Frans M Klis

Summary

Affiliation: University of Amsterdam
Country: The Netherlands

Publications

  1. ncbi request reprint Cell wall construction in Saccharomyces cerevisiae
    Frans M Klis
    Swammerdam Institute for Life Sciences, University of Amsterdam, BioCentrum Amsterdam, The Netherlands
    Yeast 23:185-202. 2006
  2. ncbi request reprint Trends and highlights in Candida research. The 8th ASM Conference about Candida and Candidiasis, Denver (Colorado, USA), 13-17 March 2006
    Frans M Klis
    Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
    FEMS Yeast Res 6:667-8. 2006
  3. ncbi request reprint Extraction of cell surface-associated proteins from living yeast cells
    Frans M Klis
    Swammerdam Institute for Life Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    Yeast 24:253-8. 2007
  4. doi request reprint A mass spectrometric view of the fungal wall proteome
    Frans M Klis
    Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
    Future Microbiol 6:941-51. 2011
  5. doi request reprint Covalently linked wall proteins in ascomycetous fungi
    Frans M Klis
    Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
    Yeast 27:489-93. 2010
  6. doi request reprint Covalently linked cell wall proteins of Candida albicans and their role in fitness and virulence
    Frans M Klis
    Swammerdam Institute for Life Sciences, University of Amsterdam, 1018 WV Amsterdam, The Netherlands
    FEMS Yeast Res 9:1013-28. 2009
  7. doi request reprint Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions
    Grazyna J Sosinska
    Swammerdam Institute for Life Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV, Amsterdam, The Netherlands
    Microbiology 154:510-20. 2008
  8. pmc The cell wall of the human pathogen Candida glabrata: differential incorporation of novel adhesin-like wall proteins
    Piet W J De Groot
    Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    Eukaryot Cell 7:1951-64. 2008
  9. ncbi request reprint Mass spectrometric identification of covalently bound cell wall proteins from the fission yeast Schizosaccharomyces pombe
    Piet W J De Groot
    SILS Biomolecular Mass Spectrometry, University of Amsterdam, The Netherlands
    Yeast 24:267-78. 2007
  10. pmc Surface stress induces a conserved cell wall stress response in the pathogenic fungus Candida albicans
    Clemens J Heilmann
    Department of Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    Eukaryot Cell 12:254-64. 2013

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Cell wall construction in Saccharomyces cerevisiae
    Frans M Klis
    Swammerdam Institute for Life Sciences, University of Amsterdam, BioCentrum Amsterdam, The Netherlands
    Yeast 23:185-202. 2006
    ..Finally, we use both biochemical and genomic data to infer that the architectural principles used by S. cerevisiae to build its cell wall are also used by many other ascomycetous yeasts and also by some mycelial ascomycetous fungi...
  2. ncbi request reprint Trends and highlights in Candida research. The 8th ASM Conference about Candida and Candidiasis, Denver (Colorado, USA), 13-17 March 2006
    Frans M Klis
    Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
    FEMS Yeast Res 6:667-8. 2006
  3. ncbi request reprint Extraction of cell surface-associated proteins from living yeast cells
    Frans M Klis
    Swammerdam Institute for Life Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    Yeast 24:253-8. 2007
    ..Similarly, biotinylation of cell surface proteins should be carried out at low temperatures in the absence of dimethylsulphoxide...
  4. doi request reprint A mass spectrometric view of the fungal wall proteome
    Frans M Klis
    Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
    Future Microbiol 6:941-51. 2011
    ..The wall proteome of the opportunistic human pathogen Candida albicans amply illustrates these properties. Finally, we discuss the relevance of our insights for the identification of new vaccine candidates...
  5. doi request reprint Covalently linked wall proteins in ascomycetous fungi
    Frans M Klis
    Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
    Yeast 27:489-93. 2010
    ..We also discuss the hybrid nature of many wall proteins and the frequent occurrence of families of wall proteins with a common multi-domain structure. Finally, some quantitative data regarding wall proteins are presented...
  6. doi request reprint Covalently linked cell wall proteins of Candida albicans and their role in fitness and virulence
    Frans M Klis
    Swammerdam Institute for Life Sciences, University of Amsterdam, 1018 WV Amsterdam, The Netherlands
    FEMS Yeast Res 9:1013-28. 2009
    ..We conclude that covalently linked CWPs of C. albicans play a crucial role in fitness and virulence and that their expression is tightly controlled...
