Heidi M B Lesscher

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc Amygdala protein kinase C epsilon controls alcohol consumption
    H M B Lesscher
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA, USA
    Genes Brain Behav 8:493-9. 2009
  2. doi request reprint Inflexible and indifferent alcohol drinking in male mice
    Heidi M B Lesscher
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, The Netherlands
    Alcohol Clin Exp Res 34:1219-25. 2010
  3. doi request reprint A grandparent-influenced locus for alcohol preference on mouse chromosome 2
    Heidi M B Lesscher
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Pharmacogenet Genomics 19:719-29. 2009
  4. pmc Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current
    Doo Sup Choi
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:11890-9. 2008
  5. ncbi request reprint Endogenous cannabinoids are not involved in cocaine reinforcement and development of cocaine-induced behavioural sensitization
    Heidi M B Lesscher
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Eur Neuropsychopharmacol 15:31-7. 2005
  6. pmc Amygdala 14-3-3ζ as a novel modulator of escalating alcohol intake in mice
    Heidi M B Lesscher
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e37999. 2012
  7. doi request reprint Compulsive drug use and its neural substrates
    Heidi M B Lesscher
    Department of Animals in Science and Society, Utrecht University, Utrecht, The Netherlands
    Rev Neurosci 23:731-45. 2012
  8. ncbi request reprint Amygdala protein kinase C epsilon regulates corticotropin-releasing factor and anxiety-like behavior
    H M B Lesscher
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA 94608, USA
    Genes Brain Behav 7:323-33. 2008
  9. ncbi request reprint Mu-opioid receptors are not involved in acute cocaine-induced locomotor activity nor in development of cocaine-induced behavioral sensitization in mice
    Heidi M B Lesscher
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Stratenum, Universiteitsweg 100, Utrecht, The Netherlands
    Neuropsychopharmacology 30:278-85. 2005
  10. ncbi request reprint Increased gabaergic input to ventral tegmental area dopaminergic neurons associated with decreased cocaine reinforcement in mu-opioid receptor knockout mice
    D S Mathon
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Neuroscience 130:359-67. 2005

Collaborators

Detail Information

Publications10

  1. pmc Amygdala protein kinase C epsilon controls alcohol consumption
    H M B Lesscher
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA, USA
    Genes Brain Behav 8:493-9. 2009
    ..These mice have a >50% reduction in the abundance of PKCepsilon in the amygdala compared with wild-type mice. We conclude that amygdala PKCepsilon is important for ethanol consumption in mice...
  2. doi request reprint Inflexible and indifferent alcohol drinking in male mice
    Heidi M B Lesscher
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, The Netherlands
    Alcohol Clin Exp Res 34:1219-25. 2010
    ....
  3. doi request reprint A grandparent-influenced locus for alcohol preference on mouse chromosome 2
    Heidi M B Lesscher
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Pharmacogenet Genomics 19:719-29. 2009
    ..In addition, mouse chromosome substitution strains were used to further evaluate the contribution of chromosome 2 to ethanol consumption...
  4. pmc Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current
    Doo Sup Choi
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:11890-9. 2008
    ..These findings indicate that PKCdelta contributes to a high level of behavioral response to ethanol, which is negatively associated with risk of developing an alcohol use disorder in humans...
  5. ncbi request reprint Endogenous cannabinoids are not involved in cocaine reinforcement and development of cocaine-induced behavioural sensitization
    Heidi M B Lesscher
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Eur Neuropsychopharmacol 15:31-7. 2005
    ..These findings suggest that CB1 receptors are not involved in acute cocaine reinforcement nor in cocaine-induced behavioural sensitization...
  6. pmc Amygdala 14-3-3ζ as a novel modulator of escalating alcohol intake in mice
    Heidi M B Lesscher
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e37999. 2012
    ..This study identifies amygdala 14-3-3ζ as a novel key modulator that is engaged during escalation of alcohol use...
  7. doi request reprint Compulsive drug use and its neural substrates
    Heidi M B Lesscher
    Department of Animals in Science and Society, Utrecht University, Utrecht, The Netherlands
    Rev Neurosci 23:731-45. 2012
    ..The studies discussed here provide a promising line of research that will advance our knowledge of the neural circuits involved in the self-destructive behavior that characterizes drug addiction...
  8. ncbi request reprint Amygdala protein kinase C epsilon regulates corticotropin-releasing factor and anxiety-like behavior
    H M B Lesscher
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA 94608, USA
    Genes Brain Behav 7:323-33. 2008
    ..These results are consistent with a novel mechanism of PKCepsilon control over anxiety-like behavior through regulation of CRF in the amygdala...
  9. ncbi request reprint Mu-opioid receptors are not involved in acute cocaine-induced locomotor activity nor in development of cocaine-induced behavioral sensitization in mice
    Heidi M B Lesscher
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Stratenum, Universiteitsweg 100, Utrecht, The Netherlands
    Neuropsychopharmacology 30:278-85. 2005
    ..The present findings suggest that mu-opioid receptors are not required for the acute locomotor response to cocaine nor are they essential for the development of cocaine-induced behavioral sensitization...
  10. ncbi request reprint Increased gabaergic input to ventral tegmental area dopaminergic neurons associated with decreased cocaine reinforcement in mu-opioid receptor knockout mice
    D S Mathon
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Neuroscience 130:359-67. 2005
    ....