Judith Klumperman

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc Imaging and imagination: understanding the endo-lysosomal system
    Eline van Meel
    Cell Microscopy Center, Department of Cell Biology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Histochem Cell Biol 129:253-66. 2008
  2. doi request reprint hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins
    Maaike S Pols
    Department of Cell Biology, University Medical Centre Utrecht, AZU Room H02 313, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands
    Nat Commun 4:1361. 2013
  3. ncbi request reprint Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments
    Marloes Réchards
    Cell Microscopy Center, Department of Cell Biology, University Medical Center and Institute for Biomembranes, 3584 CX Utrecht, The Netherlands
    Traffic 7:354-64. 2006
  4. doi request reprint The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion
    Maaike S Pols
    Department of Cell Biology, University Medical Center Utrecht, Heidelberglaan 100, 3584, CX Utrecht, The Netherlands
    Traffic 14:219-32. 2013
  5. ncbi request reprint SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors
    Muriel Mari
    Cell Microscopy Center, Department of Cell Biology, Institute of Biomembranes, University Medical Centre UMC Utrecht, AZU Rm G02 525, 3584 CX Utrecht, The Netherlands
    Traffic 9:380-93. 2008
  6. ncbi request reprint Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes
    Marloes Réchards
    Department of Cell Biology, University Medical Center and Institute for Biomembranes, Center for Biomedical Genetics, Utrecht University, 3584 CX Utrecht, The Netherlands
    Traffic 4:553-65. 2003
  7. ncbi request reprint Immuno-electron tomography of ER exit sites reveals the existence of free COPII-coated transport carriers
    Dagmar Zeuschner
    Department of Cell Biology, Institute of Biomembranes, UMC Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Nat Cell Biol 8:377-83. 2006
  8. ncbi request reprint ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles
    Martin Sachse
    Department of Cell Biology, University Medical Center and Institute for Biomembranes, 3584 CX Utrecht, The Netherlands
    J Cell Sci 117:1699-708. 2004
  9. ncbi request reprint Glycosylation is important for cell surface expression of the water channel aquaporin-2 but is not essential for tetramerization in the endoplasmic reticulum
    Giel Hendriks
    Department of Cell Biology, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands
    J Biol Chem 279:2975-83. 2004
  10. ncbi request reprint Rab4 function in membrane recycling from early endosomes depends on a membrane to cytoplasm cycle
    Karin Mohrmann
    Department of Cell Biology, University Medical Center Utrecht and Institute of Biomembranes, Utrecht 3584 CX, The Netherlands
    J Biol Chem 277:32029-35. 2002

Collaborators

  • Ger J Strous
  • Dennis J Selkoe
  • Minoru Fukuda
  • Satyajit Mayor
  • Haibo Zhao
  • Sylvie Urbé
  • Stefana M Petrescu
  • Heidi de Wit
  • Peter M T Deen
  • Catherine Rabouille
  • Johannes L Bos
  • Holger Rehmann
  • F Patrick Ross
  • Viola Oorschot
  • Maaike S Pols
  • Eline van Meel
  • Marloes Réchards
  • Martin Sachse
  • Dagmar Zeuschner
  • Peter van der Sluijs
  • Corlinda Ten Brink
  • Gerco Hassink
  • Viorica Ivan
  • Muriel Mari
  • Carolien van Rijnsoever
  • Nadia Dubé
  • Ann De Mazière
  • Willie J C Geerts
  • Suzanne van Dijk
  • Weiming Xia
  • Giel Hendriks
  • Karin Mohrmann
  • Prajakta Gosavi
  • M G Swetha
  • Davide Monteferrario
  • Livia E Sima
  • Peter van Kerkhof
  • Emma Martinez-Sanchez
  • Sylvie M Noordermeer
  • Bert A van der Reijden
  • Johan Slotman
  • Stuart Kornfeld
  • Marielle Boonen
  • Matthijs R H Kooistra
  • Marjolein J Vliem
  • Miriam V Bujny
  • Claus M Petersen
  • Leon Parker
  • Weilan Ye
  • Janice Griffith
  • Willem Jan Pannekoek
  • Pete J Cullen
  • Hans J Geuze
  • Bruno M Humbel
  • Elly van Donselaar
  • Jan W Slot
  • Willem Annaert
  • Abraham J Koster
  • Bas W M van Balkom
  • Marco Koudijs
  • Viola M J Oorschot
  • Lisya Gerez
  • Wim G Annaert

