Jan A K W Kiel

Summary

Affiliation: University of Groningen
Country: The Netherlands

Publications

  1. pmc Degeneration of penicillin production in ethanol-limited chemostat cultivations of Penicillium chrysogenum: A systems biology approach
    Rutger D Douma
    Department of Biotechnology, Delft University of Technology, Kluyver Centre for Genomics of Industrial Fermentation, BC Delft, The Netherlands
    BMC Syst Biol 5:132. 2011
  2. ncbi request reprint PEX genes in fungal genomes: common, rare or redundant
    Jan A K W Kiel
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, PO Box 14, NL 9750 AA Haren, The Netherlands
    Traffic 7:1291-303. 2006
  3. ncbi request reprint The 4th Hansenula polymorpha Worldwide Network Conference, Haren (The Netherlands), 3-5 September 2006
    Jan A K W Kiel
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, PO Box 14, NL 9750 AA, Haren, The Netherlands
    FEMS Yeast Res 7:167-71. 2007
  4. ncbi request reprint Overproduction of translation elongation factor 1-alpha (eEF1A) suppresses the peroxisome biogenesis defect in a Hansenula polymorpha pex3 mutant via translational read-through
    Jan A K W Kiel
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, The Netherlands
    FEMS Yeast Res 7:1114-25. 2007
  5. doi request reprint Proteins involved in microbody biogenesis and degradation in Aspergillus nidulans
    Jan A K W Kiel
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, PO Box 14, NL 9750 AA Haren, The Netherlands
    Fungal Genet Biol 46:S62-71. 2009
  6. doi request reprint Matching the proteome to the genome: the microbody of penicillin-producing Penicillium chrysogenum cells
    Jan A K W Kiel
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, AA Haren, The Netherlands
    Funct Integr Genomics 9:167-84. 2009
  7. pmc Autophagy in unicellular eukaryotes
    Jan A K W Kiel
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, PO Box 14, 9750 Haren, The Netherlands
    Philos Trans R Soc Lond B Biol Sci 365:819-30. 2010
  8. ncbi request reprint Penicillium chrysogenum Pex5p mediates differential sorting of PTS1 proteins to microbodies of the methylotrophic yeast Hansenula polymorpha
    Jan A K W Kiel
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, P O Box 14, Haren NL 9750 AA, The Netherlands
    Fungal Genet Biol 41:708-20. 2004
  9. ncbi request reprint Atg21p is essential for macropexophagy and microautophagy in the yeast Hansenula polymorpha
    Adriana N Leão-Helder
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
    FEBS Lett 577:491-5. 2004
  10. doi request reprint Novel genetic tools for Hansenula polymorpha
    Ruchi Saraya
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, Kluyver Centre for Genomics of Industrial Fermentation, University of Groningen, Groningen, The Netherlands
    FEMS Yeast Res 12:271-8. 2012

Collaborators

Detail Information

Publications49

  1. pmc Degeneration of penicillin production in ethanol-limited chemostat cultivations of Penicillium chrysogenum: A systems biology approach
    Rutger D Douma
    Department of Biotechnology, Delft University of Technology, Kluyver Centre for Genomics of Industrial Fermentation, BC Delft, The Netherlands
    BMC Syst Biol 5:132. 2011
    ....
  2. ncbi request reprint PEX genes in fungal genomes: common, rare or redundant
    Jan A K W Kiel
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, PO Box 14, NL 9750 AA Haren, The Netherlands
    Traffic 7:1291-303. 2006
    ..These proteins belong to two groups of peroxins that we propose to designate the Pex11p and Pex23p families. This redundancy may complicate future studies on peroxisome biogenesis and proliferation in fungal species...
  3. ncbi request reprint The 4th Hansenula polymorpha Worldwide Network Conference, Haren (The Netherlands), 3-5 September 2006
    Jan A K W Kiel
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, PO Box 14, NL 9750 AA, Haren, The Netherlands
    FEMS Yeast Res 7:167-71. 2007
  4. ncbi request reprint Overproduction of translation elongation factor 1-alpha (eEF1A) suppresses the peroxisome biogenesis defect in a Hansenula polymorpha pex3 mutant via translational read-through
    Jan A K W Kiel
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, The Netherlands
    FEMS Yeast Res 7:1114-25. 2007
    ..Subsequent co-overexpression of TEF2 in this strain fully restored its peroxisome biogenesis defect and resulted in the formation of major amounts of full-length Pex3p, presumably via translational read-through...
