P J Lucassen

Summary

Affiliation: University of Amsterdam
Country: The Netherlands

Publications

  1. ncbi request reprint Stress, depression and hippocampal apoptosis
    Paul J Lucassen
    Centre for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    CNS Neurol Disord Drug Targets 5:531-46. 2006
  2. pmc Opposite effects of early maternal deprivation on neurogenesis in male versus female rats
    Charlotte A Oomen
    SILS Centre for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 4:e3675. 2009
  3. ncbi request reprint Chronic psychosocial stress differentially affects apoptosis in hippocampal subregions and cortex of the adult tree shrew
    P J Lucassen
    Division of Medical Pharmacology, LACDR, Leiden University, Leiden, The Netherlands
    Eur J Neurosci 14:161-6. 2001
  4. doi request reprint Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: possible key role of placental 11beta-hydroxysteroid dehydrogenase type 2
    P J Lucassen
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Neurosci 29:97-103. 2009
  5. ncbi request reprint Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis
    J L Mayer
    Swammerdam Institute for Life Sciences, Centre for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    J Neuroendocrinol 18:629-31. 2006
  6. ncbi request reprint Dissociation between apoptosis, neurogenesis, and synaptic potentiation in the dentate gyrus of adrenalectomized rats
    H J Krugers
    Section Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SW Amsterdam, The Netherlands
    Synapse 61:221-30. 2007
  7. doi request reprint Hippocampal GR expression is increased in elderly depressed females
    Q Wang
    SILS Center for NeuroScience, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands
    Neuropharmacology 62:527-33. 2012
  8. doi request reprint Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action
    P J Lucassen
    Centre for Neuroscience, Swammerdam Institute of Life Sciences, University of Amsterdam, P O box 94214, 1090 GE Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 20:1-17. 2010
  9. doi request reprint Reduction in hippocampal neurogenesis after social defeat is long-lasting and responsive to late antidepressant treatment
    P Van Bokhoven
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University and VU Medical Center, Amsterdam, The Netherlands
    Eur J Neurosci 33:1833-40. 2011
  10. ncbi request reprint Neurogenesis and Alzheimer's disease: Biology and pathophysiology in mice and men
    M W Marlatt
    Swammerdam Institute for Life Science Center for Neuroscience, University of Amsterdam, The Netherlands
    Curr Alzheimer Res 7:113-25. 2010

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Stress, depression and hippocampal apoptosis
    Paul J Lucassen
    Centre for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    CNS Neurol Disord Drug Targets 5:531-46. 2006
    ..Modulation of apoptosis and neurogenesis, by drugs interfering with stress components like MR and/or GR, and/or mediators of the cell death cascade, may therefore provide important drug targets for the modulation of mood and memory...
  2. pmc Opposite effects of early maternal deprivation on neurogenesis in male versus female rats
    Charlotte A Oomen
    SILS Centre for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 4:e3675. 2009
    ..o. in antidepressant action and is highly abundant early postnatally. We here tested the hypothesis that early life stress differentially affects hippocampal structural plasticity in female versus male offspring...
  3. ncbi request reprint Chronic psychosocial stress differentially affects apoptosis in hippocampal subregions and cortex of the adult tree shrew
    P J Lucassen
    Division of Medical Pharmacology, LACDR, Leiden University, Leiden, The Netherlands
    Eur J Neurosci 14:161-6. 2001
    ..As previous stereological investigations failed to detect any loss in the principal neuronal layers, psychosocial stress, therefore, must affect other (structural) parameters like dendritic tree, interneurons, neurogenesis, or glia...
  4. doi request reprint Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: possible key role of placental 11beta-hydroxysteroid dehydrogenase type 2
    P J Lucassen
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Neurosci 29:97-103. 2009
    ..Hence, stress-induced placental 11beta-HSD2 expression may be critical in protecting the fetal brain from maternal stress-induced effects on adult neurogenesis...
  5. ncbi request reprint Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis
    J L Mayer
    Swammerdam Institute for Life Sciences, Centre for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    J Neuroendocrinol 18:629-31. 2006
    ..These data indicate that similarly to its clinical efficacy, mifepristone's effects on adult neurogenesis are rapid and positive, and may therefore be important for its mechanism of action...
