Catharina J M Klijn

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi request reprint [Effectiveness of endarterectomy for symptomatic stenosis of the internal carotid artery; more risk factors important than only the severity of the stenosis]
    C J M Klijn
    afd Neurologie, Universitair Medisch Centrum Utrecht, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 151:2770-5. 2007
  2. doi request reprint Haemodynamic stroke: clinical features, prognosis, and management
    Catharina J M Klijn
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands
    Lancet Neurol 9:1008-17. 2010
  3. doi request reprint The risk of aneurysmal subarachnoid hemorrhage during pregnancy, delivery, and the puerperium in the Utrecht population: case-crossover study and standardized incidence ratio estimation
    Andreas T Tiel Groenestege
    Department of Neurology, G03 225, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 40:1148-51. 2009
  4. doi request reprint Diagnosing cerebral collateral flow patterns: accuracy of non-invasive testing
    Jeroen Hendrikse
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 25:430-7. 2008
  5. doi request reprint Limb-shaking transient ischaemic attacks in patients with internal carotid artery occlusion: a case-control study
    Suzanne Persoon
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Brain 133:915-22. 2010
  6. ncbi request reprint Prevalence and volume of internal border zone lesions in patients with impaired cerebral carbon dioxide vasomotor reactivity: a follow-up study
    Robertus H C Bisschops
    Department of Radiology, University Medical Center, Utrecht, The Netherlands
    Arch Neurol 60:1233-6. 2003
  7. ncbi request reprint Cognitive impairment is related to cerebral lactate in patients with carotid artery occlusion and ipsilateral transient ischemic attacks
    Floor C Bakker
    Department of Neurology, University Medical Center Utrecht, PO Box 85090, 3508 AB Utrecht, The Netherlands
    Stroke 34:1419-24. 2003
  8. ncbi request reprint Symptomatic carotid artery occlusion: flow territories of major brain-feeding arteries
    Peter Jan van Laar
    Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Radiology 242:526-34. 2007
  9. ncbi request reprint Spect measurements of regional cerebral perfusion and carbondioxide reactivity: correlation with cerebral collaterals in internal carotid artery occlusive disease
    Michiel J de Boorder
    Department of Radiology, University Medical Center, Utrecht, The Netherlands
    J Neurol 253:1285-91. 2006
  10. pmc Bilateral carotid artery occlusion with transient or moderately disabling ischaemic stroke: clinical features and long-term outcome
    Suzanne Persoon
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, G03 228, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    J Neurol 256:1728-35. 2009

Collaborators

Detail Information

Publications46

  1. ncbi request reprint [Effectiveness of endarterectomy for symptomatic stenosis of the internal carotid artery; more risk factors important than only the severity of the stenosis]
    C J M Klijn
    afd Neurologie, Universitair Medisch Centrum Utrecht, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 151:2770-5. 2007
    ..This is based on 5 factors: sex, age, the most severe symptom in the last 6 months (stroke, TIA, or ischaemic retinopathy), the number of weeks since the last incident and the morphological characteristics of the plaque...
  2. doi request reprint Haemodynamic stroke: clinical features, prognosis, and management
    Catharina J M Klijn
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands
    Lancet Neurol 9:1008-17. 2010
    ..Further research is needed to define criteria for the diagnosis of haemodynamic stroke and to investigate treatment options in controlled studies...
  3. doi request reprint The risk of aneurysmal subarachnoid hemorrhage during pregnancy, delivery, and the puerperium in the Utrecht population: case-crossover study and standardized incidence ratio estimation
    Andreas T Tiel Groenestege
    Department of Neurology, G03 225, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 40:1148-51. 2009
    ..It is unclear whether the risk of aneurysmal subarachnoid hemorrhage (aSAH) is increased during pregnancy, labor, and the puerperium. We compared the risk of aSAH during this period with the risk outside this period...
  4. doi request reprint Diagnosing cerebral collateral flow patterns: accuracy of non-invasive testing
    Jeroen Hendrikse
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 25:430-7. 2008
    ....
