Jürgen Kuball

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain
    Jürgen Kuball
    Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Exp Med 206:463-75. 2009
  2. pmc Pitfalls of vaccinations with WT1-, Proteinase3- and MUC1-derived peptides in combination with MontanideISA51 and CpG7909
    Jürgen Kuball
    Department of Hematology, University Medical Center Utrecht, Lundlaan 6, Utrecht, The Netherlands
    Cancer Immunol Immunother 60:161-71. 2011
  3. doi request reprint γ9 and δ2CDR3 domains regulate functional avidity of T cells harboring γ9δ2TCRs
    Cordula Gründer
    Departments of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 120:5153-62. 2012
  4. pmc The immunological phenotype of rituximab-sensitive chronic graft-versus-host disease: a phase II study
    Suzanne van Dorp
    Department of Immunology, UMC Utrecht, Utrecht, The Netherlands
    Haematologica 96:1380-4. 2011
  5. pmc Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities
    Matthias Wolfl
    Fred Hutchinson Cancer Research Center, Program in Immunology, Seattle, WA, USA
    Blood 110:201-10. 2007
  6. ncbi request reprint Re-targeting T-cells against cancer by gene-transfer of tumor-reactive receptors
    Victoria Marcu-Malina
    Department of Hematology and VanCreveld Clinic, University Medical Center Utrecht, Utrecht, The Netherlands
    Expert Opin Biol Ther 9:579-91. 2009
  7. doi request reprint Current insights into ocular graft-versus-host disease
    Anjo Riemens
    Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Opin Ophthalmol 21:485-94. 2010
  8. doi request reprint Redirecting αβ T cells against cancer cells by transfer of a broadly tumor-reactive γδT-cell receptor
    Victoria Marcu-Malina
    Department of Hematology, University Medical Center UMC Utrecht, Utrecht, The Netherlands
    Blood 118:50-9. 2011
  9. pmc Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire
    Matthias Wolfl
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol 181:6435-46. 2008
  10. pmc Facilitating matched pairing and expression of TCR chains introduced into human T cells
    Jürgen Kuball
    The Fred Hutchinson Cancer Research Center, Program in Immunology, Seattle, WA 98109, USA
    Blood 109:2331-8. 2007

Collaborators

Detail Information

Publications12

  1. pmc Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain
    Jürgen Kuball
    Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Exp Med 206:463-75. 2009
    ..This strategy was effective with mouse and human TCRs specific for different antigens and, thus, should be readily translated to TCRs with any specificity...
  2. pmc Pitfalls of vaccinations with WT1-, Proteinase3- and MUC1-derived peptides in combination with MontanideISA51 and CpG7909
    Jürgen Kuball
    Department of Hematology, University Medical Center Utrecht, Lundlaan 6, Utrecht, The Netherlands
    Cancer Immunol Immunother 60:161-71. 2011
    ..Reflecting the time-consuming efforts of clinical trials and the fact that 1/3 of ongoing peptide vaccination trails use CpG and/or Montanide, our data need to be taken into consideration...
  3. doi request reprint γ9 and δ2CDR3 domains regulate functional avidity of T cells harboring γ9δ2TCRs
    Cordula Gründer
    Departments of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 120:5153-62. 2012
    ....
  4. pmc The immunological phenotype of rituximab-sensitive chronic graft-versus-host disease: a phase II study
    Suzanne van Dorp
    Department of Immunology, UMC Utrecht, Utrecht, The Netherlands
    Haematologica 96:1380-4. 2011
    ..Imbalances in B-cell homeostasis could be used to identify patients a priori with a higher chance of response to rituximab treatment (Eudra-CT 2008-004125-42)...
  5. pmc Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities
    Matthias Wolfl
    Fred Hutchinson Cancer Research Center, Program in Immunology, Seattle, WA, USA
    Blood 110:201-10. 2007
    ....
  6. ncbi request reprint Re-targeting T-cells against cancer by gene-transfer of tumor-reactive receptors
    Victoria Marcu-Malina
    Department of Hematology and VanCreveld Clinic, University Medical Center Utrecht, Utrecht, The Netherlands
    Expert Opin Biol Ther 9:579-91. 2009
    ..To facilitate rapid generation of cells for therapy, T-cells can be programmed with genes encoding for an antigen-specific T-cell receptor (TCR) or chimeric receptors...
  7. doi request reprint Current insights into ocular graft-versus-host disease
    Anjo Riemens
    Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Opin Ophthalmol 21:485-94. 2010
    ..To update our knowledge on hematopoietic stem cell transplantation (SCT) and graft-versus-host disease (GVHD) and summarize the current treatment options for ocular GVHD...
  8. doi request reprint Redirecting αβ T cells against cancer cells by transfer of a broadly tumor-reactive γδT-cell receptor
    Victoria Marcu-Malina
    Department of Hematology, University Medical Center UMC Utrecht, Utrecht, The Netherlands
    Blood 118:50-9. 2011
    ..In summary, γ9δ2 TCRs are an attractive alternative to broadly redirect αβT cells against cancer cells with both an improved efficacy and safety profile compared with currently used αβTCRs...
  9. pmc Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire
    Matthias Wolfl
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol 181:6435-46. 2008
    ..This example is the first on viral immune escape via exploitation of a "hole" in the T cell repertoire, and may represent an important general mechanism of viral persistence...
  10. pmc Facilitating matched pairing and expression of TCR chains introduced into human T cells
    Jürgen Kuball
    The Fred Hutchinson Cancer Research Center, Program in Immunology, Seattle, WA 98109, USA
    Blood 109:2331-8. 2007
    ..This approach should improve both the efficacy and safety of ongoing efforts to use TCR transfer as a strategy to generate tumor-reactive T cells...
  11. doi request reprint Rituximab treatment before reduced-intensity conditioning transplantation associates with a decreased incidence of extensive chronic GVHD
    Suzanne van Dorp
    Department of Hematology and Van Creveld Clinic, UMC Utrecht, The Netherlands
    Biol Blood Marrow Transplant 15:671-8. 2009
    ..8% to 20.1%. We hypothesize that most likely host B cells initiate cGVHD, and thus, host B cell depletion prior to RICT by Rtx might be a valuable strategy to reduce extensive cGVHD after RICT...