P J Lucassen

Summary

Affiliation: University of Amsterdam
Country: The Netherlands

Publications

  1. pmc A single-day treatment with mifepristone is sufficient to normalize chronic glucocorticoid induced suppression of hippocampal cell proliferation
    Pu Hu
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e46224. 2012
  2. pmc Neuropathology of stress
    Paul J Lucassen
    SILS Center for NeuroScience, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands
    Acta Neuropathol 127:109-35. 2014
  3. pmc Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats
    Charlotte A Oomen
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 214:249-60. 2011
  4. doi request reprint Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action
    P J Lucassen
    Centre for Neuroscience, Swammerdam Institute of Life Sciences, University of Amsterdam, P O box 94214, 1090 GE Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 20:1-17. 2010
  5. doi request reprint Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients
    Paul J Lucassen
    Centre for Neuroscience, Swammerdam Institute of Life Sciences, University of Amsterdam, P O box 94214, 1090 GE Amsterdam, The Netherlands
    Neuropharmacology 58:940-9. 2010
  6. ncbi request reprint Dissociation between apoptosis, neurogenesis, and synaptic potentiation in the dentate gyrus of adrenalectomized rats
    H J Krugers
    Section Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SW Amsterdam, The Netherlands
    Synapse 61:221-30. 2007
  7. doi request reprint Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: possible key role of placental 11beta-hydroxysteroid dehydrogenase type 2
    P J Lucassen
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Neurosci 29:97-103. 2009
  8. ncbi request reprint Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis
    J L Mayer
    Swammerdam Institute for Life Sciences, Centre for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    J Neuroendocrinol 18:629-31. 2006
  9. doi request reprint Hippocampal GR expression is increased in elderly depressed females
    Q Wang
    SILS Center for NeuroScience, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands
    Neuropharmacology 62:527-33. 2012
  10. doi request reprint Reduction in hippocampal neurogenesis after social defeat is long-lasting and responsive to late antidepressant treatment
    P Van Bokhoven
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University and VU Medical Center, Amsterdam, The Netherlands
    Eur J Neurosci 33:1833-40. 2011