  5. doi request reprint Limb-shaking transient ischaemic attacks in patients with internal carotid artery occlusion: a case-control study
    Suzanne Persoon
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Brain 133:915-22. 2010
    ....
  6. ncbi request reprint Prevalence and volume of internal border zone lesions in patients with impaired cerebral carbon dioxide vasomotor reactivity: a follow-up study
    Robertus H C Bisschops
    Department of Radiology, University Medical Center, Utrecht, The Netherlands
    Arch Neurol 60:1233-6. 2003
    ..The precise etiology of border zone infarcts is controversial. Hemodynamic impairment due to obstructive disease of the internal carotid artery (ICA) is suggested as a cause of border zone infarcts...
  7. ncbi request reprint Cognitive impairment is related to cerebral lactate in patients with carotid artery occlusion and ipsilateral transient ischemic attacks
    Floor C Bakker
    Department of Neurology, University Medical Center Utrecht, PO Box 85090, 3508 AB Utrecht, The Netherlands
    Stroke 34:1419-24. 2003
    ..We sought to assess whether cognitive impairment in these patients is associated with hemodynamic compromise and/or impaired cerebral metabolism...
  8. ncbi request reprint Symptomatic carotid artery occlusion: flow territories of major brain-feeding arteries
    Peter Jan van Laar
    Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Radiology 242:526-34. 2007
    ..To prospectively investigate the extent of flow territories of the contralateral internal carotid artery (ICA) and vertebrobasilar arteries in patients with symptomatic ICA occlusion...
  9. ncbi request reprint Spect measurements of regional cerebral perfusion and carbondioxide reactivity: correlation with cerebral collaterals in internal carotid artery occlusive disease
    Michiel J de Boorder
    Department of Radiology, University Medical Center, Utrecht, The Netherlands
    J Neurol 253:1285-91. 2006
    ..The aim of the present study was to assess the regional variation in cerebral perfusion, vasomotor reactivity (VMR) and the role of cerebral collaterals in patients with symptomatic internal carotid artery (ICA)...
  10. pmc Bilateral carotid artery occlusion with transient or moderately disabling ischaemic stroke: clinical features and long-term outcome
    Suzanne Persoon
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, G03 228, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    J Neurol 256:1728-35. 2009
    ..Although this study was not designed to compare conservative treatment with surgical intervention, the favourable outcome suggests that a policy of medical therapy and control of risk factors may be justified in these patients...
  11. pmc Day-to-day test-retest variability of CBF, CMRO2, and OEF measurements using dynamic 15O PET studies
    Jochem P Bremmer
    Department of Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Imaging Biol 13:759-68. 2011
    ....
  12. ncbi request reprint Cerebrovascular reactivity within perfusion territories in patients with an internal carotid artery occlusion
    Reinoud P H Bokkers
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Neurol Neurosurg Psychiatry 82:1011-6. 2011
    ....
  13. doi request reprint Treatment of brain arteriovenous malformations: a systematic review and meta-analysis
    Janneke Van Beijnum
    Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    JAMA 306:2011-9. 2011
    ..Outcomes following treatment of brain arteriovenous malformations (AVMs) with microsurgery, embolization, stereotactic radiosurgery (SRS), or combinations vary greatly between studies...
  14. doi request reprint Assessment of the contribution of the external carotid artery to brain perfusion in patients with internal carotid artery occlusion
    Peter Jan van Laar
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 39:3003-8. 2008
    ..The purpose of this study was to prospectively investigate the contribution of the ipsilateral external carotid artery (ECA) to cerebral perfusion in patients with internal carotid artery occlusion...
  15. ncbi request reprint Management of patients with symptomatic carotid artery occlusion
    L Jaap Kappelle
    University Department of Neurology, University Medical Center Utrecht and the Rudolf Magnus Institute for Neurosciences, Utrecht, The Netherlands
    Clin Exp Hypertens 24:631-7. 2002
    ..For stenosis of the contralateral internal or ipsilateral external carotid artery endarterectomy may be considered. Ongoing symptoms may cease after tapering of antihypertensive medication...
