A N A Milne

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. doi Loss of CDC4/FBXW7 in gastric carcinoma
    A N Milne
    Department of Pathology, University Medical Centre, Utrecht, The Netherlands
    Cell Oncol 32:347-59. 2010
  2. pmc Nature meets nurture: molecular genetics of gastric cancer
    Anya N Milne
    Pathology Department H04 2 25, University Medical Centre Utrecht, Postbus 85500, 3508GA Utrecht, The Netherlands
    Hum Genet 126:615-28. 2009
  3. doi Cyclin E low molecular weight isoforms occur commonly in early-onset gastric cancer and independently predict survival
    A N A Milne
    Department of Pathology, University Medical Centre, Utrecht, The Netherlands
    J Clin Pathol 61:311-6. 2008
  4. ncbi Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis
    Anya N A Milne
    Department of Pathology, University Medical Centre, 3508 GA Utrecht, The Netherlands
    Hum Pathol 38:903-13. 2007
  5. ncbi Early onset gastric cancer: on the road to unraveling gastric carcinogenesis
    Anya N Milne
    Department of Pathology, H04 312, University Medical Centre Utrecht, Post Box 85500, 3508 GA Utrecht, The Netherlands
    Curr Mol Med 7:15-28. 2007
  6. ncbi Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers
    Anya N A Milne
    Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
    Mod Pathol 19:564-72. 2006
  7. pmc Increased cyclooxygenase-2 expression in juvenile polyposis syndrome
    W Arnout van Hattem
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Gastroenterol Hepatol 7:93-7. 2009
  8. pmc Genetic defects underlying Peutz-Jeghers syndrome (PJS) and exclusion of the polarity-associated MARK/Par1 gene family as potential PJS candidates
    W W J de Leng
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Genet 72:568-73. 2007
  9. ncbi A novel region of amplification at 11p12-13 in gastric cancer, revealed by representational difference analysis, is associated with overexpression of CD44v6, especially in early-onset gastric carcinomas
    Ralph Carvalho
    Department of Pathology, Academisch Medisch Centrum, Amsterdam, The Netherlands
    Genes Chromosomes Cancer 45:967-75. 2006
  10. ncbi Exclusion of RUNX3 as a tumour-suppressor gene in early-onset gastric carcinomas
    Ralph Carvalho
    Department of Pathology, Academisch Medisch Centrum, Amsterdam, The Netherlands
    Oncogene 24:8252-8. 2005

Collaborators

Detail Information

Publications13

  1. doi Loss of CDC4/FBXW7 in gastric carcinoma
    A N Milne
    Department of Pathology, University Medical Centre, Utrecht, The Netherlands
    Cell Oncol 32:347-59. 2010
    ..Mutations in colonic adenomas, and the frequent losses on 4q described in gastric cancer prompt speculation about the role of CDC4/FBXW7 in gastric carcinogenesis...
  2. pmc Nature meets nurture: molecular genetics of gastric cancer
    Anya N Milne
    Pathology Department H04 2 25, University Medical Centre Utrecht, Postbus 85500, 3508GA Utrecht, The Netherlands
    Hum Genet 126:615-28. 2009
    ..The role of E-cadherin in the nature (genotype) of diffuse gastric cancer is highlighted, and finally the ever growing discipline of SNP analysis (including IL1B) is discussed...
  3. doi Cyclin E low molecular weight isoforms occur commonly in early-onset gastric cancer and independently predict survival
    A N A Milne
    Department of Pathology, University Medical Centre, Utrecht, The Netherlands
    J Clin Pathol 61:311-6. 2008
    ..Post-translational cleavage of full-length cyclin E from the N-terminus can produce low molecular weight (LMW) isoforms of cyclin E containing the C-terminus only...
  4. ncbi Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis
    Anya N A Milne
    Department of Pathology, University Medical Centre, 3508 GA Utrecht, The Netherlands
    Hum Pathol 38:903-13. 2007
    ..The frequent gains, losses, and hypermethylation reported in this study indicate that the involved genes or chromosomal regions may be relevant to gastric carcinogenesis...
  5. ncbi Early onset gastric cancer: on the road to unraveling gastric carcinogenesis
    Anya N Milne
    Department of Pathology, H04 312, University Medical Centre Utrecht, Post Box 85500, 3508 GA Utrecht, The Netherlands
    Curr Mol Med 7:15-28. 2007
    ..An overview of the various pathways of importance in gastric cancer, as discovered through in-vitro, primary cancer and mouse model studies, is presented and the clinical importance of CDH1 mutations is discussed...
  6. ncbi Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers
    Anya N A Milne
    Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
    Mod Pathol 19:564-72. 2006
    ..Our results provide further evidence that early-onset gastric cancer exhibits a distinctive expression profile that may have practical implications...
  7. pmc Increased cyclooxygenase-2 expression in juvenile polyposis syndrome
    W Arnout van Hattem
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Gastroenterol Hepatol 7:93-7. 2009
    ..To investigate the role of COX-2 in juvenile polyps, we compared the expression of COX-2 in juvenile polyps from a well-defined group of juvenile polyposis patients and sporadic juvenile polyps...
  8. pmc Genetic defects underlying Peutz-Jeghers syndrome (PJS) and exclusion of the polarity-associated MARK/Par1 gene family as potential PJS candidates
    W W J de Leng
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Genet 72:568-73. 2007
    ..LKB1 defects are the major cause of PJS and genes of the MARK family do not represent alternative PJS genes. Other mechanisms of inactivation of LKB1 may cause PJS in the remaining families...
  9. ncbi A novel region of amplification at 11p12-13 in gastric cancer, revealed by representational difference analysis, is associated with overexpression of CD44v6, especially in early-onset gastric carcinomas
    Ralph Carvalho
    Department of Pathology, Academisch Medisch Centrum, Amsterdam, The Netherlands
    Genes Chromosomes Cancer 45:967-75. 2006
    ..005), irrespective of histology. These findings provide further evidence for both the relevance of CD44 in GC and for distinct molecular characteristics of EOGCs when compared with those of GCs occurring at a later age...
  10. ncbi Exclusion of RUNX3 as a tumour-suppressor gene in early-onset gastric carcinomas
    Ralph Carvalho
    Department of Pathology, Academisch Medisch Centrum, Amsterdam, The Netherlands
    Oncogene 24:8252-8. 2005
    ..Together, these observations indicate that chromosome 1 aberrations occur frequently in EOGCs and are reflected in the LOH and IHC patterns found. Our findings refute a role for RUNX3 as a TSG in EOGCs...
  11. ncbi Do collision tumors of the gastroesophageal junction exist? A molecular analysis
    Anya N A Milne
    Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Surg Pathol 28:1492-8. 2004
    ..These findings imply that it is not possible to recognize true collision tumors from immunohistologic appearance alone and suggest that the long-standing histologic criteria for the diagnosis of these neoplasms have no molecular basis...
  12. ncbi Early-onset gastric carcinomas display molecular characteristics distinct from gastric carcinomas occurring at a later age
    Ralph Carvalho
    Department of Pathology, Academisch Medisch Centrum, Amsterdam, The Netherlands
    J Pathol 204:75-83. 2004
    ..Finally, Epstein-Barr virus was not detected in any of the cases analysed. On the basis of these results, early-onset gastric carcinomas appear to have characteristics distinct from gastric carcinomas occurring at a later age...
  13. doi Pancreatic intraepithelial neoplasia and pancreatic tumorigenesis: of mice and men
    Niki A Ottenhof
    Department of Pathology, University Medical Center, Utrecht, The Netherlands
    Arch Pathol Lab Med 133:375-81. 2009
    ....