Haarman
    University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands Electronic address
    Brain Behav Immun 40:219-25. 2014
    ..Conclusion: This study is the first to demonstrate the presence of focal neuroinflammation in the right hippocampus in bipolar I disorder. ..
  27. ncbi The Mood Disorder Questionnaire (MDQ) for detecting (hypo)manic episodes: its validity and impact of recall bias
    Lynn Boschloo
    Interdisciplinary Center Psychopathology and Emotion Regulation ICPE University Center Psychiatry UCP, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Affect Disord 151:203-8. 2013
    ..This study will therefore examine the validity of the widely-used Mood Disorder Questionnaire (MDQ) in detecting a (hypo)manic episode and explore the impact of recall bias...
  28. ncbi Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms?
    Jacqueline Quak
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Psychoneuroendocrinology 45:202-10. 2014
    ....
  29. doi Relationship between clinical features and inflammation-related monocyte gene expression in bipolar disorder - towards a better understanding of psychoimmunological interactions
    Bartholomeus C M Haarman
    Department of Psychiatry, Leiden, The Netherlands
    Bipolar Disord 16:137-50. 2014
    ..We hypothesized a priori that increased monocyte pro-inflammatory gene expression would be found more frequently in patients with a lifetime history of psychotic symptoms...
  30. ncbi Guideline recommendations for long-term treatment of depression with antidepressants in primary care--a critical review
    Ellen Piek
    Department of General Practice, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Gen Pract 16:106-12. 2010
    ..Long-term treatment with antidepressants is considered effective in preventing recurrence of major depressive disorder (MDD). It is unclear whether this is true for primary care...
  31. doi Is the lack of association between cognitive complaints and objective cognitive functioning in patients with bipolar disorder moderated by depressive symptoms?
    Marieke J van der Werf-Eldering
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Affect Disord 130:306-11. 2011
    ..To investigate the association between cognitive complaints and objective cognitive functioning in bipolar patients, with a focus on the moderating role of depressive symptoms...
  32. ncbi Treatment of unipolar psychotic depression: the use of evidence in practice guidelines
    Jaap Wijkstra
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    World J Biol Psychiatry 10:409-15. 2009
    ..However, most current guidelines recommend the combination over an antidepressant alone...
  33. ncbi More medical comorbidities in patients with bipolar disorder from the United States than from the Netherlands and Germany
    Robert M Post
    Bipolar Collaborative Network, Bethesda, MD UCLA Mood Disorders Research Program and VA Medical Center, Los Angeles, CA Mayo Clinic Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Rochester, MI Department of Psychiatry, SW Medical Center, University of Texas, Dallas, TX Linder Center of Hope, Mason, OH Biological Psychiatry Program, University of Cincinnati Medical College, Cincinnati, OH University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands and Newcastle University, Institute of Neuroscience, Newcastle upon Tyne, UK
    J Nerv Ment Dis 202:265-70. 2014
    ....
  34. ncbi Efficacy and safety of lamotrigine as add-on treatment to lithium in bipolar depression: a multicenter, double-blind, placebo-controlled trial
    Marc L M van der Loos
    Isala Klinieken, Lokatie Sophia, Department of Psychiatry, Dr van Heesweg 2, Zwolle, The Netherlands
    J Clin Psychiatry 70:223-31. 2009
    ..This study compared the acute effects of lamotrigine and placebo as add-on therapy to ongoing treatment with lithium in patients with bipolar depression...
  35. ncbi Evidence that patients with single versus recurrent depressive episodes are differentially sensitive to treatment discontinuation: a meta-analysis of placebo-controlled randomized trials
    Nil Kaymaz
    Department of Psychiatry, University of Maastricht, Maastricht, The Netherlands
    J Clin Psychiatry 69:1423-36. 2008
    ..It is unclear, however, to what degree duration of the continuation phase, level of abruptness of antidepressant discontinuation, or the number of previous episodes moderate the prophylactic effect of antidepressants...
  36. doi Screening for bipolar disorders in patients with alcohol or substance use disorders: performance of the mood disorder questionnaire
    Jan van Zaane
    Department of Psychiatry, EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Drug Alcohol Depend 124:235-41. 2012
    ..Screening properties of the mood disorder questionnaire (MDQ) to detect bipolar disorder (BD) in patients with substance use disorders are unknown...
  37. doi Inhibit yourself and understand the other: neural basis of distinct processes underlying Theory of Mind
    Lisette van der Meer
    University of Groningen, University Medical Center Groningen, Department of Neuroscience, Antonius Deusinglaan 2, P O Box 196, 9700 AD Groningen, The Netherlands
    Neuroimage 56:2364-74. 2011
    ..Furthermore, evidence for partially shared neural mechanisms for inhibition in complex social situations and basic motor response inhibition was found...
  38. ncbi Is autoimmune thyroiditis part of the genetic vulnerability (or an endophenotype) for bipolar disorder?
    Ronald Vonk
    Reinier van Arkel group, s Hertogenbosch, Department of Psychiatry, University Medical Centre Utrecht, The Netherlands
    Biol Psychiatry 62:135-40. 2007
    ..This study was intended to examine whether autoimmune thyroiditis is related to the disease itself, to the (genetic) vulnerability to develop bipolar disorder, or both...