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Genomes and Genes | P J LucassenSummaryAffiliation: University of Amsterdam Country: The Netherlands Publications
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Publications
Stress, depression and hippocampal apoptosisPaul J Lucassen
Centre for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
CNS Neurol Disord Drug Targets 5:531-46. 2006..Modulation of apoptosis and neurogenesis, by drugs interfering with stress components like MR and/or GR, and/or mediators of the cell death cascade, may therefore provide important drug targets for the modulation of mood and memory...- Chronic psychosocial stress differentially affects apoptosis in hippocampal subregions and cortex of the adult tree shrewP J Lucassen
Division of Medical Pharmacology, LACDR, Leiden University, Leiden, The Netherlands
Eur J Neurosci 14:161-6. 2001..As previous stereological investigations failed to detect any loss in the principal neuronal layers, psychosocial stress, therefore, must affect other (structural) parameters like dendritic tree, interneurons, neurogenesis, or glia... 
Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: possible key role of placental 11beta-hydroxysteroid dehydrogenase type 2P J Lucassen
SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
Eur J Neurosci 29:97-103. 2009..Hence, stress-induced placental 11beta-HSD2 expression may be critical in protecting the fetal brain from maternal stress-induced effects on adult neurogenesis...- Dissociation between apoptosis, neurogenesis, and synaptic potentiation in the dentate gyrus of adrenalectomized ratsH J Krugers
Section Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SW Amsterdam, The Netherlands
Synapse 61:221-30. 2007..This suggests that changes in cell proliferation and apoptotic cell death in the DG are not necessarily key factors determining the efficacy of synaptic potentiation... - Hippocampal GR expression is increased in elderly depressed femalesQ Wang
SILS Center for NeuroScience, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands
Neuropharmacology 62:527-33. 2012..Whether this sex difference in hippocampal GR-ir in depression relates to the increased incidence of depression in females awaits further study. This article is part of a Special Issue entitled 'Anxiety and Depression'... - Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesisJ L Mayer
Swammerdam Institute for Life Sciences, Centre for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
J Neuroendocrinol 18:629-31. 2006..These data indicate that similarly to its clinical efficacy, mifepristone's effects on adult neurogenesis are rapid and positive, and may therefore be important for its mechanism of action... - Reduction in hippocampal neurogenesis after social defeat is long-lasting and responsive to late antidepressant treatmentP Van Bokhoven
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University and VU Medical Center, Amsterdam, The Netherlands
Eur J Neurosci 33:1833-40. 2011..Thus, the neurogenic deficit induced by this social defeat paradigm is long-lasting, but can still be normalized by late imipramine treatment... - Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant actionP J Lucassen
Centre for Neuroscience, Swammerdam Institute of Life Sciences, University of Amsterdam, P O box 94214, 1090 GE Amsterdam, The Netherlands
Eur Neuropsychopharmacol 20:1-17. 2010..Normalization of reductions in neurogenesis appears at least partly, implicated in antidepressant action... - Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: Implications for neurogenesisDirk Jan Saaltink
Department of Medical Pharmacology, Leiden University Medical Center Leiden Amsterdam Center for Drug Research, P O Box 9503, 2300 RA, Leiden, The Netherlands
J Comp Neurol 520:Spc1. 2012..In addition, we propose unique roles for DCL in adult neurogenesis and we suggest high levels of neuronal plasticity in tanycytes, SCN, and ICj. J. Comp. Neurol. 520:2805-2823, 2012. © 2012 Wiley Periodicals, Inc... - Neurogenesis and Alzheimer's disease: Biology and pathophysiology in mice and menM W Marlatt
Swammerdam Institute for Life Science Center for Neuroscience, University of Amsterdam, The Netherlands
Curr Alzheimer Res 7:113-25. 2010..Continued research in this area and use of these models is critical for evaluating if neurogenesis based therapeutic strategies will indeed have the potential to aid those with degenerative conditions... - Early-life stress mediated modulation of adult neurogenesis and behaviorA Korosi
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands
Behav Brain Res 227:400-9. 2012..Finally, special attention will be paid to the prominent sex differences in early-life stress-induced alterations in neurogenesis... - Changes in adult neurogenesis in neurodegenerative diseases: cause or consequence?A Thompson
Centre for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