Detail Information

Publications20

  1. pmc Imaging and imagination: understanding the endo-lysosomal system
    Eline van Meel
    Cell Microscopy Center, Department of Cell Biology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Histochem Cell Biol 129:253-66. 2008
    ..Throughout our review, we highlight some examples in the literature showing how imaging, especially electron microscopy, has made major contributions to our understanding of the endo-lysosomal system today...
  2. doi request reprint hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins
    Maaike S Pols
    Department of Cell Biology, University Medical Centre Utrecht, AZU Room H02 313, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands
    Nat Commun 4:1361. 2013
    ....
  3. ncbi request reprint Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments
    Marloes Réchards
    Cell Microscopy Center, Department of Cell Biology, University Medical Center and Institute for Biomembranes, 3584 CX Utrecht, The Netherlands
    Traffic 7:354-64. 2006
    ..Malfunctioning of PS-1 in this role may have important consequences for the progress of AD...
  4. doi request reprint The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion
    Maaike S Pols
    Department of Cell Biology, University Medical Center Utrecht, Heidelberglaan 100, 3584, CX Utrecht, The Netherlands
    Traffic 14:219-32. 2013
    ..Thus, our data show that both hVps41 and hVps39 are required for late endosomal-lysosomal fusion events and the delivery of endocytic cargo to lysosomes in human cells...
  5. ncbi request reprint SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors
    Muriel Mari
    Cell Microscopy Center, Department of Cell Biology, Institute of Biomembranes, University Medical Centre UMC Utrecht, AZU Rm G02 525, 3584 CX Utrecht, The Netherlands
    Traffic 9:380-93. 2008
    ..Our data emphasize an important role of EEs in recycling to the TGN and indicate that different, specialized exit events occur on the same EE vacuole...
  6. ncbi request reprint Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes
    Marloes Réchards
    Department of Cell Biology, University Medical Center and Institute for Biomembranes, Center for Biomedical Genetics, Utrecht University, 3584 CX Utrecht, The Netherlands
    Traffic 4:553-65. 2003
    ....
  7. ncbi request reprint Immuno-electron tomography of ER exit sites reveals the existence of free COPII-coated transport carriers
    Dagmar Zeuschner
    Department of Cell Biology, Institute of Biomembranes, UMC Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Nat Cell Biol 8:377-83. 2006
    ..Our studies unambiguously establish the existence of free, bona fide COPII-coated transport carriers at the ER-Golgi interface, suggesting that assembly of COPII coats in vivo can result in vesicle formation...
  8. ncbi request reprint ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles
    Martin Sachse
    Department of Cell Biology, University Medical Center and Institute for Biomembranes, 3584 CX Utrecht, The Netherlands
    J Cell Sci 117:1699-708. 2004
    ..Moreover, our data suggest that disassembly of the coat is required for the formation of internal vesicles...
  9. ncbi request reprint Glycosylation is important for cell surface expression of the water channel aquaporin-2 but is not essential for tetramerization in the endoplasmic reticulum
    Giel Hendriks
    Department of Cell Biology, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands
    J Biol Chem 279:2975-83. 2004
    ..These results are important for understanding the molecular mechanisms responsible for the intracellular retention of AQP2 in nephrogenic diabetes insipidus...
  10. ncbi request reprint Rab4 function in membrane recycling from early endosomes depends on a membrane to cytoplasm cycle
    Karin Mohrmann
    Department of Cell Biology, University Medical Center Utrecht and Institute of Biomembranes, Utrecht 3584 CX, The Netherlands
    J Biol Chem 277:32029-35. 2002
    ..We show here, using a rab4 construct that is permanently hooked onto membranes, that the membrane-bound pool of rab4 is targeted by a mitotic kinase...
