Rene H Medema

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi request reprint Entosis: aneuploidy by invasion
    Aniek Janssen
    Department of Medical Oncology and Cancer Genomics Centre, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Nat Cell Biol 13:199-201. 2011
  2. pmc Localized Aurora B activity spatially controls non-kinetochore microtubules during spindle assembly
    Marvin E Tanenbaum
    Department of Medical Oncology and Cancer Genomics Centre, University Medical Center Utrecht, The Netherlands
    Chromosoma 120:599-607. 2011
  3. pmc Targeting the mitotic checkpoint to kill tumor cells
    Aniek Janssen
    Department of Medical Oncology and Cancer Genomics Center, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Horm Cancer 2:113-6. 2011
  4. pmc The decision to enter mitosis: feedback and redundancy in the mitotic entry network
    Arne Lindqvist
    Department of Medical Oncology, University Medical Center Utrecht, 3584 CG Utrecht, Netherlands
    J Cell Biol 185:193-202. 2009
  5. pmc Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1
    Renske van Leuken
    Department of Medical Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands
    PLoS ONE 4:e5282. 2009
  6. pmc Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry
    Daniël Splinter
    Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Biol 8:e1000350. 2010
  7. doi request reprint Relaying the checkpoint signal from kinetochore to APC/C
    Rene H Medema
    Department of Medical Oncology and Cancer Genomics Center, University Medical Center Utrecht, Utrecht, The Netherlands
    Dev Cell 16:6-8. 2009
  8. doi request reprint Boosting and suppressing mitotic phosphorylation
    Rene H Medema
    Department of Medical Oncology and Cancer Genomics Center, UMC Utrecht, The Netherlands
    Trends Biochem Sci 36:578-84. 2011
  9. ncbi request reprint The X factor: skewing X inactivation towards cancer
    Rene H Medema
    Department of Medical Oncology, University Medical Center Utrecht, Universiteitsweg 100, Stratenum, 3584CG Utrecht, The Netherlands
    Cell 129:1253-4. 2007
  10. doi request reprint Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
    Nannette Jelluma
    Department of Medical Oncology, Laboratory of Experimental Oncology, UMC Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Cell 132:233-46. 2008

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Entosis: aneuploidy by invasion
    Aniek Janssen
    Department of Medical Oncology and Cancer Genomics Centre, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Nat Cell Biol 13:199-201. 2011
    ..Entosis, the invasion of a living cell into another cell's cytoplasm, is now shown to perturb cytokinesis and induce the formation of aneuploid cells...
  2. pmc Localized Aurora B activity spatially controls non-kinetochore microtubules during spindle assembly
    Marvin E Tanenbaum
    Department of Medical Oncology and Cancer Genomics Centre, University Medical Center Utrecht, The Netherlands
    Chromosoma 120:599-607. 2011
    ....
  3. pmc Targeting the mitotic checkpoint to kill tumor cells
    Aniek Janssen
    Department of Medical Oncology and Cancer Genomics Center, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Horm Cancer 2:113-6. 2011
    ..We demonstrate that increased cell death is associated with a dramatic increase in segregation errors. This suggests that inhibition of the mitotic checkpoint might represent a useful anti-cancer strategy...
  4. pmc The decision to enter mitosis: feedback and redundancy in the mitotic entry network
    Arne Lindqvist
    Department of Medical Oncology, University Medical Center Utrecht, 3584 CG Utrecht, Netherlands
    J Cell Biol 185:193-202. 2009
    ....
  5. pmc Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1
    Renske van Leuken
    Department of Medical Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands
    PLoS ONE 4:e5282. 2009
    ..We conclude that Plk1 facilitates efficient Aurora A degradation through APC/C-Cdh1 activation after mitosis, with a potential role for hCdc14A...
  6. pmc Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry
    Daniël Splinter
    Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Biol 8:e1000350. 2010
    ....
  7. doi request reprint Relaying the checkpoint signal from kinetochore to APC/C
    Rene H Medema
    Department of Medical Oncology and Cancer Genomics Center, University Medical Center Utrecht, Utrecht, The Netherlands
    Dev Cell 16:6-8. 2009
    ..Two Developmental Cell papers in this issue by Kulukian et al. and Malureanu et al. now provide insight into how checkpoint components Mad2 and BubR1 relay the checkpoint signal from kinetochores to APC/C...