  6. ncbi request reprint Dissociation between apoptosis, neurogenesis, and synaptic potentiation in the dentate gyrus of adrenalectomized rats
    H J Krugers
    Section Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SW Amsterdam, The Netherlands
    Synapse 61:221-30. 2007
    ..This suggests that changes in cell proliferation and apoptotic cell death in the DG are not necessarily key factors determining the efficacy of synaptic potentiation...
  7. doi request reprint Hippocampal GR expression is increased in elderly depressed females
    Q Wang
    SILS Center for NeuroScience, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands
    Neuropharmacology 62:527-33. 2012
    ..Whether this sex difference in hippocampal GR-ir in depression relates to the increased incidence of depression in females awaits further study. This article is part of a Special Issue entitled 'Anxiety and Depression'...
  8. doi request reprint Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action
    P J Lucassen
    Centre for Neuroscience, Swammerdam Institute of Life Sciences, University of Amsterdam, P O box 94214, 1090 GE Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 20:1-17. 2010
    ..Normalization of reductions in neurogenesis appears at least partly, implicated in antidepressant action...
  9. doi request reprint Reduction in hippocampal neurogenesis after social defeat is long-lasting and responsive to late antidepressant treatment
    P Van Bokhoven
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University and VU Medical Center, Amsterdam, The Netherlands
    Eur J Neurosci 33:1833-40. 2011
    ..Thus, the neurogenic deficit induced by this social defeat paradigm is long-lasting, but can still be normalized by late imipramine treatment...
  10. ncbi request reprint Neurogenesis and Alzheimer's disease: Biology and pathophysiology in mice and men
    M W Marlatt
    Swammerdam Institute for Life Science Center for Neuroscience, University of Amsterdam, The Netherlands
    Curr Alzheimer Res 7:113-25. 2010
    ..Continued research in this area and use of these models is critical for evaluating if neurogenesis based therapeutic strategies will indeed have the potential to aid those with degenerative conditions...
  11. doi request reprint Early-life stress mediated modulation of adult neurogenesis and behavior
    A Korosi
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands
    Behav Brain Res 227:400-9. 2012
    ..Finally, special attention will be paid to the prominent sex differences in early-life stress-induced alterations in neurogenesis...
  12. ncbi request reprint Increased P27KIP1 protein expression in the dentate gyrus of chronically stressed rats indicates G1 arrest involvement
    V M Heine
    Section Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM, PO Box 94084, Amsterdam, The Netherlands
    Neuroscience 129:593-601. 2004
    ..These results indicate that chronic stress causes cycling cells in the adult hippocampus to arrest in G1, thereby providing more mechanistic insight in the stress-induced decrease in cell proliferation...
  13. doi request reprint Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior
    C P Fitzsimons
    Department of Medical Pharmacology, Leiden University Medical Center Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Mol Psychiatry 18:993-1005. 2013
    ....
  14. ncbi request reprint Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: Implications for neurogenesis
    Dirk Jan Saaltink
    Department of Medical Pharmacology, Leiden University Medical Center Leiden Amsterdam Center for Drug Research, P O Box 9503, 2300 RA, Leiden, The Netherlands
    J Comp Neurol 520:Spc1. 2012
    ..In addition, we propose unique roles for DCL in adult neurogenesis and we suggest high levels of neuronal plasticity in tanycytes, SCN, and ICj. J. Comp. Neurol. 520:2805-2823, 2012. © 2012 Wiley Periodicals, Inc...
  15. doi request reprint Changes in adult neurogenesis in neurodegenerative diseases: cause or consequence?
    A Thompson
    Centre for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    Genes Brain Behav 7:28-42. 2008
    ..We discuss recent literature in relation to Alzheimer's disease and dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, alcoholism, ischemia, epilepsy and major depression...
  16. ncbi request reprint Reduced neuronal activity and reactivation in Alzheimer's disease
    D F Swaab
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Prog Brain Res 117:343-77. 1998
    ..A number of pharmacological and non-pharmacological studies support the concept that activation of the brain indeed has beneficial effects on several aspects of cognition and other central functions...