Genes Brain Behav 7:28-42. 2008..We discuss recent literature in relation to Alzheimer's disease and dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, alcoholism, ischemia, epilepsy and major depression... - Reduced neuronal activity and reactivation in Alzheimer's diseaseD F Swaab
Netherlands Institute for Brain Research, Amsterdam, The Netherlands
Prog Brain Res 117:343-77. 1998..A number of pharmacological and non-pharmacological studies support the concept that activation of the brain indeed has beneficial effects on several aspects of cognition and other central functions... - Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brainA M Karssen
Divisions of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
Endocrinology 142:2686-94. 2001..This finding suggests a more prominent role for corticosterone in control of human brain function than hitherto recognized... - Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: implications for neurogenesisDirk Jan Saaltink
Department of Medical Pharmacology, Leiden University Medical Center, P O Box 9503, 2300 RA, Leiden, The Netherlands
J Comp Neurol 520:2805-23. 2012..In addition, we propose unique roles for DCL in adult neurogenesis and we suggest high levels of neuronal plasticity in tanycytes, SCN, and ICj... - Increased P27KIP1 protein expression in the dentate gyrus of chronically stressed rats indicates G1 arrest involvementV M Heine
Section Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM, PO Box 94084, Amsterdam, The Netherlands
Neuroscience 129:593-601. 2004..These results indicate that chronic stress causes cycling cells in the adult hippocampus to arrest in G1, thereby providing more mechanistic insight in the stress-induced decrease in cell proliferation... 
Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposureP J Lucassen
Division of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research, Sylvius Laboratories, Leiden, The Netherlands
Am J Pathol 158:453-68. 2001....- Differential effect of corticosterone on spatial learning abilities in apolipoprotein E knockout and C57BL/6J miceJ Grootendorst
Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, University of Leiden, 2300 RA Leiden, The Netherlands
Brain Res 953:281-5. 2002..These results suggest that corticosterone mediates the lasting effects of environmental challenges on apoE-genotype related cognitive performance... - Chronic stress: implications for neuronal morphology, function and neurogenesisMarian Joels
SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Front Neuroendocrinol 28:72-96. 2007.... - Changes in neurogenesis in dementia and Alzheimer mouse models: are they functionally relevant?H Georg Kuhn
Center for Brain Repair and Rehabilitation, Institute for Neuroscience and Physiology, Goteborg University, Medicianregatan 11, 40530 Goteborg, Sweden
Eur Arch Psychiatry Clin Neurosci 257:281-9. 2007..It is the scope of this review to summarize and analyze the recent data from neurogenesis research with respect to Alzheimer's disease and its animal models... - Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stressCharlotte A Oomen
SILS Centre for Neuroscience, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
Eur J Neurosci 26:3395-401. 2007..This neurogenic action of mifepristone could potentially contribute to its clinical mechanism of action... - Abnormal motoneuron migration, differentiation, and axon outgrowth in spinal muscular atrophyGoran Simic
Department of Neuroscience, School of Medicine, Croatian Institute for Brain Research, Medical School Zagreb, Zagreb University, Salata 12, 10000 Zagreb, Croatia
Acta Neuropathol 115:313-26. 2008.... - Doublecortin (DCX) and doublecortin-like (DCL) are differentially expressed in the early but not late stages of murine neocortical developmentKarin Boekhoorn
Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
J Comp Neurol 507:1639-52. 2008..Given its involvement in mitosis, DCL appears to have a unique role in the early neuroepithelium that is different from later developmental stages when DCX is coexpressed... - Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizuresJan A Gorter
Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Epilepsia 44:647-58. 2003.... - What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated?Boldizsar Czeh
Clinical Neurobiology Laboratory, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
Eur Arch Psychiatry Clin Neurosci 257:250-60. 2007.... - Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout miceKristina Sennvik
Experimental Genetics Group, Department Human Genetics, KULeuven Campus Gasthuisberg ON1 06 602, B 3000 Leuven, Belgium
FASEB J 21:2149-61. 2007..We suggest that the tau-4R isoform essentially contributes to hippocampal development by controlling proliferation and differentiation of neuronal precursors... - Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituitary-adrenal axis activationVivi M Heine
Institute for Neurobiology, Faculty of Science, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
