Nick S Macklon

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi request reprint Female reproductive ageing: current knowledge and future trends
    Frank J Broekmans
    Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands
    Trends Endocrinol Metab 18:58-65. 2007
  2. doi request reprint Pregnancy complications in women with polycystic ovary syndrome
    Carolien M Boomsma
    Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands
    Semin Reprod Med 26:72-84. 2008
  3. doi request reprint Does glucocorticoid therapy in the peri-implantation period have an impact on IVF outcomes?
    Carolien M Boomsma
    Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Opin Obstet Gynecol 20:249-56. 2008
  4. ncbi request reprint Gonadotrophins in ovulation induction
    N S Macklon
    Department of Reproductive Medicine, University Medical Centre, Utrecht, The Netherlands
    Reprod Biomed Online 10:25-31. 2005
  5. pmc The LIFESTYLE study: costs and effects of a structured lifestyle program in overweight and obese subfertile women to reduce the need for fertility treatment and improve reproductive outcome. A randomised controlled trial
    Meike A Q Mutsaerts
    Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    BMC Womens Health 10:22. 2010
  6. ncbi request reprint The science behind 25 years of ovarian stimulation for in vitro fertilization
    Nick S Macklon
    Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Endocr Rev 27:170-207. 2006
  7. doi request reprint The impact of ovarian stimulation with recombinant FSH in combination with GnRH antagonist on the endometrial transcriptome in the window of implantation
    Nick S Macklon
    Department of Reproductive Medicine and Gynecology, University Medical Center, Utrecht, Netherlands
    Reprod Sci 15:357-65. 2008
  8. doi request reprint Homocysteine metabolism in the pre-ovulatory follicle during ovarian stimulation
    Jolanda C Boxmeer
    Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Hum Reprod 23:2570-6. 2008
  9. doi request reprint Ovarian stimulation for in vitro fertilization alters the intrauterine cytokine, chemokine, and growth factor milieu encountered by the embryo
    Carolien M Boomsma
    Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands
    Fertil Steril 94:1764-8. 2010
  10. doi request reprint IVF outcomes are associated with biomarkers of the homocysteine pathway in monofollicular fluid
    Jolanda C Boxmeer
    Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Hum Reprod 24:1059-66. 2009

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Female reproductive ageing: current knowledge and future trends
    Frank J Broekmans
    Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands
    Trends Endocrinol Metab 18:58-65. 2007
    ..Genetic factors regulating the size of the follicle pool and the rate of its depletion might be identified in the near future and, possibly, assist the accurate prediction of a woman's reproductive lifespan...
  2. doi request reprint Pregnancy complications in women with polycystic ovary syndrome
    Carolien M Boomsma
    Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands
    Semin Reprod Med 26:72-84. 2008
    ..Although metformin appears to be safe, there are too few data from prospective, randomized controlled trials to support treatment during pregnancy...
  3. doi request reprint Does glucocorticoid therapy in the peri-implantation period have an impact on IVF outcomes?
    Carolien M Boomsma
    Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Opin Obstet Gynecol 20:249-56. 2008
    ..The present study aims to summarize the available evidence and make recommendations about the use of glucocorticoids...
  4. ncbi request reprint Gonadotrophins in ovulation induction
    N S Macklon
    Department of Reproductive Medicine, University Medical Centre, Utrecht, The Netherlands
    Reprod Biomed Online 10:25-31. 2005
    ..However, prediction models based on initial screening parameters enable the optimal dose of FSH to be determined, and the identification of patients with a poor prognosis for successful treatment...
  5. pmc The LIFESTYLE study: costs and effects of a structured lifestyle program in overweight and obese subfertile women to reduce the need for fertility treatment and improve reproductive outcome. A randomised controlled trial
    Meike A Q Mutsaerts
    Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    BMC Womens Health 10:22. 2010
    ..We hypothesize that the intervention will decrease the need for fertility treatment, diminish overweight-related pregnancy complications, and will improve perinatal outcome...
  6. ncbi request reprint The science behind 25 years of ovarian stimulation for in vitro fertilization
    Nick S Macklon
    Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Endocr Rev 27:170-207. 2006
    ..After a brief discussion of the relevant aspect of ovarian physiology, the development, application, and consequences of ovarian stimulation strategies are reviewed in detail...
  7. doi request reprint The impact of ovarian stimulation with recombinant FSH in combination with GnRH antagonist on the endometrial transcriptome in the window of implantation
    Nick S Macklon
    Department of Reproductive Medicine and Gynecology, University Medical Center, Utrecht, Netherlands
    Reprod Sci 15:357-65. 2008
    ..These data suggest that dysregulation of the endometrial transcriptome in the stimulated cycle is not fully attributable to supraphysiological sex steroid levels at the folliculo-luteal transition...