Collaborators

Detail Information

Publications32

  1. pmc A single-day treatment with mifepristone is sufficient to normalize chronic glucocorticoid induced suppression of hippocampal cell proliferation
    Pu Hu
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e46224. 2012
    ..Here we aimed to better understand how mifepristone achieves this effect and questioned whether an even shorter (single day) mifepristone treatment (instead of 4 days) also suffices to normalize neurogenesis...
  2. pmc Neuropathology of stress
    Paul J Lucassen
    SILS Center for NeuroScience, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands
    Acta Neuropathol 127:109-35. 2014
    ....
  3. pmc Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats
    Charlotte A Oomen
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 214:249-60. 2011
    ..However, the underlying mechanisms that account for a reduced hippocampal volume are unknown...
  4. doi request reprint Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action
    P J Lucassen
    Centre for Neuroscience, Swammerdam Institute of Life Sciences, University of Amsterdam, P O box 94214, 1090 GE Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 20:1-17. 2010
    ..Normalization of reductions in neurogenesis appears at least partly, implicated in antidepressant action...
  5. doi request reprint Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients
    Paul J Lucassen
    Centre for Neuroscience, Swammerdam Institute of Life Sciences, University of Amsterdam, P O box 94214, 1090 GE Amsterdam, The Netherlands
    Neuropharmacology 58:940-9. 2010
    ..Whether the reduction is a cause or consequence of depression awaits to be determined...
  6. ncbi request reprint Dissociation between apoptosis, neurogenesis, and synaptic potentiation in the dentate gyrus of adrenalectomized rats
    H J Krugers
    Section Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SW Amsterdam, The Netherlands
    Synapse 61:221-30. 2007
    ..This suggests that changes in cell proliferation and apoptotic cell death in the DG are not necessarily key factors determining the efficacy of synaptic potentiation...
  7. doi request reprint Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: possible key role of placental 11beta-hydroxysteroid dehydrogenase type 2
    P J Lucassen
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Neurosci 29:97-103. 2009
    ..Hence, stress-induced placental 11beta-HSD2 expression may be critical in protecting the fetal brain from maternal stress-induced effects on adult neurogenesis...
  8. ncbi request reprint Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis
    J L Mayer
    Swammerdam Institute for Life Sciences, Centre for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    J Neuroendocrinol 18:629-31. 2006
    ..These data indicate that similarly to its clinical efficacy, mifepristone's effects on adult neurogenesis are rapid and positive, and may therefore be important for its mechanism of action...
  9. doi request reprint Hippocampal GR expression is increased in elderly depressed females
    Q Wang
    SILS Center for NeuroScience, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands
    Neuropharmacology 62:527-33. 2012
    ..Whether this sex difference in hippocampal GR-ir in depression relates to the increased incidence of depression in females awaits further study. This article is part of a Special Issue entitled 'Anxiety and Depression'...
  10. doi request reprint Reduction in hippocampal neurogenesis after social defeat is long-lasting and responsive to late antidepressant treatment
    P Van Bokhoven
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University and VU Medical Center, Amsterdam, The Netherlands
    Eur J Neurosci 33:1833-40. 2011
    ..Thus, the neurogenic deficit induced by this social defeat paradigm is long-lasting, but can still be normalized by late imipramine treatment...
  11. pmc Opposite effects of early maternal deprivation on neurogenesis in male versus female rats
    Charlotte A Oomen
    SILS Centre for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 4:e3675. 2009
    ..o. in antidepressant action and is highly abundant early postnatally. We here tested the hypothesis that early life stress differentially affects hippocampal structural plasticity in female versus male offspring...
  12. ncbi request reprint Neurogenesis and Alzheimer's disease: Biology and pathophysiology in mice and men
    M W Marlatt
    Swammerdam Institute for Life Science Center for Neuroscience, University of Amsterdam, The Netherlands
    Curr Alzheimer Res 7:113-25. 2010
    ..Continued research in this area and use of these models is critical for evaluating if neurogenesis based therapeutic strategies will indeed have the potential to aid those with degenerative conditions...
  13. ncbi request reprint Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood
    Charlotte A Oomen
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1098 XH Amsterdam, The Netherlands
    J Neurosci 30:6635-45. 2010
    ..Rather, adversity early in life can prepare the organism to perform optimally under conditions associated with high corticosteroid levels in adulthood...
  14. doi request reprint Corticosteroid effects on cellular physiology of limbic cells
    Marian Joels
    SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Brain Res 1293:91-100. 2009
    ..Finally, the time- and region-specific corticosteroid actions strongly depend on the individual's life history...
  15. ncbi request reprint Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituitary-adrenal axis activation
    Vivi M Heine
    Institute for Neurobiology, Faculty of Science, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
    Neurobiol Aging 25:361-75. 2004
    ..Surprisingly, we found no correlation between cell birth and corticosterone levels or stress response parameters in any age group...
  16. ncbi request reprint Early-life stress mediated modulation of adult neurogenesis and behavior
    A Korosi
