Iris D Nagtegaal

Summary

Affiliation: University Medical Center
Country: The Netherlands

Publications

  1. pmc Local and distant recurrences in rectal cancer patients are predicted by the nonspecific immune response; specific immune response has only a systemic effect--a histopathological and immunohistochemical study
    I D Nagtegaal
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    BMC Cancer 1:7. 2001
  2. ncbi Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control
    Iris D Nagtegaal
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Oncol 20:1729-34. 2002
  3. ncbi The role of pathologists in the quality control of diagnosis and treatment of rectal cancer-an overview
    I D Nagtegaal
    Department of Pathology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Eur J Cancer 38:964-72. 2002
  4. ncbi Short-term preoperative radiotherapy interferes with the determination of pathological parameters in rectal cancer
    Iris D Nagtegaal
    Department of Pathology, Leiden University Medical Centre, The Netherlands
    J Pathol 197:20-7. 2002
  5. ncbi Loss of membranous Ep-CAM in budding colorectal carcinoma cells
    Marleen J E M Gosens
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mod Pathol 20:221-32. 2007
  6. pmc Beyond KRAS mutation status: influence of KRAS copy number status and microRNAs on clinical outcome to cetuximab in metastatic colorectal cancer patients
    Leonie J M Mekenkamp
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Cancer 12:292. 2012
  7. pmc Receptor conversion in distant breast cancer metastases
    Laurien D C Hoefnagel
    Department of Pathology, University Medical Center Utrecht, The Netherlands
    Breast Cancer Res 12:R75. 2010
  8. ncbi Improvement of staging by combining tumor and treatment parameters: the value for prognostication in rectal cancer
    Marleen J E M Gosens
    Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands
    Clin Gastroenterol Hepatol 5:997-1003. 2007
  9. doi Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial
    Willem van Gijn
    Leiden University Medical Centre, Leiden, The Netherlands
    Lancet Oncol 12:575-82. 2011
  10. doi What is the role for the circumferential margin in the modern treatment of rectal cancer?
    Iris D Nagtegaal
    Department of Pathology 824, University Medical Center Nijmegen, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    J Clin Oncol 26:303-12. 2008