  7. doi request reprint Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions
    Grazyna J Sosinska
    Swammerdam Institute for Life Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV, Amsterdam, The Netherlands
    Microbiology 154:510-20. 2008
    ..Addition of the iron chelator ferrozine at saturating levels of O(2) resulted in higher cell wall levels of Hwp1 and Rbt5, suggesting that the responses to hypoxic conditions and iron restriction are related...
  8. pmc The cell wall of the human pathogen Candida glabrata: differential incorporation of novel adhesin-like wall proteins
    Piet W J De Groot
    Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    Eukaryot Cell 7:1951-64. 2008
    ..We propose that the large repertoire of adhesin(-like) genes of C. glabrata contributes to its adaptability and virulence...
  9. ncbi request reprint Mass spectrometric identification of covalently bound cell wall proteins from the fission yeast Schizosaccharomyces pombe
    Piet W J De Groot
    SILS Biomolecular Mass Spectrometry, University of Amsterdam, The Netherlands
    Yeast 24:267-78. 2007
    ..cerevisiae and Candida albicans, the amount of carbohydrate added to the proteins was found to be two- to three-fold decreased, consistent with earlier reported differences in outer chain N-glycosylation...
  10. pmc Surface stress induces a conserved cell wall stress response in the pathogenic fungus Candida albicans
    Clemens J Heilmann
    Department of Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    Eukaryot Cell 12:254-64. 2013
    ..We propose that surface stresses lead to a conserved cell wall remodeling response that is mainly governed by Mkc1 and is characterized by chitin reinforcement of the wall and the expression of remedial wall remodeling enzymes...
  11. ncbi request reprint Characterization of the transcriptional response to cell wall stress in Saccharomyces cerevisiae
    Andre Boorsma
    Swammerdam Institute for Life Sciences Microbiology, University of Amsterdam, BioCentrum Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    Yeast 21:413-27. 2004
    ..Taken together, our data indicate that cell wall stress results in activation of various signalling pathways including the cell wall integrity pathway...
  12. doi request reprint Hyphal induction in the human fungal pathogen Candida albicans reveals a characteristic wall protein profile
    Clemens J Heilmann
    Swammerdam Institute for Life Sciences, Universiteit van Amsterdam, Science Park 904, 1098XH Amsterdam, The Netherlands
    Microbiology 157:2297-307. 2011
    ..This is, to our knowledge, the first systematic, quantitative analysis of the changes in the wall proteome of C. albicans upon hyphal induction. Finally, we propose new wall-protein-derived candidates for vaccine development...
  13. ncbi request reprint Comprehensive proteomic analysis of Saccharomyces cerevisiae cell walls: identification of proteins covalently attached via glycosylphosphatidylinositol remnants or mild alkali-sensitive linkages
    Qing Yuan Yin
    Laboratory for Mass Spectrometry of Biomacromolecules, Swammerdam Institute for Life Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    J Biol Chem 280:20894-901. 2005
    ..Therefore, it will probably be equally effective in many other fungi...
  14. pmc Role of cell cycle-regulated expression in the localized incorporation of cell wall proteins in yeast
    Gertien J Smits
    Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, 1018 WV Amsterdam, The Netherlands
    Mol Biol Cell 17:3267-80. 2006
    ..Studies of mutants in which septum formation is perturbed indicate that the normal asymmetric localization of Cwp1p also depends on the normal timing of septum formation, composition of the septum, or both...
  15. doi request reprint Beyond the wall: Candida albicans secret(e)s to survive
    Alice G Sorgo
    Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    FEMS Microbiol Lett 338:10-7. 2013
    ..Overall, we discuss the importance of the secretome for virulence and suggest potential targets for better and faster diagnostic methods...
  16. pmc Inferring condition-specific modulation of transcription factor activity in yeast through regulon-based analysis of genomewide expression
    Andre Boorsma
    Swammerdam Institute for Life Sciences, University of Amsterdam, BioCentrum Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 3:e3112. 2008
    ....
  17. doi request reprint Mass spectrometric quantification of the adaptations in the wall proteome of Candida albicans in response to ambient pH
    Grazyna J Sosinska
    Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
    Microbiology 157:136-46. 2011
    ..These results demonstrate that ambient pH strongly affects the wall proteome of C. albicans, show that our quantitative approach can give detailed insights into the dynamics of the wall proteome, and point to potential vaccine targets...