  8. doi request reprint Homocysteine metabolism in the pre-ovulatory follicle during ovarian stimulation
    Jolanda C Boxmeer
    Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Hum Reprod 23:2570-6. 2008
    ..This study aims to investigate whether ovarian stimulation deranges the homocysteine pathway thereby affecting the pre-ovulatory follicle...
  9. doi request reprint Ovarian stimulation for in vitro fertilization alters the intrauterine cytokine, chemokine, and growth factor milieu encountered by the embryo
    Carolien M Boomsma
    Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands
    Fertil Steril 94:1764-8. 2010
    ..To elucidate the impact of ovarian stimulation on the intrauterine milieu represented by the cytokine, chemokine, and growth factor profile in endometrial secretions aspirated before embryo transfer...
  10. doi request reprint IVF outcomes are associated with biomarkers of the homocysteine pathway in monofollicular fluid
    Jolanda C Boxmeer
    Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Hum Reprod 24:1059-66. 2009
    ..The aim of this study was to investigate whether biomarkers of the homocysteine pathway are associated with in vitro fertilization (IVF) outcome...
  11. doi request reprint The motile and invasive capacity of human endometrial stromal cells: implications for normal and impaired reproductive function
    Charlotte H E Weimar
    Laboratory of Neuroimmunology and Developmental Origins of Disease NIDOD, University Medical Center Utrecht, Utrecht 3584 EA, The Netherlands
    Hum Reprod Update 19:542-57. 2013
    ....
  12. doi request reprint Embryo implantation: biology, evaluation, and enhancement
    Yvonne E M Koot
    Department of Reproductive Medicine and Gynaecology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Curr Opin Obstet Gynecol 25:274-9. 2013
    ..In assisted reproductive technologies, implantation failure continues to impair treatment outcomes, with distressing results for patients and physicians...
  13. doi request reprint Early initiation of gonadotropin-releasing hormone antagonist treatment results in a more stable endocrine milieu during the mid- and late-follicular phases: a randomized controlled trial comparing gonadotropin-releasing hormone antagonist initiation on c
    Ouijdane Hamdine
    Department of Reproductive Medicine and Gynecology University Medical Centre Utrecht, Utrecht, The Netherlands
    Fertil Steril 100:867-74. 2013
    ..To compare the effect of initiating GnRH antagonist (GnRH-a) on cycle day (CD) 2 vs. CD 6 on LH, E₂, and P levels in the mid and late follicular phases...
  14. doi request reprint Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology
    Fatima Hammiche
    Department of Obstetrics and Gynecology Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Fertil Steril 95:1820-3. 2011
    ....
  15. ncbi request reprint A mild treatment strategy for in-vitro fertilisation: a randomised non-inferiority trial
    Esther M E W Heijnen
    Department of Reproductive Medicine and Gynaecology, University Medical Centre, Utrecht, Netherlands
    Lancet 369:743-9. 2007
    ....
  16. doi request reprint Is bacterial vaginosis associated with a pro-inflammatory cytokine profile in endometrial secretions of women undergoing IVF?
    Carolien M Boomsma
    Department of Reproductive Medicine and Gynecology, University Medical Centre Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Reprod Biomed Online 21:133-41. 2010
    ..However, no distinct difference in pro- and anti-inflammatory profiles is present. An effect on endometrial receptivity is unlikely...
  17. doi request reprint The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increases the chance of pregnancy
    Marijana Vujkovic
    Department of Obstetrics and Gynecology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Fertil Steril 94:2096-101. 2010
    ..To investigate associations between preconception dietary patterns and IVF/intracytoplasmic sperm injection (ICSI) outcomes validated by biomarkers of the homocysteine pathway...
  18. ncbi request reprint The fate of the mosaic embryo: chromosomal constitution and development of Day 4, 5 and 8 human embryos
    Margarida Avo Santos
    Department of Reproductive Medicine and Gynaecology, University Medical Centre, Utrecht, The Netherlands
    Hum Reprod 25:1916-26. 2010
    ..However, the significance of mosaicism for the developmental potential of early embryos is unknown. We assessed chromosomal constitution and development of embryos from compaction to the peri-implantation stage...
  19. ncbi request reprint Low folate in seminal plasma is associated with increased sperm DNA damage
    Jolanda C Boxmeer
    Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Fertil Steril 92:548-56. 2009
    ..To determine associations between vitamin B status, homocysteine (tHcy), semen parameters, and sperm DNA damage...
  20. pmc Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos
    Charlotte H E Weimar
    Laboratory of Neuroimmunology and Developmental Origins of Disease NIDOD, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e41424. 2012
    ....
