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Genomes and Genes | G H KoppelmanSummaryAffiliation: University Medical Center Groningen Country: The Netherlands Publications
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Publications
Genetic testing for asthmaG H Koppelman
Dept of Paediatric Pulmonology and Paediatric Allergology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
Eur Respir J 32:775-82. 2008..Studies in general and at-risk populations are needed to investigate and validate this approach...- Successful grant writingGerard H Koppelman
Department of Paediatric Pulmonology and Paediatric Allergology, Beatrix Children s Hospital, Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, The Netherlands
Paediatr Respir Rev 13:63-6. 2012..If you are able to formulate these long term goals, it is relevant to explore the market and investigate all potential grant opportunities. Finally, we will provide an outline of key elements of successful research grants... 
Meta-analysis of genome-wide linkage studies of asthma and related traitsSamuel Denham
Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
Respir Res 9:38. 2008....- The development of socio-economic health differences in childhood: results of the Dutch longitudinal PIAMA birth cohortAnnemarie Ruijsbroek
Centre for Prevention and Health Services Research, National Institute for Public Health and Environment, Bilthoven, The Netherlands
BMC Public Health 11:225. 2011..The goal of this study was to prospectively study the development of socio-economic health differences in the Netherlands, and to investigate possible explanations for socio-economic variation in childhood health... - Recent advances in the epigenetics and genomics of asthmaGerard H Koppelman
Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children s Hospital, University of Groningen, Groningen, The Netherlands
Curr Opin Allergy Clin Immunol 11:414-9. 2011..Here, we review recent evidence for the role of epigenetics and genomics in asthma... - Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsivenessGerard H Koppelman
Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
Am J Respir Crit Care Med 180:929-35. 2009..Bronchial hyperresponsiveness (BHR) is a hallmark of asthma and results from increased sensitivity of the airways to physical or chemical stimulants. BHR and asthma are linked to chromosome 5q31-q33... 
Gene by environment interaction in asthmaGerard H Koppelman
Department of Pediatric Pulmonology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
Curr Allergy Asthma Rep 6:103-11. 2006..Gene by environment interaction is important in asthma pathogenesis, and future studies should take the interaction of both factors into account...- X-chromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohortsR W B Bottema
Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Allergy 65:865-74. 2010..Regulatory T cells may suppress development of atopy. We evaluated whether single-nucleotide polymorphisms (SNPs) of FOXP3 are associated with atopy development in childhood... - Interleukin 13, CD14, pet and tobacco smoke influence atopy in three Dutch cohorts: the allergenic studyR W B Bottema
Dept of Pulmonology, University Medical Center Groningen, P O Box 196, 9700 AD Groningen, The Netherlands
Eur Respir J 32:593-602. 2008..Additionally, pooled data improved effect estimates and genetic effects could be detected in interaction with important environmental factors... - TLR-related pathway analysis: novel gene-gene interactions in the development of asthma and atopyN E Reijmerink
Department of Pulmonology, University Medical Center Groningen, University of Groningen, The Netherlands
Allergy 65:199-207. 2010..Numerous studies have shown associations of TLR-related pathway genes with asthma and atopy phenotypes. So far it has not been investigated whether gene-gene interactions in this pathway contribute to atopy and asthma development... - Polymorphisms in the TLR6 gene associated with the inverse association between childhood acute lymphoblastic leukemia and atopic diseaseK G E Miedema
Department of Pediatric Oncology Hematology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Leukemia 26:1203-10. 2012..Further investigation is warranted to examine in more detail the role of innate immunity in the development of childhood ALL... - Toll-like receptors and microbial exposure: gene-gene and gene-environment interaction in the development of atopyN E Reijmerink
Department of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands
Eur Respir J 38:833-40. 2011..Furthermore, complex two- and three-factor interactions exist between genes and the environment. The TLRs and related genes interact with proxy parameters of high microbial exposure in atopy development... - Interaction of T-cell and antigen presenting cell co-stimulatory genes in childhood IgER W B Bottema
Dept of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Eur Respir J 35:54-63. 2010..In conclusion, serum IgE levels are regulated by multiple gene-gene interaction effects in the co-stimulatory pathway. We suggest using research strategies that model multiple gene-gene interactions in genetic studies... - Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthmaM Kerkhof
Department of Epidemiology, University Medical Center Groningen, Groningen, The Netherlands
Thorax 65:690-7. 2010..Epidemiological studies have reported adverse effects of ambient air pollution on the prevalence of asthma. Laboratory studies have suggested that innate immune responses are involved... - E-cadherin gene polymorphisms in asthma patients using inhaled corticosteroidsD Ierodiakonou
Dept of Epidemiology, University Medical Center Groningen, University of Groningen, The Netherlands
Eur Respir J 38:1044-52. 2011..These effects are modified by the use of inhaled corticosteroids... - Lung function decline in asthma: association with inhaled corticosteroids, smoking and sexA Dijkstra
Department of Pulmonary Rehabilitation, Beatrixoord, Haren, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
Thorax 61:105-10. 2006..This effect was dose dependent and was not present in women or in men with > or =5 pack years of smoking at follow up. The lack of effect of ICS on the decline in FEV(1) in women needs further study... - Smoke exposure interacts with ADAM33 polymorphisms in the development of lung function and hyperresponsivenessN E Reijmerink
Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Allergy 64:898-904. 2009..In utero and postnatal cigarette smoke exposure (CSE) are associated with reduced lung function, and development of BHR and asthma. We hypothesized that this may occur via interaction with ADAM33... - Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposureM L A Schuttelaar
Departments of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Allergy 64:1758-65. 2009..Filaggrin gene (FLG) mutations contribute to the development of eczema and asthma, but their contribution to sensitization and hay fever remains unclear... - SERPINE1 -675 4G/5G polymorphism is associated with asthma severity and inhaled corticosteroid responseA Dijkstra
Dept of Pulmonology, Center Groningen and University of Groningen, Groningen, The Netherlands
Eur Respir J 38:1036-43. 2011..These findings suggest that SERPINE1 is not an asthma susceptibility gene, but rather affects the severity, progression and long-term ICS response in asthma... - Association of polymorphisms in the TLR4 gene with the risk of developing neutropenia in children with leukemiaK G E Miedema
Department of Pediatric Oncology and Pediatric Hematology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Leukemia 25:995-1000. 2011.... - HbA(1c) levels in non-diabetic Dutch children aged 8-9 years: the PIAMA birth cohort studyH Jansen
Department of Epidemiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
Diabet Med 26:122-7. 2009..The aim of this study is to describe the distribution of HbA(1c) in non-diabetic Dutch children aged 8-9 years and to investigate potential associations of HbA(1c) in this group... - Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthmaH Jongepier
Department of Pulmonary Diseases, University Hospital, Groningen, The Netherlands
Clin Exp Allergy 34:757-60. 2004..The ADAM33 gene is associated with asthma and airway hyper-responsiveness and is postulated as a gene for airway remodelling... - Phenotype definition, age, and gender in the genetics of asthma and atopyR W B Bottema
Department of Pulmonology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, The Netherlands
Immunol Allergy Clin North Am 25:621-39. 2005..To acquire sufficient power for these types of analyses, international collaboration may be the only way to elucidate the intricate, gene-environmental interactions in atopy and asthma in an age- and gender-dependent manor... - Genome screen for asthma and bronchial hyperresponsiveness: interactions with passive smoke exposureDeborah A Meyers
Center for Human Genomics, Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 115:1169-75. 2005..Passive smoke exposure, characterized by parental smoking, has been shown to be a risk factor for the development of atopy and asthma... - Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28Timothy D Howard