  18. pmc Proteomic analysis of Candida albicans cell walls reveals covalently bound carbohydrate-active enzymes and adhesins
    Piet W J De Groot
    Swammerdam Institute for Life Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    Eukaryot Cell 3:955-65. 2004
    ..3p, Pir1p, Pga29p, Rbt5p, and Ssr1p) are unknown. These results indicate that a substantial number of the covalently linked CWPs of C. albicans are actively involved in cell wall remodeling and expansion and in host-pathogen interactions...
  19. pmc Mass spectrometric quantitation of covalently bound cell wall proteins in Saccharomyces cerevisiae
    Qing Yuan Yin
    Laboratory for Biomacromolecular Mass Spectrometry, Swammerdam Institute for Life Sciences, University of Amsterdam, WV Amsterdam, The Netherlands
    FEMS Yeast Res 7:887-96. 2007
    ..The levels of Crh1p, Crh2p, Ecm33p, Gas5p, Pst1p and Pir3p increased about three- to fivefold, whereas the level of Scw4p was significantly decreased. We propose that our methods are widely applicable to other fungi...
  20. ncbi request reprint Comprehensive genomic analysis of cell wall genes in Aspergillus nidulans
    Piet W J De Groot
    Swammerdam Institute for Life Sciences, University of Amsterdam, Nieuwe Achtegracht 166, 1018 WV Amsterdam, The Netherlands
    Fungal Genet Biol 46:S72-81. 2009
    ..nidulans, including ten predicted GPI proteins, most of which belong to carbohydrate-active enzyme families that are also found in the walls of ascomycetous yeasts...
  21. doi request reprint Mass spectrometric analysis of the secretome of Candida albicans
    Alice G Sorgo
    Swammerdam Institute for Life Sciences, Universiteit van Amsterdam, Nieuwe Achtergracht 166, 1018WV Amsterdam, The Netherlands
    Yeast 27:661-72. 2010
    ..In summary, the number of identified secretory proteins in the growth medium has been substantially extended, and growth conditions strongly affect the composition of the secretome...
  22. doi request reprint Comparative analysis of transcriptome and fitness profiles reveals general and condition-specific cellular functions involved in adaptation to environmental change in Saccharomyces cerevisiae
    Anna Zakrzewska
    Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, Netherlands Institute for Systems Biology, University of Amsterdam, Amsterdam, The Netherlands
    OMICS 14:603-14. 2010
    ..Finally, we discuss the implications of our results for combinatorial drug design...
  23. ncbi request reprint Mass spectrometry-based proteomics of fungal wall glycoproteins
    Qing Yuan Yin
    Swammerdam Institute for Life Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    Trends Microbiol 16:20-6. 2008
    ....
  24. ncbi request reprint Genome-wide identification of fungal GPI proteins
    Piet W J De Groot
    Laboratory for Microbiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    Yeast 20:781-96. 2003
    ..pombe and N. crassa are homologous to known or putative GPI proteins from other fungi. We conclude that our algorithm is selective and can also be used for GPI protein identification in other fungi...
  25. pmc Activation of the protein kinase C1 pathway upon continuous heat stress in Saccharomyces cerevisiae is triggered by an intracellular increase in osmolarity due to trehalose accumulation
    Femke I C Mensonides
    Swammerdam Institute of Life Sciences, Department of Molecular Microbial Physiology, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    Appl Environ Microbiol 71:4531-8. 2005
    ....
  26. ncbi request reprint Features and functions of covalently linked proteins in fungal cell walls
    Piet W J De Groot
    Swammerdam Institute for Life Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    Fungal Genet Biol 42:657-75. 2005
    ..We present evidence that the cell wall of mycelial species of the Ascomycotina is similarly organized and contains glycoproteins with comparable functions...
  27. doi request reprint The conserved PA14 domain of cell wall-associated fungal adhesins governs their glycan-binding specificity
    Piet W J De Groot
    Swammerdam Institute for Life Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV, Amsterdam, The Netherlands
    Mol Microbiol 68:535-7. 2008
    ....
