M J H Kas

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi request reprint Refinement of behavioural traits in animals for the genetic dissection of eating disorders
    Martien J H Kas
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Eur J Pharmacol 480:13-20. 2003
  2. ncbi request reprint Dissecting complex behaviours in the post-genomic era
    Martien J H Kas
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, Behavioural Genomics Section, University Medical Centre Utrecht, Utrecht, The Netherlands
    Trends Neurosci 27:366-9. 2004
  3. ncbi request reprint Differential regulation of agouti-related protein and neuropeptide Y in hypothalamic neurons following a stressful event
    Martien J H Kas
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, 3584 CG Utrecht, The Netherlands
    J Mol Endocrinol 35:159-64. 2005
  4. ncbi request reprint Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men
    M J H Kas
    Department of Pharmacology and Anatomy, Behavioural Genomics Section, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Mol Psychiatry 12:324-30. 2007
  5. doi request reprint High-resolution genetic mapping of mammalian motor activity levels in mice
    M J H Kas
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Genes Brain Behav 8:13-22. 2009
  6. doi request reprint Dopaminergic and brain-derived neurotrophic factor signalling in inbred mice exposed to a restricted feeding schedule
    C Gelegen
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, Behavioural Genomics Section, University Medical Centre Utrecht, Utrecht, The Netherlands
    Genes Brain Behav 7:552-9. 2008
  7. doi request reprint Chromosomal mapping of excessive physical activity in mice in response to a restricted feeding schedule
    C Gelegen
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Centre Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:317-26. 2010
  8. pmc The MC4 receptor and control of appetite
    R A H Adan
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, Utrecht, The Netherlands
    Br J Pharmacol 149:815-27. 2006
  9. doi request reprint Neurobiology driving hyperactivity in activity-based anorexia
    R A H Adan
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre, Utrecht, The Netherlands
    Curr Top Behav Neurosci 6:229-50. 2011
  10. pmc The impact of hyperactivity and leptin on recovery from anorexia nervosa
    A A van Elburg
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    J Neural Transm 114:1233-7. 2007

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Refinement of behavioural traits in animals for the genetic dissection of eating disorders
    Martien J H Kas
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Eur J Pharmacol 480:13-20. 2003
    ..This would probably optimise phenotype-based candidate gene analysis in humans...
  2. ncbi request reprint Dissecting complex behaviours in the post-genomic era
    Martien J H Kas
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, Behavioural Genomics Section, University Medical Centre Utrecht, Utrecht, The Netherlands
    Trends Neurosci 27:366-9. 2004
    ..Here, we plead for multi-day automated behavioural observations in carefully designed environments...
  3. ncbi request reprint Differential regulation of agouti-related protein and neuropeptide Y in hypothalamic neurons following a stressful event
    Martien J H Kas
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, 3584 CG Utrecht, The Netherlands
    J Mol Endocrinol 35:159-64. 2005
    ..This may contribute to increased sensitivity for alpha-MSH to activate the HPA axis following a repeated stressful experience...
  4. ncbi request reprint Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men
    M J H Kas
    Department of Pharmacology and Anatomy, Behavioural Genomics Section, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Mol Psychiatry 12:324-30. 2007
    ....
  5. doi request reprint High-resolution genetic mapping of mammalian motor activity levels in mice
    M J H Kas
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Genes Brain Behav 8:13-22. 2009
    ..Our findings provide a novel QTL and a potential downstream target underlying motor circuitry development and the expression of physical activity levels...
  6. doi request reprint Dopaminergic and brain-derived neurotrophic factor signalling in inbred mice exposed to a restricted feeding schedule
    C Gelegen
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, Behavioural Genomics Section, University Medical Centre Utrecht, Utrecht, The Netherlands
    Genes Brain Behav 7:552-9. 2008
    ..Differences in gene expression and behaviour between A/J and C57BL/6J mice indicate that mouse genetic mapping populations based on these progenitor lines are valuable for identifying molecular determinants of anorexia-related traits...
  7. doi request reprint Chromosomal mapping of excessive physical activity in mice in response to a restricted feeding schedule
    C Gelegen
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Centre Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:317-26. 2010
    ..Therefore, our data open new roads for interspecies genetic studies of AN and for unraveling novel mechanisms and potential effective treatment strategies for these neurobehavioral traits...
  8. pmc The MC4 receptor and control of appetite
    R A H Adan
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, Utrecht, The Netherlands
    Br J Pharmacol 149:815-27. 2006
    ..Application of MCR agonists in humans has already revealed side effects, such as penile erections, which may complicate introduction of these drugs in the treatment of obesity...
  9. doi request reprint Neurobiology driving hyperactivity in activity-based anorexia
    R A H Adan
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre, Utrecht, The Netherlands
    Curr Top Behav Neurosci 6:229-50. 2011
    ..In anorexia nervosa patients, this altered activity of the dopamine system may be involved not only in hyperactivity but also in aberrant cognitive processing related to food...