  8. doi request reprint Boosting and suppressing mitotic phosphorylation
    Rene H Medema
    Department of Medical Oncology and Cancer Genomics Center, UMC Utrecht, The Netherlands
    Trends Biochem Sci 36:578-84. 2011
    ..In this review, we discuss the underlying mechanisms that enforce the dramatic global shift in protein phosphorylation as well as the mechanisms that allow for highly localized substrate phosphorylation in mitosis...
  9. ncbi request reprint The X factor: skewing X inactivation towards cancer
    Rene H Medema
    Department of Medical Oncology, University Medical Center Utrecht, Universiteitsweg 100, Stratenum, 3584CG Utrecht, The Netherlands
    Cell 129:1253-4. 2007
    ..Now, Zuo et al. (2007) reveal that an X-linked gene encoding the transcription factor FOXP3 is a breast cancer tumor suppressor that represses expression of HER2/ErbB2...
  10. doi request reprint Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
    Nannette Jelluma
    Department of Medical Oncology, Laboratory of Experimental Oncology, UMC Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Cell 132:233-46. 2008
    ..Mps1 thus coordinates attachment error correction and checkpoint signaling, two crucial responses to unproductive chromosome attachments...
  11. pmc Systematic dissection of dynein regulators in mitosis
    Jonne A Raaijmakers
    Department of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands
    J Cell Biol 201:201-15. 2013
    ....
  12. pmc Cyclin G-associated kinase promotes microtubule outgrowth from chromosomes during spindle assembly
    Marvin E Tanenbaum
    Department of Medical Oncology, University Medical Center Utrecht, The Netherlands
    Chromosoma 119:415-24. 2010
    ..These results identify a role for GAK and clathrin in microtubule outgrowth from kinetochores/chromosomes and suggest that GAK acts through clathrin to control microtubule outgrowth around chromosomes...
  13. doi request reprint Kif15 cooperates with eg5 to promote bipolar spindle assembly
    Marvin E Tanenbaum
    Department of Medical Oncology and Cancer Genomics Centre, University Medical Center Utrecht, The Netherlands
    Curr Biol 19:1703-11. 2009
    ..However, it is currently unclear whether and how additional motors can contribute to centrosome separation and bipolar spindle formation...
  14. pmc Mps1 promotes rapid centromere accumulation of Aurora B
    Maike S van der Waal
    Department of Medical Oncology, University Medical Center Utrecht, Universiteitsweg 100, STR 2 129, 3584 CG Utrecht, The Netherlands
    EMBO Rep 13:847-54. 2012
    ....
  15. pmc Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation
    Jonne A Raaijmakers
    Department of Experimental Oncology and Cancer Genomics Center, University Medical Center Utrecht, Utrecht, The Netherlands
    EMBO J 31:4179-90. 2012
    ..Together, these results reveal how the forces are produced to drive prophase centrosome separation and identify a novel mechanism of resistance to kinesin-5 inhibitors...
  16. pmc Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells
    Aniek Janssen
    Department of Medical Oncology, Cancer Genomics Center, UMC Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 106:19108-13. 2009
    ..Thus, targeting the mitotic checkpoint and chromosome alignment simultaneously may selectively kill tumor cells by enhancing chromosome mis-segregations...
  17. ncbi request reprint RAMA1 is a novel kinetochore protein involved in kinetochore-microtubule attachment
    Jonne A Raaijmakers
    Department of Medical Oncology and Cancer Genomics Center, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cell Sci 122:2436-45. 2009
    ..Taken together, these results identify RAMA1 as a novel kinetochore protein and suggest that RAMA1 may have a direct role in mediating kinetochore-microtubule interactions...
  18. doi request reprint Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
    Libor Macurek
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht 3584CG, The Netherlands
    Nature 455:119-23. 2008
    ..Taken together, these data demonstrate that the initial activation of PLK1 is a primary function of aurora A...
  19. doi request reprint Aurora-A and hBora join the game of Polo
    Libor Macurek
    Department of Medical Oncology and Cancer Genomics Center, University Medical Center Utrecht, Utrecht, The Netherlands
    Cancer Res 69:4555-8. 2009
    ..Such insight is important for the expected utility of small-molecule inhibitors targeting Plk1 or Aurora-A, and it might help us to improve their application...