  28. ncbi request reprint An in vitro assay for (1 --> 6)-beta-D-glucan synthesis in Saccharomyces cerevisiae
    Edwin Vink
    Swammerdaam Institute for Life Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    Yeast 21:1121-31. 2004
    ..Extracts from rho2, rho3, rho4 and rho5 null mutants had wild-type in vitro activity. In contrast, Rho1p overproduction led to increased in vitro synthesis, implicating Rho1p in the regulation of (1 --> 6)-beta-D-glucan synthesis...
  29. pmc Cellular processes and pathways that protect Saccharomyces cerevisiae cells against the plasma membrane-perturbing compound chitosan
    Anna Zakrzewska
    Molecular Microbial Physiology, Swammerdam Institute of Life Sciences, Nieuwe Achtergracht 166, 1018WV Amsterdam, The Netherlands
    Eukaryot Cell 6:600-8. 2007
    ..We propose that global fitness analysis of yeast in combination with T-profiler is a powerful tool to identify specific cellular processes and pathways that are required for survival under stress conditions...
  30. pmc Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans
    Alice G Sorgo
    Swammerdam Institute for Life Sciences, Universiteit van Amsterdam, Science Park 904, 1098 XH Amsterdam, Netherlands
    Eukaryot Cell 10:1071-81. 2011
    ..We also present candidate proteins from the secretome for clinical marker development...
  31. doi request reprint Iron restriction-induced adaptations in the wall proteome of Candida albicans
    Alice G Sorgo
    Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
    Microbiology 159:1673-82. 2013
    ..Strikingly, peptides derived from the CFEM domain of the haem-binding proteins Csa1, Pga10 and Rbt5 were capable of forming iron adduct ions during MS analysis, consistent with a key role of this domain in haem binding. ..
  32. ncbi request reprint The protein kinase Kic1 affects 1,6-beta-glucan levels in the cell wall of Saccharomyces cerevisiae
    Edwin Vink
    Swammerdam Institute for Life Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV, Amsterdam, The Netherlands
    Microbiology 148:4035-48. 2002
    ..It is proposed that Kic1 affects cell wall construction in multiple ways and in particular in regulating 1,6-beta-glucan levels in the wall...
  33. pmc Transcriptional response of Saccharomyces cerevisiae to the plasma membrane-perturbing compound chitosan
    Anna Zakrzewska
    Molecular Microbial Physiology and Molecular Biology and Microbial Food Safety, Swammerdam Institute of Life Sciences, Amsterdam, The Netherlands
    Eukaryot Cell 4:703-15. 2005
    ..We propose that the transcriptional response to chitosan may be representative of other plasma membrane-perturbing compounds...
  34. ncbi request reprint Dynamics of cell wall structure in Saccharomyces cerevisiae
    Frans M Klis
    Swammerdam Institute for Life Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    FEMS Microbiol Rev 26:239-56. 2002
    ..Finally, some potential targets for new antifungal compounds related to cell wall construction are discussed...
  35. doi request reprint Cell Wall-Related Bionumbers and Bioestimates of Saccharomyces cerevisiae and Candida albicans
    Frans M Klis
    Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    Eukaryot Cell 13:2-9. 2014
    ..Finally, we propose that the numbers and estimates described here offer a solid starting point for similar studies of other cell compartments and other yeast species. ..
  36. ncbi request reprint The Aspergillus niger MADS-box transcription factor RlmA is required for cell wall reinforcement in response to cell wall stress
    Robbert A Damveld
    Institute of Biology, Leiden University, Clusius Laboratory, Fungal Genetics Research Group, Wassenaarseweg 64, 2333 AL, Leiden, The Netherlands
    Mol Microbiol 58:305-19. 2005
    ..We propose that such a cell wall salvage mechanism is wide spread in filamentous fungi...
  37. ncbi request reprint Characterisation of CwpA, a putative glycosylphosphatidylinositol-anchored cell wall mannoprotein in the filamentous fungus Aspergillus niger
    Robbert A Damveld
    Institute of Biology, Clusius Laboratory, Leiden University, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
    Fungal Genet Biol 42:873-85. 2005
    ..A CwpA-specific antiserum was raised and in combination with fractionation experiments, we show that this protein was abundantly present as an HF-extractable protein in the cell wall of A. niger...
