M G Netea

Summary

Affiliation: University Medical Center Nijmegen
Country: The Netherlands

Publications

  1. ncbi request reprint The role of endogenous interleukin (IL)-18, IL-12, IL-1beta, and tumor necrosis factor-alpha in the production of interferon-gamma induced by Candida albicans in human whole-blood cultures
    Mihai G Netea
    Department of Medicine and Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Infect Dis 185:963-70. 2002
  2. ncbi request reprint Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Eur J Immunol 32:1188-95. 2002
  3. ncbi request reprint Interleukin-18 induces production of proinflammatory cytokines in mice: no intermediate role for the cytokines of the tumor necrosis factor family and interleukin-1beta
    M G Netea
    Department of Medicine, University Hospital Nijmegen, The Netherlands
    Eur J Immunol 30:3057-60. 2000
  4. ncbi request reprint Acellular components of Chlamydia pneumoniae stimulate cytokine production in human blood mononuclear cells
    M G Netea
    Department of Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands
    Eur J Immunol 30:541-9. 2000
  5. ncbi request reprint Native LDL potentiate TNF alpha and IL-8 production by human mononuclear cells
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands Biochemistry, University Medical Center St Radboud, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    J Lipid Res 43:1065-71. 2002
  6. ncbi request reprint Lethal Escherichia coli and Salmonella typhimurium endotoxemia is mediated through different pathways
    M G Netea
    Division of General Internal Medicine, Department of Medicine, Nijmegen University Medical Center, Nijmegen, The Netherlands
    Eur J Immunol 31:2529-38. 2001
  7. pmc Differential roles of interleukin-18 (IL-18) and IL12 for induction of gamma interferon by staphylococcal cell wall components and superantigens
    R J Stuyt
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Infect Immun 69:5025-30. 2001
  8. ncbi request reprint Recombinant murine granulocyte colony-stimulating factor protects against acute disseminated Candida albicans infection in nonneutropenic mice
    B J Kullberg
    Department of Medicine, Catholic University Nijmegen and University Hospital, The Netherlands
    J Infect Dis 177:175-81. 1998
  9. ncbi request reprint An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis
    L A Joosten
    Rheumatology Research Laboratory and Department of Internal Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Immunol 165:6553-8. 2000
  10. ncbi request reprint Contributions of Neisseria meningitidis LPS and non-LPS to proinflammatory cytokine response
    T Sprong
    Department of Internal Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Leukoc Biol 70:283-8. 2001

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint The role of endogenous interleukin (IL)-18, IL-12, IL-1beta, and tumor necrosis factor-alpha in the production of interferon-gamma induced by Candida albicans in human whole-blood cultures
    Mihai G Netea
    Department of Medicine and Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Infect Dis 185:963-70. 2002
    ..Blocking the biologic activities of IL-18, IL-12, and IL-1beta in patients (e.g., for treatment of autoimmune diseases) may result in increased susceptibility to C. albicans infection...
  2. ncbi request reprint Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Eur J Immunol 32:1188-95. 2002
    ..pneumoniae stimulates cytokine production in a serum-dependent manner, but independently of complement, MBL and LBP. C. pneumoniae induces the pro-inflammatory cytokines TNF and IL-1beta through TLR2, but not TLR4 and CD14...
  3. ncbi request reprint Interleukin-18 induces production of proinflammatory cytokines in mice: no intermediate role for the cytokines of the tumor necrosis factor family and interleukin-1beta
    M G Netea
    Department of Medicine, University Hospital Nijmegen, The Netherlands
    Eur J Immunol 30:3057-60. 2000
    ....
  4. ncbi request reprint Acellular components of Chlamydia pneumoniae stimulate cytokine production in human blood mononuclear cells
    M G Netea
    Department of Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands
    Eur J Immunol 30:541-9. 2000
    ..In conclusion, acellular components of C. pneumoniae are a potent stimulus for cytokine production, and this mechanism may have an important role in the inflammatory aspects of atherogenesis...
  5. ncbi request reprint Native LDL potentiate TNF alpha and IL-8 production by human mononuclear cells
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands Biochemistry, University Medical Center St Radboud, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    J Lipid Res 43:1065-71. 2002
    ..This may represent an important pathogenetic mechanism in atherogenesis induced by hyperlipoproteinemia...
  6. ncbi request reprint Lethal Escherichia coli and Salmonella typhimurium endotoxemia is mediated through different pathways
    M G Netea
    Division of General Internal Medicine, Department of Medicine, Nijmegen University Medical Center, Nijmegen, The Netherlands
    Eur J Immunol 31:2529-38. 2001
    ..In conclusion, TNF and LT play a central role in the lethality due to E. coli LPS, whereas the lethal effects of S. typhimurium LPS are mediated through mechanisms also involving other cytokines such as IFN-gamma, IL-1 and IL-18...
  7. pmc Differential roles of interleukin-18 (IL-18) and IL12 for induction of gamma interferon by staphylococcal cell wall components and superantigens
    R J Stuyt
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Infect Immun 69:5025-30. 2001
    ..In contrast to its role in the interactions between staphylococci and host cells, IL-18 does not appear to play a major role in superantigen-induced IFN-gamma...