  20. pmc The chromosomal passenger complex: guiding Aurora-B through mitosis
    Gerben Vader
    Department of Medical Oncology, University Medical Center, 3584 CG Utrecht, Netherlands
    J Cell Biol 173:833-7. 2006
    ..Also, we summarize posttranslational modifications that occur on the CPC and discuss their roles in regulating localization and function of this mitotic complex...
  21. pmc Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis
    Adrian T Saurin
    Molecular Cancer Research and Cancer Genomics Centre, University Medical Center Utrecht, Utrecht 3584 CG, The Netherlands
    Nat Commun 2:316. 2011
    ..These data demonstrate a direct role for Aurora B in initiating the mitotic checkpoint rapidly at the onset of mitosis...
  22. doi request reprint Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations
    Aniek Janssen
    Department of Medical Oncology and Cancer Genomics Center, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, Netherlands
    Science 333:1895-8. 2011
    ..Our data show that segregation errors can cause translocations and provide insights into the role of whole-chromosome instability in tumorigenesis...
  23. ncbi request reprint Activation of FoxO transcription factors contributes to the antiproliferative effect of cAMP
    H Bea Kuiperij
    Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Oncogene 24:2087-95. 2005
    ..From these results we conclude that inhibition of PKB and subsequent activation of FoxO transcription factors mediates an antiproliferative effect of cAMP...
  24. ncbi request reprint Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
    Geert J P L Kops
    Department of Physiological Chemistry, University Medical Center Utrecht and Center for Biomedical Genetics, 3584 CG Utrecht, The Netherlands
    Nature 419:316-21. 2002
    ..The model of Forkhead involvement in regulating longevity stems from genetic analysis in Caenorhabditis elegans, and we conclude that this model also extends to mammalian systems...
  25. ncbi request reprint FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)
    Armando van der Horst
    Department of Physiological Chemistry, Center for Biomedical Genetics, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    J Biol Chem 279:28873-9. 2004
    ..These data demonstrate that acetylation functions in a second pathway of negative control for FOXO factors and provides a novel mechanism whereby hSir2(SIRT1) can promote cellular survival and increase lifespan...
  26. pmc The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions
    Gerben Vader
    Department of Medical Oncology, University Medical Center, 3584 CG Utrecht, The Netherlands
    Mol Biol Cell 18:4553-64. 2007
    ....
  27. doi request reprint Polo-box domains confer target specificity to the Polo-like kinase family
    Barbara C M van de Weerdt
    Department of Medical Oncology, Str2 118, University Medical Center Utrecht, The Netherlands
    Biochim Biophys Acta 1783:1015-22. 2008
    ..Thus, PBDs convey a significant deal of target specificity, indicating that there is only a limited amount of functional redundancy possible within the Plk family...
  28. pmc Protein phosphatase 2A (B55α) prevents premature activation of forkhead transcription factor FoxM1 by antagonizing cyclin A/cyclin-dependent kinase-mediated phosphorylation
    Monica Alvarez-Fernandez
    Department of Medical Oncology and Cancer Genomics Centre, UMC Utrecht, Universiteitsweg 100, Stratenum 2 118, Utrecht 3584 CG, The Netherlands
    J Biol Chem 286:33029-36. 2011
    ..Taken together, these data demonstrate that B55α acts to antagonize Cyclin A/Cdk-dependent activation of FoxM1, to ensure that FoxM1 activity is restricted to the G(2) phase of the cell cycle...
  29. ncbi request reprint The case for Survivin as mitotic regulator
    Susanne M A Lens
    Department of Medical Oncology, Laboratory for Experimental Oncology, University Medical Center Utrecht, Stratenum 2 118 Universiteitsweg 100 3584 CG Utrecht, The Netherlands
    Curr Opin Cell Biol 18:616-22. 2006
    ..This function of Survivin appears to be conserved throughout evolution. Although these findings do not exclude a role for Survivin as apoptosis inhibitor, they make a very strong case for Survivin as mitotic regulator...