  10. pmc The impact of hyperactivity and leptin on recovery from anorexia nervosa
    A A van Elburg
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    J Neural Transm 114:1233-7. 2007
    ..No major relationship of activity with the course of recovery was detected, suggesting that in contrast to the acute stage of the disease, leptin and activity levels during the recovery process are dissociated...
  11. ncbi request reprint Agouti-related protein prevents self-starvation
    M J H Kas
    Department of Medical Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Mol Psychiatry 8:235-40. 2003
    ..We conclude that self-starvation may result from insufficient suppression of central melanocortin receptor activity...
  12. doi request reprint Leptin's effect on hyperactivity: potential downstream effector mechanisms
    J J G Hillebrand
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre, Utrecht, The Netherlands
    Physiol Behav 94:689-95. 2008
    ..The mechanisms involved in this process are, however, unknown. Here we describe potential downstream effector mechanisms involved in the attenuation of hyperactivity by leptin treatment in ABA rats...
  13. doi request reprint Phenotyping mouse chromosome substitution strains reveal multiple QTLs for febrile seizure susceptibility
    E V S Hessel
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Genes Brain Behav 8:248-55. 2009
    ..This will increase our understanding of human FS, working toward the identification of new therapeutic targets...
  14. doi request reprint Variations in ventral root axon morphology and locomotor behavior components across different inbred strains of mice
    J G de Mooij-van Malsen
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuroscience 164:1477-83. 2009
    ..These data verifies the complex nature of the mammalian motor system that may be further dissected using genetic mapping populations derived from these inbred strains...
  15. doi request reprint Evidence for epigenetic interactions for loci on mouse chromosome 1 regulating open field activity
    J G de Mooij-van Malsen
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Behav Genet 39:176-82. 2009
    ..Our findings indicate that epigenetic interactions can play an important role in the identification of behavioral QTLs and must be taken into consideration when applying behavioral genetic strategies...
  16. ncbi request reprint The appetite suppressant d-fenfluramine reduces water intake, but not food intake, in activity-based anorexia
    J J G Hillebrand
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universtiteitsweg 100, 3584 CG Utrecht, The Netherlands
    J Mol Endocrinol 36:153-62. 2006
    ..We conclude that d-FEN treatment does not enhance ABA under the experimental conditions of this study, but strongly reduces water intake in ABA rats...
  17. ncbi request reprint Novel approach to the behavioural characterization of inbred mice: automated home cage observations
    L de Visser
    Department of Animals Science and Society, Utrecht University, Utrecht, The Netherlands
    Genes Brain Behav 5:458-66. 2006
    ..Moreover, it avoids the confounding influence of human intervention and saves time-consuming human observations...
  18. doi request reprint In search for significant cognitive features in Klinefelter syndrome through cross-species comparison of a supernumerary X chromosome
    H Bruining
    Department of Psychiatry Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University of Utrecht, The Netherlands
    Genes Brain Behav 10:658-62. 2011
    ..Similar cross-species evaluations of standard mouse behavioral paradigms in different genetic contexts may be powerful tools to optimize genotype-phenotype relationships...
  19. ncbi request reprint alpha-MSH enhances activity-based anorexia
    Jacquelien J G Hillebrand
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3594 CG Utrecht, The Netherlands
    Peptides 26:1690-6. 2005
    ..Here it is shown that chronic alpha-MSH treatment enhances ABA by increasing running wheel activity (RWA), decreasing food intake and increasing HPA axis activation...
  20. ncbi request reprint Voluntary access to a warm plate reduces hyperactivity in activity-based anorexia
    Jacquelien J G Hillebrand
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Physiol Behav 85:151-7. 2005
    ..These data suggest that ABA rats prefer to prevent hypothermia passively by choosing a warm plate rather than actively regulating body temperature by hyperactivity...
  21. ncbi request reprint Olanzapine reduces physical activity in rats exposed to activity-based anorexia: possible implications for treatment of anorexia nervosa?
    Jacquelien J G Hillebrand
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Biol Psychiatry 58:651-7. 2005
    ..This study investigated whether treatment with olanzapine (Zyprexa) reduces the development of ABA in rats. The effect of olanzapine treatment in AN patients was also evaluated in a small open-label study...
  22. ncbi request reprint Phenotypic segregation of aphakia and Pitx3-null mutants reveals that Pitx3 deficiency increases consolidation of specific movement components
    Martien J H Kas
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Behav Brain Res 186:208-14. 2008
    ..Thus, Pitx3 is not involved in the expression of nighttime motor activity levels, but is critical for selective mdDA neuronal activity and associated with increased consolidation of movement...