Collaborators

Detail Information

Publications45

  1. pmc Local and distant recurrences in rectal cancer patients are predicted by the nonspecific immune response; specific immune response has only a systemic effect--a histopathological and immunohistochemical study
    I D Nagtegaal
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    BMC Cancer 1:7. 2001
    ..Data concerning involvement of individual cell types are readily available but little is known about the coordinate interactions between both forms of immune response...
  2. ncbi Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control
    Iris D Nagtegaal
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Oncol 20:1729-34. 2002
    ..We have evaluated criteria by which pathologists can judge the quality or completeness of the resection specimen in a randomized trial for rectal cancer...
  3. ncbi The role of pathologists in the quality control of diagnosis and treatment of rectal cancer-an overview
    I D Nagtegaal
    Department of Pathology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Eur J Cancer 38:964-72. 2002
    ..In this review, we describe the standard evaluation of a rectal cancer specimen with special attention to preoperative irradiated specimens...
  4. ncbi Short-term preoperative radiotherapy interferes with the determination of pathological parameters in rectal cancer
    Iris D Nagtegaal
    Department of Pathology, Leiden University Medical Centre, The Netherlands
    J Pathol 197:20-7. 2002
    ..001). Remarkable histological alterations occurred within a week after 5 days of irradiation of rectal carcinomas. The prognostic value of these factors therefore needs to be re-evaluated for irradiated patients...
  5. ncbi Loss of membranous Ep-CAM in budding colorectal carcinoma cells
    Marleen J E M Gosens
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mod Pathol 20:221-32. 2007
    ..Our observations indicate that loss of membranous Ep-CAM is associated with nuclear beta-catenin localization and suggest that this contributes to reduced cell-cell adhesions, increased migratory potential and tumor budding...
  6. pmc Beyond KRAS mutation status: influence of KRAS copy number status and microRNAs on clinical outcome to cetuximab in metastatic colorectal cancer patients
    Leonie J M Mekenkamp
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Cancer 12:292. 2012
    ..We assessed the influence of modification of KRAS by gene copy number aberration (CNA) and microRNAs (miRNAs) in correlation to clinical outcome in mCRC patients treated with cetuximab in combination with chemotherapy and bevacizumab...
  7. pmc Receptor conversion in distant breast cancer metastases
    Laurien D C Hoefnagel
    Department of Pathology, University Medical Center Utrecht, The Netherlands
    Breast Cancer Res 12:R75. 2010
    ....
  8. ncbi Improvement of staging by combining tumor and treatment parameters: the value for prognostication in rectal cancer
    Marleen J E M Gosens
    Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands
    Clin Gastroenterol Hepatol 5:997-1003. 2007
    ..By using rectal cancer as a model we explored the hypothesis that a combination of tumor- and treatment-related parameters will result in improved prognostication...
  9. doi Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial
    Willem van Gijn
    Leiden University Medical Centre, Leiden, The Netherlands
    Lancet Oncol 12:575-82. 2011
    ..The TME trial investigated the value of preoperative short-term radiotherapy in combination with total mesorectal excision (TME). Long-term results are reported after a median follow-up of 12 years...
  10. doi What is the role for the circumferential margin in the modern treatment of rectal cancer?
    Iris D Nagtegaal
    Department of Pathology 824, University Medical Center Nijmegen, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    J Clin Oncol 26:303-12. 2008
    ..Since the initial description of its clinical importance in 1986, the involvement of this margin (also called lateral or radial resection margin) has been associated with a poor prognosis...
  11. doi Chromosome 20p11 gains are associated with liver-specific metastasis in patients with colorectal cancer
    Leonie J M Mekenkamp
    Department of Pathology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Gut 62:94-101. 2013
    ..This study aimed to identify clinicopathological features and chromosomal aberrations of primary tumours associated with organ-specific CRC metastasis...
  12. ncbi Prognostic value of apoptosis in rectal cancer patients of the dutch total mesorectal excision trial: radiotherapy is redundant in intrinsically high-apoptotic tumors
    Elza C de Bruin
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Cancer Res 12:6432-6. 2006
    ..This study assesses the prognostic value of both intrinsic and radiotherapy-induced apoptosis and evaluates the relevance of radiotherapy for outcome of rectal cancer patients...
  13. ncbi High intrinsic apoptosis, but not radiation-induced apoptosis, predicts better survival in rectal carcinoma patients
    Corrie A M Marijnen
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Int J Radiat Oncol Biol Phys 57:434-43. 2003
    ..We evaluated the relevance of intrinsic and radiation-induced apoptosis and proliferation for prognosis in rectal cancer patients...
  14. pmc Risk factors for adverse outcome in patients with rectal cancer treated with an abdominoperineal resection in the total mesorectal excision trial
    Marcel den Dulk
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Surg 246:83-90. 2007
    ....
  15. doi Mucinous adenocarcinomas: poor prognosis in metastatic colorectal cancer
    Leonie J M Mekenkamp
    Department of Pathology, Radboud University Nijmegen Medical Centre, The Netherlands
    Eur J Cancer 48:501-9. 2012
    ..We investigated the prognostic value of mucinous histology in two large phase III studies in metastatic CRC...
