Onno Kranenburg

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi request reprint The KRAS oncogene: past, present, and future
    Onno Kranenburg
    Department of Surgery, University Medical Center Utrecht, Utrecht
    Biochim Biophys Acta 1756:81-2. 2005
  2. ncbi request reprint Stimulation of angiogenesis by Ras proteins
    Onno Kranenburg
    Department of Surgery, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Biochim Biophys Acta 1654:23-37. 2004
  3. ncbi request reprint Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells
    Frederik J H Hoogwater
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Gastroenterology 138:2357-67. 2010
  4. ncbi request reprint Hypoxia after liver surgery imposes an aggressive cancer stem cell phenotype on residual tumor cells
    Klaas M Govaert
    From the Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Surg 259:750-9. 2014
  5. pmc Oncogenic KRAS desensitizes colorectal tumor cells to epidermal growth factor receptor inhibition and activation
    Winan J van Houdt
    Department of Surgery, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Neoplasia 12:443-52. 2010
  6. doi request reprint Accelerated perinecrotic outgrowth of colorectal liver metastases following radiofrequency ablation is a hypoxia-driven phenomenon
    Maarten W Nijkamp
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Surg 249:814-23. 2009
  7. pmc The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion
    Ernst J A Steller
    Department of Surgery, University Medical Center Utrecht, The Netherlands
    EMBO Rep 12:931-7. 2011
  8. ncbi request reprint Beta-amyloid (Abeta) causes detachment of N1E-115 neuroblastoma cells by acting as a scaffold for cell-associated plasminogen activation
    Onno Kranenburg
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Cell Neurosci 28:496-508. 2005
  9. ncbi request reprint Synergistic effect of interstitial laser coagulation and doxorubicin in a murine tumor recurrence model of solitary colorectal liver metastasis
    Liesbeth M Veenendaal
    Department of Surgery, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Surg Oncol 13:168-75. 2006
  10. doi request reprint A role for CD95 signaling in ischemia/reperfusion-induced invasion and outgrowth of colorectal micrometastases in mouse liver
    Maarten W Nijkamp
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    J Surg Oncol 104:198-204. 2011

Collaborators

Detail Information

Publications39

  1. ncbi request reprint The KRAS oncogene: past, present, and future
    Onno Kranenburg
    Department of Surgery, University Medical Center Utrecht, Utrecht
    Biochim Biophys Acta 1756:81-2. 2005
  2. ncbi request reprint Stimulation of angiogenesis by Ras proteins
    Onno Kranenburg
    Department of Surgery, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Biochim Biophys Acta 1654:23-37. 2004
    ..In addition, tumor cell-activated stromal cells also contribute to the stimulation of angiogenesis by further enhancing the production and secretion of pro-angiogenic factors into the tumor stroma...
  3. ncbi request reprint Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells
    Frederik J H Hoogwater
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Gastroenterology 138:2357-67. 2010
    ..The determinants of death receptor signaling output are poorly defined. Here we investigated the role of oncogenic K-Ras in determining death receptor function and metastatic potential...
  4. ncbi request reprint Hypoxia after liver surgery imposes an aggressive cancer stem cell phenotype on residual tumor cells
    Klaas M Govaert
    From the Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Surg 259:750-9. 2014
    ..To assess the contribution of hypoxia and bone marrow-derived cells to aggressive outgrowth of micrometastases after liver surgery...
  5. pmc Oncogenic KRAS desensitizes colorectal tumor cells to epidermal growth factor receptor inhibition and activation
    Winan J van Houdt
    Department of Surgery, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Neoplasia 12:443-52. 2010
    ..Our results demonstrate a causal role for oncogenic KRAS in desensitizing tumor cells not only to EGFR inhibitors but also to EGF itself...
  6. doi request reprint Accelerated perinecrotic outgrowth of colorectal liver metastases following radiofrequency ablation is a hypoxia-driven phenomenon
    Maarten W Nijkamp
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Surg 249:814-23. 2009
    ....
  7. pmc The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion
    Ernst J A Steller
    Department of Surgery, University Medical Center Utrecht, The Netherlands
    EMBO Rep 12:931-7. 2011
    ..Cofilin activation is required for CD95-stimulated formation of membrane protrusions and increased tumour cell invasion...
