Geert J P L Kops

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi On the road to cancer: aneuploidy and the mitotic checkpoint
    Geert J P L Kops
    Laboratory of Experimental Oncology, Department of Medical Oncology, University Medical Center, Utrecht, 3584 CG, The Netherlands
    Nat Rev Cancer 5:773-85. 2005
  2. pmc Mps1 promotes rapid centromere accumulation of Aurora B
    Maike S van der Waal
    Department of Medical Oncology, University Medical Center Utrecht, Universiteitsweg 100, STR 2 129, 3584 CG Utrecht, The Netherlands
    EMBO Rep 13:847-54. 2012
  3. doi Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations
    Aniek Janssen
    Department of Medical Oncology and Cancer Genomics Center, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, Netherlands
    Science 333:1895-8. 2011
  4. pmc Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy
    Saskia J E Suijkerbuijk
    Department of Physiological Chemistry and Cancer Genomics Centre, University Medical Center Utrecht, Utrecht, The Netherlands
    Cancer Res 70:4891-900. 2010
  5. pmc APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome
    Geert J P L Kops
    Department of Physiological Chemistry and Cancer Genomics Centre, UMC Utrecht, Utrecht, The Netherlands
    J Cell Sci 123:1623-33. 2010
  6. pmc Release of Mps1 from kinetochores is crucial for timely anaphase onset
    Nannette Jelluma
    Department of Physiological Chemistry and Cancer Genomics Centre, UMC Utrecht, 3584 CG, Utrecht, Netherlands
    J Cell Biol 191:281-90. 2010
  7. pmc Finding the middle ground: how kinetochores power chromosome congression
    Geert J P L Kops
    Department of Physiological Chemistry and Cancer Genomics Centre, University Medical Center Utrecht, Stratenum 3 217, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Cell Mol Life Sci 67:2145-61. 2010
  8. doi Dividing the goods: co-ordination of chromosome biorientation and mitotic checkpoint signalling by mitotic kinases
    Geert J P L Kops
    Department of Physiological Chemistry and Cancer Genomics Centre, UMC Utrecht, Utrecht, The Netherlands
    Biochem Soc Trans 37:971-5. 2009
  9. pmc Centromere binding and a conserved role in chromosome stability for SUMO-dependent ubiquitin ligases
    Loes A L van de Pasch
    Molecular Cancer Research, University Medical Centre Utrecht, Universiteitsweg 100, Utrecht, The Netherlands
    PLoS ONE 8:e65628. 2013
  10. doi Universal quantitative kinase assay based on diagonal SCX chromatography and stable isotope dimethyl labeling provides high-definition kinase consensus motifs for PKA and human Mps1
    Marco L Hennrich
    Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584CH, Utrecht, The Netherlands
    J Proteome Res 12:2214-24. 2013