  16. ncbi Combinations of tumor and treatment parameters are more discriminative for prognosis than the present TNM system in rectal cancer
    Iris D Nagtegaal
    Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands
    J Clin Oncol 25:1647-50. 2007
  17. ncbi The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma
    Koen C M J Peeters
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Surg 246:693-701. 2007
    ..To investigate the efficacy of preoperative short-term radiotherapy in patients with mobile rectal cancer undergoing total mesorectal excision (TME) surgery...
  18. doi Histopathological evaluation of resected colorectal cancer liver metastases: what should be done?
    Nikki Knijn
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Histopathology 63:149-56. 2013
    ..This review identifies several of these factors...
  19. pmc Chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts and differences are typically non-recurrent
    Leonie J M Mekenkamp
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 9:e86833. 2014
    ..We conclude, based on detailed analysis and large independent datasets, that chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts, and differences are typically non-recurrent. ..
  20. ncbi Clinical nature and prognosis of locally recurrent rectal cancer after total mesorectal excision with or without preoperative radiotherapy
    Mandy Van Den Brink
    Department of Medical Decision Making, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Oncol 22:3958-64. 2004
    ....
  21. doi Lymph nodes, tumor deposits, and TNM: are we getting better?
    Iris D Nagtegaal
    Department of Pathology 824, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    J Clin Oncol 29:2487-92. 2011
    ..New editions of the TNM staging system for colorectal cancer have been subject to extensive criticism. In the current study, we evaluate each edition of TNM and analyze stage migration caused by the different versions...
  22. doi Lymph node retrieval in rectal cancer is dependent on many factors--the role of the tumor, the patient, the surgeon, the radiotherapist, and the pathologist
    Leonie J M Mekenkamp
    Department of Pathology, Radboud University Nijmegen Medical Centre, The Netherlands
    Am J Surg Pathol 33:1547-53. 2009
    ..016). We conclude that in pathology laboratories a median of at least 8 lymph nodes need to be examined in rectal cancer specimens, but that higher numbers are desirable and achievable in most cases, even after preoperative radiotherapy...
  23. doi Pathology is a necessary and informative tool in oncology clinical trials
    Iris D Nagtegaal
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Pathol 232:185-9. 2014
    ..We describe critical issues in biomarker evaluation and development and emphasize the importance of the role of the pathologist in quality control of cancer treatment...
  24. ncbi Predicting lymph node metastasis in pT1 colorectal cancer: a systematic review of risk factors providing rationale for therapy decisions
    Steven L Bosch
    Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Endoscopy 45:827-34. 2013
    ..A systematic review of the predictive value of pathological risk factors for LNM in pT1 CRC was conducted to provide data for an evidence-based decision regarding follow-up or radical surgery after local excision...
  25. doi Management of sporadic duodenal adenomas and the association with colorectal neoplasms: a retrospective cohort study
    Bjorn W H van Heumen
    Departments of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Gastroenterol 46:390-6. 2012
    ..To evaluate management, outcome, and follow-up of patients with sporadic duodenal adenomas and assess the presence of colorectal neoplasms...
  26. doi Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab
    Jolien Tol
    Department of Medical Oncology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Cancer 46:1997-2009. 2010
    ..Here we assess the predictive value of other potential relevant markers involved in the epidermal growth factor receptor (EGFR) signalling pathways for response to cetuximab-based treatment...
  27. ncbi Circumferential margin involvement is still an important predictor of local recurrence in rectal carcinoma: not one millimeter but two millimeters is the limit
    Iris D Nagtegaal
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Surg Pathol 26:350-7. 2002
    ..In contrast to earlier studies, we show that an increased risk is present when margins are < or = 2 mm...
  28. pmc The CARTS study: Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery
    Guus M J Bökkerink
    Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Surg 11:34. 2011
    ..The CARTS study is a multicenter feasibility study, investigating the role of rectum saving surgery for distal rectal cancer...
  29. doi MicroRNAs in colorectal cancer metastasis
    Inge de Krijger
    Department of Pathology, Radboud University Nijmegen Medical Centre, The Netherlands
    J Pathol 224:438-47. 2011
    ..Better understanding of the complex role of miRNAs in the development of CRC metastases may provide new insights that could be of therapeutic consequence...
  30. ncbi Low rectal cancer: a call for a change of approach in abdominoperineal resection
    Iris D Nagtegaal
    Department of Pathology, University Medical Centre, St Radboud, Nijmegen, The Netherlands
    J Clin Oncol 23:9257-64. 2005
    ..Despite the major improvements that have been made due to total mesorectal excision (TME), low rectal cancer still remains a challenge...
  31. doi Prior colorectal neoplasia is associated with increased risk of ileoanal pouch neoplasia in patients with inflammatory bowel disease
    Lauranne A A P Derikx
    Inflammatory Bowel Disease Center, Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Gastroenterology 146:119-28.e1. 2014
    ..We aimed to determine the cumulative incidence of pouch neoplasia in patients with IBD and identify risk factors for developing pouch neoplasia...
