Peter Meerlo

Summary

Affiliation: University of Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint Hippocampal cell proliferation across the day: increase by running wheel activity, but no effect of sleep and wakefulness
    Karin Van der Borght
    Department of Molecular Neurobiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Behav Brain Res 167:36-41. 2006
  2. doi request reprint Restricted and disrupted sleep: effects on autonomic function, neuroendocrine stress systems and stress responsivity
    Peter Meerlo
    Department of Molecular Neurobiology, Center for Behavior and Neurosciences, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Sleep Med Rev 12:197-210. 2008
  3. pmc New neurons in the adult brain: the role of sleep and consequences of sleep loss
    Peter Meerlo
    Department of Molecular Neurobiology, Center for Behavior and Neurosciences, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Sleep Med Rev 13:187-94. 2009
  4. doi request reprint Physical exercise leads to rapid adaptations in hippocampal vasculature: temporal dynamics and relationship to cell proliferation and neurogenesis
    Karin Van der Borght
    Department of Molecular Neurobiology, University of Groningen, Groningen, The Netherlands
    Hippocampus 19:928-36. 2009
  5. doi request reprint The novel antidepressant agomelatine normalizes hippocampal neuronal activity and promotes neurogenesis in chronically stressed rats
    Girstaute Dagyte
    Department of Molecular Neurobiology, University of Groningen, The Netherlands
    CNS Neurosci Ther 16:195-207. 2010
  6. pmc Chronically restricted sleep leads to depression-like changes in neurotransmitter receptor sensitivity and neuroendocrine stress reactivity in rats
    Arianna Novati
    Department of Molecular Neurobiology, Center for Behavior and Neurosciences, University of Groningen, Haren, The Netherlands
    Sleep 31:1579-85. 2008
  7. doi request reprint Enhanced hippocampal neurogenesis in the absence of microglia T cell interaction and microglia activation in the murine running wheel model
    Marta Olah
    Department of Medical Physiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Glia 57:1046-61. 2009
  8. doi request reprint Sleep deprivation impairs spatial working memory and reduces hippocampal AMPA receptor phosphorylation
    Roelina Hagewoud
    Department of Molecular Neurobiology, Center for Behavior and Neurosciences, University of Groningen, Haren, The Netherlands
    J Sleep Res 19:280-8. 2010
  9. doi request reprint Despite higher glucocorticoid levels and stress responses in female rats, both sexes exhibit similar stress-induced changes in hippocampal neurogenesis
    Henriëtte J Hulshof
    Department of Molecular Neurobiology, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands
    Behav Brain Res 234:357-64. 2012
  10. doi request reprint Sleep deprivation impairs contextual fear conditioning and attenuates subsequent behavioural, endocrine and neuronal responses
    Roelina Hagewoud
    Department of Behavioral Physiology, Center for Behavior and Neurosciences, University of Groningen, Haren, The Netherlands
    J Sleep Res 20:259-66. 2011

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Hippocampal cell proliferation across the day: increase by running wheel activity, but no effect of sleep and wakefulness
    Karin Van der Borght
    Department of Molecular Neurobiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Behav Brain Res 167:36-41. 2006
    ..However, running affected cell proliferation differentially at two times of day. These data demonstrate that the steady rate in cell proliferation is not indispensable, but can be changed by behavioral activity...
  2. doi request reprint Restricted and disrupted sleep: effects on autonomic function, neuroendocrine stress systems and stress responsivity
    Peter Meerlo
    Department of Molecular Neurobiology, Center for Behavior and Neurosciences, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Sleep Med Rev 12:197-210. 2008
    ..Indeed, epidemiological studies suggest that sleep complaints and sleep restriction may be important risk factors for a variety of diseases that are often linked to stress, including cardiovascular diseases and mood disorders...
  3. pmc New neurons in the adult brain: the role of sleep and consequences of sleep loss
    Peter Meerlo
    Department of Molecular Neurobiology, Center for Behavior and Neurosciences, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Sleep Med Rev 13:187-94. 2009
    ..These effects of sleep loss may endanger hippocampal integrity, thereby leading to cognitive dysfunction and contributing to the development of mood disorders...
  4. doi request reprint Physical exercise leads to rapid adaptations in hippocampal vasculature: temporal dynamics and relationship to cell proliferation and neurogenesis
    Karin Van der Borght
    Department of Molecular Neurobiology, University of Groningen, Groningen, The Netherlands
    Hippocampus 19:928-36. 2009
    ..Together these experiments show that the hippocampus displays a remarkable angiogenic and neurogenic plasticity and rapidly responds to changes in physical activity...