Neurobiol Aging 25:361-75. 2004..Surprisingly, we found no correlation between cell birth and corticosterone levels or stress response parameters in any age group... - Neuronal number, volume, and apoptosis of the left dentate gyrus of chronically stressed pigs correlate negatively with basal saliva cortisol levelsEline M van der Beek
Human and Animal Physiology Group, Department of Animal Science, Wageningen University, Wageningen, The Netherlands
Hippocampus 14:688-700. 2004..The present lateralization after stress is, however, consistent with lateralized hippocampal volume changes in stress-related human disorders and suggests that these effects are not limited to this species alone... - Alterations of neuroplasticity in depression: the hippocampus and beyondEberhard Fuchs
Clinical Neurobiology Laboratory, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
Eur Neuropsychopharmacol 14:S481-90. 2004..These findings support current theories proposing that major depressive disorders may be associated with impairment of structural plasticity and neural cellular resilience, and that antidepressants may act by correcting this dysfunction... - Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk-1 protein expressionVivi M Heine
Institute Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Eur J Neurosci 21:1304-14. 2005..This demonstrates that changes in angiogenic factors are implicated in the decreased adult proliferation found after chronic stress... - The stress system in the human brain in depression and neurodegenerationDick F Swaab
Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
Ageing Res Rev 4:141-94. 2005..Although cortisol and CRH may well be causally involved in the signs and symptoms of depression, there is so far no evidence for any major irreversible damage in the human hippocampus in this disorder... - Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamusMarian Joels
SILS CNS, University of Amsterdam, The Netherlands
Stress 7:221-31. 2004..All of these endpoints provide potential targets for novel treatment strategies of stress-related brain disorders... - Branching of calyceal afferents during postnatal development in the rat auditory brainstemAdrian Rodriguez-Contreras
Department of Neuroscience, Erasmus MC, University Medical Center Rotterdam, 3000 DR Rotterdam, The Netherlands
J Comp Neurol 496:214-28. 2006..Our data suggest that, once a calyceal synapse forms in the MNTB, it stays... - Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathyKarin Boekhoorn
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
J Neurosci 26:3514-23. 2006.... - Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampusKarin Boekhoorn
Center for Neuroscience, Swammerdam Institute of Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Neurobiol Dis 24:1-14. 2006..They reflect clear differences in proliferative responsivity, particularly in the glia and vascular components, and suggest different underlying mechanisms in these groups... - Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversibleVivi M Heine
Institute for Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Eur J Neurosci 19:131-44. 2004..This may have important implications for our understanding of the reversibility of stress-related hippocampal volume changes, such as occur, for example, in depression... - Gene expression patterns in rat dentate granule cells: comparison between fresh and fixed tissueYongjun Qin
Section Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098SM Amsterdam, The Netherlands
J Neurosci Methods 131:205-11. 2003..The present approach validates expression profiling from small amounts of fixed neurons as a powerful tool to investigate molecular processes if fresh tissue is not available... - Very low levels of the glucocorticoid receptor beta isoform in the human hippocampus as shown by Taqman RT-PCR and immunocytochemistryRoel H DeRijk
Division of Medical Pharmacology, Leiden University, 2300 RA Leiden, The Netherlands
Brain Res Mol Brain Res 116:17-26. 2003..A functionally relevant role for the GRbeta in control of the human hippocampus is therefore not very likely. Whether this is altered in disease conditions awaits further research... - Doublecortin-like, a microtubule-associated protein expressed in radial glia, is crucial for neuronal precursor division and radial process stabilityErno Vreugdenhil
Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, PO Box 9502, 2300 RA Leiden, The Netherlands
Eur J Neurosci 25:635-48. 2007..In addition, they indicate crucial involvement of DCLK in RG proliferation and their radial process stability, a finding that has thus far not been attributed to DCX or DCLK... - Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortexPaul J Lucassen
Institute for Neurobiology, Faculty of Science, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Biol Psychiatry 55:789-96. 2004..These findings are consistent with current theories that ascribe enhanced general cell survival to antidepressant action...