  30. pmc Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression
    Arne Lindqvist
    Department of Medical Oncology and Cancer Genomics Center, Utrecht, Netherlands
    EMBO J 28:3196-206. 2009
    ..Our findings uncover Wip1 as a first in class recovery competence gene, and suggest that the principal function of Wip1 in cellular transformation is to retain proliferative capacity in the face of oncogene-induced stress...
  31. pmc Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes
    Nannette Jelluma
    Department of Physiological Chemistry and Cancer Genomics Centre, UMC Utrecht, Utrecht, The Netherlands
    PLoS ONE 3:e2415. 2008
    ..Two of the causes of CIN are weakened mitotic checkpoint signaling and persistent merotelic attachments that result in lagging chromosomes during anaphase...
  32. ncbi request reprint Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B
    Renske J van Leuken
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cell Cycle 7:2710-9. 2008
    ..Our observations suggest Usp39 to be involved in splicing of Aurora B and other mRNAs that are essential for proper spindle checkpoint function...
  33. ncbi request reprint Polo-like kinases: a team in control of the division
    Barbara C M van de Weerdt
    Department of Medical Oncology, University Medical Center, Utrecht, The Netherlands
    Cell Cycle 5:853-64. 2006
    ..In this review, we will focus our attention on human Plk1 and its family members Plk2-4 and the many roles they play during mitosis. Furthermore, we will describe the currently knowledge of the regulation of these functions...
  34. ncbi request reprint Restarting the cell cycle when the checkpoint comes to a halt
    Marcel A T M van Vugt
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cancer Res 65:7037-40. 2005
    ..Here, we discuss these novel insights and discuss their possible implications for the treatment of cancer...
  35. doi request reprint A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases
    Marvin E Tanenbaum
    Department of Experimental Oncology and Cancer Genomics Center, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    Curr Biol 21:1356-65. 2011
    ..The Aurora kinases have several well-described functions during cell division, but it remains unclear whether they control global spindle microtubule dynamics...
  36. pmc Recovery from a DNA-damage-induced G2 arrest requires Cdk-dependent activation of FoxM1
    Monica Alvarez-Fernandez
    Department of Medical Oncology, UMC Utrecht, Universiteitsweg 100, Stratenum 2 118, Utrecht 3584 CG, The Netherlands
    EMBO Rep 11:452-8. 2010
    ..Indeed, we find that cells need to retain sufficient levels of Cdk activity during the DNA-damage response to maintain cellular competence to recover from a DNA-damaging insult...
  37. ncbi request reprint FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner
    Jamila Laoukili
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cell Cycle 7:2720-6. 2008
    ..Based on these data we propose that Cdh1-dependent degradation of FoxM1 is required to shut down transcriptional activation of mitotic regulators during exit from mitosis...
  38. pmc Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly
    Marvin E Tanenbaum
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    EMBO J 27:3235-45. 2008
    ..Taken together, these results suggest that complexes of dynein, Lis1 and CLIP-170 crosslink and slide microtubules within the spindle, thereby producing an inward force that pulls centrosomes together...
  39. pmc Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain
    Jamila Laoukili
    Laboratory of Experimental Oncology, Department of Medical Oncology, University Medical Center, Stratenum 2 118, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Mol Cell Biol 28:3076-87. 2008
    ....
  40. doi request reprint Comparative phosphoproteomic analysis of checkpoint recovery identifies new regulators of the DNA damage response
    Vincentius A Halim
    Department of Medical Oncology and Cancer Genomics Center, University Medical Center Utrecht, 3584 CG Utrecht, Netherlands
    Sci Signal 6:rs9. 2013
    ..Thus, by controlling p53 abundance in cells recovering from DNA damage, astrin maintains the cells in a state competent to resume the cell cycle...
  41. doi request reprint Mechanisms of centrosome separation and bipolar spindle assembly
    Marvin E Tanenbaum
    Department of Medical Oncology, University Medical Center, CG Utrecht, The Netherlands
    Dev Cell 19:797-806. 2010
    ..Here, we discuss different pathways that promote initial centrosome separation and bipolar spindle assembly...
  42. ncbi request reprint Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty
    Boudewijn M T Burgering
    Department of Physiological Chemistry and Center for Biomedical Genetics, University Medical Center Utrecht, The Netherlands
    J Leukoc Biol 73:689-701. 2003
    ..This review summarizes our current understanding of the mechanisms by which PKB/Akt and FOXO factors regulate these decisions...