Collaborators

Detail Information

Publications27

  1. ncbi On the road to cancer: aneuploidy and the mitotic checkpoint
    Geert J P L Kops
    Laboratory of Experimental Oncology, Department of Medical Oncology, University Medical Center, Utrecht, 3584 CG, The Netherlands
    Nat Rev Cancer 5:773-85. 2005
    ..Defects in the mitotic checkpoint generate aneuploidy and might facilitate tumorigenesis, but more severe disabling of checkpoint signalling is a possible anticancer strategy...
  2. pmc Mps1 promotes rapid centromere accumulation of Aurora B
    Maike S van der Waal
    Department of Medical Oncology, University Medical Center Utrecht, Universiteitsweg 100, STR 2 129, 3584 CG Utrecht, The Netherlands
    EMBO Rep 13:847-54. 2012
    ....
  3. doi Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations
    Aniek Janssen
    Department of Medical Oncology and Cancer Genomics Center, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, Netherlands
    Science 333:1895-8. 2011
    ..Our data show that segregation errors can cause translocations and provide insights into the role of whole-chromosome instability in tumorigenesis...
  4. pmc Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy
    Saskia J E Suijkerbuijk
    Department of Physiological Chemistry and Cancer Genomics Centre, University Medical Center Utrecht, Utrecht, The Netherlands
    Cancer Res 70:4891-900. 2010
    ..Our findings provide a molecular explanation for chromosomal instability in patients with biallelic genetic mutations in BUBR1...
  5. pmc APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome
    Geert J P L Kops
    Department of Physiological Chemistry and Cancer Genomics Centre, UMC Utrecht, Utrecht, The Netherlands
    J Cell Sci 123:1623-33. 2010
    ..rerio gene zgc:110659 are functional equivalents of human APC16. Our findings show that APC/C is composed of previously undescribed subunits, and raise the question of why metazoan APC/C is molecularly different from unicellular APC/C...
  6. pmc Release of Mps1 from kinetochores is crucial for timely anaphase onset
    Nannette Jelluma
    Department of Physiological Chemistry and Cancer Genomics Centre, UMC Utrecht, 3584 CG, Utrecht, Netherlands
    J Cell Biol 191:281-90. 2010
    ..We propose that release of Mps1 from kinetochores is essential for mitotic checkpoint silencing and a fast metaphase-to-anaphase transition...
  7. pmc Finding the middle ground: how kinetochores power chromosome congression
    Geert J P L Kops
    Department of Physiological Chemistry and Cancer Genomics Centre, University Medical Center Utrecht, Stratenum 3 217, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Cell Mol Life Sci 67:2145-61. 2010
    ..Here we review the current knowledge and concepts on the processes that underlie chromosome congression, including initial attachment to spindle microtubules, biorientation, and movements, from the perspective of the kinetochore...
  8. doi Dividing the goods: co-ordination of chromosome biorientation and mitotic checkpoint signalling by mitotic kinases
    Geert J P L Kops
    Department of Physiological Chemistry and Cancer Genomics Centre, UMC Utrecht, Utrecht, The Netherlands
    Biochem Soc Trans 37:971-5. 2009
    ..A group of unrelated kinases controls various aspects of both processes. The present short review outlines our current understanding of the roles of these kinases in maintaining chromosomal stability...
  9. pmc Centromere binding and a conserved role in chromosome stability for SUMO-dependent ubiquitin ligases
    Loes A L van de Pasch
    Molecular Cancer Research, University Medical Centre Utrecht, Universiteitsweg 100, Utrecht, The Netherlands
    PLoS ONE 8:e65628. 2013
    ..The study shows that STUbLs have a conserved role in maintenance of chromosome stability and links SUMO-dependent ubiquitination to a centromere-specific function during mitosis...
  10. doi Universal quantitative kinase assay based on diagonal SCX chromatography and stable isotope dimethyl labeling provides high-definition kinase consensus motifs for PKA and human Mps1
    Marco L Hennrich
    Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584CH, Utrecht, The Netherlands
    J Proteome Res 12:2214-24. 2013
    ..Our generic method, which makes use of proteolytic cell lysates as a source for peptide-substrate libraries, can be implemented for any kinase present in the kinome...
  11. doi Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint
    Geert J P L Kops
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Chromosoma 121:509-25. 2012
    ..Future challenges in this area are highlighted towards the goal of building a comprehensive molecular model of this process...
  12. pmc Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis
    Tale Sliedrecht
    Department of Physiological Chemistry, Cancer Genomics Centre, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 5:e10251. 2010
    ..Proper functioning of the attachment and checkpoint processes is thus important to prevent chromosomal instability. Both processes rely on the mitotic kinase Mps1...
  13. pmc Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells
    Aniek Janssen
    Department of Medical Oncology, Cancer Genomics Center, UMC Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 106:19108-13. 2009
    ..Thus, targeting the mitotic checkpoint and chromosome alignment simultaneously may selectively kill tumor cells by enhancing chromosome mis-segregations...