  38. ncbi request reprint The CRH family coding for cell wall glycosylphosphatidylinositol proteins with a predicted transglycosidase domain affects cell wall organization and virulence of Candida albicans
    Giacomo Pardini
    Institute of Microbiology, University Hospital Lausanne, CH 1011 Lausanne, Switzerland
    J Biol Chem 281:40399-411. 2006
    ..In conclusion, this work establishes the role of UTR2, CRH11, and CRH12 in cell wall organization and integrity...
  39. ncbi request reprint Systematic identification in silico of covalently bound cell wall proteins and analysis of protein-polysaccharide linkages of the human pathogen Candida glabrata
    Michael Weig
    Institute of Medical Microbiology and National Reference Center for Systemic Mycoses, University of Gottingen, Germany
    Microbiology 150:3129-44. 2004
    ..Immunological analysis of mild-alkali-extracted CWPs showed the presence of a ScPir2p homologue. Together, these experimental data and in silico predictions represent the first systematic analysis of the C. glabrata cell wall proteome...
  40. ncbi request reprint Expression of agsA, one of five 1,3-alpha-D-glucan synthase-encoding genes in Aspergillus niger, is induced in response to cell wall stress
    Robbert A Damveld
    Clusius Laboratory, Institute of Biology, Leiden University, Wassenaarseweg 64, 2333 AL, Leiden, The Netherlands
    Fungal Genet Biol 42:165-77. 2005
    ..niger, but was also observed in Penicillium chrysogenum. We propose that this response to cell wall stress commonly occurs in filamentous fungi...
  41. pmc A novel screening method for cell wall mutants in Aspergillus niger identifies UDP-galactopyranose mutase as an important protein in fungal cell wall biosynthesis
    Robbert A Damveld
    Institute of Biology Leiden, Leiden University, Molecular Microbiology, Leiden, The Netherlands
    Genetics 178:873-81. 2008
    ..Our results indicate that galactofuranose formation is important for fungal cell wall biosynthesis and represents an attractive target for the development of antifungals...
  42. ncbi request reprint Flocculation, adhesion and biofilm formation in yeasts
    Kevin J Verstrepen
    Harvard University Bauer Center for Genomics Research, 7 Divinity Avenue, Room 104, Cambridge, MA 02138, USA
    Mol Microbiol 60:5-15. 2006
    ..These aspects of fungal adhesion exemplify the impressive phenotypic plasticity of yeasts, allowing them to adapt quickly to stressful environments and exploit new opportunities...
  43. ncbi request reprint Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
    Herman J Pel
    DSM Food Specialties, PO Box 1, 2600 MA Delft, The Netherlands
    Nat Biotechnol 25:221-31. 2007
    ..niger. Noteworthy is the large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors, and the presence of putative gene clusters for fumonisin and ochratoxin A synthesis...
  44. ncbi request reprint The cell wall stress response in Aspergillus niger involves increased expression of the glutamine : fructose-6-phosphate amidotransferase-encoding gene (gfaA) and increased deposition of chitin in the cell wall
    Arthur F J Ram
    Institute of Biology, Leiden University, Clusius Laboratory, Fungal Genetics Research Group, Wassenaarseweg 64, 2333 AL, Leiden, The Netherlands
    Microbiology 150:3315-26. 2004
    ..These observations suggest that cell wall stress in fungi may generally lead to activation of the chitin biosynthetic pathway...
  45. ncbi request reprint The structure of cell wall alpha-glucan from fission yeast
    Christian H Grün
    Bijvoet Center, Department of Bio Organic Chemistry, Section of Glycoscience and Biocatalysis, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Glycobiology 15:245-57. 2005
    ..This mature form of cell wall alpha-glucan is essential for fission-yeast morphogenesis...
  46. ncbi request reprint Identification of cell wall-associated proteins from Phytophthora ramorum
    Harold J G Meijer
    Laboratory of Phytopathology, Plant Sciences Group, Wageningen University, Binnenhaven 5, NL 6709 PD Wageningen, The Netherlands
    Mol Plant Microbe Interact 19:1348-58. 2006
    ..We propose that the cell wall proteins thus identified are important for pathogenicity...
  47. ncbi request reprint Identification of fungal cell wall mutants using susceptibility assays based on Calcofluor white and Congo red
    Arthur F J Ram
    Institute of Biology Leiden, Leiden University, Molecular Microbiology, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
    Nat Protoc 1:2253-6. 2006
    ..The protocol can be completed in 4-6 h (excluding the incubation time required for fungal growth)...