Jack J M Ligtenberg
Affiliation: University Medical Center Groningen
Country: The Netherlands
- Clinical review: treatment of new-onset atrial fibrillation in medical intensive care patients--a clinical frameworkMengalvio E Sleeswijk
Flevo Hospital, Hospitaalweg 1, 1315 RA, Almere, The Netherlands
Crit Care 11:233. 2007..A randomised controlled trial in medical intensive care unit patients with placebo treatment in the control arm is therefore still defendable...
- Mean glucose level is not an independent risk factor for mortality in mixed ICU patientsJack J M Ligtenberg
University Medical Centre Groningen, Intensive and Respiratory Care Unit ICB, 30 001, 9700 RB, Groningen, The Netherlands
Intensive Care Med 32:435-8. 2006..To find out if there is an association between hyperglycaemia and mortality in mixed ICU patients...
- Quality of interhospital transport of critically ill patients: a prospective auditJack J M Ligtenberg
Intensive and Respiratory Care Unit ICB, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
Crit Care 9:R446-51. 2005..The transport itself must be as safe as possible and should not pose additional risks. We performed a prospective audit of the quality of interhospital transports to our university hospital-based medical ICU...
- Accuracy and feasibility of point-of-care and continuous blood glucose analysis in critically ill ICU patientsAnouk M Corstjens
Department of Anesthesiology, University Medical Center Groningen, Groningen, The Netherlands
Crit Care 10:R135. 2006..The study was performed as a single-centre, prospective, observational study in a 12-bed medical ICU of a university hospital...
- p38-MAPK inhibition and endotoxin induced tubular dysfunction in menJan G Zijlstra
Intensive and Respiratory Care Unit, Department of Internal Medicine, University Hospital Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
J Endotoxin Res 10:402-5. 2004..CONCLUSIONS: Endotoxin infusion induces measurable tubular damage. Blocking the p38-MAPK may prevent this damage. The mechanism is unclear, but blocking TNF-alpha release is a possible explanation...
- Simulator-based crew resource management training for interhospital transfer of critically ill patients by a mobile ICUJoep M Droogh
Department of Critical Care, University Medical Center Groningen, University of Groningen, The Netherlands
Jt Comm J Qual Patient Saf 38:554-9. 2012..The MICU transport program includes simulator-based crew resource management (CRM) training for the intensivists and ICU nurses, who, with the drivers, constitute the MICU crews...
- Quality of interhospital transport of the critically ill: impact of a Mobile Intensive Care Unit with a specialized retrieval teamJanke S Wiegersma
Department of Critical Care, University Medical Center Groningen, Hanzeplein 1, PO Box 30, 001, 9700 RB Groningen, The Netherlands
Crit Care 15:R75. 2011..To evaluate the effects of this implementation, we performed a prospective audit comparing adverse events and patient stability during MICU transfers with our previous data on transfers performed by standard ambulance...
- Towards a feasible algorithm for tight glycaemic control in critically ill patients: a systematic review of the literatureSofie Meijering
Intensive and Respiratory Care Unit ICB, University Medical Center Groningen, Groningen, The Netherlands
Crit Care 10:R19. 2006..One of the steps we took before we implemented a glucose regulation protocol was to review published trials employing insulin/glucose algorithms in critically ill patients...
- Inter-hospital transport of critically ill patients; expect surprisesJoep M Droogh
Department of Critical Care, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
Crit Care 16:R26. 2012..As a consequence technical problems may arise and have to be dealt with on the road. In this study, all technical problems encountered while transporting patients with our mobile intensive care unit service (MICU) were evaluated...
- Hyperglycaemia in critically ill patients: marker or mediator of mortality?Anouk M Corstjens
Department of Anaesthesiology, Intensive and Respiratory Care Unit, University Medical Center Groningen, Groningen, The Netherlands
Crit Care 10:216. 2006..To be able to compare results of future studies involving glucose regulation, better definitions of hyperglycaemia (and consequently of normoglycaemia) and patient populations are needed...
- A good deathBrigitte C Beuks
Intensive and Respiratory Care, Department of Internal Medicine, University Medical Centre Groningen, University of Groningen, 30 001, 9700 RB, Groningen, The Netherlands
Intensive Care Med 32:752-3. 2006..Taking measures to ensure a "good deathbed" is an obligation for doctors and nursing staff. However, due to the focus on cure this palliative goal is not always pursued...
- Efficacy of magnesium-amiodarone step-up scheme in critically ill patients with new-onset atrial fibrillation: a prospective observational studyMengalvio E Sleeswijk
Intensive and Respiratory Care Unit, Department of Internal Medicine, University of Groningen, Groningen, The Netherlands
J Intensive Care Med 23:61-6. 2008..The magnesium-amiodarone step-up scheme reduces the need for amiodarone, effectively converts new-onset atrial fibrillation into a sinus rhythm within 24 hours, and seems to be safe in critically ill patients...
- Cardiac troponin I release and cytokine response during experimental human endotoxaemiaEsther A P van Bockel
Intensive and Respiratory Care Unit, Department of Internal Medicine, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
Intensive Care Med 29:1598-600. 2003..To study the relationship between cytokine levels and cardiac troponin I (cTnI)...