  5. doi request reprint The novel antidepressant agomelatine normalizes hippocampal neuronal activity and promotes neurogenesis in chronically stressed rats
    Girstaute Dagyte
    Department of Molecular Neurobiology, University of Groningen, The Netherlands
    CNS Neurosci Ther 16:195-207. 2010
    ..Taken together, these data show a beneficial action of agomelatine in the stress-compromised brain, where it restores stress-affected hippocampal neuronal activity and promotes adult hippocampal neurogenesis...
  6. pmc Chronically restricted sleep leads to depression-like changes in neurotransmitter receptor sensitivity and neuroendocrine stress reactivity in rats
    Arianna Novati
    Department of Molecular Neurobiology, Center for Behavior and Neurosciences, University of Groningen, Haren, The Netherlands
    Sleep 31:1579-85. 2008
    ....
  7. doi request reprint Enhanced hippocampal neurogenesis in the absence of microglia T cell interaction and microglia activation in the murine running wheel model
    Marta Olah
    Department of Medical Physiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Glia 57:1046-61. 2009
    ..Thus, our results draw attention on the species and model differences that might exist regarding the regulation of adult hippocampal neurogenesis...
  8. doi request reprint Sleep deprivation impairs spatial working memory and reduces hippocampal AMPA receptor phosphorylation
    Roelina Hagewoud
    Department of Molecular Neurobiology, Center for Behavior and Neurosciences, University of Groningen, Haren, The Netherlands
    J Sleep Res 19:280-8. 2010
    ..Together, these findings provide further insight into the possible mechanism of SD-induced hippocampal dysfunction and memory impairment...
  9. doi request reprint Despite higher glucocorticoid levels and stress responses in female rats, both sexes exhibit similar stress-induced changes in hippocampal neurogenesis
    Henriëtte J Hulshof
    Department of Molecular Neurobiology, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands
    Behav Brain Res 234:357-64. 2012
    ..In conclusion, despite the male-female differences in HPA-axis activity, the effect of repeated stress exposure on hippocampal cell differentiation was not significantly different between sexes...
  10. doi request reprint Sleep deprivation impairs contextual fear conditioning and attenuates subsequent behavioural, endocrine and neuronal responses
    Roelina Hagewoud
    Department of Behavioral Physiology, Center for Behavior and Neurosciences, University of Groningen, Haren, The Netherlands
    J Sleep Res 20:259-66. 2011
    ..Upon re-exposure to the context, this is reflected in a diminished behavioural freezing response, an attenuated HPA axis response and a reduction of the normal increase of phosphorylated CREB expression in the hippocampus and amygdala...
  11. ncbi request reprint Sleep restriction by forced activity reduces hippocampal cell proliferation
    Viktor Roman
    Department of Molecular Neurobiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, PO Box 14, 9750 AA Haren, The Netherlands
    Brain Res 1065:53-9. 2005
    ..In conclusion, since new cells in the hilus mostly differentiate into glia, our findings indicate that sleep loss may reduce hippocampal gliogenesis...
  12. pmc A time for learning and a time for sleep: the effect of sleep deprivation on contextual fear conditioning at different times of the day
    Roelina Hagewoud
    Department of Behavioral Physiology, Center for Behavior and Neurosciences, University of Groningen, Haren, The Netherlands
    Sleep 33:1315-22. 2010
    ..In these studies, both acquisition and subsequent sleep deprivation were performed in the animals' main resting phase. However, in everyday life, subjects most often learn during their active phase...
  13. pmc Coping with sleep deprivation: shifts in regional brain activity and learning strategy
    Roelina Hagewoud
    Department of Molecular Neurobiology, University of Groningen, The Netherlands
    Sleep 33:1465-73. 2010
    ..Sleep deprivation has adverse effects on hippocampal function. However, whether the striatal memory system can compensate for sleep-deprivation-induced hippocampal impairments is unknown...
  14. ncbi request reprint Cerebral adenosine A₁ receptors are upregulated in rodent encephalitis
    Soumen Paul
    University of Groningen, University Medical Center Groningen, Nuclear Medicine and Molecular Imaging, Hanzeplein 1, 9713GZ Groningen, The Netherlands
    Neuroimage 92:83-9. 2014
    ..Both the quantitative PET data and immunohistochemical analysis indicate that A1Rs are upregulated in brain areas where active virus is present...