  8. ncbi request reprint Beta-amyloid (Abeta) causes detachment of N1E-115 neuroblastoma cells by acting as a scaffold for cell-associated plasminogen activation
    Onno Kranenburg
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Cell Neurosci 28:496-508. 2005
    ..Our results suggest that plasmin-mediated cell detachment could contribute to the pathological effects of Abeta in diseased brain...
  9. ncbi request reprint Synergistic effect of interstitial laser coagulation and doxorubicin in a murine tumor recurrence model of solitary colorectal liver metastasis
    Liesbeth M Veenendaal
    Department of Surgery, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Surg Oncol 13:168-75. 2006
    ..However, local recurrence rates are still high. To overcome this problem, we investigated the potential of additional systemic therapy after ILC in a murine model...
  10. doi request reprint A role for CD95 signaling in ischemia/reperfusion-induced invasion and outgrowth of colorectal micrometastases in mouse liver
    Maarten W Nijkamp
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    J Surg Oncol 104:198-204. 2011
    ..Ischemia/reperfusion (I/R) injury in the liver is associated with accelerated outgrowth of micrometastases. The aim of the study was to test the role of CD95 signaling in accelerated outgrowth of colorectal liver metastases following I/R...
  11. doi request reprint Radiofrequency ablation of colorectal liver metastases induces an inflammatory response in distant hepatic metastases but not in local accelerated outgrowth
    Maarten W Nijkamp
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    J Surg Oncol 101:551-6. 2010
    ..Here we have evaluated whether an altered density of inflammatory cells could be observed in the perinecrotic (TZ) metastases compared to hepatic metastases in the distant reference zone (RZ)...
  12. doi request reprint Synergistic killing of colorectal cancer cells by oxaliplatin and ABT-737
    Danielle A E Raats
    Department of Surgery, University Medical Center Utrecht, The Netherlands
    Cell Oncol (Dordr) 34:307-13. 2011
    ..The Bcl2-inhibitor ABT-737 is particularly effective in cells with high Noxa levels. Therefore, we tested whether oxaliplatin and ABT-737 display synergy in killing CRC cells...
  13. ncbi request reprint Circulating CD95-ligand as a potential prognostic marker for recurrence in patients with synchronous colorectal liver metastases
    Frederik J H Hoogwater
    Department of Surgery, G 04 228, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Anticancer Res 31:4507-12. 2011
    ..To assess whether circulating soluble CD95 ligand (sCD95L) levels are associated with recurrence-free survival (RFS) in patients with synchronous colorectal liver metastases...
  14. ncbi request reprint Differential Notch and TGFbeta signaling in primary colorectal tumors and their corresponding metastases
    Liesbeth M Veenendaal
    Department of Surgery, University Medical Center Utrecht, The Netherlands
    Cell Oncol 30:1-11. 2008
    ..The relationship between the activity of these pathways and the expression of epithelial and mesenchymal markers was investigated in a series of primary colorectal tumors and their corresponding metastases...
  15. ncbi request reprint Cyclooxygenase-2 is a target of KRASD12, which facilitates the outgrowth of murine C26 colorectal liver metastases
    Niels Smakman
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Cancer Res 11:41-8. 2005
    ..This study was designed to clarify that relationship and to assess the contribution of KRAS-dependent COX-2 to the seeding of CRC cells in the liver and to their outgrowth as liver metastases in an experimental mouse model...
  16. ncbi request reprint Dual effect of Kras(D12) knockdown on tumorigenesis: increased immune-mediated tumor clearance and abrogation of tumor malignancy
    Niels Smakman
    Department of Surgery, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Oncogene 24:8338-42. 2005
    ..Thus, mutant Kras(D12) suppresses Il-18 production in colorectal tumor cells, which may contribute to evasion of the local immune system during tumor development...
  17. doi request reprint Proteomics in studying cancer stem cell biology
    Onno Kranenburg
    Department of Surgery, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, The Netherlands
    Expert Rev Proteomics 9:325-36. 2012
    ..Here, the authors review the novel insights that these studies have provided and present a comprehensive strategy for the use of proteomics in studying cancer SC biology...
