Affiliation: University Medical Center
Country: The Netherlands
- Klumperman J, Kuliawat R, Griffith J, Geuze H, Arvan P. Mannose 6-phosphate receptors are sorted from immature secretory granules via adaptor protein AP-1, clathrin, and syntaxin 6-positive vesicles. J Cell Biol. 1998;141:359-71 pubmed..Thus, we hypothesize that during secretory granule maturation, MPR-ligand complexes and syntaxin 6 are removed from IGs by AP-1/clathrin-coated vesicles, and then delivered to endosomes. ..
- Klumperman J. Transport between ER and Golgi. Curr Opin Cell Biol. 2000;12:445-9 pubmed..The anterograde membrane flow is compensated for by a retrograde pathway, which, in addition to the recycling of membrane and proteins to the endoplasmic reticulum, may play a role in anterograde cargo concentration. ..