Wietse Kuis

Summary

Affiliation: University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Is chronic fatigue syndrome a connective tissue disorder? A cross-sectional study in adolescents
    E M van de Putte
    Department of Pediatric, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, Netherlands
    Pediatrics 115:e415-22. 2005
  2. ncbi request reprint Mirrored symptoms in mother and child with chronic fatigue syndrome
    Elise M van de Putte
    Department of Pediatrics, Wilhelmina Children s Hospital, University Medical Center, Utrecht, The Netherlands
    Pediatrics 117:2074-9. 2006
  3. pmc Chronic fatigue syndrome and health control in adolescents and parents
    E M van de Putte
    Department of Paediatrics, Wilhelmina Children s Hospital, University Medical Center, Utrecht, Netherlands
    Arch Dis Child 90:1020-4. 2005
  4. doi request reprint Bystander suppression of experimental arthritis by nasal administration of a heat shock protein peptide
    Evelien Zonneveld-Huijssoon
    Department of Pediatric Immunology, Centre for Molecular and Cellular Intervention, University Medical Centre Utrecht, The Netherlands
    Ann Rheum Dis 70:2199-206. 2011
  5. doi request reprint Self-investigation in adolescent chronic fatigue syndrome: narrative changes and health improvement
    Stefan M van Geelen
    Division of Pediatric Psychology, University Medical Center Utrecht, Utrecht, The Netherlands
    Patient Educ Couns 83:227-33. 2011
  6. doi request reprint Health and identity: Self-positioning in adolescent chronic fatigue syndrome and juvenile idiopathic arthritis
    Coralie E Fuchs
    1Division of Paediatric Psychology, University Medical Centre Utrecht, The Netherlands
    Clin Child Psychol Psychiatry 18:383-97. 2013
  7. doi request reprint Vaccination leads to an aberrant FOXP3 T-cell response in non-remitting juvenile idiopathic arthritis
    Arash Ronaghy
    Department of Pediatrics, Center for Cellular and Molecular Intervention, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 70:2037-43. 2011
  8. doi request reprint Adolescent chronic fatigue syndrome: a follow-up study
    Stefan M van Geelen
    Department of Pediatrics, University Medical Center Utrecht, Lundlaan 6, Utrecht, The Netherlands
    Arch Pediatr Adolesc Med 164:810-4. 2010
  9. doi request reprint Effects of an educational video film in fatigued children and adolescents: a randomised controlled trial
    Rob J Bakker
    Department of Pediatrics, Antonius Ziekenhuis, Sneek, The Netherlands
    Arch Dis Child 96:457-60. 2011
  10. doi request reprint The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children
    Marieke J H van Summeren
    Department of Paediatrics, University Medical Centre Utrecht, PO Box 85090, 3508 AB Utrecht, The Netherlands
    Br J Nutr 102:1171-8. 2009

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Is chronic fatigue syndrome a connective tissue disorder? A cross-sectional study in adolescents
    E M van de Putte
    Department of Pediatric, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, Netherlands
    Pediatrics 115:e415-22. 2005
    ....
  2. ncbi request reprint Mirrored symptoms in mother and child with chronic fatigue syndrome
    Elise M van de Putte
    Department of Pediatrics, Wilhelmina Children s Hospital, University Medical Center, Utrecht, The Netherlands
    Pediatrics 117:2074-9. 2006
    ....
  3. pmc Chronic fatigue syndrome and health control in adolescents and parents
    E M van de Putte
    Department of Paediatrics, Wilhelmina Children s Hospital, University Medical Center, Utrecht, Netherlands
    Arch Dis Child 90:1020-4. 2005
    ..To explore the locus of health control in adolescents with chronic fatigue syndrome (CFS) and their parents in comparison with healthy adolescents and their parents...