  14. ncbi Cell cycle and death control: long live Forkheads
    Boudewijn M T Burgering
    Dept Physiological Chemistry and Centre for Biomedical Genetics, University Medical Centre Utrecht, Stratenum, The Netherlands
    Trends Biochem Sci 27:352-60. 2002
    ..Recent discoveries about FOXO regulation by PI3K-PKB signalling suggest that the PI3K-PKB-FOXO pathway might participate in similar processes in higher eukaryotes...
  15. doi The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase
    Saskia J E Suijkerbuijk
    Molecular Cancer Research and Cancer Genomics Centre, Department of Medical Oncology, UMC Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Dev Cell 22:1321-9. 2012
    ..We propose that parallel evolution of BUBR1 orthologs rendered its kinase function dispensable in vertebrates, producing an unusual, triad-containing pseudokinase...
  16. doi Evolution and function of the mitotic checkpoint
    Mathijs Vleugel
    Department of Medical Oncology, Department of Molecular Cancer Research and Cancer Genomics Centre, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    Dev Cell 23:239-50. 2012
    ....
  17. pmc Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes
    Nannette Jelluma
    Department of Physiological Chemistry and Cancer Genomics Centre, UMC Utrecht, Utrecht, The Netherlands
    PLoS ONE 3:e2415. 2008
    ..Two of the causes of CIN are weakened mitotic checkpoint signaling and persistent merotelic attachments that result in lagging chromosomes during anaphase...
  18. pmc A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes
    Radhika A Varier
    Department of Physiological Chemistry and Netherlands Proteomics Center, University Medical Centre Utrecht, Utrecht, The Netherlands
    EMBO J 29:3967-78. 2010
    ..Based on our observations, we propose that a histone H3 phospho-methyl switch regulates TFIID-mediated transcription during mitotic progression of the cell cycle...
  19. doi Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
    Nannette Jelluma
    Department of Medical Oncology, Laboratory of Experimental Oncology, UMC Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Cell 132:233-46. 2008
    ..Mps1 thus coordinates attachment error correction and checkpoint signaling, two crucial responses to unproductive chromosome attachments...
  20. ncbi The kinetochore and spindle checkpoint in mammals
    Geert J P L Kops
    Department of Physiological Chemistry, UMC Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Front Biosci 13:3606-20. 2008
    ..This review focuses on molecular aspects of mitotic checkpoint signaling in mammals, including sensing improper attachments and transducing this information to the cell-cycle machinery...
  21. ncbi The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2
    Marie Stahl
    Department of Molecular Biology H8, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Immunol 168:5024-31. 2002
    ..Thus, we propose that inactivation of FoxO transcription factors by IL-2 plays a critical role in T cell proliferation and survival...
  22. ncbi Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
    Geert J P L Kops
    Department of Physiological Chemistry, University Medical Center Utrecht and Center for Biomedical Genetics, 3584 CG Utrecht, The Netherlands
    Nature 419:316-21. 2002
    ..The model of Forkhead involvement in regulating longevity stems from genetic analysis in Caenorhabditis elegans, and we conclude that this model also extends to mammalian systems...
  23. pmc Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D
    Marc Schmidt
    Division of Molecular Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Mol Cell Biol 22:7842-52. 2002
    ..Ectopic expression of cyclin D1 can partially overcome FoxO factor-induced cell cycle arrest, demonstrating that downregulation of D-type cyclins represents a physiologically relevant mechanism of FoxO-induced cell cycle inhibition...
  24. ncbi Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a
    Tobias B Dansen
    Department of Biochemistry of Lipids, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    J Lipid Res 45:81-8. 2004
    ..We propose a model for the way in which SCP2 could protect fatty acids from peroxidation...
  25. pmc Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors
    Geert J P L Kops
    Department of Physiological Chemistry, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    Mol Cell Biol 22:2025-36. 2002
    ..We therefore propose that Forkhead inactivation by PKB signaling in quiescent cells is a crucial step in cell cycle reentry and contributes to the processes of transformation and regeneration...
  26. pmc Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss
    Beth A A Weaver
    Ludwig Institute for Cancer Research, 3080 CMM East, 9500 Gilman Drive, La Jolla, CA 92093 0670, USA
    J Cell Biol 162:551-63. 2003
    ..Thus, CENP-E is required for enhancing recruitment of its binding partner BubR1 to each unattached kinetochore and for stimulating BubR1 kinase activity, implicating it as an essential amplifier of a basal mitotic checkpoint signal...
  27. pmc Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint
    Geert J P L Kops
    Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093 0670, USA
    Proc Natl Acad Sci U S A 101:8699-704. 2004
    ..Thus, suppression of mitotic checkpoint signaling is invariably lethal as the consequence of massive chromosome loss, findings that have implications for inhibiting proliferation of tumor cells...