- Automated erythrocytapheresis in severe falciparum malaria: A critical appraisalJellie A Nieuwenhuis
Intensive and Respiratory Care Unit, Department of Internal Medicine, Groningen University Medical Centre, University of Groningen, The Netherlands
Acta Trop 98:201-6. 2006..No studies have been conducted to evaluate its clinical efficacy, and this adjunct therapy should therefore be considered as salvage therapy. Apheresis of red cells appears feasible, safe and effective in rapidly reducing parasite count...
- Bench-to-bedside review: Angiopoietin signalling in critical illness - a future target?Matijs van Meurs
Department of Critical Care, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands
Crit Care 13:207. 2009..In this review we describe this signalling system, giving special attention to what is known about it in critically ill patients and its potential as a target for therapy...
- Brugada electrocardiographic pattern elicited by cyclic antidepressants overdoseWilma E Monteban-Kooistra
Intensive and Respiratory Care Unit ICB, Dept Cardiology, University Medical Center Groningen, 30 001, 9700 RB, Groningen, Netherlands
Intensive Care Med 32:281-5. 2006..Toxicity of TCA frequently results in the need for critical care support. We retrospectively studied characteristics and electrocardiographic indicators of toxicity of all TCA poisoned patients...
- Severe hypercortisolism: a medical emergency requiring urgent interventionHelen L Lutgers
Department of Critical Care, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
Crit Care Med 38:1598-601. 2010..To illustrate the importance of recognizing symptoms of severe hypercortisolism in the intensive care unit and key emergency measures to reduce this extreme hypercortisolism...
- Inhibition of p38 mitogen-activated protein kinase: dose-dependent suppression of leukocyte and endothelial response after endotoxin challenge in humansJan Willem Fijen
Intensive and Respiratory Care Unit, Department of Internal Medicine, University Hospital Groningen, The Netherlands
Crit Care Med 30:841-5. 2002..We studied the activity of a single oral dose of RWJ-67657, a synthetic p38 mitogen-activated protein kinase inhibitor, in preventing dual leukocyte/endothelial activation after endotoxin infusion in healthy volunteers...
- Diagnosis and treatment of relative adrenal insufficiency: confusing but at a higher level?Jack J M Ligtenberg
Intensive Care Unit, Department of Medicine, University Medical Center Groningen, PO Box 30 001, NL 9700 RB Groningen, The Netherlands
J Crit Care 21:77-8. 2006
- Oxygen therapy for sepsis patients in the emergency department: a little less?Renate Stolmeijer
Departments of aEmergency bCritical Care, University Medical Center Groningen UMCG, Groningen, The Netherlands
Eur J Emerg Med 21:233-5. 2014..Of the hyperoxic patients, 8% died in hospital versus 6% with normoxia. Less than 8% of patients had hypoxia with 10 l O2/min; 66% were hyperoxic. Titration of oxygen therapy to normoxia in the emergency department should be evaluated. ..
- The relative adrenal insufficiency syndrome revisited: which patients will benefit from low-dose steroids?Jack J M Ligtenberg
Department of Medicine, Intensive and Respiratory Care Unit, Groningen University Medical Center, Groningen, The Netherlands
Curr Opin Crit Care 10:456-60. 2004..This review will examine recent evidence to elucidate these questions...
- Relationship of baseline glucose and mortality during medical critical illness?Jack J M Ligtenberg
Chest 127:2283. 2005
- Cost analysis of intensive glycemic control in critically ill adult patientsJan G Zijlstra
Chest 130:1953-4. 2006
- Severe hypoglycemia following venlafaxine intoxication: a case reportJohn H J M Meertens
J Clin Psychopharmacol 27:414-5. 2007
- Fluid resuscitation during active hemorrhage: need for a step forwardJack J M Ligtenberg
J Trauma 53:1196-7; author reply 1197-8. 2002
- Exogenous insulin and hypoglycemia as prognostic factors in critically ill patientsIwan C C van der Horst
JAMA 291:558-9; author reply 559-60. 2004
- Unraveling the mystery of adrenal failure in the critically illJack J M Ligtenberg
Crit Care Med 32:1447-8; author reply 1448. 2004
- Closed-format intensive care: time to act nowJack J M Ligtenberg
Crit Care Med 34:2513; author reply 2513. 2006
- Troponin in septic and critically ill patientsEsther A P van Bockel
Chest 127:687-8; author reply 688. 2005
- The randomized controlled trial needs critical careMatijs van Meurs
Crit Care Med 36:3118-9; author reply 3119. 2008
- Benefits of tight glycemic control still outweigh the harm of hypoglycemiaHella F Borggreve
Crit Care Med 36:663-4; author reply 664. 2008
- Tight glucose control and hypoglycemia: should we bother?Jack J M Ligtenberg
Crit Care Med 35:1218. 2007
- Multicentric, randomized, controlled trial to evaluate blood glucose control by the model predictive control algorithm versus routine glucose management protocols in intensive care unit patients: Response to Plank et alJack J M Ligtenberg
Diabetes Care 29:1987. 2006