  18. doi request reprint Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition
    Winan J van Houdt
    Department of Surgery, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands
    Cell Oncol 32:245-57. 2010
    ..Here we have studied whether endogenous oncogenic K-ras affects the dependency of colorectal tumor cells on MEK/ERK signaling...
  19. doi request reprint CD95 is a key mediator of invasion and accelerated outgrowth of mouse colorectal liver metastases following radiofrequency ablation
    Maarten W Nijkamp
    Department of Surgery, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    J Hepatol 53:1069-77. 2010
    ..Therefore, we tested whether CD95 signaling plays a role in accelerated outgrowth of colorectal liver metastases following RFA...
  20. doi request reprint The secretome of colon cancer stem cells contains drug-metabolizing enzymes
    Benjamin L Emmink
    Department of Surgery, University Medical Center Utrecht, G04 228, PO Box 85500, 3508GA Utrecht, The Netherlands
    J Proteomics 91:84-96. 2013
    ..In addition, CSCs may modulate drug responses in nearby tumor cells by detoxifying chemotherapeutic drugs in the extracellular space...
  21. doi request reprint Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan
    Benjamin L Emmink
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Gastroenterology 141:269-78. 2011
    ..We studied the relationship between resistance to the topoisomerase I inhibitor irinotecan and tumor-initiating potential in human colonosphere cultures and in mice with colorectal xenograft tumors...
  22. doi request reprint Ageing and hepatic steatosis exacerbate ischemia/reperfusion-accelerated outgrowth of colorectal micrometastases
    Jarmila D W van der Bilt
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Surg Oncol 15:1392-8. 2008
    ..The aim of this study was to assess the influence of ischemia time, gender, age, and liver steatosis on the accelerated outgrowth of colorectal metastases following I/R...
  23. ncbi request reprint KRAS(D13) Promotes apoptosis of human colorectal tumor cells by ReovirusT3D and oxaliplatin but not by tumor necrosis factor-related apoptosis-inducing ligand
    Niels Smakman
    Department of Surgery, University Medical Center Utrecht, The Netherlands
    Cancer Res 66:5403-8. 2006
    ..Oncogenic KRAS(D13) increases tumor cell sensitivity to activation of the cell-intrinsic apoptosis pathway without affecting ReovirusT3D replication...
  24. ncbi request reprint Control of colorectal metastasis formation by K-Ras
    Niels Smakman
    Department of Surgery G04 228, University Medical Center Utrecht, Heidelberglaan 100, PO Box 85500, 3508GA Utrecht, The Netherlands
    Biochim Biophys Acta 1756:103-14. 2005
    ..In this review, we discuss the potential influence of mutant K-Ras on each of these phases. Furthermore, we have evaluated the clinical evidence that suggests a role for K-Ras in the formation of colorectal metastases...
  25. ncbi request reprint Glycation induces formation of amyloid cross-beta structure in albumin
    Barend Bouma
    Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Biol Chem 278:41810-9. 2003
    ..This would explain how glycated ligands and amyloid ligands can bind to the same multiligand "cross-beta structure" receptors and to tPA...
  26. pmc PDGFRB promotes liver metastasis formation of mesenchymal-like colorectal tumor cells
    Ernst J A Steller
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Neoplasia 15:204-17. 2013
    ..These results suggest that PDGFRB may contribute to the aggressive phenotype of colorectal tumors with mesenchymal properties, most likely downstream of platelet activation and TGFB signaling...
  27. ncbi request reprint Recombinant endostatin forms amyloid fibrils that bind and are cytotoxic to murine neuroblastoma cells in vitro
    Onno Kranenburg
    Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    FEBS Lett 539:149-55. 2003
    ..Our results demonstrate a previously unrecognized functional difference between soluble and insoluble endostatin, only the latter acting as a cytotoxic amyloid substance...
  28. ncbi request reprint Combined KRAS and TP53 mutation status is not predictive in CAPOX-treated metastatic colorectal cancer
    Menno T de Bruijn
    Department of Surgery, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    Anticancer Res 31:1379-85. 2011
    ..Therefore, whether or not the combined mutation status of KRAS and TP53 could predict response to chemotherapy in metastatic colorectal cancer was tested...