  5. doi request reprint Proteins involved in microbody biogenesis and degradation in Aspergillus nidulans
    Jan A K W Kiel
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, PO Box 14, NL 9750 AA Haren, The Netherlands
    Fungal Genet Biol 46:S62-71. 2009
    ..However, both processes have features that more closely resemble organelle formation/degradation in mammals rather than yeast. Thus, filamentous fungi like A. nidulans are ideal model systems for peroxisome homeostasis in man...
  6. doi request reprint Matching the proteome to the genome: the microbody of penicillin-producing Penicillium chrysogenum cells
    Jan A K W Kiel
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, AA Haren, The Netherlands
    Funct Integr Genomics 9:167-84. 2009
    ..We show that this protein indeed localizes to P. chrysogenum microbodies...
  7. pmc Autophagy in unicellular eukaryotes
    Jan A K W Kiel
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, PO Box 14, 9750 Haren, The Netherlands
    Philos Trans R Soc Lond B Biol Sci 365:819-30. 2010
    ..Additionally, a detailed analysis will be presented on the state of knowledge on autophagy in non-yeast unicellular eukaryotes with emphasis on the role of this process in differentiation...
  8. ncbi request reprint Penicillium chrysogenum Pex5p mediates differential sorting of PTS1 proteins to microbodies of the methylotrophic yeast Hansenula polymorpha
    Jan A K W Kiel
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, P O Box 14, Haren NL 9750 AA, The Netherlands
    Fungal Genet Biol 41:708-20. 2004
    ..polymorpha counterpart. This was also suggested by the observation that Pc-Pex5p sorted a reporter protein fused to various functional PTS1 signals with different efficiencies...
  9. ncbi request reprint Atg21p is essential for macropexophagy and microautophagy in the yeast Hansenula polymorpha
    Adriana N Leão-Helder
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
    FEBS Lett 577:491-5. 2004
    ..In atg21 cells subjected to macropexophagy conditions, sequestration of peroxisomes tagged for degradation is initiated but fails to complete...
  10. doi request reprint Novel genetic tools for Hansenula polymorpha
    Ruchi Saraya
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, Kluyver Centre for Genomics of Industrial Fermentation, University of Groningen, Groningen, The Netherlands
    FEMS Yeast Res 12:271-8. 2012
    ..Finally, we show the implementation of Gateway technology and a single-step PCR strategy to create deletions in H. polymorpha...
  11. ncbi request reprint Reprogramming Hansenula polymorpha for penicillin production: expression of the Penicillium chrysogenum pcl gene
    Loknath Gidijala
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB University of Groningen, Haren, The Netherlands
    FEMS Yeast Res 7:1160-7. 2007
    ..Mutation of the PTS1 of PCL (SKI-COOH) to SKL-COOH restored sorting of the fusion protein to peroxisomes only. Additionally, we demonstrate that peroxisomal PCL-SKL produced in H. polymorpha displays normal enzymatic activities...
  12. doi request reprint Peroxisome fission in Hansenula polymorpha requires Mdv1 and Fis1, two proteins also involved in mitochondrial fission
    Shirisha Nagotu
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, PO Box 14, 9750 AA Haren, The Netherlands
    Traffic 9:1471-84. 2008
    ..Also, in H. polymorpha mdv1 or fis1 cells, the number of Dnm1-GFP spots is strongly reduced. These spots still associate to organelles but are functionally inactive...
  13. ncbi request reprint Hansenula polymorpha Swi1p and Snf2p are essential for methanol utilisation
    Paulina Ozimek
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    FEMS Yeast Res 4:673-82. 2004
    ..The level of Pex5p, the receptor involved in import of alcohol oxidase and dihydroxyacetone synthase into peroxisomes, was also reduced in both disruption strains compared to that in wild-type cells...
  14. ncbi request reprint Atg8 is essential for macropexophagy in Hansenula polymorpha
    Iryna Monastyrska
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, PO Box 14, 9750 AA Haren, The Netherlands
    Traffic 6:66-74. 2005
    ..We hypothesize that H. polymorpha Atg8 facilitates sealing of the sequestering membranes during selective peroxisome degradation...
  15. pmc An engineered yeast efficiently secreting penicillin
    Loknath Gidijala
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, Haren, The Netherlands
    PLoS ONE 4:e8317. 2009
    ..g. immunosuppressive and cytostatic agents), whose production involves NRPS's...
