A N A Milne
Affiliation: University Medical Center Utrecht
Country: The Netherlands
Milne A, Sitarz R, Carvalho R, Carneiro F, Offerhaus G. Early onset gastric cancer: on the road to unraveling gastric carcinogenesis. Curr Mol Med. 2007;7:15-28 pubmed
..An overview of the various pathways of importance in gastric cancer, as discovered through in-vitro, primary cancer and mouse model studies, is presented and the clinical importance of CDH1 mutations is discussed. ..
Milne A, Sitarz R, Carvalho R, Polak M, Ligtenberg M, Pauwels P, et al
. Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis. Hum Pathol. 2007;38:903-13 pubmed
..The frequent gains, losses, and hypermethylation reported in this study indicate that the involved genes or chromosomal regions may be relevant to gastric carcinogenesis. ..
Milne A, Carvalho R, Jansen M, Kranenbarg E, van de Velde C, Morsink F, et al
. Cyclin E low molecular weight isoforms occur commonly in early-onset gastric cancer and independently predict survival. J Clin Pathol. 2008;61:311-6 pubmed publisher
..In contrast, no correlation with survival was found with the N-terminal antibody which detects only full-length cyclin E. EOGCs have a unique molecular phenotype and LMW isoforms of cyclin E may independently influence survival in EOGC. ..
Milne A, Leguit R, Corver W, Morsink F, Polak M, de Leng W, et al
. Loss of CDC4/FBXW7 in gastric carcinoma. Cell Oncol. 2010;32:347-59 pubmed publisher
..Mutations in colonic adenomas, and the frequent losses on 4q described in gastric cancer prompt speculation about the role of CDC4/FBXW7 in gastric carcinogenesis...