  8. ncbi request reprint Recombinant murine granulocyte colony-stimulating factor protects against acute disseminated Candida albicans infection in nonneutropenic mice
    B J Kullberg
    Department of Medicine, Catholic University Nijmegen and University Hospital, The Netherlands
    J Infect Dis 177:175-81. 1998
    ..These results indicate that rG-CSF enhances host resistance to disseminated candidiasis in nonneutropenic mice through activation of granulocytes and their recruitment to the site of infection...
  9. ncbi request reprint An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis
    L A Joosten
    Rheumatology Research Laboratory and Department of Internal Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Immunol 165:6553-8. 2000
    ..The present study indicates that IL-18 is a proinflammatory cytokine during the onset of murine SCW arthritis, and this inflammatory role of IL-18 is IFN-gamma independent...
  10. ncbi request reprint Contributions of Neisseria meningitidis LPS and non-LPS to proinflammatory cytokine response
    T Sprong
    Department of Internal Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Leukoc Biol 70:283-8. 2001
    ..The principal conclusion is that non-LPS parts of N. meningitidis may play a role in the pathogenesis of meningococcal sepsis by inducing substantial TNF-alpha, IL-1beta, and IFN-gamma production...
  11. doi request reprint Interleukin-18 resistance in patients with obesity and type 2 diabetes mellitus
    G R C Zilverschoon
    Department of General Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Int J Obes (Lond) 32:1407-14. 2008
    ..Paradoxically, concentrations of circulating IL-18 in obese subjects and in patients with type 2 diabetes are increased. The objective of this study is to provide an explanation for this paradox...
  12. doi request reprint Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process
    E J Giamarellos-Bourboulis
    Department of Internal Medicine, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Ann Rheum Dis 68:273-8. 2009
    ..In the present study we have investigated whether production of proinflammatory cytokines by crystals was exacerbated during costimulation with Toll-like receptor (TLR) ligands...
  13. pmc Hyperlipoproteinemia enhances susceptibility to acute disseminated Candida albicans infection in low-density-lipoprotein-receptor-deficient mice
    M G Netea
    Department of Medicine, University Hospital Nijmegen, The Netherlands
    Infect Immun 65:2663-7. 1997
    ..This latter phenomenon was probably due to increased binding of yeast cells to macrophages of LDLR-/- mice. These data suggest that hyperlipoproteinemia is deleterious in systemic candidiasis...
  14. ncbi request reprint Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia
    M G Netea
    Departments ofMedicine and Surgery, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 164:2644-9. 2000
    ..coli LPS) or TNF (S. typhimurium LPS) synthesis by anti-IL-18 treatment may also be involved...
  15. ncbi request reprint Candida-specific interferon-gamma deficiency and toll-like receptor polymorphisms in patients with chronic mucocutaneous candidiasis
    C A A van der Graaf
    Department of Internal Medicine 541, University Medical Centre St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Neth J Med 61:365-9. 2003
    ..These data support the hypothesis that deficient IFNgamma production is involved in the pathogenesis of CMC, whereas a role for genetic polymorphisms of Toll-like receptor 2 and 4 is not obvious in these patients...
  16. ncbi request reprint Increased susceptibility of TNF-alpha lymphotoxin-alpha double knockout mice to systemic candidiasis through impaired recruitment of neutrophils and phagocytosis of Candida albicans
    M G Netea
    Department of Medicine, University Hospital Nijmegen, The Netherlands
    J Immunol 163:1498-505. 1999
    ..albicans...
  17. ncbi request reprint Increased voluntary exercise in mice deficient for tumour necrosis factor-alpha and lymphotoxin-alpha
    M G Netea
    Department of Medicine, Nijmegen University Centre for Infectious Diseases, Nijmegen, The Netherlands
    Eur J Clin Invest 37:737-41. 2007
    ..We hypothesized that proinflammatory cytokines, in particular tumour necrosis factor-alpha (TNFalpha) and lymphotoxin-alpha (LT) transmit signals leading to fatigue...
  18. ncbi request reprint Recognition of fungal pathogens by Toll-like receptors
    M G Netea
    Department of Medicine, Radboud University Medical Center Nijmegen, Geert Grooteplein 8, P O Box 9101, Nijmegen, The Netherlands
    Eur J Clin Microbiol Infect Dis 23:672-6. 2004
    ..These new data have substantially increased our knowledge of the recognition of fungal pathogens, and the study of TLRs remains one of the most active areas of research in the field of fungal infections...
  19. pmc Modulation of muramyl dipeptide stimulation of cytokine production by blood components
    J H M van der Meer
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80602, USA
    Clin Exp Immunol 156:428-33. 2009
    ..The inhibition of MDP stimulation was dependent upon cellular components, with erythrocyte-derived haemoglobin and neutrophils collaborating in the inhibition of MDP effects in whole blood...