  4. doi request reprint Bystander suppression of experimental arthritis by nasal administration of a heat shock protein peptide
    Evelien Zonneveld-Huijssoon
    Department of Pediatric Immunology, Centre for Molecular and Cellular Intervention, University Medical Centre Utrecht, The Netherlands
    Ann Rheum Dis 70:2199-206. 2011
    ..A study was undertaken to determine whether mucosal administration of these bystander epitopes can be similarly effective in suppressing arthritis...
  5. doi request reprint Self-investigation in adolescent chronic fatigue syndrome: narrative changes and health improvement
    Stefan M van Geelen
    Division of Pediatric Psychology, University Medical Center Utrecht, Utrecht, The Netherlands
    Patient Educ Couns 83:227-33. 2011
    ..A small-scale intervention study into narrative self-investigation in adolescent chronic fatigue syndrome (CFS)...
  6. doi request reprint Health and identity: Self-positioning in adolescent chronic fatigue syndrome and juvenile idiopathic arthritis
    Coralie E Fuchs
    1Division of Paediatric Psychology, University Medical Centre Utrecht, The Netherlands
    Clin Child Psychol Psychiatry 18:383-97. 2013
    ..With this emphasis on positions relating to their illness, there seems to be little room left for stronger positions. It is regarded of clinical importance to address these issues in this crucial developmental period. ..
  7. doi request reprint Vaccination leads to an aberrant FOXP3 T-cell response in non-remitting juvenile idiopathic arthritis
    Arash Ronaghy
    Department of Pediatrics, Center for Cellular and Molecular Intervention, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 70:2037-43. 2011
    ....
  8. doi request reprint Adolescent chronic fatigue syndrome: a follow-up study
    Stefan M van Geelen
    Department of Pediatrics, University Medical Center Utrecht, Lundlaan 6, Utrecht, The Netherlands
    Arch Pediatr Adolesc Med 164:810-4. 2010
    ..To describe the symptomatic and educational long-term outcomes, health care use, and risk factors of nonrecovery in adolescent chronic fatigue syndrome (CFS)...
  9. doi request reprint Effects of an educational video film in fatigued children and adolescents: a randomised controlled trial
    Rob J Bakker
    Department of Pediatrics, Antonius Ziekenhuis, Sneek, The Netherlands
    Arch Dis Child 96:457-60. 2011
    ..In many cases standard management for chronic fatigue syndrome (CFS) in children and adolescents is ineffective...
  10. doi request reprint The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children
    Marieke J H van Summeren
    Department of Paediatrics, University Medical Centre Utrecht, PO Box 85090, 3508 AB Utrecht, The Netherlands
    Br J Nutr 102:1171-8. 2009
    ..These findings demonstrate that in healthy, prepubertal children, modest supplementation with MK-7 increases circulating concentrations of MK-7 and increases osteocalcin carboxylation...
  11. doi request reprint CD30 discriminates heat shock protein 60-induced FOXP3+ CD4+ T cells with a regulatory phenotype
    Isme de Kleer
    Center for Molecular and Cellular Immunology, University Medical Center Utrecht, The Netherlands
    J Immunol 185:2071-9. 2010
    ..These findings have implications for the generation and isolation of pure populations of Ag-specific Tregs, with the potential to prevent and treat human inflammatory diseases...
  12. ncbi request reprint Alexithymia in adolescents with chronic fatigue syndrome
    Elise M van de Putte
    Department of Pediatrics, Wilhelmina Children s Hospital, University Medical Center Utrecht The Netherlands
    J Psychosom Res 63:377-80. 2007
    ..Comorbidity such as anxiety and depression were analyzed as possible confounding factors. Secondly, alexithymia was investigated as a prognostic factor for the recovery of CFS...
  13. doi request reprint FOXP3+ CD4+ Tregs lose suppressive potential but remain anergic during transient inflammation in human
    Alvin W L Schadenberg
    Department of Pediatric Immunology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Immunol 41:1132-42. 2011
    ..These data show that inflammation inhibits Treg function through soluble factors present in plasma. These results underscore the functional role of FOXP3(+) Tregs during inflammation in vivo...
