Genomes and Genes


J L Kluiver


Affiliation: University Medical Center Groningen
Country: The Netherlands


  1. Kluiver J, Gibcus J, Hettinga C, Adema A, Richter M, Halsema N, et al. Rapid generation of microRNA sponges for microRNA inhibition. PLoS ONE. 2012;7:e29275 pubmed publisher
    ..In conclusion, we describe and validate a method to rapidly generate miRNA sponges for miRNA loss-of-function studies. ..
  2. Kluiver J, Slezak Prochazka I, Smigielska Czepiel K, Halsema N, Kroesen B, van den Berg A. Generation of miRNA sponge constructs. Methods. 2012;58:113-7 pubmed publisher
    ..In summary, our approach allows rapid generation of single or combination miRNA sponges that can be used for long-term miRNA loss-of-function studies. ..
  3. Winkle M, van den Berg A, Tayari M, Sietzema J, Terpstra M, Kortman G, et al. Long noncoding RNAs as a novel component of the Myc transcriptional network. FASEB J. 2015;29:2338-46 pubmed publisher
    ..This study is the first to show that lncRNAs are an important factor within the Myc-regulated transcriptional program and indicates a marked difference between Myc-repressed lncRNAs and mRNAs. ..
  4. Tayari M, Winkle M, Kortman G, Sietzema J, de Jong D, Terpstra M, et al. Long Noncoding RNA Expression Profiling in Normal B-Cell Subsets and Hodgkin Lymphoma Reveals Hodgkin and Reed-Sternberg Cell-Specific Long Noncoding RNAs. Am J Pathol. 2016;186:2462-72 pubmed publisher
    ..Three lncRNAs showed a tumor cell-specific expression pattern in HL tissues and might therefore be of value as a biomarker. ..
  5. Li J, Kluiver J, Osinga J, Westers H, van Werkhoven M, Seelen M, et al. Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell Carcinoma. Neoplasia. 2016;18:339-46 pubmed publisher
    ..Our results indicate that SETD2 inactivation enables PTECs to bypass the senescence barrier, facilitating a malignant transformation toward ccRCC. ..