  20. ncbi request reprint Severely impaired IL-12/IL-18/IFNgamma axis in patients with hyper IgE syndrome
    M G Netea
    Radboud University Medical Centre and Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands
    Eur J Clin Invest 35:718-21. 2005
    ..The aim of this study was to investigate whether activation of the interleukin-12/interleukin-18/interferon-gamma axis, known to be crucial for the activation of cellular immune responses, is impaired in patients with HIES...
  21. doi request reprint Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammatory cytokine expression
    H J Jansen
    Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation, and Immunity, 6525 GA, Nijmegen, The Netherlands
    Endocrinology 153:5866-74. 2012
    ..Autophagy may function to dampen inflammatory gene expression and thereby limit excessive inflammation in adipose tissue during obesity...
  22. pmc Milder clinical hyperimmunoglobulin E syndrome phenotype is associated with partial interleukin-17 deficiency
    F L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Exp Immunol 159:57-64. 2010
    ..These data demonstrate that defective IL-17 production in response to specific pathogens can differ between patients with HIES and that the extent of the defective Th17 response determines their clinical phenotype...
  23. ncbi request reprint Hypoglycaemia downregulates endotoxin-induced production of tumour necrosis factor-alpha, but does not affect IL-1beta, IL-6, or IL-10
    B E de Galan
    Department of General Internal Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Cytokine 22:71-6. 2003
    ..We conclude that hypoglycaemia specifically downregulates TNFalpha production capacity. Diabetic patients already have a suppressed TNFalpha production capacity at non-hypoglycaemic levels...
  24. ncbi request reprint Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of atherosclerosis in patients with familial hypercholesterolaemia
    M G Netea
    University Medical Center, St Radboud, Nijmegen, The Netherlands
    Eur J Clin Invest 34:94-9. 2004
    ..We have investigated whether the presence of the Asp299Gly polymorphism in patients with familial hypercholesterolaemia (FH) has a similar protective effect, and whether it influences the effects of HMG-CoA reductase treatment...
  25. doi request reprint Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: a crucial role for Kr├╝ppel-like factor 2
    L J H van Tits
    Institute for Genetic and Metabolic Disease, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Atherosclerosis 214:345-9. 2011
    ..Macrophages are key players in atherogenesis because of their properties to form foam cells that produce a large variety of pro-inflammatory mediators. We addressed the potency of phenotypic different macrophages to accumulate oxidized LDL...
  26. pmc Influence of anti-tumour necrosis factor therapy on cardiovascular risk factors in patients with active rheumatoid arthritis
    C Popa
    Rheumatology Department, UMC St Radboud, Geert Grooteplein 8, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 64:303-5. 2005
    ....
  27. pmc Low-density lipoprotein receptor-deficient mice are protected against lethal endotoxemia and severe gram-negative infections
    M G Netea
    Department of Medicine, University Hospital Nijmegen, The Netherlands
    J Clin Invest 97:1366-72. 1996
    ..At least part of this protection is achieved through decreased in vivo production of pro-inflammatory cytokines, in spite of increased cytokine production capacity...
  28. ncbi request reprint NOD2 3020insC mutation and the pathogenesis of Crohn's disease: impaired IL-1beta production points to a loss-of-function phenotype
    M G Netea
    Departments of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neth J Med 63:305-8. 2005
    ..e. a gain of function. In previous papers we proposed the former, since we could show decreased cytokine production with a net proinflammatory status after exposure to muramyl dipeptide (MDP)...
  29. ncbi request reprint Reduced adrenal response and increased mortality after systemic Klebsiella pneumoniae infection in interleukin-6-deficient mice
    F H van Enckevort
    Department of Endocrinology 531, Nijmegen University Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Cytokine Netw 12:581-6. 2001
    ..Furthermore, the reduced adrenal response may be an explanation for the strong inflammatory response with higher TNF-alpha plasma levels in IL-6-/- mice...
  30. ncbi request reprint Autophagy is redundant for the host defense against systemic Candida albicans infections
    S P Smeekens
    Department of Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands
    Eur J Clin Microbiol Infect Dis 33:711-22. 2014
    ..Based on these complementary in vitro and in vivo studies, it can be concluded that autophagy is redundant for the host response against systemic infections with C. albicans. ..
  31. doi request reprint Primary immunodeficiencies of pattern recognition receptors
    M G Netea
    Department of Medicine and Nijmegen, Institute for Infection, Inflammation and Immunity N4i, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Intern Med 272:517-27. 2012
    ..Their discovery has led to important insights into the pathophysiology of infections, and may offer potential novel therapeutic targets for immunotherapy...
  32. pmc The impact of caspase-12 on susceptibility to candidemia
    D C Rosentul
    Department of Medicine, Radboud University Nijmegen Medical Centre, internal postal code 463, P O Box 9101, Geert Grooteplein 8, 6500 HB, Nijmegen, The Netherlands
    Eur J Clin Microbiol Infect Dis 31:277-80. 2012
    ..Although the functional CASPASE-12 allele has been suggested to increase susceptibility to bacterial sepsis, this could not be confirmed in our larger cohort of fungal sepsis patients...