  29. doi request reprint CD95 signaling in colorectal cancer
    Frederik J H Hoogwater
    Department of Surgery, University Medical Center Utrecht, The Netherlands
    Biochim Biophys Acta 1826:189-98. 2012
    ..We conclude that locking CD95 in apoptosis-mode may be a more promising anti-cancer strategy than simply inhibiting or stimulating CD95...
  30. ncbi request reprint Ischemia/reperfusion accelerates the outgrowth of hepatic micrometastases in a highly standardized murine model
    Jarmila D W van der Bilt
    Laboratory of Experimental Oncology, Department of Surgery, University Medical Center Utrecht, The Netherlands
    Hepatology 42:165-75. 2005
    ..In conclusion, I/R is a strong stimulus of recurrent intrahepatic tumor growth. Measures to prevent I/R-induced late tissue necrosis cross-protect against this phenomenon...
  31. ncbi request reprint Amyloid endostatin induces endothelial cell detachment by stimulation of the plasminogen activation system
    Arie Reijerkerk
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Cancer Res 1:561-8. 2003
    ..Our results suggest that amyloid endostatin may inhibit angiogenesis and tumor growth by stimulating the fibrinolytic system...
  32. ncbi request reprint Surgical implantation of an abdominal imaging window for intravital microscopy
    Laila Ritsma
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences KNAW University Medical Centre Utrecht, Utrecht, The Netherlands
    Nat Protoc 8:583-94. 2013
    ..Here we describe the detailed protocol for the optimal surgical implantation of the AIW, which takes ∼1 h, and subsequent multiphoton imaging, which takes up to 1 month...
  33. ncbi request reprint NS-398, a selective cyclooxygenase-2 inhibitor, reduces experimental bladder carcinoma outgrowth by inhibiting tumor cell proliferation
    Niels Smakman
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Urology 66:434-40. 2005
    ..COX-2 overexpression is frequently observed in bladder carcinoma and has been correlated with an increased disease stage and with reduced patient survival...
  34. pmc Sensitization to apoptosis underlies KrasD12-dependent oncolysis of murine C26 colorectal carcinoma cells by reovirus T3D
    Niels Smakman
    Department of Surgery, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Virol 79:14981-5. 2005
    ..Rather, reovirus-induced tumor cell apoptosis was completely abrogated as a result of Kras knockdown. We conclude that sensitization of C26 tumor cells to reovirus-induced apoptosis underlies the Ras dependency of reovirus T3D oncolysis...
  35. doi request reprint How CD95 stimulates invasion
    Ernst J A Steller
    Department of Surgery, University Medical Centre, Utrecht, The Netherlands
    Cell Cycle 10:3857-62. 2011
    ..In this review we discuss how CD95-initiated signalling pathways may cooperate to facilitate cell migration and tissue invasion...
  36. ncbi request reprint Validation of bioluminescence imaging of colorectal liver metastases in the mouse
    Niels Smakman
    Department of Surgery, University Medical Center Utrecht, Urecht, The Netherlands
    J Surg Res 122:225-30. 2004
    ..Modern visualization techniques make it possible to image tumor growth noninvasively. In the present report, we validated bioluminescence imaging of liver metastases by comparing it to standard HRA measurements and liver weight...
  37. ncbi request reprint Tissue-type plasminogen activator is a multiligand cross-beta structure receptor
    Onno Kranenburg
    Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Curr Biol 12:1833-9. 2002
    ..Our results classify tPA as a multiligand receptor and show that cross-beta structure is the common denominator in tPA binding ligands...
  38. ncbi request reprint Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes
    Sabrina Oliveira
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80 082, 3508 TB Utrecht, The Netherlands
    Int J Pharm 331:211-4. 2007
    ..For both targets, strong enhancement of gene silencing activity was noted after addition of diINF-7 fusogenic peptide, identifying endosomal escape as a limiting factor for siRNA silencing efficiency...
  39. pmc Perinecrotic hypoxia contributes to ischemia/reperfusion-accelerated outgrowth of colorectal micrometastases
    Jarmila D W van der Bilt
    Department of Surgery G04 228, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Am J Pathol 170:1379-88. 2007
    ..Prevention of tissue hypoxia or inhibition of HIF-1alpha may represent attractive approaches to limiting recurrent tumor growth after hepatic surgery...