Research Topics
Species | Peter MeerloSummaryAffiliation: University of Groningen Country: The Netherlands Publications
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Detail Information
Publications
Hippocampal cell proliferation across the day: increase by running wheel activity, but no effect of sleep and wakefulnessKarin Van der Borght
Department of Molecular Neurobiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, P.O. Box 14, 9750 AA Haren, The Netherlands
Behav Brain Res 167:36-41. 2006..However, running affected cell proliferation differentially at two times of day. These data demonstrate that the steady rate in cell proliferation is not indispensable, but can be changed by behavioral activity...
Restricted and disrupted sleep: effects on autonomic function, neuroendocrine stress systems and stress responsivityPeter Meerlo
Department of Molecular Neurobiology, Center for Behavior and Neurosciences, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
Sleep Med Rev 12:197-210. 2008..Indeed, epidemiological studies suggest that sleep complaints and sleep restriction may be important risk factors for a variety of diseases that are often linked to stress, including cardiovascular diseases and mood disorders...
New neurons in the adult brain: the role of sleep and consequences of sleep lossPeter Meerlo
Department of Molecular Neurobiology, Center for Behavior and Neurosciences, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
Sleep Med Rev 13:187-94. 2009..These effects of sleep loss may endanger hippocampal integrity, thereby leading to cognitive dysfunction and contributing to the development of mood disorders...- Physical exercise leads to rapid adaptations in hippocampal vasculature: temporal dynamics and relationship to cell proliferation and neurogenesisKarin Van der Borght
Department of Molecular Neurobiology, University of Groningen, Groningen, The Netherlands
Hippocampus 19:928-36. 2009..Together these experiments show that the hippocampus displays a remarkable angiogenic and neurogenic plasticity and rapidly responds to changes in physical activity... - Chronically restricted sleep leads to depression-like changes in neurotransmitter receptor sensitivity and neuroendocrine stress reactivity in ratsArianna Novati
Department of Molecular Neurobiology, Center for Behavior and Neurosciences, University of Groningen, Haren, The Netherlands
Sleep 31:1579-85. 2008.... - The novel antidepressant agomelatine normalizes hippocampal neuronal activity and promotes neurogenesis in chronically stressed ratsGirstaute Dagyte
Department of Molecular Neurobiology, University of Groningen, The Netherlands
CNS Neurosci Ther 16:195-207. 2010..Taken together, these data show a beneficial action of agomelatine in the stress-compromised brain, where it restores stress-affected hippocampal neuronal activity and promotes adult hippocampal neurogenesis... - Enhanced hippocampal neurogenesis in the absence of microglia T cell interaction and microglia activation in the murine running wheel modelMarta Olah
Department of Medical Physiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Glia 57:1046-61. 2009..Thus, our results draw attention on the species and model differences that might exist regarding the regulation of adult hippocampal neurogenesis... - Sleep deprivation impairs spatial working memory and reduces hippocampal AMPA receptor phosphorylationRoelina Hagewoud
Department of Molecular Neurobiology, Center for Behavior and Neurosciences, University of Groningen, Haren, The Netherlands
J Sleep Res 19:280-8. 2010..Together, these findings provide further insight into the possible mechanism of SD-induced hippocampal dysfunction and memory impairment... - Sleep deprivation impairs contextual fear conditioning and attenuates subsequent behavioural, endocrine and neuronal responsesRoelina Hagewoud
Department of Behavioral Physiology, Center for Behavior and Neurosciences, University of Groningen, Haren, The Netherlands
J Sleep Res 20:259-66. 2011..Upon re-exposure to the context, this is reflected in a diminished behavioural freezing response, an attenuated HPA axis response and a reduction of the normal increase of phosphorylated CREB expression in the hippocampus and amygdala... - Coping with sleep deprivation: shifts in regional brain activity and learning strategyRoelina Hagewoud
Department of Molecular Neurobiology, University of Groningen, The Netherlands
Sleep 33:1465-73. 2010..Sleep deprivation has adverse effects on hippocampal function. However, whether the striatal memory system can compensate for sleep-deprivation-induced hippocampal impairments is unknown... - A time for learning and a time for sleep: the effect of sleep deprivation on contextual fear conditioning at different times of the dayRoelina Hagewoud