  14. doi request reprint Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis
    Wilco de Jager
    Department of Pediatrics, Centre for Cellular and Molecular Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 60:2782-93. 2009
    ..Since IL-18 can drive NK cell function, we examined how the high plasma levels of this cytokine are related to the documented NK cell failure in these patients...
  15. ncbi request reprint Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome
    Joost Frenkel
    Division of Pediatrics, Wilhelmina Children s Hospital, KE 04 133 1, University Medical Center Utrecht, PO Box 85090, 3580 AB Utrecht, The Netherlands
    Arthritis Rheum 46:2794-803. 2002
    ....
  16. ncbi request reprint Heat shock proteins in juvenile idiopathic arthritis: keys for understanding remitting arthritis and candidate antigens for immune therapy
    Berent Prakken
    Department of Pediatric Immunology, University Medical Center Utrecht, University Hospital for Children and Youth, PO Box 85090, Utrecht 3508 AB, The Netherlands
    Curr Rheumatol Rep 4:466-73. 2002
    ..Taken together, these data imply that immune modulation with hsps can be an effective way to restore natural occurring T cell responses, and, thus, treat JIA and rheumatoid arthritis...
  17. ncbi request reprint Stem cell transplantation for autoimmune disorders. Refractory juvenile idiopathic arthritis
    Nico M Wulffraat
    Department of Paediatric Immunology and Rheumatology, Wilhelmina Children s Hospital, University Medical Center Utrecht, P O Box 85090, Utrecht 3508 AB, The Netherlands
    Best Pract Res Clin Haematol 17:277-89. 2004
    ..It is still unclear why especially patients with systemic juvenile idiopathic arthritis are at risk of episodes of reactive haemophagocytosis...
  18. ncbi request reprint Case report: severe central nervous system involvement in juvenile dermatomyositis
    Elisabeth F Elst
    Department of Pediatric Immunology, University Medical Center of Utrecht, Wilhelmina Children s Hospital, mailbox KC 03 063 0, 3508 AB Utrecht, The Netherlands
    J Rheumatol 30:2059-63. 2003
    ..The clinical symptoms and further investigations in our patients show CNS involvement in JDM. Although rarely reported, CNS vasculopathy can be a serious and life-threatening complication of JDM...
  19. doi request reprint Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis
    Sebastiaan J Vastert
    Department of Paediatric Immunology, Wilhelmina Children s Hospital, University Medical Centre Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Rheumatology (Oxford) 49:441-9. 2010
    ..Interestingly, SoJIA patients display decreased levels of perforin in NK cells and diminished NK cell function as well. Here, we analysed PRF1 and its putative promoter in SoJIA patients with or without a history of MAS...
  20. doi request reprint Risk factors for persistent fatigue with significant school absence in children and adolescents
    Robert J Bakker
    Department of Pediatrics, Antonius Ziekenhuis, Sneek, Netherlands
    Pediatrics 124:e89-95. 2009
    ..To assess children and adolescents with severe fatigue who are referred to pediatricians and to examine whether factors can be identified at their first visit that predict worse outcomes at 1 year...
  21. doi request reprint Vitamin K status is associated with childhood bone mineral content
    Marieke J H van Summeren
    Department of Paediatric Immunology, University Medical Centre Utrecht, PO Box 85090, Utrecht, The Netherlands
    Br J Nutr 100:852-8. 2008
    ..In order to determine the significance of these findings for childhood bone health, additional paediatric studies are needed...
  22. ncbi request reprint Overt and occult rheumatic diseases: the child with chronic fever
    Joost Frenkel
    Department of General Pediatrics, Wilhelmina Children s Hospital, University Medical Center Utrecht, Suite KE 04 133 1, P O Box 85090, The Netherlands
    Best Pract Res Clin Rheumatol 16:443-69. 2002
    ..We discuss how this knowledge has influenced diagnosis and treatment of these rare genetic disorders and how it might change our approach to the more common rheumatic diseases...