  21. doi request reprint Peri-implantation glucocorticoid administration for assisted reproductive technology cycles
    Carolien M Boomsma
    Obstetrics and Gynaecology, University Medical Center Utrecht, Utrecht, Netherlands 2Centre for Reproductive Medicine, UHCWNHS Trust, Coventry, UK
    Cochrane Database Syst Rev 6:CD005996. 2012
    ....
  22. doi request reprint Recurrent pre-clinical pregnancy loss is unlikely to be a 'cause' of unexplained infertility
    Yvonne E M Koot
    Department of Reproductive Medicine and Gynaecology, University Medical Centre Utrecht, F05 126, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Hum Reprod 26:2636-41. 2011
    ....
  23. ncbi request reprint Ovarian stimulation and embryo quality
    Esther B Baart
    Department of Reproductive Medicine and Gynaecology, University Medical Center, Utrecht, The Netherlands
    Reprod Biomed Online 18:45-50. 2009
    ....
  24. doi request reprint In-vitro model systems for the study of human embryo-endometrium interactions
    Charlotte H E Weimar
    Laboratory of Neuroimmunology and Developmental Origins of Disease NIDOD, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands Electronic address
    Reprod Biomed Online 27:461-76. 2013
    ..They provide valuable tools to study early embryo development and pathophysiology of reproductive disorders and have revealed novel disease mechanisms such as the role of epigenetic modifications in recurrent miscarriage...
  25. doi request reprint Reprint of: In-vitro model systems for the study of human embryo-endometrium interactions
    Charlotte H E Weimar
    Laboratory of Neuroimmunology and Developmental Origins of Disease NIDOD, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands Electronic address
    Reprod Biomed Online 27:673-88. 2013
    ..They provide valuable tools to study early embryo development and pathophysiology of reproductive disorders and have revealed novel disease mechanisms such as the role of epigenetic modifications in recurrent miscarriage...
  26. doi request reprint The impact of ovarian stimulation for IVF on the developing embryo
    Margarida Avo Santos
    University Medical Centre Utrecht, Reproductive Medicine and Gynaecology, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Reproduction 139:23-34. 2010
    ....
  27. doi request reprint The molecular basis of recurrent pregnancy loss: impaired natural embryo selection
    G Teklenburg
    Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Mol Hum Reprod 16:886-95. 2010
    ..Thus, as the clinical correlate of inappropriate uterine receptivity, 'superfertility' should be considered as a genuine reproductive disorder that requires targeted intervention...
  28. doi request reprint Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment
    Maaike S M van Mourik
    University Medical Center Utrecht, Department of Psychoneuroimmunology, Room KC 03 068 0, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    J Leukoc Biol 85:4-19. 2009
    ..The aim of this review is to discuss mechanisms at play and their relative importance to the establishment of pregnancy...
  29. ncbi request reprint Multiple birth resulting from ovarian stimulation for subfertility treatment
    Bart C J M Fauser
    Department of Reproductive Medicine, University Medical Centre, Heidelberglaan 100, 3584 CX Utrecht, Netherlands
    Lancet 365:1807-16. 2005
    ..The background of ovarian hyperstimulation, trends supporting current practice, and strategies to reduce the chance of multiple pregnancy are highlighted...
  30. pmc Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation
    Gijs Teklenburg
    Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 5:e10258. 2010
    ..The role of cyclic decidualization of the endometrium in the implantation process and the nature of the decidual cytokines and growth factors that mediate the crosstalk with the embryo are unknown...
  31. doi request reprint Review: in vitro models for the study of early human embryo-endometrium interactions
    Gijs Teklenburg
    Department of Reproduction and Gynaecology, University Medical Center Utrecht, Utrecht, The Netherlands
    Reprod Sci 16:811-8. 2009
    ..Although there are limitations to current approaches, a number of research questions that could be addressed using these techniques are identified...
  32. ncbi request reprint Preconception folic acid treatment affects the microenvironment of the maturing oocyte in humans
    Jolanda C Boxmeer
    Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Fertil Steril 89:1766-70. 2008
    ..To investigate the influence of folic acid supplementation on the follicular fluid concentrations of folate and total homocysteine and their relationship to the diameter of the follicle...
  33. ncbi request reprint Effect of B vitamins and genetics on success of in-vitro fertilisation
    Jolanda C Boxmeer
    Lancet 368:200. 2006
  34. ncbi request reprint Contemporary pharmacological manipulation in assisted reproduction
    Judith A F Huirne
    Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Vrije Universiteit Medisch Centrum, Amsterdam, The Netherlands
    Drugs 64:297-322. 2004
    ....