Jun Liu

Summary

Affiliation: University of Twente
Country: The Netherlands

Publications

  1. doi In vitro and in vivo bioluminescent imaging of hypoxia in tissue-engineered grafts
    Jun Liu
    Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands
    Tissue Eng Part C Methods 16:479-85. 2010
  2. doi Timing, rather than the concentration of cyclic AMP, correlates to osteogenic differentiation of human mesenchymal stem cells
    Ramakrishnaiah Siddappa
    MIRA Institute for Biomedical Technology and Technical Medicine, Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands
    J Tissue Eng Regen Med 4:356-65. 2010
  3. doi cAMP/PKA signaling inhibits osteogenic differentiation and bone formation in rodent models
    Ramakrishnaiah Siddappa
    Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands
    Tissue Eng Part A 15:2135-43. 2009
  4. doi Noninvasive imaging of bone-specific collagen I expression in a luciferase transgenic mouse model
    Jun Liu
    Department of Tissue Regeneration, MIRA Research Institute, University of Twente, Enschede, The Netherlands
    Tissue Eng Part C Methods 16:1297-304. 2010
  5. doi The effect of PKC activation and inhibition on osteogenic differentiation of human mesenchymal stem cells
    Jun Liu
    Mira Institute for Biomedical Technology, Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands
    J Tissue Eng Regen Med 4:329-39. 2010
  6. pmc Sonic Hedgehog-activated engineered blood vessels enhance bone tissue formation
    Nicolas C Rivron
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, 7500AE, University of Twente, Enschede, The Netherlands
    Proc Natl Acad Sci U S A 109:4413-8. 2012
  7. doi Development and analysis of multi-layer scaffolds for tissue engineering
    Bernke J Papenburg
    Membrane Science and Technology, Faculty of Science and Technology, Institute for Biomedical Technology and Technical Medicine MIRA, University of Twente, P O Box 217, 7500 AE, Enschede, The Netherlands
    Biomaterials 30:6228-39. 2009
  8. ncbi The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering
    Ramakrishnaiah Siddappa
    University of Twente, Institute for Biomedical Technology, Department of Tissue Regeneration, P O Box 217, Enschede 7500 AE, The Netherlands
    Curr Stem Cell Res Ther 2:209-20. 2007

Collaborators

  • Jan de Boer
  • Jeroen Rouwkema
  • Nicolas C Rivron
  • Roman Truckenm├╝ller
  • Ramakrishnaiah Siddappa
  • Clemens van Blitterswijk
  • Roel Arends
  • Bernke J Papenburg
  • Hugo Fernandes
  • Joyce Doorn
  • Eli Langerwerf
  • Christine van de Klundert
  • Gustavo A Higuera
  • Winfried Mulder
  • Ana M C Barradas
  • Ilse Steeghs
  • Clemens A van Blitterswijk
  • Dimitrios Stamatialis
  • Matthias Wessling

Detail Information

Publications8

  1. doi In vitro and in vivo bioluminescent imaging of hypoxia in tissue-engineered grafts
    Jun Liu
    Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands
    Tissue Eng Part C Methods 16:479-85. 2010
    ..We conclude that this reporter system is a versatile tool to investigate cellular O(2) availability in TE both in vitro and in vivo...
  2. doi Timing, rather than the concentration of cyclic AMP, correlates to osteogenic differentiation of human mesenchymal stem cells
    Ramakrishnaiah Siddappa
    MIRA Institute for Biomedical Technology and Technical Medicine, Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands
    J Tissue Eng Regen Med 4:356-65. 2010
    ..Taken together, our results demonstrate that cAMP can either stimulate or inhibit osteogenesis in hMSCs, depending on the duration, rather than the strength, of the signal provided...
  3. doi cAMP/PKA signaling inhibits osteogenic differentiation and bone formation in rodent models
    Ramakrishnaiah Siddappa
    Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands
    Tissue Eng Part A 15:2135-43. 2009
    ..The species discrepancy in response to various osteogenic signals is a critical need to be tested in clinically relevant models to translate the fundamental findings in lower species level to clinical applications...
  4. doi Noninvasive imaging of bone-specific collagen I expression in a luciferase transgenic mouse model
    Jun Liu
    Department of Tissue Regeneration, MIRA Research Institute, University of Twente, Enschede, The Netherlands
    Tissue Eng Part C Methods 16:1297-304. 2010
    ..We conclude that Col(I)-Luc transgenic mice can be applied in the field of bone tissue engineering for monitoring bone repair processes and for investigating osteoinductive molecules or scaffolds...
  5. doi The effect of PKC activation and inhibition on osteogenic differentiation of human mesenchymal stem cells
    Jun Liu
    Mira Institute for Biomedical Technology, Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands
    J Tissue Eng Regen Med 4:329-39. 2010
    ..In conclusion, inhibition of the conventional PKCs/PKCmicro and activation of PKCdelta could further benefit osteogenic differentiation of hMSCs in vitro and in vivo, which is currently under investigation...
  6. pmc Sonic Hedgehog-activated engineered blood vessels enhance bone tissue formation
    Nicolas C Rivron
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, 7500AE, University of Twente, Enschede, The Netherlands
    Proc Natl Acad Sci U S A 109:4413-8. 2012
    ..These findings open the door for new strategies to treat large bone defects by closely mimicking natural endochondral bone repair...
  7. doi Development and analysis of multi-layer scaffolds for tissue engineering
    Bernke J Papenburg
    Membrane Science and Technology, Faculty of Science and Technology, Institute for Biomedical Technology and Technical Medicine MIRA, University of Twente, P O Box 217, 7500 AE, Enschede, The Netherlands
    Biomaterials 30:6228-39. 2009
    ..Under dynamic conditions, medium flow through the channels improves nutrient availability to the cells on the various layers, drastically increasing cell proliferation on all layers...
  8. ncbi The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering
    Ramakrishnaiah Siddappa
    University of Twente, Institute for Biomedical Technology, Department of Tissue Regeneration, P O Box 217, Enschede 7500 AE, The Netherlands
    Curr Stem Cell Res Ther 2:209-20. 2007
    ..We will discuss how and to what extent the process is different from that in other cell types with special emphasis on applications in bone tissue engineering...