  23. doi request reprint Psychological intervention for adolescents with juvenile idiopathic arthritis: for whom and when?
    Coralie Elisabeth Fuchs
    From the Department of Pediatric Psychology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Rheumatol 40:528-34. 2013
    ..To study which adolescents with juvenile idiopathic arthritis (JIA) benefit from psychological intervention, and what is the best moment for it...
  24. pmc Systemic JIA: new developments in the understanding of the pathophysiology and therapy
    Sebastiaan J Vastert
    Department of Pediatric Immunology Wilhelmina Children s Hospital, University Medical Center Utrecht, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
    Best Pract Res Clin Rheumatol 23:655-64. 2009
    ..These therapies might also change the long-term outcome of this disease. However, controlled trials set up in international collaboration are needed to determine the optimal treatment strategies for all sJIA patients...
  25. doi request reprint High prevalence of methotrexate intolerance in juvenile idiopathic arthritis: development and validation of a methotrexate intolerance severity score
    Maja Bulatović
    University Medical Centre Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 63:2007-13. 2011
    ..To design and validate a new questionnaire for identifying patients with methotrexate (MTX) intolerance, and to determine the prevalence of MTX intolerance in patients with juvenile idiopathic arthritis (JIA) using this questionnaire...
  26. ncbi request reprint Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis
    Sylvia Kamphuis
    Department of Paediatric Immunology, IACOPO Institute for Translational Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands
    Lancet 366:50-6. 2005
    ..We sought to identify HSP60 T-cell epitopes to find potential targets for HSP60 immunotherapy and to assess whether immune responses to these epitopes contribute to the distinct clinical outcome of this disease...
  27. ncbi request reprint Autologous stem cell transplantation for autoimmunity induces immunologic self-tolerance by reprogramming autoreactive T cells and restoring the CD4+CD25+ immune regulatory network
    Isme de Kleer
    University Medical Center Utrecht, Wilhelmina Children s Hospital, Home Mailbox KC 03 063 0, Department of Pediatric Immunology, PO Box 85090, 3508 AB Utrecht, The Netherlands
    Blood 107:1696-702. 2006
    ....
  28. doi request reprint Pan-DR-binding Hsp60 self epitopes induce an interleukin-10-mediated immune response in rheumatoid arthritis
    Huib de Jong
    University Medical Centre Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 60:1966-76. 2009
    ..This study was undertaken to characterize the disease specificity and function of pan-DR-binding Hsp60-derived epitopes as possible modulators of autoimmune inflammation in RA...
  29. doi request reprint Self-investigation to explore the impact of juvenile arthritis on adolescent life: a case-study
    Coralie E Fuchs
    Department of Pediatric Psychology, Wilhelmina Children s Hospital, University Medical Center Utrecht, The Netherlands
    Patient Educ Couns 72:163-7. 2008
    ..To gain insight into the personal experience and feelings of an adolescent with a chronic disease...
  30. pmc Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study
    Wilco de Jager
    Department of Pediatric Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 66:589-98. 2007
    ..Although onset and disease course differ, the subtypes of JIA share the occurrence of chronic inflammation of the joints, with infiltrations of immunocompetent cells that secrete inflammatory mediators...
  31. ncbi request reprint Radiologic features in juvenile idiopathic arthritis: a first step in the development of a standardized assessment method
    Marion A J van Rossum
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 48:507-15. 2003
    ....
  32. pmc Novel self-epitopes derived from aggrecan, fibrillin, and matrix metalloproteinase-3 drive distinct autoreactive T-cell responses in juvenile idiopathic arthritis and in health
    Sylvia Kamphuis
    Department of Paediatric Immunology and IACOPO, Institute for Translational Medicine, University Medical Center Utrecht, PO Box 85090, 3508 AB Utrecht, The Netherlands
    Arthritis Res Ther 8:R178. 2006
    ..Additional experiments need to be performed to explore their qualities and role in disease pathogenesis in further detail...