  16. ncbi request reprint Cognitive impairment in patients with carotid artery occlusion and ipsilateral transient ischemic attacks
    Floor C Bakker
    Dept of Neurology Sector of Neuropsychology KG 01 327 1, University Medical Center Utrecht, 85090, 3508 AB, Utrecht, The Netherlands
    J Neurol 250:1340-7. 2003
    ..The presence of cognitive deficits in patients with isolated retinal symptoms and in those without cerebral ischemic lesions on MRI argues against an exclusive role for structural brain damage in the pathogenesis of these deficits...
  17. ncbi request reprint Effect of carotid endarterectomy on primary collateral blood flow in patients with severe carotid artery lesions
    Jeroen Hendrikse
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 34:1650-4. 2003
    ..The purpose of the present study was to assess the effect of CEA on the anatomy and function of the circle of Willis...
  18. doi request reprint High-flow extracranial-to-intracranial excimer laser-assisted nonocclusive anastomosis bypass for symptomatic carotid artery occlusion
    Tristan P C van Doormaal
    Department of Neurosurgery, University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    Neurosurgery 68:1687-94; discussion 1694. 2011
    ..A high-flow bypass is theoretically more effective than a conventional low-flow bypass in preventing strokes in patients with symptomatic carotid artery occlusion and a compromised hemodynamic state of the brain...
  19. doi request reprint Symptomatic internal carotid artery occlusion: a long-term follow-up study
    Suzanne Persoon
    Department of Neurology, University Medical Centre Utrecht, G03 228, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Neurol Neurosurg Psychiatry 82:521-6. 2011
    ..Information on outcome of patients with occlusion of the internal carotid artery (ICA) is limited by the short duration of follow-up and lack of haemodynamic studies on the brain...
  20. doi request reprint External validation of the secondary intracerebral hemorrhage score in The Netherlands
    Charlotte J J van Asch
    From the Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience C J J v A, G J E R, A A, C J M K, Department of Radiology B K V, Julius Center for Health Sciences and Primary Care J P G, A A, University Medical Center Utrecht, Utrecht, The Netherlands and Department of Radiology, University Medical Center Groningen, Groningen, The Netherlands P J v L
    Stroke 44:2904-6. 2013
    ..We aimed to validate externally in a setting outside the United States the secondary intracerebral hemorrhage (ICH) score that was developed to predict the probability of macrovascular causes in patients with nontraumatic ICH...
  21. doi request reprint Regional differences in incidence and patient characteristics of moyamoya disease: a systematic review
    Rachel Kleinloog
    Utrecht Stroke Centre, Rudolf Magnus Institute of Neuroscience, Department of Neurology and Neurosurgery, University Medical Centre Utrecht, The Netherlands
    J Neurol Neurosurg Psychiatry 83:531-6. 2012
    ..In other countries, incidences and presenting symptoms may differ from those in Japan. The literature on regional differences in incidence and patient characteristics of MMD was systematically reviewed...
  22. doi request reprint Predictors of patency of excimer laser-assisted nonocclusive extracranial-to-intracranial bypasses
    Jochem P Bremmer
    Departments of Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    J Neurosurg 110:887-95. 2009
    ..Information on predictors of patency of EC-IC bypasses in general and the ELANA bypass in particular is sparse. The authors studied 159 ELANA EC-IC bypasses to find predictors of patency...
  23. pmc Arterial spin labeling perfusion MRI at multiple delay times: a correlative study with H(2)(15)O positron emission tomography in patients with symptomatic carotid artery occlusion
    Reinoud P H Bokkers
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 30:222-9. 2010
    ..1+/-1.0 mL/min/100 g). In conclusion, ASL-MRI at multiple TIs is capable of depicting areas of regions with low CBF in patients with an occlusion of the ICA, although a systematic overestimation of CBF relative to H(2)(15)O PET was noted...