  17. ncbi request reprint Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain
    A M Karssen
    Divisions of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Endocrinology 142:2686-94. 2001
    ..This finding suggests a more prominent role for corticosterone in control of human brain function than hitherto recognized...
  18. doi request reprint Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: implications for neurogenesis
    Dirk Jan Saaltink
    Department of Medical Pharmacology, Leiden University Medical Center, P O Box 9503, 2300 RA, Leiden, The Netherlands
    J Comp Neurol 520:2805-23. 2012
    ..In addition, we propose unique roles for DCL in adult neurogenesis and we suggest high levels of neuronal plasticity in tanycytes, SCN, and ICj...
  19. pmc Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure
    P J Lucassen
    Division of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research, Sylvius Laboratories, Leiden, The Netherlands
    Am J Pathol 158:453-68. 2001
    ....
  20. ncbi request reprint Differential effect of corticosterone on spatial learning abilities in apolipoprotein E knockout and C57BL/6J mice
    J Grootendorst
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, University of Leiden, 2300 RA Leiden, The Netherlands
    Brain Res 953:281-5. 2002
    ..These results suggest that corticosterone mediates the lasting effects of environmental challenges on apoE-genotype related cognitive performance...
  21. doi request reprint Doublecortin (DCX) and doublecortin-like (DCL) are differentially expressed in the early but not late stages of murine neocortical development
    Karin Boekhoorn
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
    J Comp Neurol 507:1639-52. 2008
    ..Given its involvement in mitosis, DCL appears to have a unique role in the early neuroepithelium that is different from later developmental stages when DCX is coexpressed...
  22. ncbi request reprint Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures
    Jan A Gorter
    Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Epilepsia 44:647-58. 2003
    ....
  23. ncbi request reprint Abnormal motoneuron migration, differentiation, and axon outgrowth in spinal muscular atrophy
    Goran Simic
    Department of Neuroscience, School of Medicine, Croatian Institute for Brain Research, Medical School Zagreb, Zagreb University, Salata 12, 10000 Zagreb, Croatia
    Acta Neuropathol 115:313-26. 2008
    ....
  24. ncbi request reprint Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress
    Charlotte A Oomen
    SILS Centre for Neuroscience, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
    Eur J Neurosci 26:3395-401. 2007
    ..This neurogenic action of mifepristone could potentially contribute to its clinical mechanism of action...
  25. ncbi request reprint Changes in neurogenesis in dementia and Alzheimer mouse models: are they functionally relevant?
    H Georg Kuhn
    Center for Brain Repair and Rehabilitation, Institute for Neuroscience and Physiology, Goteborg University, Medicianregatan 11, 40530 Goteborg, Sweden
    Eur Arch Psychiatry Clin Neurosci 257:281-9. 2007
    ..It is the scope of this review to summarize and analyze the recent data from neurogenesis research with respect to Alzheimer's disease and its animal models...
  26. ncbi request reprint Chronic stress: implications for neuronal morphology, function and neurogenesis
    Marian Joels
    SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Front Neuroendocrinol 28:72-96. 2007
    ....
  27. ncbi request reprint What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated?
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 257:250-60. 2007
    ....
  28. ncbi request reprint Gene expression patterns in rat dentate granule cells: comparison between fresh and fixed tissue
    Yongjun Qin
    Section Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098SM Amsterdam, The Netherlands
    J Neurosci Methods 131:205-11. 2003
    ..The present approach validates expression profiling from small amounts of fixed neurons as a powerful tool to investigate molecular processes if fresh tissue is not available...
  29. ncbi request reprint Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible
    Vivi M Heine
    Institute for Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 19:131-44. 2004
    ..This may have important implications for our understanding of the reversibility of stress-related hippocampal volume changes, such as occur, for example, in depression...
  30. ncbi request reprint Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex
    Paul J Lucassen
    Institute for Neurobiology, Faculty of Science, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Biol Psychiatry 55:789-96. 2004
    ..Here, we investigated whether the antidepressant tianeptine would affect apoptosis in an animal model of depression, the psychosocially stressed tree shrew...