  33. ncbi request reprint Personality and chronic fatigue syndrome: methodological and conceptual issues
    Stefan M van Geelen
    Department of Psychology, Wilhelmina Children s Hospital, University Medical Center Utrecht, The Netherlands
    Clin Psychol Rev 27:885-903. 2007
    ..New insights into personality and CFS might be gained by systematically studying the self-narratives of patients with the syndrome...
  34. doi request reprint Hsp60 in inflamed muscle tissue is the target of regulatory autoreactive T cells in patients with juvenile dermatomyositis
    Elisabeth F Elst
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 58:547-55. 2008
    ..The purpose of this study was to determine whether Hsp60 could serve as an autoantigen in juvenile DM...
  35. ncbi request reprint Safety and efficacy of meningococcal c vaccination in juvenile idiopathic arthritis
    Evelien Zonneveld-Huijssoon
    Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 56:639-46. 2007
    ....
  36. pmc Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells
    Wilco de Jager
    Department of Pediatric Immunology, University Medical Center Utrecht, Wilhelmina Children s Hospital, 3584 EA Utrecht, The Netherlands
    Clin Diagn Lab Immunol 10:133-9. 2003
    ..It will provide a more complete picture in differences between activated lymphocyte cytokine profiles from healthy individuals and those from patients with chronic inflammatory diseases...
  37. ncbi request reprint CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis
    Ismé M de Kleer
    University Medical Center Utrecht, Wilhelmina Children s Hospital, Department of Pediatric Immunology and Immunology Advanced Center on Preclinical Immuno genomics Institute for Translational Medicine, Utrecht, The Netherlands
    J Immunol 172:6435-43. 2004
    ..These data suggest that CD4(+)CD25(bright) Treg cells play a role in determining the patient's fate toward either a favorable or unfavorable clinical course of disease...
  38. pmc Safety of measles, mumps and rubella vaccination in juvenile idiopathic arthritis
    Marloes W Heijstek
    Department of Paediatric Immunology, Wilhelmina Children s Hospital, University Medical Centre Utrecht, Room KC 03 0630, PO Box 85090, 3508 AB Utrecht, The Netherlands
    Ann Rheum Dis 66:1384-7. 2007
    ..To assess the effect of measles, mumps and rubella (MMR) vaccination on disease activity in children with juvenile idiopathic arthritis (JIA)...
  39. ncbi request reprint Novel pan-DR-binding T cell epitopes of adenovirus induce pro-inflammatory cytokines and chemokines in healthy donors
    Lianne M Haveman
    Department of Pediatric Immunology and Hematology, Wilhelmina Children s Hospital, University Medical Center, KC 03 063 0, Lundlaan 6, Postbus 85090, 3508 AB, Utrecht, The Netherlands
    Int Immunol 18:1521-9. 2006
    ..Based on the broad recognition and the induced cytokine and chemokine profile, the detected epitopes can be regarded as potential candidates to select adenovirus-specific T cells for immune intervention in the immunocompromised host...
  40. ncbi request reprint Development of a standardized method of assessment of radiographs and radiographic change in juvenile idiopathic arthritis: introduction of the Dijkstra composite score
    Marion A J van Rossum
    Emma Children s Hospital AMC, Pediatric Rheumatology, Amsterdam, The Netherlands
    Arthritis Rheum 52:2865-72. 2005
    ..To evaluate the sensitivity to change of a newly developed radiologic assessment tool, the Dijkstra score, and to develop a numeric composite score and progressor classification scheme to apply in juvenile idiopathic arthritis (JIA) trials...