  33. ncbi request reprint Role of the dual interaction of fungal pathogens with pattern recognition receptors in the activation and modulation of host defence
    M G Netea
    Department of Medicine, Radboud University Nijmegen Medical Center, and Nijmegen University Center for Infectious Diseases, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Clin Microbiol Infect 12:404-9. 2006
    ..Thus, signals mediated by recognition receptors are not only beneficial to the host, but in certain situations can be used by pathogenic fungi to escape immune recognition and promote infection...
  34. doi request reprint Circulating galectin-3 in infections and non-infectious inflammatory diseases
    J ten Oever
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Clin Microbiol Infect Dis 32:1605-10. 2013
    ..Although galectin-3 does not discriminate between bacterial and Candida sepsis, the sequential use of CRP and galectin-3 in distinguishing infectious diseases from non-infectious inflammation may be superior to CRP alone...
  35. doi request reprint Adjunctive immunotherapy with recombinant cytokines for the treatment of disseminated candidiasis
    F L van de Veerdonk
    Nijmegen University Centre for Infectious Diseases, and Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Microbiol Infect 18:112-9. 2012
    ....
  36. ncbi request reprint Chronic yersiniosis due to defects in the TLR5 and NOD2 recognition pathways
    M G Netea
    Nijmegen University Centre for Infectious Diseases, Nijmegen, The Netherlands
    Neth J Med 68:310-5. 2010
    ..In conclusion, we describe a patient in whom specific defects in the TLR5 and NOD2 recognition pathways led to chronic yersiniosis...
  37. ncbi request reprint The role of interferon-gamma in the increased tuberculosis risk in type 2 diabetes mellitus
    J E Stalenhoef
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, 9101, 6500 HB Nijmegen, The Netherlands
    Eur J Clin Microbiol Infect Dis 27:97-103. 2008
    ..tuberculosis. Our data suggest that a defective non-specific immune response in diabetes may contribute to an increased susceptibility to develop tuberculosis...
  38. ncbi request reprint Hypothesis: Normalisation of cytokine dysbalance explains the favourable effects of strict glucose regulation in the critically ill
    P Pickkers
    Department of Intensive Care Medicine 519, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Neth J Med 62:143-50. 2004
    ..To support our hypothesis, effects of glucose and insulin on cytokine release and effects of glucose, insulin, and cytokines on host defence, cardiac function and coagulation will be reviewed...
  39. ncbi request reprint Recognition of pathogenic microorganisms by Toll-like receptors
    M G Netea
    Department of Medicine, Radboud University Medical Center, Nijmegen, and Nijmegen University Center for Infectious Diseases, The Netherlands
    Drugs Today (Barc) 42:99-105. 2006
    ..These new data have substantially increased our knowledge of the recognition of microbial pathogens, and this remains one of the most active areas of research in the field of infectious diseases...
  40. pmc Beneficial response to anakinra and thalidomide in Schnitzler's syndrome
    H D de Koning
    Radboud University Nijmegen Medical Centre, Department of General Internal Medicine, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 65:542-4. 2006
    ..Schnitzler's syndrome is an inflammatory disorder characterised by chronic urticarial rash and monoclonal gammopathy, accompanied by periodic fever, arthralgia or arthritis, and bone pain. The cause and treatment are still unknown...
  41. ncbi request reprint Defective interferon-gamma production in patients with hairy cell leukaemia
    M G Netea
    Division of General Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Neth J Med 66:340-34. 2008
    ..Although several abnormalities of T-cell populations have been described in HCL, the effector mechanism responsible for the increased susceptibility to infections is not known...
  42. doi request reprint Molecular view on PRR cross-talk in antifungal immunity
    S Hontelez
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Cell Microbiol 14:467-74. 2012
    ..Here we will discuss the cross-talk between PRRs involved in fungal recognition, focusing on the molecular interactions occurring at the plasma membrane...
  43. doi request reprint Cutaneous granulomas in ataxia telangiectasia and other primary immunodeficiencies: reflection of inappropriate immune regulation?
    L Y T Chiam
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Dermatology 223:13-9. 2011
    ..Non-infective cutaneous granulomas with unknown pathogenesis occur in various primary immunodeficiencies (PIDs) including ataxia telangiectasia (A-T)...
  44. ncbi request reprint Successful treatment of dermatomyositis and polymyositis with anti-tumor-necrosis-factor-alpha: preliminary observations
    G J D Hengstman
    Neuromuscular Centre Nijmegen, Institute of Neurology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Eur Neurol 50:10-5. 2003
    ..These preliminary results suggest that anti-TNF-alpha treatment with infliximab is a safe and rapidly effective therapy for myositis...
  45. doi request reprint A decrease of plasma macrophage migration inhibitory factor concentration is associated with lower numbers of circulating lymphocytes in experimental Plasmodium falciparum malaria
    Q de Mast
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Parasite Immunol 30:133-8. 2008
    ..Plasma concentrations of the pro-inflammatory cytokines IL-8 and IL-1beta were only marginally elevated. We conclude that circulating MIF levels decrease early in blood-stage malaria as a result of the decline in circulating lymphocytes...