  31. ncbi request reprint Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituitary-adrenal axis activation
    Vivi M Heine
    Institute for Neurobiology, Faculty of Science, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
    Neurobiol Aging 25:361-75. 2004
    ..Surprisingly, we found no correlation between cell birth and corticosterone levels or stress response parameters in any age group...
  32. ncbi request reprint Neuronal number, volume, and apoptosis of the left dentate gyrus of chronically stressed pigs correlate negatively with basal saliva cortisol levels
    Eline M van der Beek
    Human and Animal Physiology Group, Department of Animal Science, Wageningen University, Wageningen, The Netherlands
    Hippocampus 14:688-700. 2004
    ..The present lateralization after stress is, however, consistent with lateralized hippocampal volume changes in stress-related human disorders and suggests that these effects are not limited to this species alone...
  33. ncbi request reprint Alterations of neuroplasticity in depression: the hippocampus and beyond
    Eberhard Fuchs
    Clinical Neurobiology Laboratory, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
    Eur Neuropsychopharmacol 14:S481-90. 2004
    ..These findings support current theories proposing that major depressive disorders may be associated with impairment of structural plasticity and neural cellular resilience, and that antidepressants may act by correcting this dysfunction...
  34. ncbi request reprint Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk-1 protein expression
    Vivi M Heine
    Institute Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 21:1304-14. 2005
    ..This demonstrates that changes in angiogenic factors are implicated in the decreased adult proliferation found after chronic stress...
  35. ncbi request reprint The stress system in the human brain in depression and neurodegeneration
    Dick F Swaab
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    Ageing Res Rev 4:141-94. 2005
    ..Although cortisol and CRH may well be causally involved in the signs and symptoms of depression, there is so far no evidence for any major irreversible damage in the human hippocampus in this disorder...
  36. ncbi request reprint Branching of calyceal afferents during postnatal development in the rat auditory brainstem
    Adrian Rodriguez-Contreras
    Department of Neuroscience, Erasmus MC, University Medical Center Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Comp Neurol 496:214-28. 2006
    ..Our data suggest that, once a calyceal synapse forms in the MNTB, it stays...
  37. ncbi request reprint Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy
    Karin Boekhoorn
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 26:3514-23. 2006
    ....
  38. ncbi request reprint Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus
    Karin Boekhoorn
    Center for Neuroscience, Swammerdam Institute of Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Neurobiol Dis 24:1-14. 2006
    ..They reflect clear differences in proliferative responsivity, particularly in the glia and vascular components, and suggest different underlying mechanisms in these groups...
  39. ncbi request reprint Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus
    Marian Joels
    SILS CNS, University of Amsterdam, The Netherlands
    Stress 7:221-31. 2004
    ..All of these endpoints provide potential targets for novel treatment strategies of stress-related brain disorders...
  40. ncbi request reprint Doublecortin-like, a microtubule-associated protein expressed in radial glia, is crucial for neuronal precursor division and radial process stability
    Erno Vreugdenhil
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, PO Box 9502, 2300 RA Leiden, The Netherlands
    Eur J Neurosci 25:635-48. 2007
    ..In addition, they indicate crucial involvement of DCLK in RG proliferation and their radial process stability, a finding that has thus far not been attributed to DCX or DCLK...
  41. ncbi request reprint Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice
    Kristina Sennvik
    Experimental Genetics Group, Department Human Genetics, KULeuven Campus Gasthuisberg ON1 06 602, B 3000 Leuven, Belgium
    FASEB J 21:2149-61. 2007
    ..We suggest that the tau-4R isoform essentially contributes to hippocampal development by controlling proliferation and differentiation of neuronal precursors...
  42. ncbi request reprint Very low levels of the glucocorticoid receptor beta isoform in the human hippocampus as shown by Taqman RT-PCR and immunocytochemistry
    Roel H DeRijk
    Division of Medical Pharmacology, Leiden University, 2300 RA Leiden, The Netherlands
    Brain Res Mol Brain Res 116:17-26. 2003
    ..A functionally relevant role for the GRbeta in control of the human hippocampus is therefore not very likely. Whether this is altered in disease conditions awaits further research...