  41. ncbi request reprint Temperature dependence of mutant mevalonate kinase activity as a pathogenic factor in hyper-IgD and periodic fever syndrome
    Sander M Houten
    Departments of Paediatrics Emma Children s Hospital and Clinical Chemistry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Hum Mol Genet 11:3115-24. 2002
    ..Our results suggest that minor elevations in temperature can set off a chain of events with MK becoming progressively rate-limiting, leading to a temporary deficiency of isoprenoid end-products, which induces inflammation and fever...
  42. doi request reprint Circulating calcification inhibitors and vascular properties in children after renal transplantation
    Marieke J H van Summeren
    Department of Pediatric Immunology, University Medical Centre Utrecht, Lundlaan 6, Room KE 04 133 1, 3584 EA Utrecht, The Netherlands
    Pediatr Nephrol 23:985-93. 2008
    ..Future prospective studies in pediatric ESRD and transplant patients are needed to learn more about the role of calcification inhibitors in relation to the prevention of vascular damage...
  43. pmc Long-term outcome of juvenile idiopathic arthritis following a placebo-controlled trial: sustained benefits of early sulfasalazine treatment
    Marion A J van Rossum
    Emma Children s Hospital AMC, Paediatric Rheumatology, G8 205, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Ann Rheum Dis 66:1518-24. 2007
    ..The current study determines the long-term outcome of the trial participants and evaluates whether the benefits of SSZ allocation are sustained over time...
  44. ncbi request reprint Preliminary core sets of measures for disease activity and damage assessment in juvenile systemic lupus erythematosus and juvenile dermatomyositis
    Nicolino Ruperto
    IRCCS G Gasalini, Pediatria II, Genova, Italy
    Rheumatology (Oxford) 42:1452-9. 2003
    ..To identify preliminary core sets of outcome variables for disease activity and damage assessment in juvenile systemic lupus erythematosus (JSLE) and juvenile dermatomyositis (JDM)...
  45. ncbi request reprint Expression of myeloid-related proteins 8 and 14 in systemic-onset juvenile rheumatoid arthritis
    Michael Frosch
    Institute of Experimental Dermatology and Department of Pediatrics, University of Munster, Munster, Germany
    Arthritis Rheum 48:2622-6. 2003
    ....
  46. ncbi request reprint Monitoring neutrophil activation in juvenile rheumatoid arthritis by S100A12 serum concentrations
    Dirk Foell
    Institute of Experimental Dermatology and Department of Pediatrics, University of Muenster, Muenster, Germany
    Arthritis Rheum 50:1286-95. 2004
    ..The aim of our study was to determine neutrophil activation in juvenile rheumatoid arthritis (JRA) by analyzing S100A12 (EN-RAGE; calgranulin C), a proinflammatory protein secreted by human neutrophils...
  47. ncbi request reprint Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy
    Salima Hacein-Bey-Abina
    Laboratoire INSERM, Hopital Necker Enfants Malades, Paris, France
    N Engl J Med 346:1185-93. 2002
    ..We investigated whether infusion of autologous hematopoietic stem cells that had been transduced in vitro with the gamma(c) gene can restore the immune system in patients with severe combined immunodeficiency...
  48. ncbi request reprint Improved multiplex immunoassay performance in human plasma and synovial fluid following removal of interfering heterophilic antibodies
    Wilco de Jager
    Department of Pediatric Immunology, University Medical Center Utrecht, Wilhelmina Children s Hospital, Utrecht, The Netherlands
    J Immunol Methods 300:124-35. 2005
    ..We show that pre-absorption with protein-L is a powerful tool for removal of interfering immunoglobulins from human bodily fluids to be used in immunoassays for studying changes in protein patterns...
  49. ncbi request reprint Pronounced elevation of undercarboxylated osteocalcin in healthy children
    Marieke van Summeren
    Department of Pediatric Immunology, University Medical Centre Utrecht, 3584 EA Utrecht, The Netherlands
    Pediatr Res 61:366-70. 2007
    ..These findings suggest a pronounced low vitamin K status of bone during growth. The question remains, however, whether children would benefit from higher vitamin K intake, for instance, by improved bone health or stronger bones...