  16. pmc Peroxisomes are required for efficient penicillin biosynthesis in Penicillium chrysogenum
    Wiebe H Meijer
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kluyver Centre for Genomics of Industrial Fermentation, P O Box 14, 9750 AA Haren, The Netherlands
    Appl Environ Microbiol 76:5702-9. 2010
    ..We observed that the organelle proliferation machinery requires the dynamin-like protein Dnm1...
  17. pmc De novo peroxisome biogenesis in Penicillium chrysogenum is not dependent on the Pex11 family members or Pex16
    Łukasz Opaliński
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, Kluyver Centre for Genomics of Industrial Fermentation, AG Groningen, The Netherlands
    PLoS ONE 7:e35490. 2012
    ..chrysogenum. Remarkably, distinct from earlier results with low penicillin producing laboratory strains, upregulation of peroxisome numbers in a high producing P. chrysogenum strain had no significant effect on penicillin production...
  18. ncbi request reprint Overproduction of a single protein, Pc-Pex11p, results in 2-fold enhanced penicillin production by Penicillium chrysogenum
    Jan A K W Kiel
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, PO Box 14, NL 9750 AA Haren, The Netherlands
    Fungal Genet Biol 42:154-64. 2005
    ..Our results suggest that the stimulating effect of enhanced organelle numbers may reflect an increase in the fluxes of penicillin and/or its precursors across the now much enlarged microbody membrane...
  19. ncbi request reprint ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes
    Wiebe H Meijer
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands
    Autophagy 3:106-16. 2007
    ..This suggests that in fungi an organism-specific form of selective autophagy may occur, for which specialized Atg proteins have evolved...
  20. pmc Autophagy deficiency promotes beta-lactam production in Penicillium chrysogenum
    Magdalena Bartoszewska
    Molecular Cell Biology, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Appl Environ Microbiol 77:1413-22. 2011
    ..This phenomenon is associated with an increase in the enzyme levels of the PEN biosynthetic pathway and enhanced production levels of this antibacterial compound...
  21. ncbi request reprint Selective degradation of peroxisomes in yeasts
    Anna Rita Bellu
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, 9751 NN Haren, The Netherlands
    Microsc Res Tech 61:161-70. 2003
    ..This review highlights the main achievements of the last years...
  22. ncbi request reprint A conserved alpha helical domain at the N-terminus of Pex14p is required for PTS1 and PTS2 protein import in Hansenula polymorpha
    Bart de Vries
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, 9750 AA, Haren, The Netherlands
    FEBS Lett 581:5627-34. 2007
    ..An extensive mutational analysis of the first alpha-helix (aa 10-21) demonstrated that its secondary structure, as well as residues Phe20 and Leu21, are essential for PTS1 and PTS2 matrix protein import...
  23. doi request reprint A conserved function for Inp2 in peroxisome inheritance
    Ruchi Saraya
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, Kluyver Centre for Genomics of Industrial Fermentation, AA Haren, The Netherlands
    Biochim Biophys Acta 1803:617-22. 2010
    ..Our data show that H. polymorpha Inp2 locates to peroxisomes, interacts with Myo2, and is essential for peroxisome inheritance...
  24. ncbi request reprint The Hansenula polymorpha ATG25 gene encodes a novel coiled-coil protein that is required for macropexophagy
    Iryna Monastyrska
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands
    Autophagy 1:92-100. 2005
    ..polymorpha is only observed at nitrogen limitation conditions. This suggests that nonselective microautophagy is deregulated in H. polymorpha atg25 cells...
  25. ncbi request reprint Hansenula polymorpha Vam7p is required for macropexophagy
    Patricia Stevens
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, P O Box 14, 9751 AA Haren, The Netherlands
    FEMS Yeast Res 5:985-97. 2005
    ..These morphological defects became first visible in cells that were in the mid-exponential growth phase of cultivation on methanol, and were correlated with accumulation of electron-dense extensions that were connected to mitochondria...
  26. ncbi request reprint Obstruction of polyubiquitination affects PTS1 peroxisomal matrix protein import
    Jan A K W Kiel
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, P O Box 14, NL 9750 AA Haren, The Netherlands
    Biochim Biophys Acta 1745:176-86. 2005
    ..We speculate that the degradation of Pex5p by the proteasome is important to remove receptor molecules that are stuck at a late stage of the Pex5p-mediated protein import pathway...