  46. doi request reprint Invasive fungal infection in an elderly patient with defective inflammatory macrophage function
    L Y A Chai
    Department of Medicine, Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Nijmegen, The Netherlands
    Clin Microbiol Infect 17:1546-9. 2011
    ..Herein, we describe a patient with invasive testicular aspergillosis in whom we found, for the first time, a defect in macrophage function...
  47. ncbi request reprint Skin lesions on the foot
    M G Netea
    Department of General Internal Medicine, UMC St Radboud, Nijmegen, The Netherlands
    Neth J Med 61:257, 269. 2003
  48. ncbi request reprint Critical aneurysmal dilatation of the thoracic aorta in young adolescents with variant hyperimmunoglobulin E syndrome
    J W M van der Meer
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Intern Med 259:615-8. 2006
    ..This process should be anticipated during childhood in cases with AR-HIES...
  49. ncbi request reprint Mycobacterium paratuberculosis is recognized by Toll-like receptors and NOD2
    Gerben Ferwerda
    Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands
    J Leukoc Biol 82:1011-8. 2007
    ..paratuberculosis. These results demonstrate that TLR2, TLR4, and NOD2 are involved in the recognition of M. paratuberculosis by the innate immune system...
  50. pmc Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Invest 116:1642-50. 2006
    ..We concluded that recognition of C. albicans by monocytes/macrophages is mediated by 3 recognition systems of differing importance, each of which senses specific layers of the C. albicans cell wall...
  51. ncbi request reprint Plasmodium falciparum infection causes proinflammatory priming of human TLR responses
    Matthew B B McCall
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands
    J Immunol 179:162-71. 2007
    ..Taken together, P.f. primes human TLR responses toward a more proinflammatory cytokine profile both in vitro and in vivo, a characteristic exceptional among microorganisms...
  52. pmc Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    PLoS Med 3:e277. 2006
    ..Interleukin (IL)-32 is a newly described proinflammatory cytokine that seems likely to play a role in inflammation and host defense. Little is known about the regulation of IL-32 production by primary cells of the immune system...
  53. ncbi request reprint Both TLR2 and TLR4 are involved in the recognition of Candida albicans. Reply to "TLR2, but not TLR4, triggers cytokine production by murine cells in response to Candida albicans yeasts and hyphae" by Gil and Gozalbo, Microbes and Infection 8 (2
    Mihai G Netea
    Microbes Infect 8:2821-2; author reply 2823-4. 2006
  54. ncbi request reprint Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
    Mihai G Netea
    Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Geert Grooteplein 8, 6500 HB, Nijmegen, The Netherlands
    Nat Med 12:650-6. 2006
    ..In addition, rIL-18 reversed hyperglycemia in Il18-/- mice through activation of STAT3 phosphorylation. These findings indicate a new role of IL-18 in the homeostasis of energy intake and insulin sensitivity...
  55. pmc Immune recognition of Candida albicans beta-glucan by dectin-1
    Neil A R Gow
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    J Infect Dis 196:1565-71. 2007
    ..albicans was independent of the recognition of beta-glucans by dectin-1. In conclusion, C. albicans induces production of monocyte-derived and T cell-derived cytokines through distinct pathways dependent on or independent of dectin-1...
  56. ncbi request reprint Mechanical ventilation in healthy mice induces reversible pulmonary and systemic cytokine elevation with preserved alveolar integrity: an in vivo model using clinical relevant ventilation settings
    Michiel Vaneker
    Department of Anesthesiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Anesthesiology 107:419-26. 2007
    ..To study mechanotransduction in vivo, the authors used an animal MV model with clinically relevant ventilator settings, avoiding alveolar damage...
  57. doi request reprint Redundant role of TLR9 for anti-Candida host defense
    Frank Leo van de Veerdonk
    Immunobiology 213:613-20. 2008
    ..albicans. However, the cytokine defect in TLR9-/- mice is compensated by alternative pathways, and the TLR9-dependent pathway seems to be redundant in the disseminated candidiasis model in mice...
  58. pmc Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis
    Leo A B Joosten
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 105:9017-22. 2008
    ..Whether a distorted balance between the function of Nod1 and/or Nod2 is involved in the pathogenesis of human autoinflammatory or autoimmune disease, such as rheumatoid arthritis, remains to be elucidated...
  59. doi request reprint Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages
    Gerben Ferwerda
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cell Microbiol 10:2058-66. 2008
    ..Conclusively, dectin-1 synergizes with both TLR2 and TLR4 pathways for the production of TNF-alpha in human primary PBMCs and in monocyte-derived macrophages...
  60. pmc Dendritic cell interaction with Candida albicans critically depends on N-linked mannan
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Biol Chem 283:20590-9. 2008
    ..Better insight in the carbohydrate recognition profile of C-type lectins will ultimately provide relevant information for the development of new drugs targeting specific fungal cell wall antigens...