  24. doi request reprint Arterial spin labeling perfusion MRI in children and young adults with previous ischemic stroke and unilateral intracranial arteriopathy
    Marcel M M Bulder
    UMC Utrecht Stroke Centre, Department of Neurology and Child Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 37:14-21. 2014
    ....
  25. pmc Comparison of oxygen-15 PET and transcranial Doppler CO2-reactivity measurements in identifying haemodynamic compromise in patients with symptomatic occlusion of the internal carotid artery
    Suzanne Persoon
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, G03, 232, Utrecht, Heidelberglaan 100, 3584 CX, The Netherlands
    EJNMMI Res 2:30. 2012
    ..abstract:..
  26. ncbi request reprint Excimer laser-assisted high-flow extracranial/intracranial bypass in patients with symptomatic carotid artery occlusion at high risk of recurrent cerebral ischemia: safety and long-term outcome
    Catharina J M Klijn
    University Department of Neurology, University Medical Center Utrecht, and the Rudolf Magnus Institute of Neurosciences, Utrecht, The Netherlands
    Stroke 33:2451-8. 2002
    ....
  27. doi request reprint Comparison of telephone and face-to-face assessment of the modified Rankin Scale
    Paula M Janssen
    Department of Neurology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 29:137-9. 2010
    ..We assessed the validity of a telephone interview in patients who had had an aneurysmal subarachnoid haemorrhage (SAH) by comparing it with a face-to-face assessment...
  28. doi request reprint Early intracerebral hematoma expansion after aneurysmal rupture
    Charlotte J J van Asch
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Stroke 41:2592-5. 2010
    ..Intracerebral hematomas (ICHs) often increase in size in the initial hours. It is unknown whether expansion of ICHs after aneurysmal rupture in the acute phase is always a sign of rerupture of the original aneurysm...
  29. ncbi request reprint Association between impaired carbon dioxide reactivity and ischemic lesions in arterial border zone territories in patients with unilateral internal carotid artery occlusion
    Robertus H C Bisschops
    Department of Radiology E01 132, University Medical Center, Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Arch Neurol 60:229-33. 2003
    ....
  30. ncbi request reprint Collateral flow and ischemic brain lesions in patients with unilateral carotid artery occlusion
    R H C Bisschops
    Department of Radiology, University Medical Center Utrecht, The Netherlands
    Neurology 60:1435-41. 2003
    ..To investigate the association between ischemic brain lesions and intracranial collateral blood flow in patients with unilateral occlusion of the internal carotid artery (ICA)...
  31. pmc Spinal arteriovenous shunts presenting as intracranial subarachnoid haemorrhage
    J van Beijnum
    Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands
    J Neurol 254:1044-51. 2007
    ..One of these causes is a spinal arteriovenous shunt (SAVS). The aim of this study was to investigate the characteristics of patients with SAVS who present with intracranial SAH without symptoms and signs suggesting a spinal cause...
  32. pmc Familial occurrence of brain arteriovenous malformations: a systematic review
    J van Beijnum
    Department of Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, The Netherlands
    J Neurol Neurosurg Psychiatry 78:1213-7. 2007
    ..We compared the characteristics of patients with familial BAVMs with those of patients with sporadic BAVMs...
  33. doi request reprint Arterial spin-labeling MR imaging measurements of timing parameters in patients with a carotid artery occlusion
    R P H Bokkers
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    AJNR Am J Neuroradiol 29:1698-703. 2008
    ..In this study, we investigated the consequences of an internal carotid artery (ICA) occlusion and collateral blood flow on regional timing parameters...
  34. ncbi request reprint Recent advances in moyamoya disease: pathophysiology and treatment
    Annick Kronenburg
    Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, UMC Utrecht, Postbus 85500, 3508 GA, Utrecht, The Netherlands
    Curr Neurol Neurosci Rep 14:423. 2014
    ..Many questions regarding the indication for and timing of surgery remain unanswered. In this review, we discuss recent developments in the pathogenesis and treatment of moyamoya disease. ..