  11. pmc Disruption of the Man-6-P targeting pathway in mice impairs osteoclast secretory lysosome biogenesis
    Eline van Meel
    Department of Cell Biology, University Medical Center, Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Traffic 12:912-24. 2011
    ..However, cathepsin D targeting was intact, showing that osteoclasts have a Man-6-P-independent pathway for selected acid hydrolases...
  12. ncbi request reprint Opinion: The maturing role of COPI vesicles in intra-Golgi transport
    Catherine Rabouille
    The Cell Microscopy Center, Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Nat Rev Mol Cell Biol 6:812-7. 2005
    ..Recently, their role has been challenged again, and we discuss new data that both confirm and modify our view of these carriers...
  13. doi request reprint Correlative light-electron microscopy (CLEM) combining live-cell imaging and immunolabeling of ultrathin cryosections
    Carolien van Rijnsoever
    Cell Microscopy Center, Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Nat Methods 5:973-80. 2008
  14. pmc Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport
    Gerco Hassink
    Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    Biol Open 1:607-14. 2012
    ..The endosomes display prominent clathrin coats and show increased levels of growth hormone label. We conclude that Triad1 is required for the proper function of multivesicular bodies...
  15. pmc AP-3 and Rabip4' coordinately regulate spatial distribution of lysosomes
    Viorica Ivan
    Department of Cell Biology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e48142. 2012
    ..The most peripheral lysosomes were localized beyond microtubules, within the cortical actin network. Our results uncover a novel function for AP-3 and rabip4' in regulating lysosome positioning through an interorganellar pathway...
  16. doi request reprint Trafficking and function of the tetraspanin CD63
    Maaike S Pols
    Cell Microscopy Center, Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    Exp Cell Res 315:1584-92. 2009
    ..In this review we discuss the latest insights in CD63 trafficking and its emerging function as a transport regulator of its interaction partners. Finally, the involvement of CD63 in cancer will be discussed...
  17. doi request reprint The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions
    Nadia Dubé
    Department of Physiological Chemistry, Centre for Biomedical Genetics and Cancer Genomics Centre, Utrecht, The Netherlands
    Cell Signal 20:1608-15. 2008
    ..Our results present the first direct evidence that PDZ-GEF2 plays a critical role in the maturation of adherens junctions...
  18. doi request reprint Egfl7 knockdown causes defects in the extension and junctional arrangements of endothelial cells during zebrafish vasculogenesis
    Ann De Mazière
    Cell Microscopy Center, Department of Cell Biology, University Medical Center Utrecht and Institute for Biomembranes, Utrecht, Netherlands
    Dev Dyn 237:580-91. 2008
    ..These data suggest that Egfl7 provides ECs with a cue for their extension into the vascular area and in establishing EC cell polarity...
  19. ncbi request reprint A novel flat-embedding method to prepare ultrathin cryosections from cultured cells in their in situ orientation
    Viola Oorschot
    Department of Cell Biology and Institute for Biomembranes, University Medical Center, Utrecht, The Netherlands
    J Histochem Cytochem 50:1067-80. 2002
    ..Subsequently, sections can be prepared in parallel or perpendicular to the plane of growth. Our method extends the cryosectioning technique to applications in studying polarized cells and correlative light-electron microscopy...
  20. pmc Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes
    Martin Sachse
    Department of Cell Biology, University Medical Center Utrecht and Institute of Biomembranes, 3584 CX Utrecht, The Netherlands
    Mol Biol Cell 13:1313-28. 2002
    ..Together, these data suggest a role for the bilayered clathrin coat on vacuolar endosomes in targeting of proteins to lysosomes...