  43. doi request reprint Switching Polo-like kinase-1 on and off in time and space
    Wytse Bruinsma
    Department of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Trends Biochem Sci 37:534-42. 2012
    ..We also review a number of newly discovered functions of Plk1 that provide more insights into the spatiotemporal control of Plk1-dependent substrate phosphorylation...
  44. pmc Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres
    Susanne M A Lens
    Department of Medical Oncology, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    Mol Biol Cell 17:1897-909. 2006
    ..Importantly, our data show that the function of the CPC at the centromere can be separated from its function at the central spindle and that execution of cytokinesis does not require prior concentration of the CPC at centromeres...
  45. doi request reprint Shared and separate functions of polo-like kinases and aurora kinases in cancer
    Susanne M A Lens
    Department of Medical Oncology and Cancer Genomics Centre, UMC Utrecht, Universiteitsweg 100, Stratenum 2 118, Utrecht 3584 CG, The Netherlands
    Nat Rev Cancer 10:825-41. 2010
    ..In this Review we discuss the implications of these novel insights on the clinical applicability of polo-like kinase and aurora kinase inhibitors...
  46. pmc Transcriptional regulation underlying recovery from a DNA damage-induced arrest
    Monica Alvarez-Fernandez
    UMC Utrecht, The Netherlands
    Transcription 1:32-5. 2010
    ..Here we discuss recent findings that demonstrate how transcription is fine-tuned during the DNA damage response and how this controls the capacity to recover from a DNA damage arrest in G(2) phase...
  47. doi request reprint UV-induced G2 checkpoint depends on p38 MAPK and minimal activation of ATR-Chk1 pathway
    Daniel O Warmerdam
    Department of Cell Biology and Genetics, Cancer Genomics Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    J Cell Sci 126:1923-30. 2013
    ..UV-induced G2 checkpoint activation in this situation therefore relies on signalling via the p38 MAPK and ATR-Chk1 signalling cascades...
  48. pmc Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors
    Geert J P L Kops
    Department of Physiological Chemistry, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    Mol Cell Biol 22:2025-36. 2002
    ..We therefore propose that Forkhead inactivation by PKB signaling in quiescent cells is a crucial step in cell cycle reentry and contributes to the processes of transformation and regeneration...
  49. doi request reprint Bora and Aurora-A continue to activate Plk1 in mitosis
    Wytse Bruinsma
    Department of Medical Oncology and Cancer Genomics Center, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    J Cell Sci 127:801-11. 2014
    ..This provides a cell with robust Plk1 activity once it has committed to mitosis. ..
  50. doi request reprint P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma development
    Wendy Van Veelen
    Division of Biomedical Genetics, Department of Metabolic and Endocrine Diseases, University Medical Center Utrecht, Utrecht, The Netherlands
    Int J Cancer 124:339-45. 2009
    ..Since these mutations partly inhibited P18(INK4C) function and reduced its stability, our findings implicate P18 as a tumor suppressor gene involved in human MTC and PC development...
  51. ncbi request reprint Liver surgery induces an immediate mobilization of progenitor cells in liver cancer patients: A potential role for G-CSF
    Marlies H G Langenberg
    Department of Medical Oncology, UMC Utrecht, The Netherlands
    Cancer Biol Ther 9:743-8. 2010
    ..In addition, we tested whether G-CSF could play a role in EPC mobilization in mice and in human volunteers...
  52. ncbi request reprint FoxM1: at the crossroads of ageing and cancer
    Jamila Laoukili
    Department of Medical Oncology, Laboratory of Experimental Oncology, University Medical Center Utrecht, Universiteitsweg 100, Utrecht, The Netherlands
    Biochim Biophys Acta 1775:92-102. 2007
    ..In this review, several aspects of FoxM1 function will be discussed, as well as their implication in tumorigenesis...
  53. doi request reprint Polo-like kinase 1 inhibitors and their potential role in anticancer therapy, with a focus on NSCLC
    Rene H Medema
    Department of Medical Oncology and Cancer Genomics Center, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Cancer Res 17:6459-66. 2011
    ....