G H Koppelman

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. doi request reprint Genetic testing for asthma
    G H Koppelman
    Dept of Paediatric Pulmonology and Paediatric Allergology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur Respir J 32:775-82. 2008
  2. doi request reprint Successful grant writing
    Gerard H Koppelman
    Department of Paediatric Pulmonology and Paediatric Allergology, Beatrix Children s Hospital, Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, The Netherlands
    Paediatr Respir Rev 13:63-6. 2012
  3. pmc Meta-analysis of genome-wide linkage studies of asthma and related traits
    Samuel Denham
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
    Respir Res 9:38. 2008
  4. pmc The development of socio-economic health differences in childhood: results of the Dutch longitudinal PIAMA birth cohort
    Annemarie Ruijsbroek
    Centre for Prevention and Health Services Research, National Institute for Public Health and Environment, Bilthoven, The Netherlands
    BMC Public Health 11:225. 2011
  5. doi request reprint Recent advances in the epigenetics and genomics of asthma
    Gerard H Koppelman
    Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children s Hospital, University of Groningen, Groningen, The Netherlands
    Curr Opin Allergy Clin Immunol 11:414-9. 2011
  6. pmc Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness
    Gerard H Koppelman
    Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
    Am J Respir Crit Care Med 180:929-35. 2009
  7. ncbi request reprint Gene by environment interaction in asthma
    Gerard H Koppelman
    Department of Pediatric Pulmonology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Curr Allergy Asthma Rep 6:103-11. 2006
  8. doi request reprint X-chromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohorts
    R W B Bottema
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Allergy 65:865-74. 2010
  9. doi request reprint Interleukin 13, CD14, pet and tobacco smoke influence atopy in three Dutch cohorts: the allergenic study
    R W B Bottema
    Dept of Pulmonology, University Medical Center Groningen, P O Box 196, 9700 AD Groningen, The Netherlands
    Eur Respir J 32:593-602. 2008
  10. doi request reprint TLR-related pathway analysis: novel gene-gene interactions in the development of asthma and atopy
    N E Reijmerink
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, The Netherlands
    Allergy 65:199-207. 2010