  61. pmc Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors
    Kevin M Dennehy
    Institute of Infectious Disease and Molecular Medicine, Clinical Laboratory Sciences Division of Immunology, University of Cape Town, Cape Town, South Africa
    Eur J Immunol 38:500-6. 2008
    ..These findings establish the first example of Syk- and MyD88-coupled PRR collaboration, further supporting the concept that paired receptors collaborate to control infectious agents...
  62. ncbi request reprint Individual LPS responsiveness depends on the variation of toll-like receptor (TLR) expression level
    Jun Jaekal
    Laboratory of Cytokine Immunology, Institute of Biomedical Science and Technology, Konkuk University, Seoul 143 701, Korea
    J Microbiol Biotechnol 17:1862-7. 2007
    ..The present study therefore suggests that the constitutive expression levels of TLR2 and TLR4 may contribute to the individual response to LPS...
  63. ncbi request reprint Role of TLR1 and TLR6 in the host defense against disseminated candidiasis
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    FEMS Immunol Med Microbiol 52:118-23. 2008
    ..In conclusion, TLR6 is involved in the recognition of C. albicans and modulates the Th1/Th2 cytokine balance, but this results in a mild phenotype with a normal susceptibility of TLR6-/- mice to Candida infection...
  64. ncbi request reprint Low-tidal-volume mechanical ventilation induces a toll-like receptor 4-dependent inflammatory response in healthy mice
    Michiel Vaneker
    Department of Anesthesiology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Anesthesiology 109:465-72. 2008
    ..A role for proinflammatory pathways has been proposed. The current studies analyzed the roles of Toll-like receptor (TLR) 4 and TLR2 involvement in the inflammatory response after MV in the healthy lung...
  65. ncbi request reprint Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen University, The Netherlands
    J Leukoc Biol 75:749-55. 2004
    ..Finally, the crucial role of TLRs for the host defense against infections has been strengthened recently by the description of patients partially defective in the TLR-activation pathways...
  66. ncbi request reprint Endogenous interleukin (IL)-1 alpha and IL-1 beta are crucial for host defense against disseminated candidiasis
    Alieke G Vonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 193:1419-26. 2006
    ..It is, however, unknown whether they provide protection through similar mechanisms. We investigated the effect of endogenous IL-1 alpha and IL-1 beta on disseminated C. albicans infection...
  67. ncbi request reprint Phagocytosis and intracellular killing of Candida albicans blastoconidia by neutrophils and macrophages: a comparison of different microbiological test systems
    Alieke G Vonk
    Department of Medicine 541, Division of General Internal Medicine, Nijmegen University Medical Center, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    J Microbiol Methods 49:55-62. 2002
    ....
  68. ncbi request reprint Aspergillus fumigatus evades immune recognition during germination through loss of toll-like receptor-4-mediated signal transduction
    Mihai G Netea
    Department of Medicine 541, University Medical Center St Radboud, 6500 HB Nijmegen, The Netherlands
    J Infect Dis 188:320-6. 2003
    ..Therefore, phenotypic switching during germination may be an important escape mechanism of A. fumigatus that results in counteracting the host defense...
  69. ncbi request reprint Cytokine release in healthy donors and patients with chronic granulomatous disease upon stimulation with Aspergillus fumigatus
    Adilia Warris
    Department of Microbiology, Rikshospitalet University Hospital, Oslo, Norway
    Scand J Infect Dis 35:482-7. 2003
    ....
  70. pmc Selective regulation of intercellular adhesion molecule-1 expression by interleukin-18 and interleukin-12 on human monocytes
    Rogier J L Stuyt
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Immunology 110:329-34. 2003
    ..In conclusion, IL-18 selectively up-regulates the expression of ICAM-1 on monocytes, and this contributes to the proinflammatory effects of this cytokine...
  71. ncbi request reprint Differential role of IL-18 and IL-12 in the host defense against disseminated Candida albicans infection
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, Nijmegen, The Netherlands
    Eur J Immunol 33:3409-17. 2003
    ..In conclusion, the anticandidal effects of endogenous IL-18 are mediated late during the infection by assuring a proper IFN-gamma response and promoting the infiltration of the site of infection by monocytes...
  72. ncbi request reprint Human lipoproteins have divergent neutralizing effects on E. coli LPS, N. meningitidis LPS, and complete Gram-negative bacteria
    Tom Sprong
    Department of General Internal Medicine, University Medical Centre St Radboud, Nijmegen, The Netherlands
    J Lipid Res 45:742-9. 2004
    ..meningitidis LPS. Irrespective of these differences, whole bacteria showed no neutralization by lipoproteins...
  73. ncbi request reprint Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Immunol 172:3712-8. 2004
    ..In conclusion, C. albicans induces immunosuppression through TLR2-derived signals that mediate increased IL-10 production and survival of Treg cells. This represents a novel mechanism in the pathogenesis of fungal infections...
  74. ncbi request reprint The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome
    Timothy R D J Radstake
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:999-1001. 2004
  75. ncbi request reprint Recombinant interleukin-18 protects against disseminated Candida albicans infection in mice
    Rogier J L Stuyt
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Infect Dis 189:1524-7. 2004
    ..albicans in rIL-18-treated mice. In conclusion, rIL-18 improves outcome of disseminated candidiasis in mice and may prove useful as adjuvant immunotherapy of fungal infections...