  32. pmc Ursodeoxycholic acid counteracts celecoxib in reduction of duodenal polyps in patients with familial adenomatous polyposis: a multicentre, randomized controlled trial
    Bjorn W H van Heumen
    Departments of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, 6525 GA, Nijmegen, The Netherlands
    Orphanet J Rare Dis 8:118. 2013
    ..We performed a randomized, double-blind, placebo-controlled trial to investigate the effect of celecoxib and UDCA co-treatment on duodenal adenomatosis in patients with FAP...
  33. doi Constitutive expression of γ-H2AX has prognostic relevance in triple negative breast cancer
    Anika Nagelkerke
    Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Radiother Oncol 101:39-45. 2011
    ..Here, we quantified expression of endogenous γ-H2AX and its downstream factor 53BP1 in a large number of breast cancer cell lines (n=54) and a node-negative breast cancer cohort that had not received adjuvant systemic treatment (n=122)...
  34. doi High sensitivity of both sequencing and real-time PCR analysis of KRAS mutations in colorectal cancer tissue
    Jolien Tol
    Department of Medical Oncology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Cell Mol Med 14:2122-31. 2010
    ..5% (95% confidence interval [CI] 91.7-97.9%) and 96.5% (95% CI 93.0-98.6%), respectively. The real-time PCR based assay is the method of choice in samples with a tumour cell percentage below 30%...
  35. ncbi p53 expression in human rectal tissue after radiotherapy: upregulation in normal mucosa versus functional loss in rectal carcinomas
    Corrie A M Marijnen
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Int J Radiat Oncol Biol Phys 52:720-8. 2002
    ..The effect of radiotherapy (RT) on the expression of these proteins in patients is unknown. We assessed the influence of RT on the expression of p53 and p21(waf1) in normal mucosa and rectal carcinomas in vivo...
  36. doi Has the new TNM classification for colorectal cancer improved care?
    Iris D Nagtegaal
    Department of Pathology, Radboud University Nijmegen Medical Center, Geert Grooteplein 2, 6500 HB Nijmegen, The Netherlands
    Nat Rev Clin Oncol 9:119-23. 2012
    ..This article assesses the changes that have been made since the sixth edition and discusses whether they are, in fact, informative improvements for a practicing clinician...
  37. doi Prognostic value of estrogen receptor α and progesterone receptor conversion in distant breast cancer metastases
    Laurien D C Hoefnagel
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cancer 118:4929-35. 2012
    ..The purpose of this study was to evaluate the impact of receptor conversion for ERα and PR on survival in a large group of distant non-bone breast cancer metastases...
  38. ncbi Loss of extracellular E-cadherin in the normal mucosa of duodenum and colon of patients with familial adenomatous polyposis
    Marloes Berkhout
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Pathol 37:1389-99. 2006
    ..The loss of extracellular E-cadherin in the normal duodenal and colonic mucosa of patients with FAP might play a role in the high susceptibility of these tissues for (pre-) malignant transformation...
  39. doi Adjuvant radioimmunotherapy improves survival of rats after resection of colorectal liver metastases
    Gabie M De Jong
    Division of Abdominal and Oncological Surgery, Department of Surgery, Radboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, Nijmegen, The Netherlands
    Ann Surg 253:336-41. 2011
    ..The aim of this study was to test the hypothesis that adjuvant radioimmunotherapy (RIT) prevents recurrent liver metastases and/or results in improved survival after tumorectomy in an experimental model...
  40. pmc The epithelial cell adhesion molecule (Ep-CAM) as a morphoregulatory molecule is a tool in surgical pathology
    Manon J Winter
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Pathol 163:2139-48. 2003
    ..This article outlines the results of these studies. Based on the results of these studies, we conclude that Ep-CAM immunohistochemistry can be a useful tool in the diagnosis of disturbed epithelial tissues...
  41. pmc The functional -765G→C polymorphism of the COX-2 gene may reduce the risk of developing crohn's disease
    Hilbert S de Vries
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 5:e15011. 2010
    ..COX-2 is mainly induced at sites of inflammation in response to proinflammatory cytokines such as interleukin-1α/β, interferon-γ and tumor necrosis factor-α produced by inflammatory cells...
  42. doi Prognosis and pathology of screen-detected carcinomas: how different are they?
    Iris D Nagtegaal
    Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Cancer 117:1360-8. 2011
    ..This has led to the hypothesis that screen-detected tumors are substantially biologically different from symptomatic cancers...
  43. ncbi Chromosomal and methylation alterations in sporadic and familial adenomatous polyposis-related duodenal carcinomas
    Marloes Berkhout
    Department of Gastroenterology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Mod Pathol 20:1253-62. 2007
    ..Furthermore, hypermethylation seems to be a general feature of both FAP-related duodenal carcinomas as well as sporadic duodenal carcinomas with the exception of the PAX6 gene, which is methylated only in FAP-related carcinomas...
  44. doi Lymph node examination rate, survival rate, and quality of care in colon cancer
    Karl Y Bilimoria
    JAMA 299:896-7; author reply 897-8. 2008
  45. ncbi Circumferential margin involvement is the crucial prognostic factor after multimodality treatment in patients with locally advanced rectal carcinoma
    Marleen J E M Gosens
    Departments of Surgery and Radiotherapy, Catharina Hospital, Medical Centre Rijnmond South, Rotterdam, The Netherlands
    Clin Cancer Res 13:6617-23. 2007
    ..After preoperative (radio)chemotherapy, histologic determinants for prognostication have changed. It is unclear which variables, including assessment of tumor regression, are the best indicators for local recurrence and survival...