Collaborators

Detail Information

Publications39

  1. doi request reprint Genetic testing for asthma
    G H Koppelman
    Dept of Paediatric Pulmonology and Paediatric Allergology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur Respir J 32:775-82. 2008
    ..Studies in general and at-risk populations are needed to investigate and validate this approach...
  2. doi request reprint Successful grant writing
    Gerard H Koppelman
    Department of Paediatric Pulmonology and Paediatric Allergology, Beatrix Children s Hospital, Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, The Netherlands
    Paediatr Respir Rev 13:63-6. 2012
    ..If you are able to formulate these long term goals, it is relevant to explore the market and investigate all potential grant opportunities. Finally, we will provide an outline of key elements of successful research grants...
  3. pmc Meta-analysis of genome-wide linkage studies of asthma and related traits
    Samuel Denham
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
    Respir Res 9:38. 2008
    ....
  4. pmc The development of socio-economic health differences in childhood: results of the Dutch longitudinal PIAMA birth cohort
    Annemarie Ruijsbroek
    Centre for Prevention and Health Services Research, National Institute for Public Health and Environment, Bilthoven, The Netherlands
    BMC Public Health 11:225. 2011
    ..The goal of this study was to prospectively study the development of socio-economic health differences in the Netherlands, and to investigate possible explanations for socio-economic variation in childhood health...
  5. doi request reprint Recent advances in the epigenetics and genomics of asthma
    Gerard H Koppelman
    Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children s Hospital, University of Groningen, Groningen, The Netherlands
    Curr Opin Allergy Clin Immunol 11:414-9. 2011
    ..Here, we review recent evidence for the role of epigenetics and genomics in asthma...
  6. pmc Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness
    Gerard H Koppelman
    Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
    Am J Respir Crit Care Med 180:929-35. 2009
    ..Bronchial hyperresponsiveness (BHR) is a hallmark of asthma and results from increased sensitivity of the airways to physical or chemical stimulants. BHR and asthma are linked to chromosome 5q31-q33...
  7. ncbi request reprint Gene by environment interaction in asthma
    Gerard H Koppelman
    Department of Pediatric Pulmonology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Curr Allergy Asthma Rep 6:103-11. 2006
    ..Gene by environment interaction is important in asthma pathogenesis, and future studies should take the interaction of both factors into account...
  8. doi request reprint X-chromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohorts
    R W B Bottema
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Allergy 65:865-74. 2010
    ..Regulatory T cells may suppress development of atopy. We evaluated whether single-nucleotide polymorphisms (SNPs) of FOXP3 are associated with atopy development in childhood...
  9. doi request reprint Interleukin 13, CD14, pet and tobacco smoke influence atopy in three Dutch cohorts: the allergenic study
    R W B Bottema
    Dept of Pulmonology, University Medical Center Groningen, P O Box 196, 9700 AD Groningen, The Netherlands
    Eur Respir J 32:593-602. 2008
    ..Additionally, pooled data improved effect estimates and genetic effects could be detected in interaction with important environmental factors...
  10. doi request reprint TLR-related pathway analysis: novel gene-gene interactions in the development of asthma and atopy
    N E Reijmerink
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, The Netherlands
    Allergy 65:199-207. 2010
    ..Numerous studies have shown associations of TLR-related pathway genes with asthma and atopy phenotypes. So far it has not been investigated whether gene-gene interactions in this pathway contribute to atopy and asthma development...
  11. doi request reprint Polymorphisms in the TLR6 gene associated with the inverse association between childhood acute lymphoblastic leukemia and atopic disease
    K G E Miedema
    Department of Pediatric Oncology Hematology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Leukemia 26:1203-10. 2012
    ..Further investigation is warranted to examine in more detail the role of innate immunity in the development of childhood ALL...
  12. doi request reprint Toll-like receptors and microbial exposure: gene-gene and gene-environment interaction in the development of atopy
    N E Reijmerink
    Department of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands
    Eur Respir J 38:833-40. 2011
    ..Furthermore, complex two- and three-factor interactions exist between genes and the environment. The TLRs and related genes interact with proxy parameters of high microbial exposure in atopy development...
  13. doi request reprint Interaction of T-cell and antigen presenting cell co-stimulatory genes in childhood IgE
    R W B Bottema
    Dept of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur Respir J 35:54-63. 2010
    ..In conclusion, serum IgE levels are regulated by multiple gene-gene interaction effects in the co-stimulatory pathway. We suggest using research strategies that model multiple gene-gene interactions in genetic studies...
  14. doi request reprint Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma
    M Kerkhof
    Department of Epidemiology, University Medical Center Groningen, Groningen, The Netherlands
    Thorax 65:690-7. 2010
    ..Epidemiological studies have reported adverse effects of ambient air pollution on the prevalence of asthma. Laboratory studies have suggested that innate immune responses are involved...
  15. doi request reprint E-cadherin gene polymorphisms in asthma patients using inhaled corticosteroids
    D Ierodiakonou
    Dept of Epidemiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur Respir J 38:1044-52. 2011
    ..These effects are modified by the use of inhaled corticosteroids...
  16. pmc Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex
    A Dijkstra
    Department of Pulmonary Rehabilitation, Beatrixoord, Haren, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Thorax 61:105-10. 2006
    ..Inhaled corticosteroids (ICS) provide short term benefits in asthma but the long term effects are still unknown...
  17. doi request reprint Smoke exposure interacts with ADAM33 polymorphisms in the development of lung function and hyperresponsiveness
    N E Reijmerink
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Allergy 64:898-904. 2009
    ..In utero and postnatal cigarette smoke exposure (CSE) are associated with reduced lung function, and development of BHR and asthma. We hypothesized that this may occur via interaction with ADAM33...
  18. doi request reprint Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure
    M L A Schuttelaar
    Departments of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Allergy 64:1758-65. 2009
    ..Filaggrin gene (FLG) mutations contribute to the development of eczema and asthma, but their contribution to sensitization and hay fever remains unclear...