  76. ncbi request reprint Salmonella septicemia in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: association with decreased interferon-gamma production and Toll-like receptor 4 expression
    Mihai G Netea
    University Medical Center St Radboud, and Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands
    Arthritis Rheum 48:1853-7. 2003
    ..The aim of this study was to identify the mechanisms involved in the increased susceptibility of anti-TNF-treated patients to intracellular microorganisms...
  77. ncbi request reprint Does the shape of lipid A determine the interaction of LPS with Toll-like receptors?
    Mihai G Netea
    Dept of Medicine, Division of General Internal Medicine, University Medical Center St Radboud, Geert Grooteplein 8, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Trends Immunol 23:135-9. 2002
    ..Strictly cylindrical LPS molecules (e.g. the lipid A precursor Ia or from Rhodobacter sphaeroides) have antagonistic properties at the level of TLRs...
  78. ncbi request reprint Divergent effects of tumor necrosis factor-alpha and lymphotoxin-alpha on lethal endotoxemia and infection with live Salmonella typhimurium in mice
    Edi Dharmana
    Department of Parasitology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
    Eur Cytokine Netw 13:104-9. 2002
    ..typhimurium LPS and on the infection of mice with live Salmonella microorganisms, and suggest caution when extrapolating results obtained in the lethal endotoxemia model to bacteremia in patients...
  79. ncbi request reprint CD40/CD40 ligand interactions in the host defense against disseminated Candida albicans infection: the role of macrophage-derived nitric oxide
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Eur J Immunol 32:1455-63. 2002
    ..In conclusion, absence of CD40/CD40L interactions results in increased susceptibility to disseminated infection with C. albicans through decreased NO-dependent killing of Candida by macrophages...
  80. ncbi request reprint The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis
    Mihai G Netea
    Department of Medicine, Division of General Internal Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Infect Dis 185:1483-9. 2002
    ..In conclusion, TLR4-defective C3H/HeJ mice are more susceptible to C. albicans infection, and this is associated with impaired chemokine expression and neutrophil recruitment...
  81. pmc Role of interleukin-18 in host defense against disseminated Candida albicans infection
    Rogier J L Stuyt
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Infect Immun 70:3284-6. 2002
    ..There was no effect on the organ load with Candida when gamma interferon (IFN-gamma)-deficient mice were treated with anti-IL-18 antibodies, suggesting that the protective effect of IL-18 is mediated through endogenous IFN-gamma...
  82. pmc Parenteral administration of medium- but not long-chain lipid emulsions may increase the risk for infections by Candida albicans
    Geert J Wanten
    Department of Gastroenterology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Infect Immun 70:6471-4. 2002
    ....
  83. ncbi request reprint Delayed clearance of intraabdominal abscesses caused by Candida albicans in tumor necrosis factor-alpha- and lymphotoxin-alpha-deficient mice
    Alieke G Vonk
    Nijmegen University Center for Infectious Diseases and Department of Medicine, Nijmegen, The Netherlands
    J Infect Dis 186:1815-22. 2002
    ..In conclusion, TNF and LT are critical to the stimulation of effector cells that leads to elimination of Candida from abscesses...
  84. ncbi request reprint Neisseria meningitidis can induce pro-inflammatory cytokine production via pathways independent from CD14 and toll-like receptor 4
    Tom Sprong
    Department of Internal Medicine, University Medical Centre Nijmegen, The Netherlands
    Eur Cytokine Netw 13:411-7. 2002
    ..It is concluded that pro-inflammatory cytokine induction by N. meningitidis can occur independently of CD14 and TLR4...
  85. ncbi request reprint Regulation of Staphylococcus epidermidis-induced IFN-gamma in whole human blood: the role of endogenous IL-18, IL-12, IL-1, and TNF
    Rogier J L Stuyt
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Cytokine 21:65-73. 2003
    ..In conclusion, S. epidermidis stimulates IFN-gamma which is IL-18, IL-12 and TNF-dependent, but IL-1 independent...
  86. ncbi request reprint NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Eur J Immunol 34:2052-9. 2004
    ..In conclusion, defective NOD2 function results in a pro-inflammatory cytokine bias after stimulation of mononuclear cells with TLR2 stimuli, and this could contribute to the overwhelming inflammation seen in Crohn's disease...
  87. ncbi request reprint Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release
    Mihai G Netea
    Department of Medicine, University Medical Center Nijmegen, The Netherlands
    J Immunol 173:1477-82. 2004
    ..Most interestingly, C. pneumoniae is also a potent inducer of IL-18 production through pathways independent of TLR2 and TLR4...
  88. pmc Nucleotide oligomerization domain 2 (Nod2) is not involved in the pattern recognition of Candida albicans
    Chantal A A Van der Graaf
    Department of Medicine, Radboud University Nijmegen Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Clin Vaccine Immunol 13:423-5. 2006
    ..Candida-induced cytokine production in individuals with Nod2 polymorphisms was unaffected. We conclude that Nod2 is unlikely to play an important role in the recognition of Candida albicans...
