Affiliation: University Medical Center Utrecht
Country: The Netherlands
Kranenburg O. Prometastatic NOTCH Signaling in Colon Cancer. Cancer Discov. 2015;5:115-7 pubmed publisher
..Sonoshita and colleagues identified a novel NOTCH-driven metastasis pathway that is amenable to therapeutic intervention and generated a companion diagnostic tool that allows analysis of pathway activity in human tumor tissue sections. ..
van der Waals L, Jongen J, Elias S, Veremiyenko K, Trumpi K, Trinh A, et al
. Increased Levels of Oxidative Damage in Liver Metastases Compared to Corresponding Primary Colorectal Tumors Association with Molecular Subtype and Prior Treatment. Am J Pathol. 2018;: pubmed publisher
Vellinga T, Borovski T, de Boer V, Fatrai S, van Schelven S, Trumpi K, et al
. SIRT1/PGC1Î±-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer. Clin Cancer Res. 2015;21:2870-9 pubmed publisher
..In conclusion, we propose a novel mechanism of chemotherapy resistance that may be clinically relevant and therapeutically exploitable. ..
Trumpi K, Steller E, de Leng W, Raats D, Nijman I, Morsink F, et al
. Mice lacking functional CD95-ligand display reduced proliferation of the intestinal epithelium without gross homeostatic alterations. Med Mol Morphol. 2016;49:110-8 pubmed publisher
..We conclude that CD95L has a proliferation-stimulating role during normal turnover of the small intestine, but has a marginal effect on overall intestinal homeostasis. ..
Emmink B, Laoukili J, Kipp A, Koster J, Govaert K, Fatrai S, et al
. GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer. Cancer Res. 2014;74:6717-30 pubmed publisher
..The results reveal an unexpected redox-controlled link between tumor mass formation and metastatic capacity. ..
Fatrai S, van Schelven S, Ubink I, Govaert K, Raats D, Koster J, et al
. Maintenance of Clonogenic KIT(+) Human Colon Tumor Cells Requires Secretion of Stem Cell Factor by Differentiated Tumor Cells. Gastroenterology. 2015;149:692-704 pubmed publisher
..Paracrine signaling from SCF to KIT, between differentiated tumor cells and undifferentiated stem-like tumor cells, helps maintain the stem-like features of tumor cells, predominantly under conditions of hypoxia. ..
Ubink I, Bloemendal H, Elias S, Brink M, Schwartz M, Holierhoek Y, et al
. Imatinib treatment of poor prognosis mesenchymal-type primary colon cancer: a proof-of-concept study in the preoperative window period (ImPACCT). BMC Cancer. 2017;17:282 pubmed publisher
..ClinicalTrials.gov: NCT02685046 . Registration date: February 9, 2016. ..