Department of Behavioral Physiology, Center for Behavior and Neurosciences, University of Groningen, Haren, The Netherlands
Sleep 33:1315-22. 2010..In these studies, both acquisition and subsequent sleep deprivation were performed in the animals' main resting phase. However, in everyday life, subjects most often learn during their active phase... - Sleep restriction by forced activity reduces hippocampal cell proliferationViktor Roman
Department of Molecular Neurobiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, PO Box 14, 9750 AA Haren, The Netherlands
Brain Res 1065:53-9. 2005..In conclusion, since new cells in the hilus mostly differentiate into glia, our findings indicate that sleep loss may reduce hippocampal gliogenesis... - Increased food intake and changes in metabolic hormones in response to chronic sleep restriction alternated with short periods of sleep allowanceR Paulien Barf
Department of Neuroendocrinology, Center for Behavior and Neurosciences, University of Groningen, The Netherlands
Am J Physiol Regul Integr Comp Physiol 302:R112-7. 2012..Therefore, this "week-weekend" protocol may be a better model to study the metabolic consequences of restricted sleep... - Maternal separation decreases adult hippocampal cell proliferation and impairs cognitive performance but has little effect on stress sensitivity and anxiety in adult Wistar ratsHenriëtte J Hulshof
Department of Molecular Neurobiology, University of Groningen, PO Box 14, 9750 AA Haren Gn, The Netherlands
Behav Brain Res 216:552-60. 2011..In conclusion, while interfering with the mother-infant relationship early in life did affect some aspects of adult neuroplasticity and cognitive function, it did not lead to permanent changes in stress sensitivity and emotionality... - Repetitive stimulation of adenosine A1 receptors in vivo: changes in receptor numbers, G-proteins and A1 receptor agonist-induced hypothermiaViktor Roman
Department of Molecular Neurobiology, School of Behavioral and Cognitive Neurosciences, University of Groningen, Haren, The Netherlands
Brain Res 1191:69-74. 2008..Taken together, the present findings suggest that repetitive stimulation of the A1 receptors can affect elements of the adenosinergic signaling cascade in the rat brain in a region-specific manner... - Telemetric study of sleep architecture and sleep homeostasis in the day-active tree shrew Tupaia belangeriAlex Coolen
Department of Behavioral Physiology, Center for Behavior and Neurosciences, University of Groningen, The Netherlands
Sleep 35:879-88. 2012..In this study the authors characterized sleep architecture and sleep homeostasis in the tree shrew, Tupaia belangeri, a small, omnivorous, day-active mammal that is closely related to primates... - Too little sleep gradually desensitizes the serotonin 1A receptor systemViktor Roman
Department of Molecular Neurobiology, University, of Groningen, Haren, The Netherlands
Sleep 28:1505-10. 2005..This finding provides a link between chronic sleep loss and sensitivity for disorders that are associated with altered serotonergic neurotransmission... - Differential effects of chronic partial sleep deprivation and stress on serotonin-1A and muscarinic acetylcholine receptor sensitivityViktor Roman
Department of Molecular Neurobiology, School of Behavioral and Cognitive Neurosciences, University of Groningen, Haren, The Netherlands
J Sleep Res 15:386-94. 2006..Thus, chronic stress and sleep loss may, partly via different pathways, change the brain into a direction as it is seen in mood disorders... - Despite higher glucocorticoid levels and stress responses in female rats, both sexes exhibit similar stress-induced changes in hippocampal neurogenesisHenriëtte J Hulshof
Department of Molecular Neurobiology, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands
Behav Brain Res 234:357-64. 2012..In conclusion, despite the male-female differences in HPA-axis activity, the effect of repeated stress exposure on hippocampal cell differentiation was not significantly different between sexes... - Chronic partial sleep deprivation reduces brain sensitivity to glutamate N-methyl-D-aspartate receptor-mediated neurotoxicityArianna Novati
Department of Behavioral Physiology, University of Groningen, Groningen, The Netherlands
J Sleep Res 21:3-9. 2012..These results do not support the hypothesis that sleep loss increases the sensitivity to neurodegenerative processes... - Effects of active shock avoidance learning on hippocampal neurogenesis and plasma levels of corticosteroneKarin Van der Borght
Department of Molecular Neurobiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