  15. doi request reprint Increased food intake and changes in metabolic hormones in response to chronic sleep restriction alternated with short periods of sleep allowance
    R Paulien Barf
    Department of Neuroendocrinology, Center for Behavior and Neurosciences, University of Groningen, The Netherlands
    Am J Physiol Regul Integr Comp Physiol 302:R112-7. 2012
    ..Therefore, this "week-weekend" protocol may be a better model to study the metabolic consequences of restricted sleep...
  16. doi request reprint Repetitive stimulation of adenosine A1 receptors in vivo: changes in receptor numbers, G-proteins and A1 receptor agonist-induced hypothermia
    Viktor Roman
    Department of Molecular Neurobiology, School of Behavioral and Cognitive Neurosciences, University of Groningen, Haren, The Netherlands
    Brain Res 1191:69-74. 2008
    ..Taken together, the present findings suggest that repetitive stimulation of the A1 receptors can affect elements of the adenosinergic signaling cascade in the rat brain in a region-specific manner...
  17. doi request reprint Maternal separation decreases adult hippocampal cell proliferation and impairs cognitive performance but has little effect on stress sensitivity and anxiety in adult Wistar rats
    Henriëtte J Hulshof
    Department of Molecular Neurobiology, University of Groningen, PO Box 14, 9750 AA Haren Gn, The Netherlands
    Behav Brain Res 216:552-60. 2011
    ..In conclusion, while interfering with the mother-infant relationship early in life did affect some aspects of adult neuroplasticity and cognitive function, it did not lead to permanent changes in stress sensitivity and emotionality...
  18. pmc Telemetric study of sleep architecture and sleep homeostasis in the day-active tree shrew Tupaia belangeri
    Alex Coolen
    Department of Behavioral Physiology, Center for Behavior and Neurosciences, University of Groningen, The Netherlands
    Sleep 35:879-88. 2012
    ..In this study the authors characterized sleep architecture and sleep homeostasis in the tree shrew, Tupaia belangeri, a small, omnivorous, day-active mammal that is closely related to primates...
  19. ncbi request reprint Differential effects of chronic partial sleep deprivation and stress on serotonin-1A and muscarinic acetylcholine receptor sensitivity
    Viktor Roman
    Department of Molecular Neurobiology, School of Behavioral and Cognitive Neurosciences, University of Groningen, Haren, The Netherlands
    J Sleep Res 15:386-94. 2006
    ..Thus, chronic stress and sleep loss may, partly via different pathways, change the brain into a direction as it is seen in mood disorders...
  20. ncbi request reprint Too little sleep gradually desensitizes the serotonin 1A receptor system
    Viktor Roman
    Department of Molecular Neurobiology, University, of Groningen, Haren, The Netherlands
    Sleep 28:1505-10. 2005
    ..Therefore, in the present study, we experimentally tested the hypothesis that chronic sleep restriction leads to desensitization of the (5-HT)1A receptor system...
  21. doi request reprint Chronic partial sleep deprivation reduces brain sensitivity to glutamate N-methyl-D-aspartate receptor-mediated neurotoxicity
    Arianna Novati
    Department of Behavioral Physiology, University of Groningen, Groningen, The Netherlands
    J Sleep Res 21:3-9. 2012
    ..These results do not support the hypothesis that sleep loss increases the sensitivity to neurodegenerative processes...
  22. ncbi request reprint Effects of active shock avoidance learning on hippocampal neurogenesis and plasma levels of corticosterone
    Karin Van der Borght
    Department of Molecular Neurobiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Behav Brain Res 157:23-30. 2005
    ..The present study shows that, in line with the existing data on other hippocampus-independent learning tasks, ASA training has no effect on hippocampal neurogenesis...
  23. pmc Resveratrol preserves cerebrovascular density and cognitive function in aging mice
    Charlotte A Oomen
    Department of Molecular Neurobiology, Center for Behavior and Neuroscience, University of Groningen Groningen, The Netherlands
    Front Aging Neurosci 1:4. 2009
    ..Via this mechanism resveratrol can contribute to the preservation of cognitive function during aging...