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands
    Behav Brain Res 227:400-9. 2012
    ..Finally, special attention will be paid to the prominent sex differences in early-life stress-induced alterations in neurogenesis...
  17. doi request reprint Changes in adult neurogenesis in neurodegenerative diseases: cause or consequence?
    A Thompson
    Centre for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    Genes Brain Behav 7:28-42. 2008
    ..We discuss recent literature in relation to Alzheimer's disease and dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, alcoholism, ischemia, epilepsy and major depression...
  18. ncbi request reprint Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus
    Marian Joels
    SILS CNS, University of Amsterdam, The Netherlands
    Stress 7:221-31. 2004
    ..All of these endpoints provide potential targets for novel treatment strategies of stress-related brain disorders...
  19. ncbi request reprint Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress
    Charlotte A Oomen
    SILS Centre for Neuroscience, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
    Eur J Neurosci 26:3395-401. 2007
    ..This neurogenic action of mifepristone could potentially contribute to its clinical mechanism of action...
  20. ncbi request reprint Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk-1 protein expression
    Vivi M Heine
    Institute Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 21:1304-14. 2005
    ..This demonstrates that changes in angiogenic factors are implicated in the decreased adult proliferation found after chronic stress...
  21. ncbi request reprint Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy
    Karin Boekhoorn
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 26:3514-23. 2006
    ....
  22. ncbi request reprint Reduced neuronal activity and reactivation in Alzheimer's disease
    D F Swaab
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Prog Brain Res 117:343-77. 1998
    ..A number of pharmacological and non-pharmacological studies support the concept that activation of the brain indeed has beneficial effects on several aspects of cognition and other central functions...
  23. ncbi request reprint Increased P27KIP1 protein expression in the dentate gyrus of chronically stressed rats indicates G1 arrest involvement
    V M Heine
    Section Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM, PO Box 94084, Amsterdam, The Netherlands
    Neuroscience 129:593-601. 2004
    ..These results indicate that chronic stress causes cycling cells in the adult hippocampus to arrest in G1, thereby providing more mechanistic insight in the stress-induced decrease in cell proliferation...
  24. ncbi request reprint Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus
    Karin Boekhoorn
    Center for Neuroscience, Swammerdam Institute of Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Neurobiol Dis 24:1-14. 2006
    ..They reflect clear differences in proliferative responsivity, particularly in the glia and vascular components, and suggest different underlying mechanisms in these groups...
  25. ncbi request reprint Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible
    Vivi M Heine
    Institute for Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 19:131-44. 2004
    ..This may have important implications for our understanding of the reversibility of stress-related hippocampal volume changes, such as occur, for example, in depression...
  26. ncbi request reprint Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex
    Paul J Lucassen
    Institute for Neurobiology, Faculty of Science, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Biol Psychiatry 55:789-96. 2004
    ..Here, we investigated whether the antidepressant tianeptine would affect apoptosis in an animal model of depression, the psychosocially stressed tree shrew...
  27. ncbi request reprint Chronic stress: implications for neuronal morphology, function and neurogenesis
    Marian Joels
    SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Front Neuroendocrinol 28:72-96. 2007
    ....
  28. ncbi request reprint Stress, depression and hippocampal apoptosis
    Paul J Lucassen
    Centre for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    CNS Neurol Disord Drug Targets 5:531-46. 2006
    ..Modulation of apoptosis and neurogenesis, by drugs interfering with stress components like MR and/or GR, and/or mediators of the cell death cascade, may therefore provide important drug targets for the modulation of mood and memory...
  29. ncbi request reprint Gene expression patterns in rat dentate granule cells: comparison between fresh and fixed tissue
    Yongjun Qin
    Section Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098SM Amsterdam, The Netherlands
    J Neurosci Methods 131:205-11. 2003
    ..The present approach validates expression profiling from small amounts of fixed neurons as a powerful tool to investigate molecular processes if fresh tissue is not available...
  30. ncbi request reprint Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures
    Jan A Gorter
    Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Epilepsia 44:647-58. 2003
    ....
  31. doi request reprint Doublecortin-like (DCL) expression in focal cortical dysplasia and cortical tubers
    Karin Boer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 50:2629-37. 2009
    ..The aim of our study was to define the expression and cell-specific distribution of doublecortin-like (DCL), a protein critically involved in neuronal division and radial migration during early corticogenesis, in both FCD and TSC...
  32. doi request reprint Doublecortin (DCX) and doublecortin-like (DCL) are differentially expressed in the early but not late stages of murine neocortical development
    Karin Boekhoorn
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
    J Comp Neurol 507:1639-52. 2008
    ..Given its involvement in mitosis, DCL appears to have a unique role in the early neuroepithelium that is different from later developmental stages when DCX is coexpressed...