Behav Brain Res 157:23-30. 2005..The present study shows that, in line with the existing data on other hippocampus-independent learning tasks, ASA training has no effect on hippocampal neurogenesis... - Resveratrol preserves cerebrovascular density and cognitive function in aging miceCharlotte A Oomen
Department of Molecular Neurobiology, Center for Behavior and Neuroscience, University of Groningen Groningen, The Netherlands
Front Aging Neurosci 1:4. 2009..Via this mechanism resveratrol can contribute to the preservation of cognitive function during aging... - Neonatal handling increases sensitivity to acute neurodegeneration in adult ratsKatalin M Horvath
Department of Molecular Neurobiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, 9750 AA Haren, The Netherlands
J Neurobiol 60:463-72. 2004..The present results provide evidence for an enhanced vulnerability of postnatally handled rats to acute neurodegeneration in contrast to the previously reported attenuation of spontaneous aging-related neurodegenerative processes... - Ageing-related decline in adenosine A1 receptor binding in the rat brain: an autoradiographic studyPeter Meerlo
Department of Molecular Neurobiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, Groningen, The Netherlands
J Neurosci Res 78:742-8. 2004..Since particularly in rats many studies have used animals at the age of 24 months or even less, the ageing-related decline in adenosine A1 signaling might have been underestimated... - Effects of sleep deprivation on cardiac autonomic and pituitary-adrenocortical stress reactivity in ratsAndrea Sgoifo
Department of Evolutionary and Functional Biology, Stress Phsiology Lab, University of Parma, Parma, Italy
Psychoneuroendocrinology 31:197-208. 2006..The data show that sleep deprivation not only affects the baseline activity of the stress system, but it also alters its response to a subsequent stressor... - The effect of social stimuli on the accumulation of sleep debt and need for recovery: does copulatory activity increase slow-wave sleep?Peter Meerlo
J Sleep Res 12:171-2; author reply 172. 2003 - Sex differences in sleep: the response to sleep deprivation and restraint stress in miceMuriel Koehl
Institute F Magendie, INSERM U588, University of Bordeaux 2, Bordeaux, France
Sleep 29:1224-31. 2006..The latter may reflect sex differences in stress sensitivity... - Effects of gamma-hydroxybutyrate (GHB) on vigilance states and EEG in micePeter Meerlo
Center for Sleep and Circadian Biology, Department of Neurobiology and Physiology, Northwestern University, Evanston, IL, USA
Sleep 27:899-904. 2004..In the present study, we examined the effects of GHB on sleep-wake behavior and EEG in mice. In addition, we measured effects of GHB on body temperature and arousal or stress hormones... - Sleep deprivation and daily torpor impair object recognition in Djungarian hamstersSvitlana Palchykova
Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstr. 190, Zurich, CH 8057, Switzerland
Physiol Behav 87:144-53. 2006..Sleep deprivation during the first 4 h of memory consolidation hampered also recency memory for discrete objects. Stress was not a factor contributing to the sleep deprivation-induced impairment... - The suprachiasmatic nucleus regulates sleep timing and amount in miceAmy Easton
Northwestern University, Dept of Neurobiology and Physiology, University of Groningen, USA
Sleep 27:1307-18. 2004.... - Sleep deprivation impairs object recognition in miceSvitlana Palchykova
Institute of Pharmacology and Toxicology, , , Switzerland
Neurobiol Learn Mem 85:263-71. 2006..Sleep may either actively promote memory formation, or alternatively, sleep may provide optimal conditions of non-interference for consolidation... - Individual differences in cardiovascular response to social challengeAndrea Sgoifo
Department of Evolutionary and Functional Biology, Physiology Section, University of Parma, Parco Area delle Scienze 11 A, 43100 Parma, Italy
Neurosci Biobehav Rev 29:59-66. 2005..These data underline how important it is to carefully consider individual differences in aggression and the context in which aggression is expressed, when studying cardiovascular effects of social interactions... - Cardiac autonomic reactivity and salivary cortisol in men and women exposed to social stressors: relationship with individual ethological profileAndrea Sgoifo
Department of Evolutionary and Functional Biology, University of Parma, Parco Area delle Science 11 A, Parma, Italy
Neurosci Biobehav Rev 27:179-88. 2003..These results support the hypothesis of a close relationship between the degree of physiological arousal and the style of behavioral adaptation to social stressors...