  35. doi request reprint Transcranial Doppler ultrasonography CO2 reactivity does not predict recurrent ischaemic stroke in patients with symptomatic carotid artery occlusion
    Wilmar M T Jolink
    Utrecht Stroke Center, Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands
    Cerebrovasc Dis 37:30-7. 2014
    ....
  36. doi request reprint Female risk factors for subarachnoid hemorrhage: a systematic review
    Annemijn M Algra
    UMC Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, Utrecht, Sweeden
    Neurology 79:1230-6. 2012
    ..To systematically review the literature on female risk factors and risk of SAH...
  37. doi request reprint The course of unilateral intracranial arteriopathy in young adults with arterial ischemic stroke
    Marcel M M Bulder
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, HP G03 228, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Stroke 43:1890-6. 2012
    ..Unilateral intracranial focal nonprogressive arteriopathy is often found in children with arterial ischemic stroke. We aimed to investigate the course of unilateral intracranial arteriopathy in young adults...
  38. doi request reprint Outcome after spontaneous and arteriovenous malformation-related intracerebral haemorrhage: population-based studies
    Janneke Van Beijnum
    Department of Neurology, University Medical Center Utrecht, The Netherlands
    Brain 132:537-43. 2009
    ..79, 0.67-0.93). Outcome after AVM-ICH is better than after sICH, independent of patient age and other known predictors of ICH outcome...
  39. ncbi request reprint Venous stasis retinopathy in symptomatic carotid artery occlusion: prevalence, cause, and outcome
    Catharina J M Klijn
    University Department of Neurology, University Medical Center Utrecht and the Rudolf Magnus Institute for Neurosciences, Utrecht, The Netherlands
    Stroke 33:695-701. 2002
    ..The aim of this study was to gain insight into the prevalence, cause, and outcome of VSR in patients with symptomatic CAO...
  40. pmc Cortical microinfarcts on 7T MRI in patients with spontaneous intracerebral hemorrhage
    Susanne J van Veluw
    Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 34:1104-6. 2014
    ..This explorative study shows, for the first time, that microinfarcts appear to be a very common vascular comorbidity in spontaneous ICH. Future larger studies should further assess the etiological significance of these lesions. ..
  41. ncbi request reprint Extracranial to intracranial bypass
    Catharina J M Klijn
    Department of Neurology, University Medical Center Utrecht, Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands
    Adv Neurol 92:329-33. 2003
  42. ncbi request reprint Recurrent stroke in patients with symptomatic carotid artery occlusion is associated with high-volume flow to the brain and increased collateral circulation
    D R Rutgers
    Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Stroke 35:1345-9. 2004
    ....
  43. ncbi request reprint Quantitative cerebral perfusion MRI and CO2 reactivity measurements in patients with symptomatic internal carotid artery occlusion
    M J P van Osch
    Image Sciences Institute, Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuroimage 17:469-78. 2002
    ..Our results indicate that an increase in TBP reflects a poor development of collateral flow, which is supported by a relatively low CO2 reactivity in these patients...
  44. pmc Polymorphisms in ACVRL1 and endoglin genes are not associated with sporadic and HHT-related brain AVMs in Dutch patients
    Kim Boshuisen
    Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Heidelberglaan 100, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Transl Stroke Res 4:375-8. 2013
    ..86; 95% CI: 1.32-2.61, p<0.001). We did not replicate the previously found association between a polymorphism in ACVRL1 IVS3-35A>G and BAVM in Dutch patients. However, meta-analysis did not rule out a possible effect...
  45. ncbi request reprint Collateral circulation via the ophthalmic artery or leptomeningeal vessels is associated with impaired cerebral vasoreactivity in patients with symptomatic carotid artery occlusion
    J Hofmeijer
    University Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 14:22-6. 2002
    ....
  46. ncbi request reprint Cognition and quality of life in patients with carotid artery occlusion: a follow-up study
    F C Bakker
    Department of Neurology, University Medical Center Utrecht, and Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    Neurology 62:2230-5. 2004
    ..Little is known about long-term cognitive functioning and quality of life (QoL) in patients with symptomatic carotid artery occlusion who do not undergo revascularization surgery...