Center for Human Genomics, Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
J Allergy Clin Immunol 110:743-51. 2002..0009). No significant associations were observed for SNPs in CD28. CONCLUSION: These data suggest that the costimulatory pathway, specifically CTLA4, is important in the development of atopy and asthma... - Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopyNaomi E Reijmerink
J Allergy Clin Immunol 122:651-4.e8. 2008 - The genetics of CD14 in allergic diseaseGerard H Koppelman
Beatrix Children s Hospital, University Hospital Groningen, The Netherlands
Curr Opin Allergy Clin Immunol 3:347-52. 2003..Therefore, both contacts with microbial products such as endotoxin as well as CD14, a gene involved in the immunological response to endotoxin, are discussed in this review... - Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populationsTimothy D Howard
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 112:717-22. 2003..Recently, a gene potentially involved in airway remodeling, a disintegrin and metalloprotease 33 (ADAM33), was implicated in asthma susceptibility... - Identification of polymorphisms in the human glucocorticoid receptor gene (NR3C1) in a multi-racial asthma case and control screening panelGregory A Hawkins
Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
DNA Seq 15:167-73. 2004..This data shows the variability of NR3C1 polymorphism frequencies between racial groups and confirms that NR3C1 non-synonymous coding polymorphisms are generally rare in mild/moderate asthmatics and unaffected controls... - Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21Dan Nicolae
Department of Statistics, The University of Chicago, Chicago, IL, USA
Am J Hum Genet 76:349-57. 2005.... - Polymorphisms in SPINK5 are not associated with asthma in a Dutch populationHajo Jongepier
Department of Pulmonary Rehabilitation, Beatrixoord, The Netherlands
J Allergy Clin Immunol 115:486-92. 2005..This is consistent with the finding that SPINK5 is not expressed in the lung. Because our patients were ascertained for asthma, a role of SPINK5 in atopic dermatitis cannot be excluded... - Genomewide screen for pulmonary function in 200 families ascertained for asthmaDirkje S Postma
Department of Pulmonology, University Hospital, Hanzeplein 3, 9731 GZ Groningen, The Netherlands
Am J Respir Crit Care Med 172:446-52. 2005..Thus, there may be multiple genes on chromosome 2q that are important in determining presence and degree of airflow limitation in families ascertained for obstructive airway disease... - Confirmation of GPRA: a putative drug target for asthmaDirkje S Postma
Am J Respir Crit Care Med 171:1323-4. 2005 - Confounding effect of atopy on functional effects of the CD14/-159 promoter polymorphismNaomi E Reijmerink
J Allergy Clin Immunol 117:219; author reply 220. 2006 - Identifying novel genes contributing to asthma pathogenesisJohn W Holloway
Divisions of Infection, Inflammation and Repair, University of Southampton, Southampton, UK
Curr Opin Allergy Clin Immunol 7:69-74. 2007..To illustrate recent examples of novel asthma genes such as those encoding G-protein-coupled receptor for asthma susceptibility, filaggrin and tenascin-C, and to describe the process that is needed to translate these findings to the clinic... - Gene-environment interaction in allergic disease: more questions, more answers?Gerard H Koppelman
J Allergy Clin Immunol 120:1266-8. 2007 - Genome-wide search for atopy susceptibility genes in Dutch families with asthmaGerard H Koppelman
Department of Pulmonary Rehabilitation, Beatrixoord, Haren, The Netherlands
J Allergy Clin Immunol 109:498-506. 2002..CONCLUSIONS: Atopic phenotypes show familial aggregation, although family members may differ in expression of atopy. Specific chromosomal regions appear to be important in susceptibility to different phenotypes of atopic responsiveness... - Pharmacogenomics and outcome of asthma: no clinical application for long-term steroid effects by CRHR1 polymorphismsAntoon Dijkstra
J Allergy Clin Immunol 121:1510-3. 2008 - Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthmaTimothy D Howard
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am J Hum Genet 70:230-6. 2002..0004). These data suggest that variations in IL4RA contribute to elevated total serum IgE levels, and interaction between IL4RA and IL13 markedly increases an individual's susceptibility to asthma...