  24. ncbi request reprint Neonatal handling increases sensitivity to acute neurodegeneration in adult rats
    Katalin M Horvath
    Department of Molecular Neurobiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, 9750 AA Haren, The Netherlands
    J Neurobiol 60:463-72. 2004
    ..The present results provide evidence for an enhanced vulnerability of postnatally handled rats to acute neurodegeneration in contrast to the previously reported attenuation of spontaneous aging-related neurodegenerative processes...
  25. ncbi request reprint Use of 11C-MPDX and PET to study adenosine A1 receptor occupancy by nonradioactive agonists and antagonists
    Soumen Paul
    Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Nucl Med 55:315-20. 2014
    ..Here we investigated whether A1R occupancy by nonradioactive agonists and antagonists can be assessed with this technique...
  26. ncbi request reprint Ageing-related decline in adenosine A1 receptor binding in the rat brain: an autoradiographic study
    Peter Meerlo
    Department of Molecular Neurobiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, Groningen, The Netherlands
    J Neurosci Res 78:742-8. 2004
    ..Since particularly in rats many studies have used animals at the age of 24 months or even less, the ageing-related decline in adenosine A1 signaling might have been underestimated...
  27. ncbi request reprint Effects of sleep deprivation on cardiac autonomic and pituitary-adrenocortical stress reactivity in rats
    Andrea Sgoifo
    Department of Evolutionary and Functional Biology, Stress Phsiology Lab, University of Parma, Parma, Italy
    Psychoneuroendocrinology 31:197-208. 2006
    ..The data show that sleep deprivation not only affects the baseline activity of the stress system, but it also alters its response to a subsequent stressor...
  28. ncbi request reprint The effect of social stimuli on the accumulation of sleep debt and need for recovery: does copulatory activity increase slow-wave sleep?
    Peter Meerlo
    J Sleep Res 12:171-2; author reply 172. 2003
  29. ncbi request reprint Effects of gamma-hydroxybutyrate (GHB) on vigilance states and EEG in mice
    Peter Meerlo
    Center for Sleep and Circadian Biology, Department of Neurobiology and Physiology, Northwestern University, Evanston, IL, USA
    Sleep 27:899-904. 2004
    ..In the present study, we examined the effects of GHB on sleep-wake behavior and EEG in mice. In addition, we measured effects of GHB on body temperature and arousal or stress hormones...
  30. ncbi request reprint Sex differences in sleep: the response to sleep deprivation and restraint stress in mice
    Muriel Koehl
    Institute F Magendie, INSERM U588, University of Bordeaux 2, Bordeaux, France
    Sleep 29:1224-31. 2006
    ..In this context, we examined sex differences in sleep in the mouse, not only under baseline conditions, but also after sleep deprivation and restraint stress...
  31. ncbi request reprint The suprachiasmatic nucleus regulates sleep timing and amount in mice
    Amy Easton
    Northwestern University, Dept of Neurobiology and Physiology, University of Groningen, USA
    Sleep 27:1307-18. 2004
    ....
  32. ncbi request reprint Individual differences in cardiovascular response to social challenge
    Andrea Sgoifo
    Department of Evolutionary and Functional Biology, Physiology Section, University of Parma, Parco Area delle Scienze 11 A, 43100 Parma, Italy
    Neurosci Biobehav Rev 29:59-66. 2005
    ..These data underline how important it is to carefully consider individual differences in aggression and the context in which aggression is expressed, when studying cardiovascular effects of social interactions...
  33. ncbi request reprint Sleep deprivation and daily torpor impair object recognition in Djungarian hamsters
    Svitlana Palchykova
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstr 190, Zurich, CH 8057, Switzerland
    Physiol Behav 87:144-53. 2006
    ..Sleep deprivation during the first 4 h of memory consolidation hampered also recency memory for discrete objects. Stress was not a factor contributing to the sleep deprivation-induced impairment...
  34. ncbi request reprint Sleep deprivation impairs object recognition in mice
    Svitlana Palchykova
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Neurobiol Learn Mem 85:263-71. 2006
    ..Sleep may either actively promote memory formation, or alternatively, sleep may provide optimal conditions of non-interference for consolidation...
  35. ncbi request reprint Cardiac autonomic reactivity and salivary cortisol in men and women exposed to social stressors: relationship with individual ethological profile
    Andrea Sgoifo
    Department of Evolutionary and Functional Biology, University of Parma, Parco Area delle Science 11 A, Parma, Italy
    Neurosci Biobehav Rev 27:179-88. 2003
    ..These results support the hypothesis of a close relationship between the degree of physiological arousal and the style of behavioral adaptation to social stressors...