  27. ncbi request reprint Removal of Pex3p is an important initial stage in selective peroxisome degradation in Hansenula polymorpha
    Anna Rita Bellu
    Eukaryotic Microbiology, University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute, Biological Center, P O Box 14, 9750 AA Haren, The Netherlands
    J Biol Chem 277:42875-80. 2002
    ..Taken together, our data suggest that degradation of Pex3p is part of the initial degradation machinery of individual peroxisomes...
  28. ncbi request reprint The Hansenula polymorpha PDD7 gene is essential for macropexophagy and microautophagy
    Janet A Komduur
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, Kerklaan 30, 9751 NN, Haren, The Netherlands
    FEMS Yeast Res 3:27-34. 2003
    ..Our data indicate that HpPdd7p is essential for two processes that degrade peroxisomes, namely the highly selective process of macropexophagy and microautophagy, which occurs in H. polymorpha upon nitrogen starvation...
  29. pmc Membrane curvature during peroxisome fission requires Pex11
    Łukasz Opaliński
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, Kluyver Centre for Genomics of Industrial Fermentation, Haren, The Netherlands
    EMBO J 30:5-16. 2011
    ..Finally, we demonstrate that mutations abolishing the membrane remodelling activity of the Pex11-Amph domain also hamper the function of full-length Pex11 in peroxisome fission in vivo...
  30. doi request reprint Penicillium chrysogenum Pex14/17p--a novel component of the peroxisomal membrane that is important for penicillin production
    Lukasz Opaliński
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands
    FEBS J 277:3203-18. 2010
    ..Possibly, this compensates for the fact that P. chrysogenum lacks an authenthic Pex17p. We also show that, in P. chrysogenum, Pex14/17p plays a role in making the penicillin biosynthesis process more efficient...
  31. doi request reprint Preserving organelle vitality: peroxisomal quality control mechanisms in yeast
    Eda Bener Aksam
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, Haren, The Netherlands
    FEMS Yeast Res 9:808-20. 2009
    ..This review provides an overview of the major processes involved in quality control of yeast peroxisomes...
  32. ncbi request reprint A peroxisomal lon protease and peroxisome degradation by autophagy play key roles in vitality of Hansenula polymorpha cells
    Eda Bener Aksam
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, Haren, The Netherlands
    Autophagy 3:96-105. 2007
    ....
  33. ncbi request reprint Hansenula polymorpha Tup1p is important for peroxisome degradation
    Adriana N Leão-Helder
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    FEMS Yeast Res 4:789-94. 2004
    ..The initial DNA fragment that complemented H. polymorpha pdd2-4 contained a second gene, encoding H. polymorpha Vps4p. Deletion of the VPS4 gene did not affect selective peroxisome degradation...
  34. pmc Production of functionally active Penicillium chrysogenum isopenicillin N synthase in the yeast Hansenula polymorpha
    Loknath Gidijala
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    BMC Biotechnol 8:29. 2008
    ..One of the fundamental challenges is to produce functionally active enzyme in H. polymorpha...
  35. ncbi request reprint Peroxisome homeostasis in Hansenula polymorpha
    Adriana N Leão
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, Kerklaan 30, 9751 NN, Haren, The Netherlands
    FEMS Yeast Res 4:131-9. 2003
    ..Thus, it has become essential to study in detail the role of peroxisomal membrane proteins in the degradation process. This review highlights the main achievements of the last few years, with emphasis on H. polymorpha...
  36. ncbi request reprint Transcriptional down-regulation of peroxisome numbers affects selective peroxisome degradation in Hansenula polymorpha
    Adriana Nívea Leao-Helder
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren 9750 AA, The Netherlands
    J Biol Chem 278:40749-56. 2003
    ..We show that this mechanism is a general phenomenon in H. polymorpha in the case of cells that contain only a single peroxisome...
  37. doi request reprint The Penicillium chrysogenum aclA gene encodes a broad-substrate-specificity acyl-coenzyme A ligase involved in activation of adipic acid, a side-chain precursor for cephem antibiotics
    Martijn J Koetsier
    Biochemical Laboratory, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, 9747 AG Groningen, The Netherlands
    Fungal Genet Biol 47:33-42. 2010
    ..Identification and functional characterization of aclA may aid in developing future metabolic engineering strategies for improving the production of different cephalosporins...
  38. ncbi request reprint Macropexophagy in Hansenula polymorpha: facts and views
    Jan A K W Kiel
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, Kerklaan 30, 9751 NN, Haren, The Netherlands
    FEBS Lett 549:1-6. 2003
    ..Here, we highlight recent achievements in regulation of peroxisome turnover in yeast, in particular Hansenula polymorpha, with a focus on directions of future research...