  23. ncbi request reprint Induction of brain-region-specific forms of obesity by agouti
    Martien J H Kas
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, 3584 CG Utrecht, The Netherlands
    J Neurosci 24:10176-81. 2004
    ....
  24. pmc Reduced anorexigenic efficacy of leptin, but not of the melanocortin receptor agonist melanotan-II, predicts diet-induced obesity in rats
    Gertjan van Dijk
    Department of Animal Physiology, Biological Center, Haren, The Netherlands
    Endocrinology 146:5247-56. 2005
    ..Thus, differences in leptin but not MC signaling might underlie DIO, visceral obesity, and insulin resistance...
  25. ncbi request reprint Mu-opioid receptor knockout mice show diminished food-anticipatory activity
    Martien J H Kas
    Ethology and Animal Welfare, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 17, NL 3584 CL Utrecht, The Netherlands
    Eur J Neurosci 20:1624-32. 2004
    ..These data overall suggest a role for mu-opioid receptors in adapting reward related behaviour to the requirements of the environment...
  26. ncbi request reprint Melanocortin system and eating disorders
    Roger A H Adan
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, Utrecht, The Netherlands
    Ann N Y Acad Sci 994:267-74. 2003
    ..Furthermore, we found a polymorphism, Ala67Thr AgRP, that was observed more frequently in anorexia nervosa...
  27. ncbi request reprint AgRP(83-132) and SHU9119 differently affect activity-based anorexia
    Jacquelien J G Hillebrand
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Eur Neuropsychopharmacol 16:403-12. 2006
    ..This implies that modulation of constitutive MC receptor activity rather than antagonizing putative alpha-MSH release contributes to the development and propagation of ABA...
  28. ncbi request reprint Inverse agonism gains weight
    Roger A H Adan
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Trends Pharmacol Sci 24:315-21. 2003
    ..The identification of AgRP as an endogenous inverse agonist provides physiological relevance to inverse agonism in the control of body weight...
  29. ncbi request reprint Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness
    Corine E de Rijke
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Utrecht, The Netherlands
    Biochem Pharmacol 70:308-16. 2005
    ..Taken together, no evidence was found for a functional defect of Thr67 AgRP related to MC4R interactions...
  30. doi request reprint Differential genetic regulation of motor activity and anxiety-related behaviors in mice using an automated home cage task
    Martien J H Kas
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Behav Neurosci 122:769-76. 2008
    ..g., anxiety-related and motor activity domains) with different underlying genetic origin and pharmacological responsiveness...
  31. ncbi request reprint Behavioral, physiological, and molecular differences in response to dietary restriction in three inbred mouse strains
    Cigdem Gelegen
    Department of Pharmacology and Anatomy, Behavioural Genomics Section, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, The Netherlands
    Am J Physiol Endocrinol Metab 291:E574-81. 2006
    ....
  32. ncbi request reprint Leptin treatment in activity-based anorexia
    Jacquelien J G Hillebrand
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 58:165-71. 2005
    ..Previously it was shown that leptin treatment reduced semi-starvation-induced hyperactivity in rats. The present study was performed to confirm and extend this finding, to evaluate leptin's effect on energy balance in ABA...
  33. ncbi request reprint Predictors of recovery of ovarian function during weight gain in anorexia nervosa
    Annemarie A Van Elburg
    Rudolf Magnus Institute of Neuroscience Department of Child and Adolescent Psychiatry, University Medical Center, Utrecht, The Netherlands
    Fertil Steril 87:902-8. 2007
    ..To investigate whether serum levels of follicle-stimulating hormone (FSH), inhibin B, and anti-Müllerian hormone (AMH) can be used as predictors of recovery of ovarian function in anorexia nervosa after weight gain...
  34. ncbi request reprint Effects of genetic background and environmental novelty on wheel running as a rewarding behaviour in mice
    Leonie de Visser
    Department of Animals, Science and Society, Utrecht University, Utrecht, The Netherlands Rudolf Magnus Institute of Neuroscience, UMC Utrecht, The Netherlands
    Behav Brain Res 177:290-7. 2007
    ..As it is displayed spontaneously and easy to monitor, wheel running may be well suitable to be included in high-throughput phenotyping assays...
  35. ncbi request reprint To eat or not to eat; regulation by the melanocortin system
    Jacquelien J G Hillebrand
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Utrecht, The Netherlands
    Physiol Behav 89:97-102. 2006
    ..As the MC system is involved in animal models of obesity and (possibly) anorexia, it appears that this is a target system for development of drugs for the treatment of disturbed human eating behavior...
  36. ncbi request reprint Difference in susceptibility to activity-based anorexia in two inbred strains of mice
    Cigdem Gelegen
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
    Eur Neuropsychopharmacol 17:199-205. 2007
    ....