Research Topics
| Miriam J KnolSummaryAffiliation: University Medical Center Utrecht Country: The Netherlands Publications
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Publications
Recommendations for presenting analyses of effect modification and interactionMirjam J Knol
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
Int J Epidemiol 41:514-20. 2012..The presentation can be further enriched when exposures have multiple categories. Our proposal hopefully encourages researchers to present effect modification and interaction analyses in as informative a manner as possible...
How to deal with measures of association: a short guide for the clinicianM J Knol
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Cerebrovasc Dis 33:98-103. 2012..By means of examples, we will discuss the different measures of association for the three main study designs used in clinical research: randomized controlled trial, observational cohort study and case-control study...
Potential misinterpretation of treatment effects due to use of odds ratios and logistic regression in randomized controlled trialsMirjam J Knol
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
PLoS ONE 6:e21248. 2011..This study determined the frequency of use of ORs, the frequency of overestimation of the OR as compared with its accompanying RR in published RCTs, and we assessed how often regression models that calculate RRs were used...
Estimating measures of interaction on an additive scale for preventive exposuresMirjam J Knol
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, GA, Utrecht, The Netherlands
Eur J Epidemiol 26:433-8. 2011..23; 0.49], AP = -0.29 [95%CI: -0.98; 0.40], S = 0.43 [95%CI: 0.07; 2.60]), all indicating negative interaction. Preventive factors should not be used to calculate measures of interaction on an additive scale without recoding...
Unpredictable bias when using the missing indicator method or complete case analysis for missing confounder values: an empirical exampleMirjam J Knol
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
J Clin Epidemiol 63:728-36. 2010..Using empirical data, we demonstrated the degree and direction of bias in the effect estimate when using these methods compared with multiple imputation (MI)...
Unexpected lower prevalence of depression in patients with diabetes: selection bias in a waiting room populationMiriam J Knol
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Epidemiology 20:419-23. 2009..We initially studied the association between diabetes and depression in general practice attendees. Subsequently, we investigated whether our findings were influenced by selection bias...
Antidepressant use before and after initiation of diabetes mellitus treatmentM J Knol
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Str 6 131, P O Box 85500, 3508 GA, Utrecht, The Netherlands
Diabetologia 52:425-32. 2009..We examined the temporal association between diabetes and depression by studying antidepressant and benzodiazepine use around the initiation of diabetes treatment...
When one depends on the other: reporting of interaction in case-control and cohort studiesMirjam J Knol
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands
Epidemiology 20:161-6. 2009..We did a survey of epidemiologic studies published in leading journals to examine how interaction is assessed and reported...
What do case-control studies estimate? Survey of methods and assumptions in published case-control researchMirjam J Knol
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
Am J Epidemiol 168:1073-81. 2008..At present, investigators conducting case-control studies rarely discuss what their odds ratios estimate...
Influence of antidepressants on glycaemic control in patients with diabetes mellitusM J Knol
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Pharmacoepidemiol Drug Saf 17:577-86. 2008..Anecdotal evidence suggests that antidepressants (ADs) may complicate glycaemic control. The objective of this longitudinal study was to investigate the influence of ADs on glycaemic control within diabetes patients...
No increased incidence of diabetes in antidepressant usersMirjam J Knol
Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
Int Clin Psychopharmacol 22:382-6. 2007..12-1.68) for AD and BD users compared with no AD and no BD users. We did not find an increased risk of diabetes in individuals using ADs. The association between BD use and diabetes was partly explained by chronic somatic comorbidity...
Estimating interaction on an additive scale between continuous determinants in a logistic regression modelMirjam J Knol
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
Int J Epidemiol 36:1111-8. 2007..The objective of the present study was to provide the methods to estimate interaction between continuous determinants and to illustrate these methods with a clinical example...
Depressive symptoms in subjects with diagnosed and undiagnosed type 2 diabetesMirjam J Knol
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
Psychosom Med 69:300-5. 2007..To investigate if disturbed glucose homeostasis or known diagnosis of diabetes was associated with depressive symptoms. The reason for the increased prevalence of depression in patients with Type 2 diabetes mellitus (DM2) is unknown...
Low bone mineral density in adult patients with moderate to severe atopic dermatitisI M Haeck
Department of Dermatology and Allergology, University Medical Center Utrecht, Inhouse postnumber G02 124, Utrecht, The Netherlands
Br J Dermatol 161:1248-54. 2009..Atopic dermatitis (AD) is a chronic inflammatory skin disease commonly treated with topical corticosteroids. The inflammatory nature of this disorder and the use of topical corticosteroids represent potential risk factors for bone loss...
Genetic variation in the renin-angiotensin system modifies the beneficial effects of ACE inhibitors on the risk of diabetes mellitus among hypertensivesO Bozkurt
Faculty of Science, Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
J Hum Hypertens 22:774-80. 2008....
Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysisM J Knol
Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
Diabetologia 49:837-45. 2006..A randomised controlled study is needed to test whether effective prevention or treatment of depression can reduce the incidence of type 2 diabetes and its health consequences...
Falls and gait disturbances in Huntington's diseaseYvette A M Grimbergen
Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
Mov Disord 23:970-6. 2008..These factors should be considered as future targets for therapies that aim to reduce falls in Huntington's disease...