  39. doi request reprint Pexophagy in Hansenula polymorpha
    Tim van Zutphen
    Molecular Cell Biology, University of Groningen, The Netherlands
    Methods Enzymol 451:197-215. 2008
    ..polymorpha. Emphasis is placed on various structural (fluorescence microscopy, electron microscopy) and biochemical (specific enzyme activity measurements, Western blotting) approaches...
  40. ncbi request reprint Hansenula polymorpha Pex3p is a peripheral component of the peroxisomal membrane
    Gert Jan Haan
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    J Biol Chem 277:26609-17. 2002
    ..Taken together, our data suggest that HpPex3p does not span the peroxisomal membrane but instead is tightly associated to the cytosolic face of the organelle where it may be present in focal protein clusters...
  41. ncbi request reprint Characterization of the Hansenula polymorpha PUR7 gene and its use as selectable marker for targeted chromosomal integration
    Gert Jan Haan
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    FEMS Yeast Res 2:17-24. 2002
    ..The advantages of pHIPA4 and the new triple auxotrophic strain in relation to the use of H. polymorpha as a versatile cell factory or as a model organism for fundamental studies on the principles of peroxisome homeostasis is discussed...
  42. pmc Uptake of the beta-lactam precursor alpha-aminoadipic acid in Penicillium chrysogenum is mediated by the acidic and the general amino acid permease
    Hein Trip
    Department of Microbiology, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
    Appl Environ Microbiol 70:4775-83. 2004
    ..chrysogenum. The transport measurements demonstrate that both PcGap1 and PcDip5 contribute to the alpha-aminoadipic acid flux...
  43. ncbi request reprint Peroxisome assembly in yeast
    Marten Veenhuis
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, NL 9750 AA Haren, The Netherlands
    Microsc Res Tech 61:139-50. 2003
    ..This review summarizes relevant recent data on this subject. In addition, the progress in the understanding of the principles of the peroxisomal matrix protein import machinery is discussed...
  44. ncbi request reprint Old yellow enzyme confers resistance of Hansenula polymorpha towards allyl alcohol
    Janet A Komduur
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
    Curr Genet 41:401-6. 2002
    ..Our data suggest that the proteins encoded by these genes detoxify acrolein by converting it into less harmful components...
  45. doi request reprint The role of macroautophagy in development of filamentous fungi
    Magdalena Bartoszewska
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands
    Antioxid Redox Signal 14:2271-87. 2011
    ..This review also summarizes the state of knowledge on the role of autophagy in filamentous fungi during differentiation, such as pathogenic development, programmed cell death during heteroincompatibility, and spore formation...
  46. ncbi request reprint Microautophagy and macropexophagy may occur simultaneously in Hansenula polymorpha
    Iryna Monastryska
    Laboratory of Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    FEBS Lett 568:135-8. 2004
    ..Our combined data strongly suggest that both processes occur simultaneously under these conditions. The implications of these findings on studies of autophagy and related transport pathways to the vacuole in yeast are discussed...
  47. ncbi request reprint Pexophagy: the selective autophagy of peroxisomes
    William A Dunn
    Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, Florida, USA
    Autophagy 1:75-83. 2005
    ..Utilizing several genetic screens, we have identified a number of genes that are essential for pexophagy. In this review, we will summarize our current knowledge of the molecular events of pexophagy...
  48. ncbi request reprint Ubiquitination of the peroxisomal targeting signal type 1 receptor, Pex5p, suggests the presence of a quality control mechanism during peroxisomal matrix protein import
    Jan A K W Kiel
    Abteilung für Zellbiochemie, Medizinische Fakultät der Ruhr Universität Bochum, Germany
    J Biol Chem 280:1921-30. 2005
    ..Our data suggest that during receptor recycling a portion of Pex5p becomes ubiquitinated and degraded by the proteasome. We propose that this process represents a conserved quality control mechanism in peroxisome biogenesis...
  49. ncbi request reprint Pexophagy: autophagic degradation of peroxisomes
    Yasuyoshi Sakai
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake, Kyoto 606 8502, Japan
    Biochim Biophys Acta 1763:1767-75. 2006
    ..Subsequently, the engulfed peroxisome cluster is degraded. This review discusses the current state of knowledge of pexophagy with emphasis on studies on methylotrophic yeast species...