  19. doi request reprint SERPINE1 -675 4G/5G polymorphism is associated with asthma severity and inhaled corticosteroid response
    A Dijkstra
    Dept of Pulmonology, Center Groningen and University of Groningen, Groningen, The Netherlands
    Eur Respir J 38:1036-43. 2011
    ..These findings suggest that SERPINE1 is not an asthma susceptibility gene, but rather affects the severity, progression and long-term ICS response in asthma...
  20. doi request reprint Association of polymorphisms in the TLR4 gene with the risk of developing neutropenia in children with leukemia
    K G E Miedema
    Department of Pediatric Oncology and Pediatric Hematology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Leukemia 25:995-1000. 2011
    ....
  21. ncbi request reprint HbA(1c) levels in non-diabetic Dutch children aged 8-9 years: the PIAMA birth cohort study
    H Jansen
    Department of Epidemiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Diabet Med 26:122-7. 2009
    ..The aim of this study is to describe the distribution of HbA(1c) in non-diabetic Dutch children aged 8-9 years and to investigate potential associations of HbA(1c) in this group...
  22. ncbi request reprint Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma
    H Jongepier
    Department of Pulmonary Diseases, University Hospital, Groningen, The Netherlands
    Clin Exp Allergy 34:757-60. 2004
    ..The ADAM33 gene is associated with asthma and airway hyper-responsiveness and is postulated as a gene for airway remodelling...
  23. ncbi request reprint Phenotype definition, age, and gender in the genetics of asthma and atopy
    R W B Bottema
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, The Netherlands
    Immunol Allergy Clin North Am 25:621-39. 2005
    ..To acquire sufficient power for these types of analyses, international collaboration may be the only way to elucidate the intricate, gene-environmental interactions in atopy and asthma in an age- and gender-dependent manor...
  24. ncbi request reprint Genome screen for asthma and bronchial hyperresponsiveness: interactions with passive smoke exposure
    Deborah A Meyers
    Center for Human Genomics, Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 115:1169-75. 2005
    ..Passive smoke exposure, characterized by parental smoking, has been shown to be a risk factor for the development of atopy and asthma...
  25. ncbi request reprint Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28
    Timothy D Howard
    Center for Human Genomics, Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 110:743-51. 2002
    ..Two candidate genes, CTLA4 and CD28, important homeostatic regulators of T-cell activation and subsequent IgE production, map within this candidate region...
  26. doi request reprint Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy
    Naomi E Reijmerink
    J Allergy Clin Immunol 122:651-4.e8. 2008
  27. ncbi request reprint The genetics of CD14 in allergic disease
    Gerard H Koppelman
    Beatrix Children s Hospital, University Hospital Groningen, The Netherlands
    Curr Opin Allergy Clin Immunol 3:347-52. 2003
    ..Therefore, both contacts with microbial products such as endotoxin as well as CD14, a gene involved in the immunological response to endotoxin, are discussed in this review...
  28. ncbi request reprint Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 112:717-22. 2003
    ..Recently, a gene potentially involved in airway remodeling, a disintegrin and metalloprotease 33 (ADAM33), was implicated in asthma susceptibility...
  29. ncbi request reprint Identification of polymorphisms in the human glucocorticoid receptor gene (NR3C1) in a multi-racial asthma case and control screening panel
    Gregory A Hawkins
    Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    DNA Seq 15:167-73. 2004
    ..This data shows the variability of NR3C1 polymorphism frequencies between racial groups and confirms that NR3C1 non-synonymous coding polymorphisms are generally rare in mild/moderate asthmatics and unaffected controls...
  30. pmc Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21
    Dan Nicolae
    Department of Statistics, The University of Chicago, Chicago, IL, USA
    Am J Hum Genet 76:349-57. 2005
    ....
  31. ncbi request reprint Polymorphisms in SPINK5 are not associated with asthma in a Dutch population
    Hajo Jongepier
    Department of Pulmonary Rehabilitation, Beatrixoord, The Netherlands
    J Allergy Clin Immunol 115:486-92. 2005
    ..This region has many candidate genes, including serine protease inhibitor Kazal type 5 (SPINK5), which has been associated with asthma and atopic dermatitis in family-based studies of children with atopic dermatitis...
  32. pmc Genomewide screen for pulmonary function in 200 families ascertained for asthma
    Dirkje S Postma
    Department of Pulmonology, University Hospital, Hanzeplein 3, 9731 GZ Groningen, The Netherlands
    Am J Respir Crit Care Med 172:446-52. 2005
    ..Thus, there may be multiple genes on chromosome 2q that are important in determining presence and degree of airflow limitation in families ascertained for obstructive airway disease...
  33. ncbi request reprint Confirmation of GPRA: a putative drug target for asthma
    Dirkje S Postma
    Am J Respir Crit Care Med 171:1323-4. 2005
  34. ncbi request reprint Confounding effect of atopy on functional effects of the CD14/-159 promoter polymorphism
    Naomi E Reijmerink
    J Allergy Clin Immunol 117:219; author reply 220. 2006
  35. ncbi request reprint Identifying novel genes contributing to asthma pathogenesis
    John W Holloway
    Divisions of Infection, Inflammation and Repair, University of Southampton, Southampton, UK
    Curr Opin Allergy Clin Immunol 7:69-74. 2007
    ..To illustrate recent examples of novel asthma genes such as those encoding G-protein-coupled receptor for asthma susceptibility, filaggrin and tenascin-C, and to describe the process that is needed to translate these findings to the clinic...
  36. ncbi request reprint Gene-environment interaction in allergic disease: more questions, more answers?
    Gerard H Koppelman
    J Allergy Clin Immunol 120:1266-8. 2007
  37. ncbi request reprint Genome-wide search for atopy susceptibility genes in Dutch families with asthma
    Gerard H Koppelman
    Department of Pulmonary Rehabilitation, Beatrixoord, Haren, The Netherlands
    J Allergy Clin Immunol 109:498-506. 2002
    ..Atopy is a phenotype associated with asthma that has a heritable component. However, the role of atopysusceptibility genes in the development and expression of asthma and allergic disorders is not understood...
  38. doi request reprint Pharmacogenomics and outcome of asthma: no clinical application for long-term steroid effects by CRHR1 polymorphisms
    Antoon Dijkstra
    J Allergy Clin Immunol 121:1510-3. 2008
  39. pmc Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 70:230-6. 2002
    ..0004). These data suggest that variations in IL4RA contribute to elevated total serum IgE levels, and interaction between IL4RA and IL13 markedly increases an individual's susceptibility to asthma...