  89. pmc IL-32, a proinflammatory cytokine in rheumatoid arthritis
    Leo A B Joosten
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, The Netherlands
    Proc Natl Acad Sci U S A 103:3298-303. 2006
    ..IL-32, strongly associated with TNFalpha, IL-1beta, and IL-18, appears to play a role in human RA and may be a novel target in autoimmune diseases...
  90. pmc Toll-like receptor 2 controls expansion and function of regulatory T cells
    Roger P M Sutmuller
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Invest 116:485-94. 2006
    ..albicans outgrowth. This demonstrates that in vivo TLR2 also controls the function of Tregs and establishes a direct link between TLRs and the control of immune responses through Tregs...
  91. ncbi request reprint Cytokine responses and regulation of interferon-gamma release by human mononuclear cells to Aspergillus fumigatus and other filamentous fungi
    Adilia Warris
    Department of Paediatrics 435, University Medical Centre St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Med Mycol 43:613-21. 2005
    ..fumigatus hyphae, whereas conidia induced IFNgamma stimulation is independent of these cytokines...
  92. ncbi request reprint Influence of endogenous pro-inflammatory cytokines on neutrophil-mediated damage of Candida albicans pseudohyphae, quantified in a modified tetrazolium dye assay
    Alieke G Vonk
    Department of Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Center, The Netherlands
    Med Mycol 43:551-7. 2005
    ....
  93. ncbi request reprint IFN-gamma is not induced through increased plasma concentrations of interleukin-12/interleukin-18 during human endotoxemia
    Mirrin J Dorresteijn
    Department of Intensive Care Medicine 519, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Cytokine Netw 16:191-3. 2005
    ..In contrast, IFN-gamma showed an increase from 106.6 +/- 57.1 to 152.7 +/- 57.8 (p < 0.005). These results indicate that pathways other than the IL-12/IL-18 axis may induce IFN-gamma production in human endotoxemia...
  94. pmc Differential cytokine production and Toll-like receptor signaling pathways by Candida albicans blastoconidia and hyphae
    Chantal A A Van der Graaf
    Department of Medicine 541, Radboud University Nijmegen Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Infect Immun 73:7458-64. 2005
    ..TLR4-mediated proinflammatory signals are lost during germination of Candida blastoconidia into hyphae. Phenotypic switching during germination may be an important escape mechanism of C. albicans, resulting in counteracting host defense...
  95. ncbi request reprint The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists
    Mihai G Netea
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, The Netherlands
    J Biol Chem 280:35859-67. 2005
    ..Together, our results identified a cross-talk between the Nod1 and Nod2 pathways and suggested that down-regulation of Nod1/M-Tri(DAP) pathway may be associated with Crohn disease...
  96. ncbi request reprint Toll-like receptor 4 Asp299Gly/Thr399Ile polymorphisms are a risk factor for Candida bloodstream infection
    Chantal A A Van der Graaf
    Department of Internal Medicine 463, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Cytokine Netw 17:29-34. 2006
    ..These findings show that the TLR4 Asp299Gly/Thr399Ile polymorphisms are associated with an increased susceptibility to Candida bloodstream infections, and an increased production of IL-10 is probably involved in this effect...
  97. ncbi request reprint Human dendritic cells are less potent at killing Candida albicans than both monocytes and macrophages
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Microbes Infect 6:985-9. 2004
    ..albicans hyphae. Effective handling of large numbers of C. albicans is the prime task of the innate immune system consisting of large numbers of neutrophils and monocytes...
  98. ncbi request reprint Apolipoprotein-E-deficient mice exhibit an increased susceptibility to disseminated candidiasis
    Alieke G Vonk
    Division of General Internal Medicine, Department of Medicine, University Medical Center, Nijmegen, The Netherlands
    Med Mycol 42:341-8. 2004
    ..This study suggests that lipoproteins play a significant role in host defense against candidiasis...
  99. ncbi request reprint Cytokine production of stimulated whole blood cultures in rheumatoid arthritis patients receiving short-term infliximab therapy
    Calin Popa
    Department of Internal Medicine, University Medical Center St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Cytokine 30:72-7. 2005
    ....
  100. ncbi request reprint Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release
    Mihai G Netea
    Department of Medicine, Radboud University Medical Center Nijmegen, The Netherlands
    J Immunol 174:6518-23. 2005
    ..Thus, interaction between NOD2 and specific TLR pathways may represent an important modulatory mechanism of innate immune responses...
  101. ncbi request reprint Functional consequences of the Asp299Gly Toll-like receptor-4 polymorphism
    Chantal van der Graaf
    Department of Medicine, University Medical Center St Radboud Nijmegen, The Netherlands
    Cytokine 30:264-8. 2005
    ..In addition, this is the first study to demonstrate that even homozygosity for the Asp299Gly mutation does not confer hyporesponsiveness to stimulation with TLR4 stimuli...